Article
Immunology
Yuehong Chen, Huan Liu, Yunru Tian, Zhongling Luo, Jingjing Ran, Zhiyong Miao, Qiuping Zhang, Geng Yin, Qibing Xie
Summary: This study evaluated the therapeutic effects of FFD, a small-molecule drug that targets cPLA2, on LPS-induced ALI. FFD inhibited cPLA2 activity and the cPLA2/ERK/p65 signaling pathway, suppressed p65 translocation, and reduced the production of cytokines, chemokines, and downstream hydrolysates. These findings suggest that FFD holds promise as a therapeutic option for cPLA2-involved diseases, particularly ALI.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Chemistry, Medicinal
Angelina Subeska, Merlin Ekodo Voundi, Walburga Hanekamp, Dennis Mulac, Klaus Langer, Matthias Lehr
Summary: Cytosolic phospholipase A(2)alpha (cPLA(2)alpha) is an interesting target for new anti-inflammatory drug development. The metabolic stability and permeability of potent inhibitors can be improved by introducing alkyl substituents or increasing rigidity near the ketone group. The polar ketone group is a decisive factor in the reverse transport of molecules, and its removal significantly increases permeability. However, these structural variations may lead to a decrease in the inhibitory potency against cPLA(2)alpha.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Medicine, Research & Experimental
Yishan Huo, Kainan Zhang, Songtao Han, Yangchun Feng, Yongxing Bao
Summary: The study found that LCP2 is a favorable prognostic biomarker in LUAD patients, with its expression correlated with clinical stage and lymph node metastasis. High LCP2 expression was associated with increased overall survival, potentially due to an enrichment of immune functions. Additionally, LCP2 expression was positively correlated with PD-L1 expression in LUAD tissues.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Immunology
Yafa Fetfet Malada Edelstein, Yulia Solomonov, Nurit Hadad, Leenor Alfahel, Adrian Israelson, Rachel Levy
Summary: In mutant SOD1(G93A) transgenic mice, elevated levels of misfolded SOD1 and cPLA(2)alpha were detected at 6 weeks, with a strong correlation between them. Motor neurons with increased expression of cPLA(2)alpha and TNF alpha were found to be in an inflammatory state as early as 6 weeks before disease onset, induced by accumulated misfolded SOD1 leading to cPLA(2)alpha upregulation through TNF alpha induction.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Neurosciences
Anne-Kathrin Lutz, Helen Friedericke Bauer, Valentin Ioannidis, Michael Schoen, Tobias M. Boeckers
Summary: This study validated a set of commercial and homemade SHANK3 antibodies in Western Blotting, synaptic immunocytochemistry, and immunohistochemistry, and found that only a small subset of the antibodies met the criteria of quality and specificity. The study highlights the importance of antibody specificity testing in the research field.
FRONTIERS IN SYNAPTIC NEUROSCIENCE
(2022)
Article
Anatomy & Morphology
Shuying Jiang, Toshiya Tanaka, Ren Yagami, Go Hasegawa, Hajime Umezu, Yukio Fujiyoshi, Tatsuhiko Kodama, Makoto Naito, Yoichi Ajioka
Summary: The study detected the expression of HNF4 alpha in different animal species using antibodies, showing differences in tissue distribution and alternative promoter usage leading to different isoforms in different species. Antibody K9218 was mainly expressed in tissues like hepatocytes, proximal tubules of the kidney, and intestinal mucosa, while antibody H6939 was mainly expressed in tissues such as the stomach, pancreas, and bile duct.
MICROSCOPY RESEARCH AND TECHNIQUE
(2021)
Article
Oncology
Irene Carretero-Barrio, Tamara Caniego-Casas, Marta Rosas, Maria Concepcion Sanchez, Noelia Martinez-Janez, Miguel Chiva, David Sarrio, Gema Moreno-Bueno, Jose Palacios, Belen Perez-Mies
Summary: HER2-equivocal cases represent around 15% of breast carcinomas, and 20-40% of them are HER2-amplified. The evaluation of HER2 amplification status in equivocal cases is crucial for patient management. In this study, we investigated the performance of STRAT4, a RT-qPCR platform, compared to the recommended methods for the evaluation of HER2-equivocal cases. The results showed that STRAT4 is not reliable for the assessment of HER2 amplification status in equivocal cases.
