Article
Plant Sciences
Vo Thi Dieu Trang, Maria Dalgaard Mikkelsen, Marlene Vuillemin, Sebastian Meier, Hang Thi Thuy Cao, Jan Muschiol, Valentina Perna, Thuan Thi Nguyen, Vy Ha Nguyen Tran, Jesper Holck, Tran Thi Thanh Van, Huynh Hoang Nhu Khanh, Anne S. Meyer
Summary: Fucoidanases are enzymes that hydrolyze alpha-glycosidic linkages in fucoidans, sulfated polysaccharides found in brown seaweeds. A novel fucoidanase, Fhf2, was identified in a marine bacterium and found to be more stable in a truncated form. The truncated Fhf2 showed activity on fucoidans from different seaweed species and had optimal activity at 37 degrees C and pH 8. This enzyme could be valuable in producing highly sulfated oligosaccharides for fucoidan bioactivity investigations.
FRONTIERS IN PLANT SCIENCE
(2022)
Editorial Material
Chemistry, Medicinal
Anatolii I. Usov, Maria I. Bilan, Nadezhda E. Ustyuzhanina, Nikolay E. Nifantiev
Summary: Sulfated polysaccharides known as fucoidans, obtained from brown algae, have attracted attention due to their biological activities. Fucus vesiculosus and Ascophyllum nodosum, both belonging to Fucales order, are popular sources of commercial fucoidans. Despite their similarities in chemical composition and biological actions, these fucoidans differ considerably in their polysaccharide mixtures. Carefully characterized structures from both fucoidans may have valuable applications in drug development.
Article
Chemistry, Applied
Carlos Vaamonde-Garcia, Noelia Florez-Fernandez, Maria Dolores Torres, Maria J. Lamas-Vazquez, Francisco J. Blanco, Herminia Dominguez, Rosa Meijide-Failde
Summary: Experimental findings suggest that the chemical composition of fucoidan, particularly the content of phlorotannins and the ratio of sulfate to fucose, plays a critical role in its biological activity. Factors such as concentration and molecular weight of fucoidan may also impact its beneficial effects. Additionally, there is evidence of cell-type dependent responses to fucoidan.
CARBOHYDRATE POLYMERS
(2021)
Article
Chemistry, Medicinal
Nora Kirsten, Julia Ohmes, Maria Dalgaard Mikkelsen, Thuan Thi Nguyen, Martina Bluemel, Fanlu Wang, Deniz Tasdemir, Andreas Seekamp, Anne S. Meyer, Sabine Fuchs
Summary: Fucoidans, sulfated and fucose-rich polysaccharides from brown seaweed, have multiple promising biological effects, including anti-inflammatory properties. In this study, high molecular weight (HMW) fucoidan extract with higher purity was found to reduce the inflammatory response of endothelial cells in cases of LPS-induced bacterial infection, indicating their potential use as an anti-inflammatory agent.
Article
Chemistry, Applied
Li Ren, Jie Zhang, Tiehua Zhang
Summary: Polysaccharides from Ganoderma, as the most abundant bioactive compounds, exhibit unique biological properties such as anti-tumor, anti-inflammatory, and immunomodulatory activities. They can potentially be applied for the modulation of the host immune system, including innate immunity, cellular immunity, and humoral immunity.
Review
Pharmacology & Pharmacy
Noelia Florez-Fernandez, Carlos Vaamonde-Garcia, Maria Dolores Torres, Manuela Bujan, Alexandra Muinos, Antonio Muinos, Maria J. Lamas-Vazquez, Rosa Meijide-Failde, Francisco J. Blanco, Herminia Dominguez
Summary: The anti-inflammatory properties of fucoidans have been well studied in vitro and in some in vivo experiments. In addition to this activity, the lack of toxicity and the possibility of obtaining fucoidans from a widely available and renewable source make them attractive as novel bioactives. However, the heterogeneity and variability in composition, structure, and properties of fucoidans, depending on factors such as seaweed species and extraction methods, pose challenges for standardization.
Article
Pharmacology & Pharmacy
Paula Laranjeira, Monia Pedrosa, Catia Duarte, Susana Pedreiro, Brigida Antunes, Tania Ribeiro, Francisco dos Santos, Antonio Martinho, Margarida Fardilha, M. Rosario Domingues, Manuel Abecasis, Jose Antonio Pereira da Silva, Artur Paiva
Summary: This study found that BM-MSC effectively reduced TNF-alpha, CD83, CCR7, and MIP-1 beta protein levels in mDCs and all monocyte subsets in RA patients. BM-MSC exhibited a suppressive action over antigen-presenting cells from RA patients, potentially affecting their ability to stimulate the immune adaptive response at different levels.
