Article
Cell & Tissue Engineering
Runfeng Zhang, Jiang Yu, Ningkun Zhang, Wensong Li, Jisheng Wang, Guocai Cai, Yu Chen, Yong Yang, Zhenhong Liu
Summary: The study aimed to evaluate the efficacy and safety of intracoronary autologous bone marrow mesenchymal stem cell (BM-MSC) transplantation in patients with ST-segment elevation myocardial infarction (STEMI). Results showed that BM-MSC transplantation did not significantly promote the recovery of left ventricular function and myocardial viability after acute myocardial infarction.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Cardiac & Cardiovascular Systems
Meredith A. Redd, Sarah E. Scheuer, Natalie J. Saez, Yusuke Yoshikawa, Han Sheng Chiu, Ling Gao, Mark Hicks, Jeanette E. Villanueva, Yashutosh Joshi, Chun Yuen Chow, Gabriel Cuellar-Partida, Jason N. Peart, Louise E. See Hoe, Xiaoli Chen, Yuliangzi Sun, Jacky Y. Suen, Robert J. Hatch, Ben Rollo, Di Xia, Mubarak A. H. Alzubaidi, Snezana Maljevic, Gregory A. Quaife-Ryan, James E. Hudson, Enzo R. Porrello, Melanie Y. White, Stuart J. Cordwell, John F. Fraser, Steven Petrou, Melissa E. Reichelt, Walter G. Thomas, Glenn F. King, Peter S. Macdonald, Nathan J. Palpant
Summary: Ischemia-reperfusion injury (IRI) is a major risk factor in cardiovascular disease, and acid-sensing ion channel 1a (ASIC1a) is significantly associated with cardiac IRI. Genetic ablation of ASIC1a improves cardiomyocyte viability after acute IRI, and therapeutic blockade of ASIC1a shows cardioprotective effects equivalent to benchmark drugs.
Article
Biotechnology & Applied Microbiology
Xiaoting Liang, Yuelin Zhang, Fang Lin, Mimi Li, Xin Li, Yu Chen, Jing Liu, Qingshu Meng, Xiaoxue Ma, Enhao Wang, Lu Wei, Zhiying He, Huimin Fan, Xiaohui Zhou, Yue Ding, Zhongmin Liu
Summary: Direct transplantation of mitochondria derived from mesenchymal stem cells (MSC-mt) can enhance blood vessel density, inhibit cardiac remodeling and apoptosis, thus improving heart function. MSC-mt also has protective effects on endothelial cells.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2023)
Review
Multidisciplinary Sciences
Mark M. Zaki, Emal Lesha, Khaled Said, Kiavash Kiaee, Lindsey Robinson-McCarthy, Haydy George, Angy Hanna, Evan Appleton, Songlei Liu, Alex H. M. Ng, Parastoo Khoshakhlagh, George M. Church
Summary: COVID-19 continues to burden society worldwide, with severe presentations lacking specific treatments. Cell therapies, with their customizability and regenerative function, offer great potential in treating severe COVID-19 cases beyond lung issues. There are currently 89 cell therapy trials ongoing in the field of COVID-19.
Article
Cell & Tissue Engineering
Armin Attar, Fateme Bahmanzadegan Jahromi, Shahin Kavousi, Ahmad Monabati, Asma Kazemi
Summary: Research on the role of mesenchymal stem cells (MSCs) in increasing ejection fraction (LVEF) after acute myocardial infarction (AMI) has sparked some controversy. This study found that transplantation of MSCs after AMI significantly increases LVEF, with a more pronounced effect if done within the first week after the heart attack. Further studies are needed to investigate long-term clinical outcomes such as heart failure and cardiovascular mortality.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Engineering, Environmental
Junlang Li, Yongbo Lv, Dashuai Zhu, Xuan Mei, Ke Huang, Xianyun Wang, Zhenhua Li, Sichen Zhang, Shiqi Hu, Kristen D. Popowski, Ke Cheng, Juan Wang
Summary: A comparison between intramyocardial (IM) injection and intrapericardial cavity (IPC) injection of adult stem cells in hydrogel showed that IPC injection led to better retention and therapeutic benefits, resulting in significant improvement in cardiac function. Furthermore, IPC delivery demonstrated better cellular proliferation, less apoptosis, and improved vascular regeneration in the myocardium. Additionally, IPC injections led to higher rates of MSC-exosome absorption by heart cells, indicating more extensive paracrine activity and showing promise as a solution for the low retention issue of MSCs in the infarcted heart.
