Review
Cardiac & Cardiovascular Systems
Yixi Zhao, Longtao Liu, Shengjie Yang, Guijian Liu, Limin Pan, Chun Gu, Yang Wang, Dan Li, Ran Zhao, Min Wu
Summary: Postprandial lipemia is closely related to cardiovascular disease and research focuses on TG, TRL, VLDL, CM, and remnant cholesterol. Interventions such as diet, exercise, and medications can improve postprandial lipemia, with novel drugs like pemafibrate, PCSK9, and apoCIII inhibitors garnering attention. Studies on the gut microbiota and its potential impact on lipid metabolism and postprandial lipemia warrant further investigation.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Aditi Chopra, Thilini N. Jayasinghe, Joerg Eberhard
Summary: Periodontitis can increase the levels of AGEs, even in the absence of hyperglycemia. This explains the relationship between periodontitis and related diseases such as diabetes.
Article
Pharmacology & Pharmacy
Sajed Amjadi, Fatemeh Shahnaz, Behrooz Shokouhi, Yadollah Azarmi, Mohammadreza Siahi-Shadbad, Saeed Ghanbarzadeh, Maryam Kouhsoltani, Alireza Ebrahimi, Hamed Hamishehkar
Summary: Encapsulation of rutin into nanophytosomes showed enhanced therapeutic effects in diabetic rats by controlling hyperglycemia and hyperlipidemia, regulating liver marker enzymes, improving antioxidant defenses, and alleviating diabetic complications.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Review
Endocrinology & Metabolism
Maryam Armandeh, Behnaz Bameri, Hamed Haghi-Aminjan, Roham Foroumadi, Mahshid Ataei, Shokoufeh Hassani, Mahedeh Samadi, Mohammad Reza Hooshangi Shayesteh, Mohammad Abdollahi
Summary: This review explores the mechanisms of melatonin's effect on reproductive system damage caused by diabetes. Studies suggest that melatonin can improve the impact of diabetes on reproductive tissues and has antioxidant, anti-apoptotic, and anti-inflammatory effects.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Hematology
Jie Lin, Qian Ren, Fanjie Zhang, Jing Gui, Xin Xiang, Qin Wan
Summary: This study investigated the role and mechanism of beta-hydroxybutyrate dehydrogenase 1 (Bdh1) in regulating macrophage oxidative stress in diabetes-induced atherosclerosis (AS). The results showed that Bdh1 expression was decreased in patients with diabetes-induced AS, HG-treated macrophages, and diabetic Apoe(-/-) mice. AAV-mediated Bdh1 overexpression attenuated aortic plaque formation in diabetic Apoe(-/-) mice, while silencing of Bdh1 increased reactive oxygen species (ROS) production and an inflammatory response in macrophages.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Medicine, Research & Experimental
R. Dhanya
Summary: Quercetin, a bioflavonoid, shows promising potential in managing Type 2 diabetes and its complications. Further studies are needed to establish optimal dosing regimen and improve bioavailability.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Nutrition & Dietetics
Lianghua Wen, Dan Wu, Xindong Tan, Meiqi Zhong, Jiabao Xing, Wei Li, Dan Li, Fanrong Cao
Summary: This paper summarizes the important role of catechins in alleviating diabetes and its underlying mechanisms, providing scientific direction for future research on catechin alleviating diabetes.
Article
Biochemical Research Methods
Sarah C. Skinner, Travis Nemkov, Mor Diaw, Maimouna Ndour Mbaye, Demba Diedhiou, Djiby Sow, Fatou Gueye, Philomene Lopez, Philippe Connes, Angelo D'Alessandro
Summary: Epidemiological data suggests that the prevalence of type 2 diabetes (T2D) will increase the most in sub-Saharan Africa over the next two decades. Metabolomics studies have identified biomarkers that could enhance T2D diagnosis and monitoring. However, there is a lack of research on the metabolome of individuals from sub-Saharan Africa.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Clinical Neurology
R. Nisha Aurora, Naresh M. Punjabi
Summary: The study found that in adults with type 2 diabetes, the severity of obstructive sleep apnea (OSA) is associated with postprandial hyperglycemia after dinner, but not after breakfast or lunch. This association was present in men but not in women.