Article
Biochemistry & Molecular Biology
Olesya S. Malyarenko, Timofey Malyarenko, Roza Usoltseva, Artem S. Silchenko, Alla A. Kicha, Natalia Ivanchina, Svetlana P. Ermakova
Summary: This study found that the combination of fucoidan and asterosaponins can effectively combat human melanoma cells with a potential synergistic effect. There is an additive anticancer effect between fucoidan with thornasteroside A or asteropsiside A during simultaneous treatment of cells. The activity of compounds can be influenced by the sequence of treatment and pre-treatment process.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Shaojie Zhang, Lijun An, Zhengguo Li, Xuelian Wang, Honglin Wang, Lijuan Shi, Jiahe Bao, Xiaozhong Lan, Erhao Zhang, Namrita Lall, Anna-Mari Reid, Yuhao Li, Da-Qing Jin, Jing Xu, Yuanqiang Guo
Summary: In this study, an immunological arabinan, LCP70-2A, was isolated from Ligusticum chuanxiong for the first time. Physicochemical characterization revealed its homogeneous polysaccharide nature and potential as an immunological enhancement supplement by activating macrophages and promoting the secretion of immunoregulatory factors.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Anton B. Rasin, Natalia M. Shevchenko, Artem S. Silchenko, Mikhail Kusaykin, Galina N. Likhatskaya, Tatyana N. Zvyagintseva, Svetlana P. Ermakova
Summary: This study investigated the structure of two fucoidans from Fucus evanescens algae using NMR spectroscopy and examined the effects of fucoidan/chitosan mass ratio on the properties of nanoparticles. Molecular docking and thermodynamic analysis revealed significant conformational changes of the molecules during binding, potentially enhancing binding effectiveness.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biochemistry & Molecular Biology
Marta Toth, Szabolcs Muzsai, Krzysztof Regulski, Timea Szendi-Szatmari, Zsolt Czimmerer, Eva Rajnavolgyi, Marie-Pierre Chapot-Chartier, Attila Bacsi
Summary: The human gut symbiont Lacticaseibacillus (L.) casei has a wide range of immunomodulatory effects on the human host. This study demonstrates that human monocyte-derived dendritic cells (moDCs) can engulf L. casei BL23, and the intact bacterial cell wall and morphology play a key role in this process. The absence of the bacterial cell-wall-degrading enzyme Lc-p75 leads to defective internalization and impaired cytokine secretion by moDCs, resulting in reduced T-cell activation capacity. Formation of short bacterial chains helps to exert the potent immunomodulatory properties of L. casei BL23.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Medicinal
Yani Li, Eileen McGowan, Size Chen, Jerran Santos, Haibin Yin, Yiguang Lin
Summary: Fucoidans, extracted from brown seaweed, are fucose-rich sulfated polysaccharides with various beneficial biological activities. They have been recognized for their immunomodulatory effects, especially in cancer immunotherapy. Fucoidans can activate cytotoxic T lymphocytes and have strong antitumor properties, making them promising agents for cancer treatment.
Article
Biology
Olga N. Ayrapetyan, Ekaterina D. Obluchinskaya, Elena V. Zhurishkina, Yury A. Skorik, Dmitry V. Lebedev, Anna A. Kulminskaya, Irina M. Lapina
Summary: Fucoidans, sulfated polysaccharides found in cell walls of brown algae, are considered as a promising antimicrobial component for various applications in medicine and the food industry. By comparing the antibacterial properties of different fractions of fucoidan from brown algae Fucus vesiculosus, it was found that both fractions exhibited bacteriostatic effects against various bacteria, with E. coli being the most sensitive. However, the antibacterial activity decreased with changes in chemical composition after additional treatment of the crude fraction with a solution of calcium chloride.
Article
Pharmacology & Pharmacy
Mehdi Najar, Makram Merimi, Wissam H. Faour, Catherine A. Lombard, Douaa Moussa Agha, Yassine Ouhaddi, Etienne M. Sokal, Laurence Lagneaux, Hassan Fahmi
Summary: This study explored the application of Foreskin-derived mesenchymal stromal/stem cells (FSK-MSCs) in immunotherapy. It was found that FSK-MSCs can interact with T cells and inflammatory signals, modulating the T cell response accordingly.
