标题
Nrf2: bane or blessing in cancer?
作者
关键词
Nrf2, Keap1, Cancer, Review
出版物
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 140, Issue 8, Pages 1251-1259
出版商
Springer Nature
发表日期
2014-03-05
DOI
10.1007/s00432-014-1627-1
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- RXR Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
- (2013) H. Wang et al. CANCER RESEARCH
- Apigenin sensitizes doxorubicin-resistant hepatocellular carcinoma BEL-7402/ADM cells to doxorubicin via inhibiting PI3K/Akt/Nrf2 pathway
- (2013) Ai-Mei Gao et al. CARCINOGENESIS
- Chrysin enhances sensitivity of BEL-7402/ADM cells to doxorubicin by suppressing PI3K/Akt/Nrf2 and ERK/Nrf2 pathway
- (2013) Ai-Mei Gao et al. CHEMICO-BIOLOGICAL INTERACTIONS
- Oncogenic functions of the transcription factor Nrf2
- (2013) Irene Gañán-Gómez et al. FREE RADICAL BIOLOGY AND MEDICINE
- The emerging role of the Nrf2-Keap1 signaling pathway in cancer
- (2013) M. C. Jaramillo et al. GENES & DEVELOPMENT
- Transcription factor NRF2 regulates miR-1 and miR-206 to drive tumorigenesis
- (2013) Anju Singh et al. JOURNAL OF CLINICAL INVESTIGATION
- Inhibition of nuclear factor-erythroid 2–related factor (Nrf2) by caveolin-1 promotes stress-induced premature senescence
- (2013) Daniela Volonte et al. MOLECULAR BIOLOGY OF THE CELL
- The aryl hydrocarbon receptor and estrogen receptor alpha differentially modulate nuclear factor erythroid-2-related factor 2 transactivation in MCF-7 breast cancer cells
- (2013) Raymond Lo et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- Nrf2 Protein Up-regulates Antiapoptotic Protein Bcl-2 and Prevents Cellular Apoptosis
- (2012) Suryakant K. Niture et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- E-cadherin inhibits nuclear accumulation of Nrf2: implications for chemoresistance of cancer cells
- (2012) W. D. Kim et al. JOURNAL OF CELL SCIENCE
- Small Molecule Modulators of Keap1-Nrf2-ARE Pathway as Potential Preventive and Therapeutic Agents
- (2012) Sadagopan Magesh et al. MEDICINAL RESEARCH REVIEWS
- Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis
- (2012) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Nrf2 knockout enhances intestinal tumorigenesis inApcmin/+mice due to attenuation of anti-oxidative stress pathway while potentiates inflammation
- (2012) Ka Lung Cheung et al. MOLECULAR CARCINOGENESIS
- Identification of novel NRF2-regulated genes by ChIP-Seq: influence on retinoid X receptor alpha
- (2012) B. N. Chorley et al. NUCLEIC ACIDS RESEARCH
- The nuclear cofactor RAC3/AIB1/SRC-3 enhances Nrf2 signaling by interacting with transactivation domains
- (2012) J-H Kim et al. ONCOGENE
- Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity
- (2012) S Chowdhry et al. ONCOGENE
- Suppression of the Nrf2-Dependent Antioxidant Response by Glucocorticoids and 11β-HSD1-Mediated Glucocorticoid Activation in Hepatic Cells
- (2012) Denise V. Kratschmar et al. PLoS One
- Nrf2: control of sensitivity to carcinogens
- (2011) Stephen L. Slocum et al. ARCHIVES OF TOXICOLOGY
- Enhanced sensitivity of A549 cells to the cytotoxic action of anticancer drugs via suppression of Nrf2 by procyanidins from Cinnamomi Cortex extract
- (2011) Tomokazu Ohnuma et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- MiR-28 regulates Nrf2 expression through a Keap1-independent mechanism
- (2011) Muhua Yang et al. BREAST CANCER RESEARCH AND TREATMENT
- Luteolin inhibits Nrf2 leading to negative regulation of the Nrf2/ARE pathway and sensitization of human lung carcinoma A549 cells to therapeutic drugs
- (2011) Xiuwen Tang et al. FREE RADICAL BIOLOGY AND MEDICINE
- Association of Keap1 and Nrf2 Genetic Mutations and Polymorphisms With Endometrioid Endometrial Adenocarcinoma Survival
- (2011) Tze Fang Wong et al. INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER
- miR-200a Regulates Nrf2 Activation by TargetingKeap1mRNA in Breast Cancer Cells
- (2011) Gabriel Eades et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Signal transduction by reactive oxygen species
- (2011) Toren Finkel JOURNAL OF CELL BIOLOGY
- KEAP1 gene mutations and NRF2 activation are common in pulmonary papillary adenocarcinoma
