Dll4-Notch signaling in regulation of tumor angiogenesis

Accessories to the Crime: Functions of Cells Recruited to the Tumor Microenvironment

(2012) Douglas Hanahan et al.   CANCER CELL

The Notch Ligand Delta-Like 4 Regulates Multiple Stages of Early Hemato-Vascular Development

(2012) Ricardo Laranjeiro et al.   PLoS One

Recent advances on the role of tumor exosomes in immunosuppression and disease progression

(2012) Paola Filipazzi et al.   SEMINARS IN CANCER BIOLOGY

New pathways and mechanisms regulating and responding to Delta-like ligand 4–Notch signalling in tumour angiogenesis

(2011) Chern Ein Oon et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Tumor-Derived Jagged1 Promotes Osteolytic Bone Metastasis of Breast Cancer by Engaging Notch Signaling in Bone Cells

(2011) Nilay Sethi et al.   CANCER CELL

Basic and Therapeutic Aspects of Angiogenesis

(2011) Michael Potente et al.   CELL

Endothelial basement membrane limits tip cell formation by inducing Dll4/Notch signalling in vivo

(2011) Denise Stenzel et al.   EMBO REPORTS

Notch regulation of tumor angiogenesis

(2011) Esther Bridges et al.   Future Oncology

Notch signaling and Notch signaling modifiers

(2011) Michael M. Wang   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Activation of Notch1 signaling in stromal fibroblasts inhibits melanoma growth by upregulating WISP-1

(2011) H Shao et al.   ONCOGENE

Association of High Levels of Jagged-1 and Notch-1 Expression with Poor Prognosis in Head and Neck Cancer

(2010) Jen-Tsun Lin et al.   ANNALS OF SURGICAL ONCOLOGY

Notch signaling: Emerging molecular targets for cancer therapy

(2010) Ling Yin et al.   BIOCHEMICAL PHARMACOLOGY

Combination of Dll4/Notch and Ephrin-B2/EphB4 targeted therapy is highly effective in disrupting tumor angiogenesis

(2010) Dusan Djokovic et al.   BMC CANCER

Delta-Like Ligand 4 Plays a Critical Role in Pericyte/Vascular Smooth Muscle Cell Formation during Vasculogenesis and Tumor Vessel Expansion in Ewing's Sarcoma

(2010) K. L. Schadler et al.   CLINICAL CANCER RESEARCH

Dynamics of endothelial cell behavior in sprouting angiogenesis

(2010) Hanna M Eilken et al.   CURRENT OPINION IN CELL BIOLOGY

The Wnt/β-Catenin Pathway Modulates Vascular Remodeling and Specification by Upregulating Dll4/Notch Signaling

(2010) Monica Corada et al.   DEVELOPMENTAL CELL

Notch signalling in T-cell lymphoblastic leukaemia/lymphoma and other haematological malignancies

(2010) Jon C Aster et al.   JOURNAL OF PATHOLOGY

Chronic DLL4 blockade induces vascular neoplasms

(2010) Minhong Yan et al.   NATURE

Therapeutic antibody targeting of individual Notch receptors

(2010) Yan Wu et al.   NATURE

Endothelial cells dynamically compete for the tip cell position during angiogenic sprouting

(2010) Lars Jakobsson et al.   NATURE CELL BIOLOGY

Therapeutic efficacy of a DNA vaccine targeting the endothelial tip cell antigen delta-like ligand 4 in mammary carcinoma

(2010) B K Haller et al.   ONCOGENE

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells

(2010) M. Mazzone et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Role of glycosylation of Notch in development

(2010) Hideyuki Takeuchi et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Cross-talk between miRNA and Notch signaling pathways in tumor development and progression

