Article
Cardiac & Cardiovascular Systems
Ekkehard Gruenig, Alison MacKenzie, Andrew J. Peacock, Christina A. Eichstaedt, Nicola Benjamin, Robert Nechwatal, Silvia Ulrich, Stephanie Saxer, Maurizio Bussotti, Marinella Sommaruga, Stefano Ghio, Lina Gumbiene, Egle Paleviciute, Elena Jureviciene, Antonio Cittadini, Anna A. Stanziola, Alberto M. Marra, Gabor Kovacs, Horst Olschewski, Joan-Albert Barbera, Isabel Blanco, Martijn A. Spruit, Frits M. E. Franssen, Anton Vonk Noordegraaf, Abilio Reis, Mario Santos, Sofia Goncalves Viamonte, Heleen Demeyer, Marion Delcroix, Eduardo Bossone, Martin Johnson
Summary: This study is the first multicentre and largest randomized, controlled study on the feasibility, safety, and efficacy of exercise training as add-on to medical therapy in PAH and CTEPH patients, showing that exercise training can improve patients' exercise capacity, quality of life, and WHO functional class.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Ekkehard Gruenig, Alison MacKenzie, Andrew J. Peacock, Christina A. Eichstaedt, Nicola Benjamin, Robert Nechwatal, Silvia Ulrich, Stephanie Saxer, Maurizio Bussotti, Marinella Sommaruga, Stefano Ghio, Lina Gumbiene, Egle Paleviciute, Elena Jureviciene, Antonio Cittadini, Anna A. Stanziola, Alberto M. Marra, Gabor Kovacs, Horst Olschewski, Joan-Albert Barbera, Isabel Blanco, Martijn A. Spruit, Frits M. E. Franssen, Anton Vonk Noordegraaf, Abilio Reis, Mario Santos, Sofia Goncalves Viamonte, Heleen Demeyer, Marion Delcroix, Eduardo Bossone, Martin Johnson
Summary: This study demonstrated that exercise training for patients with PAH and CTEPH can significantly improve quality of life, WHO functional class, and peak oxygen consumption, and is feasible, safe, and well-tolerated as an add-on to medical therapy.
EUROPEAN HEART JOURNAL
(2021)
Article
Cardiac & Cardiovascular Systems
Kazunori Omote, Hidemi Sorimachi, Masaru Obokata, Yogesh N. Reddy, Frederik H. Verbrugge, Massar Omar, Hilary M. DuBrock, Margaret M. Redfield, Barry A. Borlaug
Summary: This study aimed to characterize the pathophysiology of pulmonary vascular disease in left heart disease (PH-LHD) and found that PH-LHD patients displayed distinct features, such as poorer left atrial function and more severe right ventricular dysfunction at rest, as well as more severe impairments in cardiac output and oxygen delivery during exercise. Further study is required to identify innovative treatments for the pulmonary vasculature in PH-LHD.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Satyam Sarma, James P. MacNamara, Bryce N. Balmain, Christopher M. Hearon, Denis J. Wakeham, Andrew R. Tomlinson, Linda S. Hynan, Tony G. Babb, Benjamin D. Levine
Summary: Exercise intolerance is a common symptom in patients with heart failure with preserved ejection fraction (HFpEF), which is believed to be caused by a marked rise in pulmonary capillary wedge pressure (PCWP). This study investigated the effect of nitroglycerin on PCWP and exercise capacity in patients with HFpEF. The results showed that nitroglycerin successfully reduced PCWP during exercise, but did not improve peak oxygen uptake. These findings suggest that reducing PCWP alone is not sufficient to enhance exercise capacity in patients with HFpEF.
Article
Cardiac & Cardiovascular Systems
Sergio Caravita, Claudia Baratto, Aurora Filippo, Davide Soranna, Celine Dewachter, Antonella Zambon, Giovanni Battista Perego, Denisa Muraru, Michele Senni, Luigi P. Badano, Gianfranco Parati, Jean-Luc Vachiery, Marat Fudim
Summary: A study found that there is a latent pulmonary vascular disease among patients with heart failure with preserved ejection fraction. These patients have altered ventilatory control, increased pulmonary vascular reactivity, and poor prognosis.
JACC-HEART FAILURE
(2023)
Review
Biochemistry & Molecular Biology
Argen Mamazhakypov, Abdirashit Maripov, Akpay S. Sarybaev, Ralph Theo Schermuly, Akylbek Sydykov
Summary: Pulmonary hypertension (PH) is characterized by elevated pulmonary arterial pressure and vascular remodeling. Circulating osteopontin has been suggested as a biomarker of PH progression and right ventricular dysfunction. Preclinical studies have shown that osteopontin plays a role in PH pathogenesis by modulating various cellular processes. This article provides an overview of osteopontin regulation and its impact on pulmonary vascular remodeling, as well as the potential of targeting osteopontin for PH management.