Review
Hematology
Karin E. Bornfeldt
Summary: Both type 1 and type 2 diabetes are associated with an increased risk of atherosclerotic cardiovascular disease. Recent findings suggest that increased levels of circulating remnant lipoproteins in people with diabetes could be the missing link between diabetes and CVD.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Food Science & Technology
Hemei Li, Jinling Zhou, Sitong Liu, Xiuting Chen, Tiantian Qin, Guodong Huang, Peizhen Luo, Ying Hu, Xing Xia
Summary: This research investigated the mechanism of flavonoids from Cinnamomum cassia on diabetes-related cognitive impairment (DRCI) using a network pharmacology approach. The results showed that Cinnamomum cassia flavonoids inhibited the formation of advanced glycation end products (AGEs) in vitro and in the brain of diabetic rats, and restored cognitive ability in the rats. Additionally, it alleviated hippocampal damage and oxidative stress, and decreased the levels of AGEs, RAGE, and pJNK/JNK in the hippocampus.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Review
Endocrinology & Metabolism
Karen Paola Ramos-Riera, Francisca Perez-Severiano, Maria Leonor Lopez-Meraz
Summary: The brain requires a lot of energy and its function can be affected by metabolic disturbances like diabetes, leading to changes in glucose levels and the occurrence of epileptic seizures. Oxidative stress also plays a role in the development of neurological disorders in diabetic patients.
METABOLIC BRAIN DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Stephanie D. Burr, Christopher C. Dorroh, James A. Stewart
Summary: Diabetics have an increased risk of heart failure due to changes in cardiac fibroblast function caused by AGE/RAGE signaling. The study found that Rap1a, a small GTPase, may play a role in mediating these changes. Rap1a activity was found to enhance the impact of AGEs in the diabetic extracellular matrix, leading to myofibroblast transition and oxidative stress.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Rajesh Kumar Goit, Tsz Chung Ng, Ka Cheung Tam, Jessica K. W. Tsang, Andrew W. Taylor, Amy C. Y. Lo
Summary: alpha-Melanocyte-stimulating hormone (alpha-MSH) has neuroprotective effects against ischemia/reperfusion (I/R) induced brain damage in experimental stroke associated with hyperglycemia, reducing neuron death, inflammation, and oxidative stress. The use of alpha-MSH analogues may be a potential therapeutic strategy for diabetic stroke.
NEUROCHEMICAL RESEARCH
(2022)
Review
Immunology
Maria Vargas-Soria, Monica Garcia-Alloza, Miriam Corraliza-Gomez
Summary: Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels and can cause damage to various organs, including the brain. Recent research suggests a link between diabetes and neurodegenerative diseases, potentially involving neuroinflammation and microglia. This systematic review investigated the effects of diabetes on microglial physiology and found that diabetes can modulate microglial phenotypic states and activate specific pathways.
JOURNAL OF NEUROINFLAMMATION
(2023)
Review
Cardiac & Cardiovascular Systems
Peiyue Zhang, Cuiyuan Huang, Haiyin Liu, Mengting Zhang, Li Liu, Yuhong Zhai, Jing Zhang, Jian Yang, Jun Yang
Summary: NFAT is a widely expressed transcriptional activator that is involved in regulating the immune system, heart and brain development, and mediating pathological processes such as cardiac hypertrophy. Oxidative stress, characterized by excessive production of reactive oxygen species, mitochondrial dysfunction, calcium overload, and subsequent lipid peroxidation, inflammation, and apoptosis, is associated with various pathological processes. Calcium overload activates NFAT through the calcium-calcineurin pathway, which is the main regulatory mode of NFAT factors. This review focuses on the effects of NFAT transcription factors on reactive oxygen species production, calcium overload, mitochondrial dysfunction, redox reactions, lipid peroxidation, inflammation, and apoptosis in response to oxidative stress. The aim is to provide a reference for understanding the functions and characteristics of NFAT in different stages of oxidative stress and related potential targets.
JOURNAL OF CARDIOLOGY
(2024)