(2009) Zhiwei Wang et al.   CANCER LETTERS

Role of Notch signaling in colorectal cancer

(2009) L. Qiao et al.   CARCINOGENESIS

The Notch Ligands Dll4 and Jagged1 Have Opposing Effects on Angiogenesis

(2009) Rui Benedito et al.   CELL

Jagged Gives Endothelial Tip Cells an Edge

(2009) Steven Suchting et al.   CELL

The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

(2009) Raphael Kopan et al.   CELL

DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency

(2009) Timothy Hoey et al.   Cell Stem Cell

NOTCH3 Expression Is Induced in Mural Cells Through an Autoregulatory Loop That Requires Endothelial-Expressed JAGGED1

(2009) Hua Liu et al.   CIRCULATION RESEARCH

Tumor and Host-Mediated Pathways of Resistance and Disease Progression in Response to Antiangiogenic Therapy

(2009) J. M. L. Ebos et al.   CLINICAL CANCER RESEARCH

The Angiogenic Switch: Implications in the Regulation of Tumor Dormancy

(2009) L. Moserle et al.   CURRENT MOLECULAR MEDICINE

Angiogenesis: A Team Effort Coordinated by Notch

(2009) L.-K. Phng et al.   DEVELOPMENTAL CELL

Notch signaling in the hematopoietic system

(2009) Ashley R Sandy et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

NOTCH inhibition and glucocorticoid therapy in T-cell acute lymphoblastic leukemia

(2009) P J Real et al.   LEUKEMIA

Tipping the Balance: Robustness of Tip Cell Selection, Migration and Fusion in Angiogenesis

(2009) Katie Bentley et al.   PLoS Computational Biology

Interferon regulatory factor-1 (IRF-1) regulates VEGF-induced angiogenesis in HUVECs

(2008) Jeong Heon Lee et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Overexpression of delta-like 4 induces arterialization and attenuates vessel formation in developing mouse embryos

(2008) A. Trindade et al.   BLOOD

Loss of Notch signalling induced by Dll4 causes arterial calibre reduction by increasing endothelial cell response to angiogenic stimuli

(2008) Rui Benedito et al.   BMC DEVELOPMENTAL BIOLOGY

VEGF and Delta-Notch: interacting signalling pathways in tumour angiogenesis

(2008) G Thurston et al.   BRITISH JOURNAL OF CANCER

Emerging role of Notch in stem cells and cancer

(2008) Zhiwei Wang et al.   CANCER LETTERS

A Notch1 Ectodomain Construct Inhibits Endothelial Notch Signaling, Tumor Growth, and Angiogenesis

(2008) Y. Funahashi et al.   CANCER RESEARCH

Substrate specificity of γ-secretase and other intramembrane proteases

(2008) A. J. Beel et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Specific Jagged-1 Signal From Bone Marrow Microenvironment Is Required for Endothelial Progenitor Cell Development for Neovascularization

(2008) Sang-Mo Kwon et al.   CIRCULATION

Therapeutic Potential of γ -Secretase Inhibitors and Modulators

(2008) Bruno Imbimbo   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Impaired embryonic haematopoiesis yet normal arterial development in the absence of the Notch ligand Jagged1

(2008) Àlex Robert-Moreno et al.   EMBO JOURNAL

Development of targeted angiogenic medicine

(2008) S. LOGES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Rational targeting of Notch signaling in cancer

(2008) P Rizzo et al.   ONCOGENE

The many facets of Notch ligands

(2008) B D'Souza et al.   ONCOGENE

Notch signaling regulates tumor angiogenesis by diverse mechanisms

(2008) J Dufraine et al.   ONCOGENE

Endothelial expression of the Notch ligand Jagged1 is required for vascular smooth muscle development

(2008) F. A. High et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic Profiling of γ-Secretase Substrates and Mapping of Substrate Requirements

(2008) Matthew L Hemming et al.   PLOS BIOLOGY

Regulation of multiple angiogenic pathways by Dll4 and Notch in human umbilical vein endothelial cells

(2007) Laura S. Harrington et al.   MICROVASCULAR RESEARCH