Article
Biotechnology & Applied Microbiology
Chia-Chun Hsiao, Yi-Wei Chiang, Tai-Ling Chao, Zen-Uong Tsai, Ting-Xuan Wang, Yu-Wei Jiang, Hsiang-Fu Hsu, De-Chao Lu, Jann-Tay Wang, Jen-Ren Wang, An-Bang Wang, Sui-Yuan Chang, Shih-Chung Chang
Summary: In this study, a Western blot strip coated with multiple SARS-CoV-2 antigens was developed to comprehensively study antibody profiles in COVID-19 patient sera. The levels of specific antibodies directed against SARS-CoV-2 spike, S2, and nucleocapsid proteins showed a positive correlation with disease progression. The multi-antigen-coated Western blotting assay also demonstrated a correlation with the neutralizing potency of the sera. Additionally, a unique antigenic epitope was identified within the S2 subunit that was specifically recognized by COVID-19 patient serum.
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2022)
Article
Medicine, Research & Experimental
Evangelos Falidas, Eirini Kitsiouli, Despoina Spyropoulou, Evangelos Tsiambas, Asimina Kalogirou, George Tsouvelas, Stylianos Papadopoulos, Michail Mitsis, Marilena Lekka, Sofianiki Mastronikoli, Dimitrios Peschos, Odysseas Dimas, Konstantinos Vlachos
Summary: This study investigated the expression of SPLA2 in colon adenocarcinoma (CA) and found that SPLA2 over-expression was significantly associated with increased tumor diameter. This suggests that SPLA2 may influence endogenous cell responses through its enzymatic activity, and it has the potential to be a biomarker for monitoring CA patients.
Review
Cell Biology
Hao-Jie Zhang, Yi-Tuo Chen, Xin-Li Hu, Wan-Ta Cai, Xiang-Yang Wang, Wen-Fei Ni, Kai-Liang Zhou
Summary: This review summarizes the mechanisms of cPLA2 involvement in CNS trauma and potential strategies to improve clinical outcomes. It highlights the roles of neuroinflammation, lysosome membrane functions, and autophagy activity in CNS trauma damage.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Yulia Solomonov, Nurit Hadad, Rachel Levy
Summary: The present study aimed to determine whether there is a binding between cPLA(2)alpha-C2 domain and p47(Phox)-PX in mouse macrophages, to further support the role of cPLA(2)alpha in oxidase regulation also in mouse phagocytes.
MOLECULAR BIOLOGY REPORTS
(2022)
Article
Pathology
Diana M. Oramas, Cesar A. Moran
Summary: This article presents three cases of primary giant cell tumors of the lung in male patients aged between 43 and 54 years, who presented with nonspecific symptoms. After surgery, two patients were followed up for 12 months without evidence of recurrence or metastasis. These cases represent an unusual occurrence that should be considered in the differential diagnosis of primary pulmonary tumors rich in multinucleated giant cells.
AMERICAN JOURNAL OF SURGICAL PATHOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Lucas Baena Carstens, Raissa Campos D'amico, Karen Fernandes de Moura, Eduardo Morais de Castro, Flavia Centenaro, Giovanna Silva Barbosa, Guilherme Vieira Cavalcante da Silva, Isadora Brenny, Julio Cesar Honorio D'Agostini, Elisa Carolina Hlatchuk, Sabrina Pissette de Lima, Ana Paula Camargo Martins, Marina De Castro Deus, Carolline Konzen Klein, Ana Paula Kubaski Benevides, Seigo Nagashima, Cleber Machado-Souza, Ricardo A. Pinho, Cristina Pellegrino Baena, Lucia de Noronha
Summary: The activation of the inflammasome complex is significantly increased in COVID-19 patients, indicating its involvement in the pathogenesis of the disease. Additionally, levels of cell pyroptosis and inflammasome-derived cytokines are greatly elevated.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, General & Internal
Mehwish Feroz Ali, Mervyn Hosein, Saima Butt, Rehan Siddiqui
Summary: This study investigated the expression of zinc alpha-2 glycoprotein (ZAG) in oral squamous cell carcinoma (OSCC) tissue samples and its association with cancer stage and subscale parameters. The results showed that high ZAG expression is significantly associated with smaller tumor size, lymph node involvement, early stages of OSCC, and less differentiated tumors. ZAG expression in early stages of oral cancer development can assist clinicians in planning effective treatment modalities and monitoring treatment outcomes.
PAKISTAN JOURNAL OF MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Zsuzsanna Szabo, Balazs Dezso, Klara Fodor, Krisztian Szegedi, Tibor Flasko, Erzsebet Szabo, Gabor Olah, Eva Sipos, Nikoletta Dobos, Janos Gardi, Andrew V. Schally, Gabor Halmos
Summary: This study investigates the expression of LHRH and LHRH-R-I in transitional cell carcinoma (TCC) type of human bladder cancer, finding high incidence of expression of both in the samples examined. Positive immunostaining for LHRH-R-I with different expression intensity was found in all samples, showing a negative correlation with TCC grade.