- (2011) Qing Kay Li et al. JOURNAL OF HUMAN GENETICS
- SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
- (2011) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Mutation of the Nrf2 gene in non-small cell lung cancer
- (2011) Yi Hu et al. MOLECULAR BIOLOGY REPORTS
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Brusatol enhances the efficacy of chemotherapy by inhibiting the Nrf2-mediated defense mechanism
- (2011) D. Ren et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Nrf2-Keap1-ARE Signaling Pathway: The Regulation and Dual Function of Nrf2 in Cancer
- (2010) Donna D. Zhang ANTIOXIDANTS & REDOX SIGNALING
- Gain of Nrf2 Function in Non-Small-Cell Lung Cancer Cells Confers Radioresistance
- (2010) Anju Singh et al. ANTIOXIDANTS & REDOX SIGNALING
- Discovery of the Negative Regulator of Nrf2, Keap1: A Historical Overview
- (2010) Ken Itoh et al. ANTIOXIDANTS & REDOX SIGNALING
- microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease
- (2010) C. Sangokoya et al. BLOOD
- Inhibition of estrogen signaling activates the NRF2 pathway in breast cancer
- (2010) Yuan Yao et al. BREAST CANCER RESEARCH AND TREATMENT
- Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung
- (2010) Hironori Satoh et al. CARCINOGENESIS
- INrf2 (Keap1) targets Bcl-2 degradation and controls cellular apoptosis
- (2010) S K Niture et al. CELL DEATH AND DIFFERENTIATION
- The Ubiquitin-conjugating Enzyme UbcM2 Can Regulate the Stability and Activity of the Antioxidant Transcription Factor Nrf2
- (2010) Kendra S. Plafker et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Critical Role of Nitric Oxide Signaling, via ProteinS-Guanylation and Nitrated Cyclic GMP, in the Antioxidant Adaptive Response
- (2010) Shigemoto Fujii et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Expression of ABCG2 (BCRP) Is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemoresistance Phenotype
- (2010) Anju Singh et al. MOLECULAR CANCER THERAPEUTICS
- Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
- (2010) Deepti Malhotra et al. NUCLEIC ACIDS RESEARCH
- Increased cell migration and plasticity in Nrf2-deficient cancer cell lines
- (2010) G Rachakonda et al. ONCOGENE
- Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
- (2010) T. Ogura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Nrf2 Enhances Cell Proliferation and Resistance to Anticancer Drugs in Human Lung Cancer
- (2009) S. Homma et al. CLINICAL CANCER RESEARCH
- Oncogenic NRF2 mutations in squamous cell carcinomas of oesophagus and skin
- (2009) Yoo Ri Kim et al. JOURNAL OF PATHOLOGY
- Ursodeoxycholic acid stimulates Nrf2-mediated hepatocellular transport, detoxification, and antioxidative stress systems in mice
- (2008) Kosuke Okada et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth
- (2008) T. Ohta et al. CANCER RESEARCH
- Activating Transcription Factor 3 Is a Novel Repressor of the Nuclear Factor Erythroid-Derived 2 Related Factor 2 (Nrf2) Regulated Stress Pathway
- (2008) S. L. Brown et al. CANCER RESEARCH
- RNAi-Mediated Silencing of Nuclear Factor Erythroid-2-Related Factor 2 Gene Expression in Non-Small Cell Lung Cancer Inhibits Tumor Growth and Increases Efficacy of Chemotherapy
- (2008) A. Singh et al. CANCER RESEARCH
- Nrf2 enhances resistance of cancer cells to chemotherapeutic drugs, the dark side of Nrf2
- (2008) X.-J. Wang et al. CARCINOGENESIS
- Covalent Modification at Cys151 Dissociates the Electrophile Sensor Keap1 from the Ubiquitin Ligase CUL3
- (2008) Girish Rachakonda et al. CHEMICAL RESEARCH IN TOXICOLOGY
- Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
- (2008) Patrick L. Apopa et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
- Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity
- (2008) T. Yamamoto et al. MOLECULAR AND CELLULAR BIOLOGY
- NRP/B mutations impair Nrf2-dependent NQO1 induction in human primary brain tumors
- (2008) S Seng et al. ONCOGENE
- Cancer related mutations in NRF2 impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy
- (2008) T. Shibata et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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