Review
Biology
Fabrizio Guarracini, Alberto Preda, Eleonora Bonvicini, Alessio Coser, Marta Martin, Silvia Quintarelli, Lorenzo Gigli, Matteo Baroni, Sara Vargiu, Marisa Varrenti, Giovanni Battista Forleo, Patrizio Mazzone, Roberto Bonmassari, Massimiliano Marini, Andrea Droghetti
Summary: The difference between subcutaneous implantable cardioverter defibrillators (S-ICDs) and transvenous ICDs (TV-ICDs) lies in the extra-thoracic implantation of S-ICDs, without endovascular components. S-ICDs have been rapidly adopted due to their improved safety profile, especially among younger patients. Although S-ICDs show comparable efficacy, reliability, and safety outcomes to TV-ICDs, technical issues limit their employment, making them an alternative rather than a mainstream option.
Article
Cardiac & Cardiovascular Systems
David G. Rosenthal, Christina D. Fang, Christopher A. Groh, Gregory Nah, Eric Vittinghoff, Thomas A. Dewland, Vasanth Vedantham, Gregory M. Marcus
Summary: Sarcoidosis is strongly associated with heart failure, atrioventricular block, and ventricular tachycardia, surpassing established risk factors for these cardiovascular outcomes. The presence of any cardiac involvement is the best predictor of these outcomes. Cardiovascular complications in sarcoidosis patients explain a significant proportion of the increased mortality risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Chengming Ma, Xiaomeng Yin, Yunlong Xia, Wenwen Li, Lianjun Gao, Shiyu Dai, Xiaohong Yu
Summary: DAVNNRT is a rare arrhythmia that is often misdiagnosed and requires a comprehensive understanding and timely intervention. This case highlights the potential for ICD discriminators to misdiagnose DAVNNRT as VT, underscoring the need to be vigilant against misdiagnosis risks.
Article
Cardiac & Cardiovascular Systems
Shohei Kataoka, Daigo Yagishita, Kyoichiro Yazaki, Miwa Kanai, Shun Hasegawa, Morio Shoda, Junichi Yamaguchi
Summary: This study investigated the association between T-peak to T-end interval (Tp-e) and ventricular arrhythmia (VA) events in patients with cardiac sarcoidosis (CS) who had implantable cardioverter defibrillators (ICDs) or cardiac resynchronization therapy defibrillators (CRT-Ds). The results showed that a Tp-e value greater than 91 ms was significantly associated with a histological diagnosis of CS and an increased risk of fatal disease progression.
CIRCULATION JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Barry J. Maron, N. A. Mark Estes, Ethan J. Rowin, Martin S. Maron, Matthew R. Reynolds
Summary: Implantable cardioverter-defibrillators (ICDs) have been the most significant advancement in cardiovascular medicine in the past 50 years. The development of ICDs was a result of the determination and vision of pioneers, and they have now become the primary prevention tool for sudden death in countless patients worldwide. Clinical trials have shown that ICDs can reduce mortality rates and they have been successfully used in the treatment of coronary disease and inherited arrhythmia conditions.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Lior Jankelson, Leonid Garber, Mark Sherrid, Daniele Massera, Paul Jones, Chirag Barbhaiya, Douglas Holmes, Robert Knotts, Scott Bernstein, Michael Spinelli, David Park, Anthony Aizer, Larry Chinitz
Summary: This study aimed to assess the incidence of ICD therapy in patients with HCM implanted with TV-ICD vs S-ICD in real-world settings.
Article
Radiology, Nuclear Medicine & Medical Imaging
Amita Singh, Wensu Chen, Hena N. Patel, Nazia Alvi, Keigo Kawaji, Stephanie A. Besser, Roderick Tung, Jiangang Zou, Roberto M. Lang, Victor Mor-Avi, Amit R. Patel
Summary: This study assessed the effects of wideband LGE imaging on device-related artifacts in different non-MR conditional ICD subtypes. The results showed that WB LGE imaging significantly reduced DRA burden in patients with TV-ICD, but had less impact on CRT-D and S-ICD patients. Despite greater residual artifacts in S-ICD patients with WB LGE imaging, the area of artifacts was smaller and had different characteristics compared to standard LGE imaging. Further developments are needed to better resolve S-ICD artifacts.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Review
Cardiac & Cardiovascular Systems
Johanna B. Tonko, Christopher A. Rinaldi
Summary: Implantable cardioverter-defibrillators (ICDs) have revolutionized the treatment of cardiac diseases. However, there is a need for alternative ICD configurations due to expanding patient groups and increasing complications associated with traditional devices.