Expression of Concern
Nanoscience & Nanotechnology
Ramya Subramani, Shinyjoy Elangomannan, Kavitha Louis, Soundarapandian Kannan, Dhanaraj Gopi
ACS APPLIED MATERIALS & INTERFACES
(2020)
Article
Chemistry, Inorganic & Nuclear
Karuppaiya Vimala, Arumugam Maruthupandian, Ramasundaram Thangaraj, Soundarapandian Kannan
Summary: The study developed Selenium Mesoporous Silica (SMS) nanocomposites as a dual-drug delivering system with strong anti-tumor effects for molecular targeting. Through a series of experiments, perfect chemistry between the formulated nanocomposites and selected drugs was verified, enhancing specific cellular uptake and inhibitory effects, promoting apoptosis of tumor cells.
JOURNAL OF CLUSTER SCIENCE
(2021)
Article
Chemistry, Inorganic & Nuclear
Duraisamy Meena, Karuppaiya Vimala, Soundarapandian Kannan
Summary: A nanomaterial drug delivery system was designed for treating colon cancer, with controlled drug release behavior at different pH levels. The combination of DOX and Kaempferol was more efficient in inducing cytotoxic effects compared to each drug alone, with in vivo studies showing significant reduction in tumor volume without severe side effects.
JOURNAL OF CLUSTER SCIENCE
(2022)
Article
Environmental Sciences
Ananthanarayanan Yuvaraj, Muthusamy Govarthanan, Natchimuthu Karmegam, Muniyandi Biruntha, Dhanabalan Senthil Kumar, Mohan Arthanari, Rasiravathanahalli Kaveriyappan Govindarajan, Sudipta Tripathi, Swayambhu Ghosh, Ponnuchamy Kumar, Soundarapandian Kannan, Ramasundaram Thangaraj
Summary: Earthworms are capable of reducing soil contamination by heavy metals and improving soil health. The study of earthworms from different industrial sites revealed that vermicasts have lower heavy metal content and higher humic substances, which help decrease heavy metals in the soil.
Article
Environmental Sciences
Ananthanarayanan Yuvaraj, Ramasundaram Thangaraj, Natchimuthu Karmegam, Balasubramani Ravindran, Soon Woong Chang, Mukesh Kumar Awasthi, Soundarapandian Kannan
Summary: The article discusses the dumping of heavy metals in the environment due to the industrial revolution and indiscriminate use of agrochemicals, and current strategies for the remediation of metal-polluted soils and water. Biochar combined with earthworms and vermifiltration is an emerging technique that shows promise in reducing metal ion concentrations effectively.
Article
Environmental Sciences
Shenbagamoorthy Sundarraj, Mohanan Sujitha, Carlton Ranjith Wilson Alphonse, Retnamony Kalaiarasan, Rajaretinam Rajesh Kannan
Summary: The experimental study demonstrated a correlation between BPA exposure and alterations in hematopoiesis that can lead to blood cancer. Zebrafish exposed to BPA showed lethality, developmental effects, embryonic apoptosis, and changes in transcription factors related to hematopoiesis. Molecular dynamic simulation suggested a strong binding affinity between BPA and zebrafish EGFR, indicating potential mechanisms for BPA-induced effects on hematopoietic cells.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Environmental Sciences
Murugan Rajadurai, Natchimuthu Karmegam, Soundarapandian Kannan, Ananthanarayanan Yuvaraj, Ramasundaram Thangaraj
Summary: The study demonstrated that the earthworm species Drawida modesta and Lampito mauritii effectively removed polycyclic aromatic hydrocarbons (PAHs) and total petroleum hydrocarbons (TPHs) from oil-contaminated soil. Seed germination assay results showed a significant increase in germination percentage and index in earthworm inoculated treatments.