Article
Cardiac & Cardiovascular Systems
Javier Roibal Pravio, Eduardo Barge Caballero, Cayetana Barbeito Caamano, Maria Jesus Paniagua Martin, Gonzalo Barge Caballero, David Couto Mallon, Patricia Pardo Martinez, Zulaika Grille Cancela, Paula Blanco Canosa, Jose Manuel Garcia Pinilla, Jose Manuel Vazquez Rodriguez, Maria Generosa Crespo Leiro
Summary: Maximum oxygen uptake (VO2max) is an important parameter in assessing the functional capacity of heart failure (HF) patients. Clinical factors such as NYHA class, age, body mass index, hemoglobin levels, and right ventricular function significantly influence exercise capacity in HF patients. The severity of HF and age, body composition, and hemoglobin levels can impact maximal oxygen uptake in HF patients.
Article
Pharmacology & Pharmacy
Elisabetta Zampogna, Nicolino Ambrosino, Federico Mattia Oliva, Monica Rudi, Giovanni Sotgiu, Laura Saderi, Antonio Spanevello, Dina Visca
Summary: This study evaluated the impact of pulmonary rehabilitation on heart rate recovery (HRR) in individuals with asthma compared to those with COPD. The findings showed that individuals with asthma had a lower prevalence of slow HRR than those with COPD. However, exercise training significantly improved exercise capacity in both populations.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Sophia Airhart, Nima Badie, Mark Doyle, Priscilla Correa-Jacque, Curt Daniels, Raymond Benza
Summary: PAH is a chronic, progressive disease that is incurable even with effective therapy. Targeting hemodynamic improvements to reduce the risk of subsequent RV failure is key to preserving long-term outcomes in PAH. Assessing RV adaptation to stress plays a pivotal role in guiding therapy for PAH patients.
JOURNAL OF HEART AND LUNG TRANSPLANTATION
(2021)
Review
Cardiac & Cardiovascular Systems
Mattia Lunardi, Sijing Wu, Patrick W. Serruys, Yoshinobu Onuma, Osama Soliman, William Wijns, Wilfried Mullens, Faisal Sharif
Summary: More than half of heart failure patients also have pulmonary hypertension, which affects symptoms and prognosis. The role of exercise in this patient population is still unclear due to a lack of clear understanding of the relationship between exercise and changes in pulmonary artery pressure and symptoms. The limited evidence on this topic is contradictory and difficult to compare due to different exercise programs and assessment techniques. The different classes of heart failure further complicate the assessment of exercise effects on outcomes. Future studies using advanced technologies may provide more insights into the effects of exercise training in heart failure patients with pulmonary hypertension.
Article
Rehabilitation
Yoichiro Aoyagi, Etsuko Mori, Hideki Ishii, Yuji Kono, Ayako Sato, Yuki Okochi, Reisuke Funahashi, Hitoshi Kagaya
Summary: This study compared the effects of cardiac rehabilitation therapies performed in wards and rehabilitation units during the COVID-19 pandemic. The results showed that patients receiving ward-based rehabilitation had lower walking distance and speed at discharge compared to those admitted before the outbreak, and they also had shorter exercise time.
EUROPEAN JOURNAL OF PHYSICAL AND REHABILITATION MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Jeong Hoon Yang, Tomonari Harada, Ki Hong Choi, Toshimitsu Kato, Darae Kim, Noriaki Takama, Taek Kyu Park, Masahiko Kurabayashi, Sung-A Chang, Masaru Obokata
Summary: This study demonstrated that peripheral venous pressure (PVP) could reliably estimate pulmonary artery (PA) pressures during exercise in patients with heart failure with preserved ejection fraction. Compared with the traditional method of estimating right atrial pressure (RAP), the use of PVP improved the ability to identify exercise-induced pulmonary hypertension. This finding has important implications for the diagnosis and treatment of heart failure.