Article
Cardiac & Cardiovascular Systems
Wolfram Grimm, Kathrin Grimm, Brandon Greene, Mariana Parahuleva
Summary: The study showed that pacing-dependency in patients with CIEDs is significantly associated with factors such as second or third-degree AV block, atrial fibrillation at implant, low LVEF, elevated BNP, chronic kidney disease, and follow-up duration after implantation exceeding 5 years. Other clinical variables like age, gender, diabetes mellitus, underlying heart disease, prior cardiac surgery, and medication during follow-up did not predict pacing-dependency.
CARDIOLOGY JOURNAL
(2021)
Review
Cardiac & Cardiovascular Systems
Domenico Corrado, Mark S. Link, Peter J. Schwartz
Summary: Many previously unexplained life-threatening ventricular arrhythmias and sudden cardiac deaths (SCDs) in young individuals are now recognized to be genetic in nature and are ascribed to a growing number of distinct inherited arrhythmogenic diseases. Risk assessment for SCD in patients with inherited arrhythmogenic diseases is challenging due to their lower frequency compared to coronary disease. Semi-automated systems are increasingly being used to dictate therapeutic choices, but their tendency to favour implantable cardioverter defibrillator (ICD) implantation may not always be justified.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Shohreh Honarbakhsh, Alexander Protonotarios, Christopher Monkhouse, Ross J. Hunter, Perry M. Elliott, Pier D. Lambiase
Summary: The aim of this study was to characterize VA events in ARVC patients and investigate if certain parameters can predict specific VA events. The results showed that ARVC patients had a high rate of VA events, with most of them being VT resulting in ICD shocks. Severely impaired RV function was an independent predictor of VT resulting in ATP.
Article
Cardiac & Cardiovascular Systems
Shuang Qian, Adam Connolly, Caroline Mendonca-Costa, Fernando Campos, Cristobal Rodero, John Whitaker, Christopher A. Rinaldi, Martin J. Bishop
Summary: This study aims to compare the efficacy of anti-tachycardia pacing (ATP) delivered at different locations relative to the re-entrant circuit and optimize ATP by minimizing re-initiation. The results show that ATP is more effective at terminating fast ventricular tachycardia (VT) when delivered proximal to the re-entrant circuit, while attenuating re-initiation through an early termination detection algorithm improves the overall efficacy for all VTs.
Article
Oncology
Martijn H. van der Ree, Wiert F. Hoeksema, Adrian Luca, Jorrit Visser, Brian Balgobind, Michiel Zumbrink, Raymond Spier, Claudia Herrera-Siklody, Justin Lee, Matthew Bates, Jim Daniel, Clive Peedell, Judit Boda-Heggemann, Boris Rudic, Roland Merten, Edith M. Dieleman, Cristopher A. Rinaldi, Shahreen Ahmad, John Whitaker, Pranav Bhagirath, Matthew Q. Hatton, Stephen Riley, Melanie Grehn, Luis Schiappacasse, Oliver Blanck, Stephan Hohmann, Etienne Pruvot, Pieter G. Postema
Summary: This retrospective study evaluated the impact of STAR treatment on ICD functioning. The results showed that within the reported dose range, STAR treatment did not result in major ICD malfunction or clinically relevant alterations in ICD functioning. This indicates that STAR treatment is safe in terms of ICD functioning.
RADIOTHERAPY AND ONCOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sakae Takenaka, Yuta Kobayashi, Toshiyuki Nagai, Yoshiya Kato, Hirokazu Komoriyama, Nobutaka Nagano, Kiwamu Kamiya, Takao Konishi, Takuma Sato, Kazunori Omote, Yoshifumi Mizuguchi, Atsushi Tada, Tomoya Sato, Hiroyuki Iwano, Kengo Kusano, Hatsue Ishibashi-Ueda, Toshihisa Anzai
Summary: The study aimed to assess the ICD recommendations for Japanese patients with cardiac sarcoidosis (CS) based on AHA/ACC/HRS guidelines. It found that ICD implantation may be applicable to patients requiring a permanent pacemaker or with late gadolinium enhancement, regardless of left ventricular ejection fractions (LVEF) <= 35%.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Hiroshi Hayashi, Wataru Shimizu, Yuki Iwasaki, Kenji Yodogawa, Takashi Noda, Takashi Nitta, Yoshifusa Aizawa, Tohru Ohe, Takashi Kurita
Summary: The study found that ATP was effective in managing electrical storms, avoiding painful shocks in over half of the patients. Additionally, patients treated with only ATP tended to have lower all-cause mortality rates compared to those who required shocks.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Krystina B. Lewis, David Birnie, Sandra L. Carroll, Carolynne Brousseau-Whaley, Lorraine Clark, Martin Green, Girish M. Nair, Pablo B. Nery, Calum Redpath, Dawn Stacey
Summary: This study evaluated the feasibility of a decision support intervention for patients facing ICD replacement decisions. Results showed that the intervention was used as intended with high knowledge improvement, despite slow recruitment, indicating potential to enhance decision quality for ICD replacement.
