Article
Oncology
Maria Rothgart Aabo, Anne-Mette Ragle, Peter Busch Ostergren, Anders Vinther
Summary: The study examined the reliability of the graded cycling test with talk test (GCT-TT) and the 30-second chair-stand test (30s-CST) in men with prostate cancer on androgen deprivation therapy (ADT). Results showed high relative reliability for 30s-CST and slightly lower for GCT-TT. Improvement of 1.9 repetitions on a group level and three repetitions for individual patients in 30s-CST, and improvement exceeding 19.9 W in GCT-TT are considered as real improvements.
SUPPORTIVE CARE IN CANCER
(2021)
Review
Cardiac & Cardiovascular Systems
Carlo A. Pivato, Rishi Chandiramani, Marija Petrovic, Johny Nicolas, Alessandro Spirito, Davide Cao, Roxana Mehran
Summary: Depression is common in patients with ischemic heart disease, and depressed patients are more likely to develop atherosclerosis and experience major cardiac events compared with the general population. The underlying pathophysiological mechanisms of these two diseases are highly interwoven and include an increased release of stress hormones, dysregulation of the autonomic nervous system, alterations of pathways related to primary and secondary hemostasis, endothelial dysfunction, and higher level of residual inflammation. Furthermore, depression negatively impacts compliance with medication regimens. Early recognition and treatment of depression provide the opportunity to improve outcomes of patients with ischemic heart disease.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Physiology
Siti Ruzita Mahmod, Leela T. Narayanan, Rumaisa Abu Hasan, Eko Supriyanto
Summary: This study compared the effectiveness of a newly introduced time-controlled monosyllabic Talk Test (tMTT) and a self-paced Counting Talk Test (CTT) in assessing exercise intensity. The results showed that the tMTT accurately delineated all exercise stages, while the CTT only accurately delineated certain stages. However, both tests showed similar effectiveness in estimating exercise intensity.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Medicine, General & Internal
Lourdes Vicent, Jose Guerra, Rafael Vazquez-Garcia, Jose R. Gonzalez-Juanatey, Luis Martinez Dolz, Javier Segovia, Domingo Pascual-Figal, Ramon Bover, Fernando Worner, Juan Delgado, Francisco Fernandez-Aviles, Manuel Martinez-Selles
Summary: This study aimed to investigate the impact of ischemic etiology on prognosis among men and women with heart failure. The results showed that ischemic etiology was not directly associated with mortality in HF patients, but was related to previous readmissions and chronic obstructive pulmonary disease in men, and diabetes in women in ischemic HF.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Margo B. Minissian, Puja K. Mehta, Sharonne N. Hayes, Ki Park, Janet Wei, C. Noel Bairey Merz, Leslie Cho, Annabelle Santos Volgman, Islam Y. Elgendy, Mamas Mamas, Melinda B. Davis, Harmony R. Reynolds, Kelly Epps, Kathryn Lindley, Malissa Wood, Odayme Quesada, Gregory Piazza, Carl J. Pepine
Summary: The Cardiovascular Disease in Women Committee of the American College of Cardiology formed a working group to address the rising mortality rates among young women aged 35 to 54. They reviewed published evidence and identified gaps in knowledge pertaining to young women's heart disease. The report provides clinicians with evidence-based management strategies and outlines future research directions.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Clinical Neurology
Raji Balasubramanian, Jie Hu, Marta Guasch-Ferre, Jun Li, Farzaneh Sorond, Yibai Zhao, Katherine H. Shutta, Jordi Salas-Salvado, Frank Hu, Clary B. Clish, Kathryn M. Rexrode
Summary: The study identified metabolites associated with stroke and created a stroke metabolite score, which improved the prediction of stroke risk.
Article
Clinical Neurology
Yume Imahori, Davide L. Vetrano, Petter Ljungman, Erika J. Laukka, Jing Wu, Giulia Grande, Debora Rizzuto, Laura Fratiglioni, Chengxuan Qiu
Summary: This study reveals the independent and joint effects of ischemic heart disease and coexisting atrial fibrillation and heart failure on dementia risk. Ischemic heart disease is associated with an increased risk of dementia and cognitive decline in older adults, independent of atrial fibrillation, heart failure, and cerebrovascular disease.
ALZHEIMERS & DEMENTIA
(2023)
Letter
Cardiac & Cardiovascular Systems
Michael C. Honigberg, Ravi B. Patel, Ambarish Pandey, Gregg C. Fonarow, Javed Butler, Darren K. McGuire, Muthiah Vaduganathan
Summary: This study aims to evaluate the association of heart failure and ischemic heart disease with diabetes complications.
