Article
Multidisciplinary Sciences
Shengqing Gu, Stephanie Lheureux, Azin Sayad, Paulina Cybulska, Liat Hogen, Iryna Vyarvelska, Dongsheng Tu, Wendy R. Parulekar, Matthew Nankivell, Sean Kehoe, Dennis S. Chi, Douglas A. Levine, Marcus Q. Bernardini, Barry Rosen, Amit Oza, Myles Brown, Benjamin G. Neel
Summary: Researchers developed a mathematical framework to simulate tumor initiation in high-grade serous tubo-ovarian carcinoma (HGSC) and inferred that most patients harbor chemoresistant HGSC cells at diagnosis. Their study suggests that primary debulking surgery (PDS) is superior to neoadjuvant chemotherapy followed by surgery (NACT) if the tumor burden is small and complete debulking is achievable.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Cardiac & Cardiovascular Systems
David S. Goldstein, Mark J. Pekker, Patti Sullivan, Risa Isonaka, Yehonatan Sharabi
Summary: This study uses a computational model to investigate the progression of LBDs, the effect of genetic predispositions, and treatments on that progression. It predicts a triphasic decline in myocardial norepinephrine content and the effects of genetic variants and monoamine oxidase inhibition on catecholamines and alpha S levels in the myocardium.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Editorial Material
Environmental Sciences
Anargiros I. Delis, Ioannis K. Nikolos
Summary: This special issue focuses on the latest advances in hydraulic modeling based on non-linear shallow water equations (NSWEs) and their applications in practical engineering. NSWEs play a critical role in predicting tides, storm surge levels, coastline changes, and have attracted great attention for research on effective and accurate numerical methods for their solutions.
Article
Physiology
Suran Galappaththige, Pras Pathmanathan, Richard A. Gray
Summary: There are challenges in evaluating clinical cardiac mapping systems due to the inability to record transmembrane potential throughout the entire heart during patient procedures. A computational modeling framework has been developed to evaluate system performance, including the localization and characterization of arrhythmogenic sources. This framework allows for performance evaluation under various conditions and involves blind comparison against computer simulations of known transmembrane potential patterns.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Cardiac & Cardiovascular Systems
Stefania Scarsoglio, Luca Ridolfi
Summary: Computational hemodynamics is increasingly important in clinical applications and surgery involving the cardiovascular system. This review focuses on 0D-1D multiscale models of the arterial coronary system, particularly in relation to cardiac arrhythmias, which have significant effects on coronary circulation.
REVIEWS IN CARDIOVASCULAR MEDICINE
(2021)
Article
Engineering, Multidisciplinary
Vincenzo Castiglia, Nicola Campagna, Antonino Oscar Di Tommaso, Rosario Miceli, Claudio Nevoloso, Filippo Pellitteri, Christian Puccio, Fabio Viola
Summary: In this article, an improved three-branch model for supercapacitors is presented, which takes into account the residual charge phenomenon. The procedure for estimating the model parameters and the experimental setup are provided. The accuracy of the model is validated through experimental tests.
IEEE TRANSACTIONS ON INDUSTRY APPLICATIONS
(2022)
Article
Physiology
Anneloes G. Munneke, Joost Lumens, Theo Arts, Tammo Delhaas
Summary: This study implemented a multi-scale mathematical model that can realistically simulate coronary mechanics and hemodynamics. The model framework can be used as a research platform for in-depth studies on cardiac-to-coronary coupling and the effect of abnormal myocardial tissue properties on coronary hemodynamics.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Chemistry, Medicinal
Sameera Sansare, Hossain Aziz, Koyel Sen, Shivangi Patel, Bodhisattwa Chaudhuri
Summary: The fluidized bed is an essential equipment in process development and has been extensively studied for its wide application in various areas. This review paper focuses on the computational modeling of a fluidized bed in pharmaceutical applications, discussing the background of modeling and summarizing relevant research papers on pharmaceutical unit operations.