JOURNAL OF CARDIOVASCULAR NURSING
(2021)
Article
Cardiac & Cardiovascular Systems
Girish M. Nair, David H. Birnie, Glen L. Sumner, Andrew D. Krahn, Jeffrey S. Healey, Pablo B. Nery, Eli Kalfon, Atul Verma, Felix Ayala-Paredes, Benoit Coutu, Giuliano Becker, Francois Philippon, John Eikelboom, Roopinder K. Sandhu, John Sapp, Richard Leather, Derek Yung, Bernard Thibault, Christopher S. Simpson, Kamran Ahmad, Marcio Sturmer, Katherine Kavanagh, Eugene Crystal, George A. Wells, Vidal Essebag
Summary: The study identified multiple predictors of post-operative pain after CIED insertion and developed a prediction score for post-operative pain that can help identify individuals at risk for significant post-operative pain.
Article
Cardiac & Cardiovascular Systems
Simon P. Hansom, Wael Alqarawi, David H. Birnie, Mehrdad Golian, Pablo B. Nery, Calum J. Redpath, Andres Klein, Martin S. Green, Darryl R. Davis, Eva Sheppard-Perkins, F. Daniel Ramirez, Girish M. Nair, Mouhannad M. Sadek
Summary: The study compared HPSD AF ablation with LPLD ablation in terms of 1-year freedom from atrial arrhythmia, procedural times, and PV reconnection patterns, showing similar freedom rates but shorter procedure times and a higher rate of right carinal reconnections in the HPSD group during redo procedures.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2021)
Letter
Cardiac & Cardiovascular Systems
Pablo B. Nery, Girish M. Nair, David H. Birnie
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Review
Cardiac & Cardiovascular Systems
Wael Alqarawi, Omar Dewidar, Rafik Tadros, Jason D. Roberts, Christian Steinberg, Ciorsti J. MacIntyre, Zachary W. M. Laksman, Martin S. Green, Girish Nair, George Wells, Andrew D. Krahn
Summary: An evidence-based diagnostic algorithm for IVF was developed by systematically examining the yield of diagnostic testing in UCA probands. The comprehensive diagnostic testing yield was 43%, with lower yield when only definite diagnoses were used. Various tests were associated with different levels of yield in diagnosing IVF.
Article
Chemistry, Multidisciplinary
Marcelo Munoz, Cagla Eren Cimenci, Keshav Goel, Maxime Comtois-Bona, Mahir Hossain, Christopher McTiernan, Matias Zuniga-Bustos, Alex Ross, Brenda Truong, Darryl R. Davis, Wenbin Liang, Benjamin Rotstein, Marc Ruel, Horacio Poblete, Erik J. Suuronen, Emilio Alarcon
Summary: This article reports on the development and testing of a sprayable nanotherapeutic that can improve cardiac function and conductivity, reduce infarct size, and increase the number of blood vessels and cardiomyocytes in infarcted myocardium.
Article
Pharmacology & Pharmacy
Laurent Chouchana, Alice Blet, Mohammad Al-Khalaf, Tahir S. Kafil, Girish Nair, James Robblee, Milou-Daniel Drici, Marie-Blanche Valnet-Rabier, Joelle Micallef, Francesco Salvo, Jean-Marc Treluyer, Peter P. Liu
Summary: Myocarditis and pericarditis are potential adverse reactions of mRNA COVID-19 vaccines. This study found that these inflammatory heart reactions, mainly myocarditis, were more commonly reported in adolescents and young adults, particularly in male patients, but the overall risk of these reactions remains very rare.