CHEMICAL ENGINEERING JOURNAL
(2022)
Article
Biochemistry & Molecular Biology
Xiaoyan Gao, Xiaoting Liang, Baojuan Liu, Yimei Hong, Haiwei He, Ying Shen, Jiaqi Chen, Xinran Huang, Bei Hu, Weifeng Li, Xin Li, Yuelin Zhang
Summary: In this study, the role of ALKBH5 in regulating the senescence of mesenchymal stem cells (MSCs) was investigated. ALKBH5 was found to accelerate MSC senescence through the regulation of m6A modification and stability of CDKN1C mRNA. Knockdown of ALKBH5 rejuvenated aged MSCs and improved their therapeutic efficacy for myocardial infarction.
Article
Cell Biology
Hao Zhang, Chengling Zhao, Guojun Jiang, Bei Hu, Huifeng Zheng, Yimei Hong, Zhen Cui, Linli Shi, Xin Li, Fang Lin, Yue Ding, Lu Wei, Mimi Li, Xiaoting Liang, Yuelin Zhang
Summary: The study found that Apelin rejuvenated AMSCs by activating AMPK, promoting autophagy, and enhancing cardiac protection following myocardial infarction in mice.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Cell Biology
Moein Ala
Summary: Mesenchymal stem cells (MSCs) have regenerative, anti-inflammatory, and immunomodulatory properties. They attenuate various detrimental effects after myocardial infarction (MI) and improve cardiac function. MSC-derived exosomes also show promising effects in MI treatment. However, there are still modifiable factors that need to be optimized, such as timing and route of administration, as well as MSC pretreatment approaches. Future clinical trials should consider these advances to accurately assess the efficacy of MSCs or their exosomes for MI.
AGEING RESEARCH REVIEWS
(2023)
Review
Cell Biology
Yuchang Liu, Minrui Wang, Yang Yu, Chunhong Li, Chunxiang Zhang
Summary: Acute myocardial infarction, characterized by irreversible cardiomyocyte death and restricted blood supply, is the leading cause of death in coronary heart disease. Conventional reperfusion therapy can worsen myocardial injury. Stem cell therapy using mesenchymal stem cells (MSCs) has emerged as a promising approach for cardiac repair and function improvement. MSCs may exert their effects by secreting exosomes containing therapeutically active RNA, proteins, and lipids. Analyzing these vesicles can provide valuable insights into myocardial infarction pathology and guide the development of new treatments.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Cell & Tissue Engineering
Yuyan Xiong, Ruijie Tang, Junyan Xu, Wenyang Jiang, Zhaoting Gong, Lili Zhang, Yu Ning, Peisen Huang, Jun Xu, Guihao Chen, Xiaosong Li, Mengjin Hu, Jing Xu, Chunxiao Wu, Chen Jin, Xiangdong Li, Haiyan Qian, Yuejin Yang
Summary: This study found that pretreatment of mesenchymal stem cells (MSCs) with the Chinese medicine Tongxinluo (TXL) can enhance cardiac repair in acute myocardial infarction (AMI) by transferring miR-146a-5p through exosomes to target the IRAK1/NF-kappa B p65 pathway. This has significant potential for clinical translation.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cardiac & Cardiovascular Systems
Juan Hong, Shubin Fu, Lie Gao, Yanhui Cai, Eric Lazartigues, Han-Jun Wang
Summary: The dysfunction of voltage-gated potassium (Kv) channels in dorsal root ganglions plays a critical role in mediating the exaggerated exercise pressor reflex and muscle afferent sensitization in chronic heart failure (CHF) patients. Manipulating Kv channels in DRG neurons could be a potential new approach to reduce sympathoexcitation and improve exercise intolerance in CHF, ultimately enhancing quality of life and reducing mortality.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Huifeng Zheng, Xiaoting Liang, Qian Han, Zhuang Shao, Yuxiao Zhang, Linli Shi, Yimei Hong, Weifeng Li, Cong Mai, Qingwen Mo, Qingling Fu, Xiaoxue Ma, Fang Lin, Mimi Li, Bei Hu, Xin Li, Yuelin Zhang
Summary: The study demonstrates that Hemin-pretreated MSC-derived exosomes are more effective in treating myocardial infarction compared to regular MSC-derived exosomes, with exosomal miR-183-5p playing a key role in inhibiting cardiomyocyte senescence through regulation of the HMGB1/ERK pathway.
