Article
Oncology
Sandra Gonzalez Maldonado, Theron Johnson, Erna Motsch, Stefan Delorme, Rudolf Kaaks
Summary: This study evaluated the early detection accuracy of a test panel of tumor-associated autoantibodies optimized for lung cancer detection, using blood samples from the German Lung Cancer Screening Intervention Trial. The results showed low sensitivity of the test panel in detecting lung cancer, compared to low-dose computed tomography screening, but higher specificity in control groups.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiang Cai, Natthaya Triphuridet, Yeqing Zhu, Nan You, Rowena Yip, David F. Yankelevitz, Claudia Henschke
Summary: Bronchiectasis is prevalent in smokers undergoing low-dose CT screening, and the occurrence of respiratory symptoms and acute events increases with the severity of the Early Lung and Cardiac Action Program Bronchiectasis score.
Review
Oncology
J. L. Dickson, C. Horst, A. Nair, S. Tisi, R. Prendecki, S. M. Janes
Summary: Lung cancer is the leading cause of cancer death worldwide, with early detection playing a crucial role in improving survival rates. Studies have shown that low-dose computed tomography can significantly reduce lung cancer-specific mortality. Despite some barriers and concerns, this screening method should still be widely promoted.
ANNALS OF ONCOLOGY
(2022)
Review
Critical Care Medicine
Deepti Singhvi, Jessica Bon
Summary: Comorbidities significantly impact COPD patients, and targeted early screening and treatment may have a significant effect on COPD outcomes. Recent studies suggest that certain radiographic features can serve as surrogate markers for comorbid disease in COPD patients.
Review
Medicine, General & Internal
Scott J. Adams, Emily Stone, David R. Baldwin, Rozemarijn Vliegenthart, Pyng Lee, Florian J. Fintelmann
Summary: Randomised controlled trials have shown that low-dose CT lung cancer screening reduces mortality compared with chest radiography or no screening. However, uncertainties remain about optimizing clinical and cost effectiveness. This Review provides an international perspective on lung cancer screening, covering clinical trials, identification of individuals who benefit, management of screen-detected findings, smoking cessation interventions, cost-effectiveness, artificial intelligence and biomarkers, and challenges and opportunities in implementation.
Article
Medicine, General & Internal
Lisa Jungblut, Harry Etienne, Caroline Zellweger, Alessandra Matter, Miriam Patella, Thomas Frauenfelder, Isabelle Opitz
Summary: This pilot study in Switzerland assesses the implementation and performance of low-dose CT lung cancer screening and explores its potential impact on reducing mortality rates. The study enrolls participants meeting specific criteria and uses LDCT scans for assessment. Preliminary results suggest the feasibility of LDCT lung cancer screening in Switzerland.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Claire Bradley, Alison Boland, Louisa Clarke, Naomi Dallinson, Claire Eckert, Deborah Ellames, Jonathan Finn, Rhian Gabe, Neil Hancock, Martyn P. T. Kennedy, Jason Lindop, Ayad Mohamed, Gabriel Mullen, Rachael L. Murray, Suzanne Rogerson, Bethany Shinkins, Irene Simmonds, Sara Upperton, Anne Wilkinson, Philip A. Crosbie, Matthew E. J. Callister
Summary: Incorporating spirometry into LDCT screening for lung cancer may help identify individuals with undiagnosed COPD, but the downstream impacts are not well described.
Article
Radiology, Nuclear Medicine & Medical Imaging
Mario Silva, Gianluca Milanese, Stefano Sestini, Federica Sabia, Colin Jacobs, Bram van Ginneken, Mathias Prokop, Cornelia M. Schaefer-Prokop, Alfonso Marchiano, Nicola Sverzellati, Ugo Pastorino
Summary: This study analyzed the distribution of Lung-RADS v1.1 volumetric categories and lung cancer outcomes within 3 years in order to explore personalized algorithm for lung cancer screening. It found that nodule volume was a strong predictor of lung cancer risk and personalized screening algorithm by increased interval seems feasible in 80% of NLST eligible participants.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Sung Hyun Yoon, Yong Ju Kim, Kibbeum Doh, Junghoon Kim, Kyung Hee Lee, Kyung Won Lee, Jihang Kim
Summary: This study assessed interobserver agreement in Lung-RADS categorisation of subsolid nodules in low-dose screening CTs, showing higher concordance among experienced thoracic radiologists. Overall, the interobserver agreement was moderate.