CLINICAL PHARMACOLOGY & THERAPEUTICS
(2022)
Article
Cell & Tissue Engineering
Ramana Vaka, Saad Khan, Bin Ye, Yousef Risha, Sandrine Parent, David Courtman, Duncan J. Stewart, Darryl R. Davis
Summary: Inflammatory mediators implicated in the progression of COVID-19 ARDS do not alter the viability and paracrine production of three leading cell products under clinical evaluation, further validating their potential for treating severe COVID-19 ARDS.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Willy Weng, David H. Birnie, F. Daniel Ramirez, Cassidy Van Stiphout, Mehrdad Golian, Pablo B. Nery, Simon P. Hansom, Calum J. Redpath, Andres Klein, Girish M. Nair, Wael Alqarawi, Martin S. Green, Darryl R. Davis, Pasquale Santangelli, Robert D. Schaller, Francis E. Marchlinski, Mouhannad M. Sadek
Summary: This study prospectively assessed the outcomes and predictors of recurrence among AF patients who underwent repeat ablation with a standardized approach. The presence of PV reconnection was found to be the only factor independently associated with recurrence after repeat ablation.
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Correction
Cardiac & Cardiovascular Systems
Willy Weng, David H. Birnie, F. Daniel Ramirez, Cassidy Van Stiphout, Mehrdad Golian, Pablo B. Nery, Simon P. Hansom, Calum J. Redpath, Andres Klein, Girish M. Nair, Wael Alqarawi, Martin S. Green, Darryl R. Davis, Pasquale Santangeli, Robert D. Schaller, Francis E. Marchlinski, Mouhannad M. Sadek
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Jennifer L. Reed, Tasuku Terada, Sol Vidal-Almela, Heather E. Tulloch, Matheus Mistura, David H. Birnie, George A. Wells, Girish M. Nair, Harleen Hans, Kimberley L. Way, Daniele Chirico, Carley D. O'Neill, Andrew L. Pipe
Summary: This study compared the effects of 12 weeks of high-intensity interval training (HIIT) and moderate to vigorous intensity continuous training (MICT) on functional capacity and quality of life in patients with atrial fibrillation (AF). The results showed that both HIIT and MICT had similar effects in improving functional capacity, quality of life, resting heart rate, and physical activity levels in patients with persistent and permanent AF.
Article
Medicine, Research & Experimental
Ramana Vaka, Sandrine Parent, Yousef Risha, Saad Khan, David Courtman, Duncan J. Stewart, Darryl R. Davis
Summary: This study analyzed the microRNA and protein cargos within extracellular vesicles produced by three different clinical-grade stem cell products. Although there were some common microRNAs and proteins, each cell type expressed unique microRNA profiles. The extracellular vesicles promoted various biological functions and showed functional differences between stem cell products. These findings provide a framework for understanding the therapeutic effects of extracellular vesicles.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2023)
Review
Engineering, Biomedical
Kamal Malhotra, Sophie Van Remortel, Valentina Ly, Darryl R. Davis
Summary: Combining extracellular vesicles with biomaterials enhances therapeutic efficacy in preclinical heart failure models. The combination consistently improves cardiac function, highlighting its potential to modulate fibrosis and inflammation. Further research is needed to translate these results into effective clinical treatments for heart failure.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Medicine, Research & Experimental
Sandrine Parent, Ramana Vaka, Yousef Risha, Clarissa Ngo, Pushpinder Kanda, Stanley Nattel, Saad Khan, David Courtman, Duncan J. Stewart, Darryl R. Davis
Summary: This study found that extracellular vesicles isolated from cells of atrial fibrillation patients can prevent postoperative AF by reducing inflammation and fibrosis, providing a new effective strategy for prevention.
Article
Cardiac & Cardiovascular Systems
Jacqueline Joza, Girish M. Nair, David H. Birnie, Pablo B. Nery, Calum J. Redpath, Jean-Francois Sarrazin, Jean Champagne, Jordan Bernick, George A. Wells, Vidal Essebag
Summary: This study compares the clinical efficacy and safety outcomes of a high-power, short-duration (HPSD) strategy versus a low-power, long-duration (LPLD) strategy in patients with paroxysmal atrial fibrillation (AF) undergoing pulmonary vein isolation (PVI). The results show that the HPSD strategy has a significantly shorter procedural time and similar efficacy in terms of clinical arrhythmia recurrence compared to the LPLD strategy, without an increased risk of harm.
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2023)