Article
Oncology
Anastasia Prokopi, Christoph H. Tripp, Bart Tummers, Florian Hornsteiner, Sarah Spoeck, Jeremy Chase Crawford, Derek R. Clements, Mirjana Efremova, Katharina Hutter, Lydia Bellmann, Giuseppe Cappellano, Bruno L. Cadilha, Sebastian Kobold, Louis Boon, Daniela Ortner, Zlatko Trajanoski, Suzie Chen, Tanja D. de Gruijl, Juliana Idoyaga, Douglas R. Green, Patrizia Stoitzner
Summary: Immunotherapy with checkpoint inhibitors has shown impressive results in patients with melanoma, but many still do not benefit from this treatment due to factors such as lack of tumor-infiltrating T cells and loss of intratumoral dendritic cells. In a melanoma mouse model, researchers found that tumor progression is characterized by upregulation of checkpoint molecules and gradual loss of dermal conventional DC 2 subset. Monotherapy with checkpoint blockade was not effective, but boosting DC numbers and activation increased tumor immunogenicity, leading to improved T cell function and delayed tumor growth when combined with antibodies against PD-1 and TIM-3. The study highlights the importance of skin DC in cancer immunotherapy and suggests that restoring DC function is key to enhancing tumor immunogenicity and responsiveness to checkpoint blockade therapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Chemistry, Applied
Olesya S. Malyarenko, Roza V. Usoltseva, Tatyana N. Zvyagintseva, Svetlana P. Ermakova
CARBOHYDRATE POLYMERS
(2019)
Article
Biochemistry & Molecular Biology
Roza V. Usoltseva, Stanislav D. Anastyuk, Valeriy V. Surits, Natalia M. Shevchenko, Pham Duc Thinh, Pavel A. Zadorozhny, Svetlana P. Ermakova
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2019)
Article
Chemistry, Applied
Roza V. Usoltseva, Natalia M. Shevchenko, Olesya S. Malyarenko, Stanislav D. Anastyuk, Anna E. Kasprik, Nikolay V. Zvyagintsev, Svetlana P. Ermakova
CARBOHYDRATE POLYMERS
(2019)
Review
Chemistry, Medicinal
Natalia Besednova, Tatiana Zaporozhets, Tatiana Kuznetsova, Ilona Makarenkova, Lydmila Fedyanina, Sergey Kryzhanovsky, Olesya Malyarenko, Svetlana Ermakova
Review
Biochemistry & Molecular Biology
Natalya N. Besednova, Tatyana N. Zvyagintseva, Tatyana A. Kuznetsova, Ilona D. Makarenkova, Tatyana P. Smolina, Ludmila N. Fedyanina, Sergey P. Kryzhanovsky, Tatyana S. Zaporozhets
Review
Biochemistry & Molecular Biology
T. I. Imbs, T. N. Zvyagintseva, S. P. Ermakova
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2020)
Article
Chemistry, Medicinal
V. V. Surits, R. V. Usoltseva, N. M. Shevchenko, P. D. Thinh, S. P. Ermakova
CHEMISTRY OF NATURAL COMPOUNDS
(2020)
Article
Chemistry, Medicinal
Natalya Krylova, Svetlana P. Ermakova, Vyacheslav F. Lavrov, Irina A. Leneva, Galina G. Kompanets, Olga Iunikhina, Marina N. Nosik, Linna K. Ebralidze, Irina N. Falynskova, Artem S. Silchenko, Tatyana S. Zaporozhets
Article
Chemistry, Medicinal
Tatyana A. Kuznetsova, Tatyana P. Smolina, Ilona D. Makarenkova, Lydmila A. Ivanushko, Elena Persiyanova, Svetlana P. Ermakova, Artem S. Silchenko, Tatyana S. Zaporozhets, Natalya N. Besednova, Lydmila N. Fedyanina, Sergey P. Kryzhanovsky
Review
Chemistry, Medicinal
Natalya N. Besednova, Tatyana S. Zaporozhets, Tatyana A. Kuznetsova, Ilona D. Makarenkova, Sergey P. Kryzhanovsky, Lydmila N. Fedyanina, Svetlana P. Ermakova
Review
Engineering, Marine
Tatyana A. Kuznetsova, Boris G. Andryukov, Natalia N. Besednova, Tatyana S. Zaporozhets, Andrey V. Kalinin
JOURNAL OF MARINE SCIENCE AND ENGINEERING
(2020)
Review
Chemistry, Analytical
Boris G. Andryukov, Natalya N. Besednova, Roman V. Romashko, Tatyana S. Zaporozhets, Timofey A. Efimov
Article
Infectious Diseases
T. S. Zaporozhets, S. A. Sokotun, A. Simakova, E. Persiyanova
INFEKTSIYA I IMMUNITET
(2019)
Meeting Abstract
Chemistry, Medicinal
Roza Usoltseva, Natalia Shevchenko, Valeriy Surits, Olesya Malyarenko, Svetlana Ermakova
Review
Virology
T. A. Kuznetsova, E. Persiyanova, T. S. Zaporozhets, N. N. Besednova
VOPROSY VIRUSOLOGII
(2019)