JOURNAL OF PHARMACEUTICAL SCIENCES
(2022)
Article
Computer Science, Theory & Methods
Changyuan Lin, Hamzeh Khazaei
Summary: The study addresses two issues related to the performance and cost prediction and optimization of serverless applications, proposing a new framework and algorithm to achieve accurate configurations. The analytical models show over 98% accuracy in predicting performance and cost, while the PRCP algorithm can optimize serverless applications with 97% accuracy on average.
IEEE TRANSACTIONS ON PARALLEL AND DISTRIBUTED SYSTEMS
(2021)
Article
Cell Biology
Henry Sutanto, Jordi Heijman
Summary: Cardiomyocyte calcium-handling is crucial for cardiac excitation-contraction coupling, but abnormalities can lead to arrhythmias. Due to the complexity of molecular interactions, studying the exact contribution of calcium-handling abnormalities to arrhythmias is challenging. Therefore, computational modeling combined with experiments is used to unravel the precise mechanisms of calcium-mediated arrhythmias.
Article
Engineering, Electrical & Electronic
Qiming Zhao, Costas D. Sarris
Summary: This article presents a time-domain modeling and shape optimization framework for microwave structures, including metasurfaces, based on a nodal discontinuous Galerkin time-domain (DGTD) method. The framework utilizes unstructured mesh and adaptive mesh refinement to model multiscale geometries. It integrates a multitier local time-stepping technique to reduce the cost introduced by mesh refinement. By using B-spline parameterization and PCK surrogate method, the computational cost for optimization problems is significantly reduced. The proposed framework is applicable to other microwave structures and has been validated through optimization examples.
IEEE TRANSACTIONS ON MICROWAVE THEORY AND TECHNIQUES
(2022)
Article
Thermodynamics
Clinton R. Bedick, Charlotte Albunio, Peter Strakey, Donald Ferguson, Rigel Woodside
Summary: There has been significant interest in detonation-based combustion systems, such as rotating detonation engines (RDE), for their potential performance advantages in propulsion and energy applications. Research shows that solid and aqueous K2CO3 particles can undergo heating, decomposition, and ionization in RDE, offering possibilities for developing direct power extraction technologies.
COMBUSTION AND FLAME
(2022)
Article
Mathematical & Computational Biology
Luca Dede, Francesco Regazzoni, Christian Vergara, Paolo Zunino, Marco Guglielmo, Roberto Scrofani, Laura Fusini, Chiara Cogliati, Gianluca Pontone, Alfio Quarteroni
Summary: Emerging studies focus on how COVID-19 infection affects the human cardiovascular system, specifically on issues such as myocardial injury, acute coronary syndrome, and heart failure. A computational model is proposed to study the interplay between local changes and global variables in cardiac function under COVID-19 impact.
MATHEMATICAL BIOSCIENCES AND ENGINEERING
(2021)
Article
Cardiac & Cardiovascular Systems
Stepan Cerny, Wouter Oosterlinck, Burak Onan, Sandeep Singh, Patrique Segers, Cengiz Bolcal, Cem Alhan, Emiliano Navarra, Matteo Pettinari, Frank Van Praet, Herbert De Praetere, Jan Vojacek, Theodor Cebotaru, Paul Modi, Fabien Doguet, Ulrich Franke, Ahmed Ouda, Ludovic Melly, Ghislain Malapert, Louis Labrousse, Monica Gianoli, Alfonso Agnino, Tine Philipsen, Jean-Luc Jansens, Thierry Folliguet, Meindert Palmen, Daniel Pereda, Francesco Musumeci, Piotr Suwalski, Koen Cathenis, Jef van den Eynde, Johannes Bonatti
Summary: This study assessed the current activities and outcomes of robotically assisted cardiac surgery in Europe. The results showed a significant increase in the number of procedures over the study period, with a wide range of surgical types being performed. The conversion rate to larger incisions was low and the clinical outcomes were favorable, indicating the safe conduct of these high-tech minimally invasive procedures.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Physiology
Lv Tong, Caiming Zhao, Zhenyin Fu, Ruiqing Dong, Zhenghong Wu, Zefeng Wang, Nan Zhang, Xinlu Wang, Boyang Cao, Yutong Sun, Dingchang Zheng, Ling Xia, Dongdong Deng
Summary: This study explored the simulation time needed to match the arrhythmias detected in patients by inducing arrhythmias in personalized cardiac models. Results showed that a 10-second simulation time was more suitable than 3 seconds to match the clinical measurements of arrhythmias, improving simulation accuracy and efficiency.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Materials Science, Multidisciplinary
J. Mojumder, J. S. Choy, S. Leng, L. Zhong, G. S. Kassab, L. C. Lee
Summary: The study revealed a strong correlation between left ventricular growth and changes in fiber stress and sheet-normal stress under pressure overload, suggesting that fiber stress is the predominant mechanical stimulus for left ventricular growth.