JOURNAL OF ENVIRONMENTAL MANAGEMENT
(2022)
Article
Materials Science, Biomaterials
Chandrababu Rejeeth, Alok Sharma, Soundarapandian Kannan, Raju Suresh Kumar, Abdulrahman Almansour, Natarajan Arumugam, Samson Afewerki
Summary: A cost-effective novel biosensor was developed to detect PDGFR associated with cancer progression, achieving a dynamic range of 1-10,000 ng/mL and a detection limit of 1.5 pg/mL using multiwall carbon nanotubes and electrochemical PDGFR conversion sensing. The biosensor displayed good selectivity, repeatability, and stability, providing a pathway for diagnostic interface design and potential new sensor types based on ligand-receptor interactions.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Manickam Rajkumar, Karuppaiya Vimala, Darwin Dasan Tamiliniyan, Ramasundaram Thangaraj, Ramakrishnan Jaganathan, Poomani Kumaradhas, Soundarapandian Kannan
Summary: This study successfully synthesized Ge/PVA/Mg(OH)(2) nanocomposites and demonstrated their good biocompatibility, ability to inhibit Aβ protein expression, and protect neuronal cells from damage. Animal experiments also showed that this nanocomposite has a protective effect on cognitive and synaptic impairments in an AD model. Therefore, Ge/PVA/Mg(OH)(2) nanocomposite may be a potential candidate for treating AD.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Multidisciplinary Sciences
Chinnaraj Santhosh, Balamuralikrishnan Balasubramanian, Palani Vino, Maluventhen Viji, Chandrababu Rejeeth, Soundarapandian Kannan, Hammad Ullah, Kannan R. R. Rengasamy, Maria Daglia, Arumugam Maruthupandian
Summary: This study successfully biosynthesized selenium nanoparticles (Gw-SeNPs) from Goniothalamus wightii and characterized their properties. The Gw-SeNPs exhibited a polygonal shape and highly crystalline structure. They showed good antibacterial potential against both gram-positive and gram-negative pathogens, as well as demonstrated antioxidant, cytotoxic, and dye degradation abilities.
JOURNAL OF KING SAUD UNIVERSITY SCIENCE
(2022)
Article
Biotechnology & Applied Microbiology
Shenbagamoorthy Sundarraj, D. N. P. Sudarmani, Ponpandian Samuel, S. P. Sevarkodiyone
Summary: This study focused on the isolation and identification of chromium-reducing bacteria from tannery effluent. Pseudomonas putida was identified as a potential strain for chromium reduction, and its reductase gene was transferred to Escherichia coli DH5 alpha for further study. The results showed that the transformant strain had a high ability to reduce hexavalent chromium, indicating its potential for bioremediation.
JOURNAL OF APPLIED MICROBIOLOGY
(2023)
Article
Chemistry, Multidisciplinary
Shenbagamoorthy Sundarraj, Sankareswari Muneeswaran, Carlton Ranjith Wilson Alphonse, Mohanan Sujitha, Nandhagopal Soundharapandiyan, Vidhya Rajendran, Rajaretinam Rajesh Kannan
Summary: The synthesis of SiO2@TiO2 thin films and their UV protective application in microorganisms and zebrafish embryonic development were investigated. The results showed that the thin films acted as a protective layer, increasing the growth of bacteria and improving the survival rate and development of zebrafish embryos under UV exposure.
ENVIRONMENTAL SCIENCE-NANO
(2022)
Article
Chemistry, Multidisciplinary
Sreevani Vellingiri, Chandrababu Rejeeth, Nipun Babu Varukattu, Alok Sharma, Raju Suresh Kumar, Abdulrahman Almansour, Natarajan Arumugam, Samson Afewerki, Soundarapandian Kannan
Summary: In this study, iron nanoparticles were synthesized from goat blood and used as nanocarriers for drug delivery. The results showed that the nanoparticles had good drug release effects in lung cancer cells and could be used for anticancer treatment. Future research will focus on developing targeted nuclear treatment for cancer and other related diseases using different drug carrier systems.
NEW JOURNAL OF CHEMISTRY
(2022)
Review
Materials Science, Biomaterials
Jalaja Prasad Malavika, Chellappan Shobana, Shenbagamoorthy Sundarraj, Mariappan Ganeshbabu, Ponnuchamy Kumar, Ramakrishnan Kalai Selvan
Summary: Carbon quantum dots (CQDs) have attracted significant attention due to their unique characteristics and potential applications in diverse biomedical fields. This review comprehensively examines the different synthesis methods and raw materials used in recent years, and focuses on the potential application of CQDs in cancer theranostics, particularly in bio-imaging and targeted drug delivery.
BIOMATERIALS ADVANCES
(2022)
Correction
Environmental Sciences
Ananthanarayanan Yuvaraj, Muthusamy Govarthanan, Natchimuthu Karmegam, Muniyandi Biruntha, Dhanabalan Senthil Kumar, Mohan Arthanari, Rasiravathanahalli Kaveriyappan Govindarajan, Sudipta Tripathi, Swayambhu Ghosh, Ponnuchamy Kumar, Soundarapandian Kannan, Ramasundaram Thangaraj