JOURNAL OF NANOBIOTECHNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Vineeta Sharma, Amit Manhas, Santosh Gupta, Madhu Dikshit, Kumaravelu Jagavelu, Rama Shanker Verma
Summary: Cell therapy is a promising approach for cardiac repair, but current delivery strategies have limitations. This study developed an engineered cardiogel patch (EBCP) using native decellularized cardiac extracellular matrix (ECM) and chitosan, enabling efficient regeneration of injured myocardium. The study also introduced a novel bio-adhesive for suture-free placement of EBCP on injured myocardium. The EBCP showed potential in promoting cell proliferation, adhesion, migration, and cardiomyogenic differentiation, and protecting cells in a myocardial infarction (MI) rat model. The epicardial implantation of EBCP loaded with MSCs improved cell retention and cardiac recovery in the rat model.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Review
Biochemistry & Molecular Biology
Hsuan Peng, Kazuhiro Shindo, Renee R. Donahue, Ahmed Abdel-Latif
Summary: Stem cell-based cardiac therapies present challenges in cell delivery, engraftment, and differentiation, but still lead to sustained cardiac benefits. Current research focuses on exploring the mechanisms of stem cell-mediated cardiac immunomodulation, with efforts to improve current strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cardiac & Cardiovascular Systems
Mohammed Ali Azam, Cory S. Wagg, Stephane Masse, Talha Farid, Patrick F. H. Lai, Marjan Kusha, John Asta, Rafael Jaimes, Sarah Kuzmiak-Glancy, Matthew W. Kay, Gary D. Lopaschuk, Kumaraswamy Nanthakumar
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2015)
Article
Biology
Karl Magtibay, Mohammadali Beheshti, Farbod Hosseyndoust Foomany, Stephane Masse, Patrick F. H. Lai, Nima Zamiri, John Asta, Kumaraswamy Nanthakumar, David Jaffray, Sridhar Krishnan, Karthikeyan Umapathy
COMPUTERS IN BIOLOGY AND MEDICINE
(2016)
Review
Cardiac & Cardiovascular Systems
Govind Krishna Kumar Nair, Stephane Masse, John Asta, Elias Sevaptisidis, Mohammed Ali Azam, Patrick F. H. Lai, Arul Veluppillaim, Karl Magtibay, Nicholas Jackson, Kumaraswamy Nanthakumar
Article
Cardiac & Cardiovascular Systems
Karl Magtibay, Stephane Masse, John Asta, Marjan Kusha, Patrick F. H. Lai, Mohammed Ali Azam, Andreu Porta-Sanchez, Shouvik Haldar, Daniel Malebranche, Christopher Labos, D. Curtis Deno, Kumaraswamy Nanthakumar
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2017)
Article
Cardiac & Cardiovascular Systems
Nima Zamiri, Stephane Masse, Andrew Ramadeen, Marjan Kusha, Xudong Hu, Mohammed Ali Azam, Jie Liu, Patrick F. H. Lai, Edward J. Vigmond, Patrick M. Boyle, Elham Behradfar, Abdul Al-Hesayen, Menashe B. Waxman, Peter Backx, Paul Dorian, Kumaraswamy Nanthakumar
Article
Cardiac & Cardiovascular Systems
Daoyuan Si, Mohammed Ali Azam, Patrick F. H. Lai, Nima Zamiri, Galina Kichigina, John Asta, Stephane Masse, Mahmoud M. Bokhari, Andreu Porta-Sanchez, Christopher Labos, Huan Sun, Ping Yang, Kumaraswamy Nanthakumar
JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY
(2018)
Meeting Abstract
Cardiac & Cardiovascular Systems
Marianne Wauchop, Mark Gagliardi, Naimeh Rafatian, Stephane Masse, Patrick Lai, Kelvin Chan Tung, Stephanie Protze, Erika Wang, Milica Radisic, Gordon Keller, Kumar Nanthakumar, Peter Backx
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Andreu Porta-Sanchez, Karl Magtibay, Sachin Nayyar, Abhishek Bhaskaran, Patrick F. H. Lai, Stephane Masse, Christopher Labos, Beiping Qiang, Rocco Romagnuolo, Hassan Masoudpour, Labonny Biswas, Nilesh Ghugre, Michael Laflamme, Don Curtis Deno, Kumaraswamy Nanthakumar
Review
Cardiac & Cardiovascular Systems
Abhishek Bhaskaran, Timothy Liang, Ahmed Niri, Mohammed Ali Azam, Stephane Masse, John Asta, Karl Magtibay, Patrick F. H. Lai, Christopher Labos, Andrew C. T. Ha, Kumaraswamy Nanthakumar
Summary: The study found that Max(Lead) has advantages in minimizing pacing threshold changes due to lead dislodgement and in providing multiple bipoles for pacing. In sensing, Max(V) consistently outperformed traditional bipolar voltage detection, and the electric field-loop geometry was able to differentiate ventricular activation under different conditions.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Abhishek Bhaskaran, Ahmed Niri, Mohammed Ali Azam, Sachin Nayyar, Andreu Porta-Sanchez, Stephane Masse, Timothy Liang, Arulalan Veluppillai, Beibei Du, Patrick F. H. Lai, Andrew Ha, Kumaraswamy Nanthakumar
Summary: Bipolar radiofrequency (RF) ablation at power of 20-30 W was found to provide an ideal balance of safety and efficacy, while caution should be exercised with power >40 W due to a high incidence of steam pops. Monitoring lesion transmurality and avoiding steam pops were best achieved using transmyocardial bipolar electrogram (EGM) amplitude and circuit impedance, respectively.
Letter
Cardiac & Cardiovascular Systems
Mahmoud M. Bokhari, Danna A. Spears, Patrick F. Lai, Daoyuan Si, Filio Billia, John D. Parker, Abdul O. Al-Hesayen, Mohammed A. Azam, Sheila Riazi, Kumaraswamy Nanthakumar
JACC-CLINICAL ELECTROPHYSIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Shouvik K. Haldar, Karl Magtibay, Andreu Porta-Sanchez, Stephane Masse, Nicholas Mitsakakis, Patrick F. H. Lai, Mohammed Ali Azam, John Asta, Marjan Kusha, Paul Dorian, Andrew C. T. Ha, Vijay Chauhan, D. Curtis Deno, Kumaraswamy Nanthakumar
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Mohammed Ali Azam, Nima Zamiri, Stephane Masse, Marjan Kusha, Patrick F. H. Lai, Govind K. Nair, Nigel S. Tan, Christopher Labos, Kumaraswamy Nanthakumar
CIRCULATION-ARRHYTHMIA AND ELECTROPHYSIOLOGY
(2017)
Article
Cardiac & Cardiovascular Systems
Nicholas Jackson, Sigfus Gizurarson, Mohammed Ali Azam, Benjamin King, Andrew Ramadeen, Nima Zamiri, Andreu Porta-Sanchez, Abdul Al-Hesayen, John Graham, Marjan Kusha, Stephane Masse, Patrick F. H. Lai, John Parker, Rohan John, Tim-Rasmus Kiehl, Govind Krishna Kumar Nair, Paul Dorian, Kumaraswamy Nanthakumar
CIRCULATION-CARDIOVASCULAR INTERVENTIONS
(2017)