Review
Oncology
Cassidy Gawlik, Jason Lane, Mark Horattas
Summary: Tumor-to-tumor metastasis is a rare but important condition, especially in patients with a history of renal cell carcinoma. This case report highlights the presence of a thyroid nodule consistent with tumor-to-tumor metastasis from RCC into papillary thyroid carcinoma. Therefore, clinicians should remain vigilant when encountering newly discovered thyroid nodules in patients with a history of RCC.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Junni Chen, Shuai Zhang, Jiawei Chen
Summary: Esophageal cancer can metastasize to distant sites, leading to poor prognosis. Intestinal metastasis is extremely rare with atypical clinical presentations. We present a case of rectal metastasis after surgery for esophageal squamous cell carcinoma. The patient achieved good short-term efficacy with adjuvant chemoradiotherapy and carrelizumab immunotherapy, and is currently in tumor-free survival. This case report aims to deepen our understanding of rare metastasis in esophageal squamous cell carcinoma and promote the use of local radiotherapy, chemotherapy, and immunotherapy to improve survival.
FRONTIERS IN ONCOLOGY
(2023)
Review
Oncology
Xiaotao Geng, Jie Liu, Huimin Sun, Zhenguo Song, Shaoyong Qin, Yang Li, Yanan Zhang, Furong Hao, Yuanyuan Cai
Summary: This case report presents a rare case of metastatic esophageal squamous cell carcinoma, highlighting the diagnosis and treatment process. The authors hope to provide insights for clinical practice through their experience.
FRONTIERS IN ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Zhenhao Zhao, Yujie Zhang, Chao Li, Xuwen Li, Yongchao Chu, Qin Guo, Yiwen Zhang, Weiyi Xia, Peixin Liu, Hongyi Chen, Yu Wang, Chufeng Li, Tao Sun, Chen Jiang
Summary: Breast-to-brain metastatic cells can interact with surrounding cells to create a favorable environment for tumor growth. Co-delivering therapeutic siRNA and paclitaxel to the metastasis site and normalizing the microenvironment can effectively treat breast-to-brain metastasis.
JOURNAL OF CONTROLLED RELEASE
(2022)
Review
Oncology
Xiaotao Geng, Furong Hao, Guiyan Han, Yaping Zhang, Peiyan Qin
Summary: Nasopharyngeal carcinoma rarely metastasizes to the dura and multiple locations in the brain, presenting challenges in diagnosis and treatment that may require a combination of therapy modalities such as radiotherapy and chemotherapy.
FRONTIERS IN ONCOLOGY
(2021)
Editorial Material
Oncology
Kiarash Shamardani, Michelle Monje
Summary: In this study, Sanchez-Aguilera et al. utilized in vivo electrocorticography and machine learning to investigate the effects of brain metastases on neural circuit dynamics. They found that the electrophysiological profile could predict the presence and type of brain metastasis.
Article
Gastroenterology & Hepatology
Yahui Li, Qing Cheng, Zhaohui Xiong, Chorlada Paiboonrungruang, Timothy Adekoya, Yong Li, Xiaoxin Chen
Summary: By studying the lymphatic drainage system in mouse esophagus, we can gain a better understanding of lymphatic metastasis in ESCC, laying the foundation for further mechanistic and therapeutic studies.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Pathology
Daniel J. Gross, Min-Shu Hsieh, Yan Li, Joseph Dux, Natasha Rekhtman, David R. Jones, William D. Travis, Prasad S. Adusumilli
Summary: The study suggests that the phenomenon of tumor spread through air spaces (STAS) is an in vivo process rather than an artifact of tissue processing in patients undergoing limited resection (LR) for non-small cell lung carcinoma (NSCLC). It indicates that occult STAS tumor cells can be present in the remaining lung tissue after LR, potentially contributing to locoregional recurrence. This observation supports the concept that STAS plays a role in locoregional recurrence following LR.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Oncology
Chiara Vasco, Ambra Rizzo, Chiara Cordiglieri, Elena Corsini, Emanuela Maderna, Emilio Ciusani, Andrea Salmaggi
Summary: Metastasis refers to the spread of a tumor from its original site to other parts of the body. This study focused on brain metastasis and used an in vitro model to investigate the ability of breast and lung tumor cells to cross the blood-brain barrier, as well as the expression of adhesion molecules. The study also found that vesicles released by tumor cells can induce cell death in endothelial cells.
