期刊
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
卷 53, 期 2, 页码 109-115出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/FJC.0b013e3181970c01
关键词
grape seed proanthocyanidins; isoproterenol; myocardial injury; mitochondrial cytochromes
资金
- Indian Council of Medical Research (ICMR), New Delhi
The present study was done to evaluate the role of grape seed proanthocyanidins (GSPs) in isoproterenol (ISO)-induced myocardial injury in rats. Male albino Wistar rats were pretreated with GSP (50, 100, and 150 mg/kg). 6 days a week, for 5 weeks. Induction of rats with ISO (85 mg/kg body weight, intraperitoneally) for 2 days resulted in a significant elevation of thiobarbituric acid reactive substances in serum, mitochondrial cholesterol, triglycerides, and Free fatty ac ds. A significant decrease was observed in serum reduced glutathione; ascorbic acid; alpha-tocopherol; ceruloplasmin; and mitochondrial cyrochromes (h, c, cl, and aa3), phospholipids, and adenosinc triphosphate. Pretreatment with GSP (100 and 150 mg/kg) positively altered the levels of all the parameters studied and restored normal mitochondrial function when compared with ISO-induced rats. The effect at a dose of 50 mg/kg was not promising when compared with the other 2 (loses (100 and 150 mg/kg). These results confirm the efficacy of GSP in alleviating ISO-induced myocardial injury.
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