Review
Medicine, General & Internal
Ana Maria Pello Lazaro, Luis M. Blanco-Colio, Juan Antonio Franco Pelaez, Jose Tunon
Summary: Inflammation plays a significant role in atherogenesis and plaque complications, with certain drugs showing anti-inflammatory effects. Inflammatory biomarkers can predict cardiovascular events. Some anti-inflammatory drugs have been successful in reducing the incidence of cardiovascular events.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Clinical Neurology
George Howard, Maciej Banach, Brett Kissela, Mary Cushman, Paul Muntner, Suzanne E. Judd, Virginia J. Howard
Summary: This study assessed the association between stroke risk factors and incident stroke, and evaluated whether the magnitude of this association is uniform across different age groups. The results showed that the associations of hypertension and diabetes with stroke significantly decreased in older age groups, while the associations of smoking, atrial fibrillation, and left ventricular hypertrophy with stroke did not vary with age.
Article
Biochemistry & Molecular Biology
Svetlana P. Chumakova, Olga I. Urazova, Vladimir M. Shipulin, Sergey L. Andreev, Olga A. Denisenko, Margarita V. Gladkovskaya, Larisa S. Litvinova, Mikhail A. Bubenchikov
Summary: This study aimed to investigate the angiopoietic endothelial dysfunction in ischemic cardiomyopathy (ICMP) patients. It was found that there was an imbalance in the number of endothelial progenitor cells (EPCs) and desquamated cells (EDCs) in ICMP patients. Additionally, alterations in the levels of HIF-1α, HIF-2α, ADMA, and endothelin-1 were observed in ICMP patients.
Article
Cardiac & Cardiovascular Systems
Arsalan Abu-Much, Eyal Nof, Nicola Luigi Bragazzi, Anan Younis, David Hochstein, Arwa Younis, Nir Shlomo, Alexander Fardman, Ilan Goldenberg, Robert Klempfner, Roy Beinart
Summary: This study found that Israeli Arab patients with established IHD have a higher all-cause mortality rate, with a 49% increased risk compared to Jewish patients.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Chemistry, Multidisciplinary
Zhan Zhang, Rinkoo Dalan, Zhenyu Hu, Jiong-Wei Wang, Nicholas Ws Chew, Kian-Keong Poh, Ru-San Tan, Tuck Wah Soong, Yunlu Dai, Lei Ye, Xiaoyuan Chen
Summary: Ischemic heart disease (IHD) is a leading cause of disability and death worldwide. Reactive oxygen species (ROS) play a key role in the progression of diabetes, hypertension, and hypercholesterolemia, which are independent risk factors for atherosclerosis and the development of IHD. Nanomedicines, as smart and multifunctional nanocarriers, are being extensively studied and explored for their synergistic therapeutic effects.
ADVANCED MATERIALS
(2022)
Review
Cardiac & Cardiovascular Systems
Shivaraj Patil, Chaitanya Rojulpote, Aman Amanullah
Summary: Cardiovascular disease, especially ischemic heart disease, is a major global cause of illness and death. Primary aldosteronism is the main cause of secondary hypertension, but it is often under-diagnosed. Recent studies have shown that excessive production of aldosterone is associated with an increased risk of ischemic heart disease, which is disproportionate to the effects caused by hypertension alone. Understanding primary hyperaldosteronism and the distinctive pathophysiology of ischemic heart disease in this condition is crucial for improving outcomes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Immunology
Xiaoqian Sun, Yanqin Li, Qiong Deng, Yueyao Hu, Jianteng Dong, Wei Wang, Yong Wang, Chun Li
Summary: Macrophages undergo metabolic reprogramming, which influences their inflammatory function. In ischemic heart disease, the polarization and metabolic shifts of macrophages can affect the balance of inflammatory effects and determine disease progression and prognosis.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Susanne Gron Nielsen, Anders Vinther
JOURNAL OF CARDIOPULMONARY REHABILITATION AND PREVENTION
(2016)
Article
Endocrinology & Metabolism
Susanne Gron Nielsen, Julie Hagstrom Danielsen, Sandra Schade Jacobsen, Peter Lommer Kristensen, Heidi Storgaard, Stig Molsted, Tina Vilsboll
Summary: Individualized supervised exercise for 12 weeks resulted in clinically relevant improvements in working and functional capacity, as well as health-related quality of life for patients with intermediate to high risk of T2D complications. Despite a higher dropout rate and adverse events, significant improvements were seen regardless of risk-stratification levels.
DIABETES RESEARCH AND CLINICAL PRACTICE
(2022)
Article
Oncology
Nanna Maria Hammer, Lisbeth Kofoed Egestad, Susanne Gron Nielsen, Eik Bjerre, Christoffer Johansend, Ingrid Egerod, Bernardine Pinto, Julie Midtgaard