EXPERIMENTAL MECHANICS
(2021)
Article
Multidisciplinary Sciences
Nicole Tueni, Jeremy Vizet, Martin Genet, Angelo Pierangelo, Jean-Marc Allain
SCIENTIFIC REPORTS
(2020)
Article
Cardiac & Cardiovascular Systems
Daniel Alexander Castellanos, Katerina Skardova, Abhijit Bhattaru, Ezgi Berberoglu, Gerald Greil, Animesh Tandon, Jeanne Dillenbeck, Barbara Burkhardt, Tarique Hussain, Martin Genet, Radomir Chabiniok
Summary: This study evaluated a novel method for assessing left ventricular torsion in patients after surgical repair of Tetralogy of Fallot (rTOF) as an indicator of systolic dysfunction. The method of equilibrated warping showed good reliability and revealed a high prevalence of torsion loss in rTOF patients. Loss of torsion may be a common finding in these patients and could potentially aid in early detection of heart failure.
PEDIATRIC CARDIOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Sheikh Mohammad Shavik, Samuel Wall, Joakim Sundnes, Julius M. Guccione, Partho Sengupta, Scott D. Solomon, Daniel Burkhoff, Lik Chuan Lee
Summary: Global longitudinal strain and circumferential strain are reduced in HFpEF patients, suggesting impaired global left ventricular contractility. Research indicates that only a reduction in myocardial contractility and an increase in afterload can simultaneously reproduce the relevant metrics in HFpEF patients.
JOURNAL OF CARDIOVASCULAR TRANSLATIONAL RESEARCH
(2021)
Article
Cardiac & Cardiovascular Systems
Maria Gusseva, Tarique Hussain, Camille Hancock Friesen, Philippe Moireau, Animesh Tandon, Cecile Patte, Martin Genet, Keren Hasbani, Gerald Greil, Dominique Chapelle, Radomir Chabiniok
Summary: This study utilized a biomechanical model to evaluate rTOF patients and found that residual RVOTO has a greater impact on cardiac health. Individualized modeling is helpful in predicting the heart's response to percutaneous pulmonary valve replacement.
CANADIAN JOURNAL OF CARDIOLOGY
(2021)
Article
Computer Science, Artificial Intelligence
Johanna Stimm, Stefano Buoso, Ezgi Berberoglu, Sebastian Kozerke, Martin Genet, Christian T. Stoeck
Summary: The orientation of cardiac myocyte aggregates has a significant impact on cardiac electrophysiology and mechanics. This study demonstrates the feasibility of extracting a low-rank representation of predominant myocyte orientation from high-resolution magnetic resonance imaging and proposes a data-driven, personalized, parametric model for improved accuracy in personalized computational models.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Biophysics
Cecile Patte, Martin Genet, Dominique Chapelle
Summary: This paper introduces a novel poromechanical model of the lungs, which considers the mechanical behavior of the lungs and their interaction with the surrounding environment, and can be applied to studying respiratory mechanisms and clinical applications.
BIOMECHANICS AND MODELING IN MECHANOBIOLOGY
(2022)
Article
Engineering, Multidisciplinary
Felipe Alvarez-Barrientos, Daniel E. Hurtado, Martin Genet
Summary: In this study, a finite-deformation variational framework was developed for pressure-driven foams. The stress distribution in lung tissue was numerically simulated under different boundary conditions, revealing a strong dependence on kinematic constraints in the spherical alveolar model but not in the image-based alveolar model. Comparison of pressure-driven and deformation-driven models showed a significant shift in hydrostatic stresses but unaffected deviatoric stresses. These findings have implications for lung simulation related to mechanical ventilation and spontaneous breathing.