Article
Medicine, General & Internal
Pang-Shuo Perng, Yu-Hsuan Lai, Po-Hsuan Lee, Chi-Chen Huang, Hao-Hsiang Hsu, Jung-Shun Lee
Summary: Surgery or whole-brain radiotherapy (WBRT) can improve survival in patients with brain metastasis of hepatocellular carcinoma (HCC). This study aimed to investigate the safety and efficacy of multi-tyrosine kinase inhibitors (TKIs) in these patients. The results showed that TKIs were associated with better survival outcomes without increasing the risk of intracranial bleeding.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Gastroenterology & Hepatology
Anna Dupree, Hanno Ehlken, Thomas Roesch, Marina Lueken, Matthias Reeh, Yuki B. Werner, Jocelyn de Heer, Guido Schachschal, Till S. Clauditz, Oliver Mann, Jakob R. Izbicki, Stefan Groth
Summary: The study retrospectively reviewed T1 cancer patients undergoing laparoscopic LN sampling after endoscopic resection and found that using the extended LLS technique increased the detection rate of LN. Adverse events were rare, but some patients had LN metastases requiring surgery.
GASTROINTESTINAL ENDOSCOPY
(2021)
Article
Oncology
Ha Eun Kim, Young Ho Yang, Byung Jo Park, Seong Yong Park, In Kyung Min, Dae Joon Kim
Summary: This study evaluated the impact of Skeletonizing en bloc esophagectomy (SEBE) on oncologic outcomes in patients with esophageal squamous cell carcinoma. The results showed that SEBE could reduce tumor recurrence, particularly in patients with T2-3 tumors.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Chemistry, Multidisciplinary
Hyung Min Kim, Chang Wook Jeong, Cheol Kwak, Cheryn Song, Minyong Kang, Seong Il Seo, Jung Kwon Kim, Hakmin Lee, Jinsoo Chung, Eu Chang Hwang, Jae Young Park, In Young Choi, Sung-Hoo Hong
Summary: This study developed an algorithm to predict the probability of brain metastasis in patients with renal cell carcinoma using clinical data and machine learning. The adaptive boosting model outperformed other models in predicting brain metastasis.
APPLIED SCIENCES-BASEL
(2022)
Article
Immunology
Linlin Xiao, Chi Lin, Yueping Liu, Yajing Wu, Jun Wang
Summary: This article reports a rare case of an ESCC patient whose brain metastatic lesion completely disappeared after receiving ICIs treatment, providing supporting data for the use of ICIs as an option for treating brain metastases in ESCC patients.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Oncology
Carmen Criscitiello, Chiara Corti, Michelino De Laurentiis, Giampaolo Bianchini, Barbara Pistilli, Saverio Cinieri, Lucio Castellan, Grazia Arpino, Pierfranco Conte, Francesco Di Meco, Alessandra Gennari, Valentina Guarneri, Luca Visani, Lorenzo Livi, Paolo Marchetti, Fabio Puglisi, Giuseppe Viale, Lucia Del Mastro, Sabino De Placido, Giuseppe Curigliano
Summary: Approximately 20% of breast cancers overexpress HER2, which has historically been associated with a worse prognosis. However, the availability of different anti-HER2 compounds has improved outcomes for HER2-positive breast cancer. Tucatinib, an oral tyrosine kinase inhibitor, has recently been approved for the treatment of metastatic breast cancer, providing evidence of improved overall survival in patients with brain metastases.
CANCER TREATMENT REVIEWS
(2023)