CIRCULATION-HEART FAILURE
(2022)
Article
Medicine, General & Internal
Katrina O. Tonga, Brian G. Oliver
Summary: Chronic obstructive pulmonary disease (COPD) is a complex and serious disease with various physical and psychological manifestations. Pulmonary rehabilitation, including exercise, is an effective intervention for COPD. However, the efficacy of non-traditional forms of exercise in alternative medicine remains poorly understood. This study aims to fill this knowledge gap and provide a summary of the clinical evidence for traditional exercise regimens in the pulmonary rehabilitation of COPD patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Julian Mueller, Mona Lichtblau, Stephanie Saxer, Luigi-Riccardo Calendo, Arcangelo F. Carta, Simon R. Schneider, Charlotte Berlier, Michael Furian, Konrad E. Bloch, Esther Schwarz, Silvia Ulrich
Summary: This study evaluated the effects of breathing oxygen-enriched air on exercise performance in patients with PH-HFpEF and found that using oxygen significantly improved exercise performance, reduced subjective dyspnea sensation, and improved blood oxygenation.
FRONTIERS IN MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Matthew K. Burrage, Moritz Hundertmark, Ladislav Valkovic, William D. Watson, Jennifer Rayner, Nikant Sabharwal, Vanessa M. Ferreira, Stefan Neubauer, Jack J. Miller, Oliver J. Rider, Andrew J. M. Lewis
Summary: The study found that HFpEF patients have a myocardial energy deficit, leading to abnormal cardiac function and pulmonary congestion during exercise, supporting an energetic basis for transient pulmonary congestion.
Article
Rheumatology
Yair Levi, Lilach Israeli-Shani, Michael Kuchuk, Gali Epstein Shochet, Matthew Koslow, David Shitrit
JOURNAL OF RHEUMATOLOGY
(2018)
Article
Physiology
Gali Epstein Shochet, Elizabetha Brook, Omer Eyal, Evgeny Edelstein, David Shitrit
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Article
Pharmacology & Pharmacy
Ruth Rahamimov, Hagit Tifti-Orbach, Boris Zingerman, Hefziba Green, Shira Schneider, Avry Chagnac, Eytan Mor, Benjamin D. Fox, Benaya Rozen-Zvi
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
(2019)
Article
Oncology
Matthew Koslow, David Shitrit, Lilach Israeli-Shani, Orit Uziel, Einat Beery, Alexandra Osadchy, Yael Refaely, Gali Epstein Shochet, Aliza Amiel
Letter
Critical Care Medicine
Ori Wand, Elad Guber, Alexander Guber, Gali Epstein Shochet, Lilach Israeli-Shani, David Shitrit
Article
Physiology
David Langleben, Stylianos E. Orfanos, Michele Giovinazzo, Robert D. Schlesinger, Robert Naeije, Benjamin D. Fox, Ali O. Abualsaud, Fay Blenkhorn, Lawrence G. Rudski, John D. Catravas
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2019)
Letter
Critical Care Medicine
Ori Wand, Elad Guber, Alexander Guber, Gali Epstein Shochet, Lilach Israeli-Shani, David Shitrit
Article
Health Care Sciences & Services
Alexander Guber, Gali Epstein Shochet, Sarah Kohn, David Shitrit
JOURNAL OF MEDICAL SYSTEMS
(2019)
Letter
Critical Care Medicine
Ori Wand, Avraham Unterman, Gali Epstein Shochet, David Shitrit
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2020)
Article
Respiratory System
Benjamin D. Fox, Yael Shostak, Barak Pertzov, Baruch Vainshelboim, Shimon Itzhakian, Irit Terner, Mordechai R. Kramer
BMC PULMONARY MEDICINE
(2019)
Article
Respiratory System
Benjamin Daniel Fox, Marina Bondarenco, Isaac Shpirer, Noam Natif, Sivan Perl
Summary: The study suggests that transitioning to home NIV after a hypercapnic hospitalisation may be useful for younger, cooperative patients with chronic respiratory disease, but may not be beneficial and potentially harmful for older patients or those with cardiac failure.
BMJ OPEN RESPIRATORY RESEARCH
(2022)
Article
Respiratory System
Sivan Perl, Marina Bondarenco, Noam Natif, Yitschak Shpirer, Sharon Enghelberg, Benjamin Fox
RESPIRATORY RESEARCH
(2020)
Article
Medicine, General & Internal
Daniel Erez, Matthew Koslow, Gali Epstein Shochet, Zamir Dovrish, Lilach Lsraeli-Shani, David Dahan, Daniel King, David Shitrit
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2019)
Article
Medicine, General & Internal
David Dahan, Gali Epstein Shochet, Ester Fizitsky, Miriam Almagor, David Shitrit
ISRAEL MEDICAL ASSOCIATION JOURNAL
(2018)
Article
Respiratory System
Ori Wand, Benjamin D. Fox, Osnat Shtraichman, Osnat Moreh-Rahav, Mordechai R. Kramer
SARCOIDOSIS VASCULITIS AND DIFFUSE LUNG DISEASES
(2020)