INTERNATIONAL JOURNAL OF ENGINEERING SCIENCE
(2021)
Correction
Cardiac & Cardiovascular Systems
Daniel Alexander Castellanos, Katerina Skardova, Abhijit Bhattaru, Ezgi Berberoglu, Gerald Greil, Animesh Tandon, Jeanne Dillenbeck, Barbara Burkhardt, Tarique Hussain, Martin Genet, Radomir Chabiniok
PEDIATRIC CARDIOLOGY
(2022)
Article
Multidisciplinary Sciences
Ezgi Berberoglu, Christian T. Stoeck, Philippe Moireau, Sebastian Kozerke, Martin Genet
Summary: The study found that radial strain is more sensitive to image resolution and noise, while the quantification of circumferential and longitudinal strains is robust. There is a need for higher-resolution 3D tagged MRI to achieve sufficient accuracy in radial strain quantification.
Article
Geography, Physical
Marion Genet, Anne-Laure Daniau, Florent Mouillot, Vincent Hanquiez, Sabine Schmidt, Valerie David, Muriel Georget, Fatima Abrantes, Pierre Anschutz, Franck Bassinot, Jerome Bonnin, Bernard Dennielou, Frederique Eynaud, David A. Hodell, Thierry Mulder, Filipa Naughton, Linda Rossignol, Polychronis Tzedakis, Maria Fernanda Sanchez-Goni
Summary: Marine microcharcoal records are valuable for understanding changes in biomass burning over multiple glacial cycles, but quantitative reconstructions require calibration studies of the fire-microcharcoal relationship. Analysis of sediment samples from the Iberian margin and Gulf of Cadiz reveals influences of water depth and distance from river mouth on microcharcoal concentrations, as well as a latitudinal variation primarily driven by burnt vegetation types on the adjacent continent.
QUATERNARY SCIENCE REVIEWS
(2021)
Article
Computer Science, Artificial Intelligence
Ezgi Berberoglu, Christian T. Stoeck, Sebastian Kozerke, Martin Genet
Summary: Cardiovascular magnetic resonance (CMR) imaging is the gold standard for assessing left-ventricular (LV) function non-invasively. Previous studies have shown the prognostic value of deformation metrics extracted from regular SSFP CMR images, although they have limitations in detecting myocardial torsion. Tagged CMR allows for the assessment of local myocardial deformation, including torsion, but is limited in quantifying radial strain. To overcome these limitations, a fusion of global shape motion from SSFP images and local deformation from tagged images is proposed. Joint analysis of SSFP and 3DTAG images provides better quantification of LV strain and twist compared to using either data source alone.
MEDICAL IMAGE ANALYSIS
(2022)
Article
Engineering, Biomedical
Nicole Tueni, Jean-Marc Allain, Martin Genet
Summary: Due to structural heterogeneities within the tissue, the myocardium displays orthotropic material behavior. However, the link between microstructure and macroscopic mechanical properties is still unclear. This study aims to investigate the relative role of cardiomyocyte orientation variation and perimysium collagen sheetlet structure in the observed orthotropic symmetry of the myocardium. The results show the importance of sheetlet layers in ensuring the tissue's anisotropic response and suggest further analysis of the size effect in the myocardial tissue shear properties.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Computer Science, Interdisciplinary Applications
Haifeng Wang, Lei Fan, Jenny S. Choy, Ghassan S. Kassab, Lik Chuan Lee
Summary: Capillary transit time is an important factor in gas exchange between the heart and other organs. Researchers have developed a computational framework that can predict the hemodynamics of the entire coronary network and calculate capillary transit time using virtual tracers. The model predictions align with experimental measurements and indicate that coronary artery stenosis leads to longer capillary transit time.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2024)
Article
Computer Science, Interdisciplinary Applications
M. Genet, C. Patte, C. Fetita, P. -Y. Brillet, D. Chapelle
COMPUTER METHODS IN BIOMECHANICS AND BIOMEDICAL ENGINEERING
(2020)