EUROPEAN RADIOLOGY
(2021)
Article
Health Care Sciences & Services
Christine Neslund-Dudas, Amy Tang, Elizabeth Alleman, Katie R. Zarins, Pin Li, Michael J. Simoff, Jennifer Elston Lafata, Katharine A. Rendle, Andrea N. Burnett Hartman, Stacey A. Honda, Caryn Oshiro, Oluwatosin Olaiya, Robert T. Greenlee, Anil Vachani, Debra P. Ritzwoller
Summary: This study aimed to determine factors associated with the uptake of lung cancer screening. The study found that age, gender, smoking history, COPD, and receiving care in a centralized screening program were positively associated with completing the screening. Insurance status, race, and neighborhood socioeconomic status were negatively associated with screening uptake.
JOURNAL OF GENERAL INTERNAL MEDICINE
(2023)
Article
Respiratory System
Robert P. Young, Ralph C. Ward, Raewyn J. Scott, Greg D. Gamble, Gerard Silvestri
Summary: The severity of AL is related to the screening outcomes of LC, reducing the risk of death; although the severe AL group has higher risks of developing and dying from LC, no significant reduction in LC mortality was observed after screening.
Article
Oncology
Sandra Gonzalez Maldonado, Lucas Cory Hynes, Erna Motsch, Claus-Peter Heussel, Hans-Ulrich Kauczor, Hilary A. Robbins, Stefan Delorme, Rudolf Kaaks
Summary: In a German trial, the LCRAT + CT and Polynomial models showed useful discrimination of screening participants for one-year lung cancer risk following CT examination. Our results illustrate the remaining heterogeneity in risk within screening-eligible subjects and the trade-off between a low-frequency screening approach and delayed detection.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark M. Hammer, Suzanne C. Byrne, Chung Yin Kong
Summary: This study investigated factors influencing the false positive rate in CT LCS and found that patient-specific and site/radiologist-specific factors significantly affected the results, particularly with less experienced radiologists having a higher false positive rate. Screening programs may compare their radiologists' false positive rates to national benchmarks through quality assurance programs.
ACADEMIC RADIOLOGY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Mark M. Hammer, Suzanne C. Byrne, Ron Blankstein
Summary: This study retrospectively evaluated the accuracy of reporting coronary calcification on lung cancer screening CTs in real-world scenarios, as well as the subsequent testing and prescribing of statins. The results showed that 65% of patients had concordant coronary calcification scores in paired cardiac CTs, while in 34% of patients, the calcifications were not mentioned or underestimated. Reporting coronary artery calcification led to new statin prescriptions, with a higher odds ratio for calcifications with significant incidental findings. Radiologists should consider reporting coronary calcifications to facilitate risk-benefit discussions with physicians.
ACADEMIC RADIOLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Eui Jin Hwang, Jin Mo Goo, Hyae Young Kim, Jaeyoun Yi, Yeol Kim
Summary: Elevating the diameter threshold for solid nodules from 6 to 9 mm may lead to a substantial reduction in unnecessary follow-up LDCTs with a small proportion of diagnostic delay of lung cancers.
EUROPEAN RADIOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
K- Jenderka, S. Delorme
Article
Multidisciplinary Sciences
Anna Mlynarska-Bujny, Sebastian Bickelhaupt, Frederik Bernd Laun, Franziska Koenig, Wolfgang Lederer, Heidi Daniel, Mark Edward Ladd, Heinz-Peter Schlemmer, Stefan Delorme, Tristan Anselm Kuder
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Sandra Gonzalez Maldonado, Erna Motsch, Anke Trotter, Hans-Ulrich Kauczor, Claus-Peter Heussel, Silke Hermann, Sylke Ruth Zeissig, Stefan Delorme, Rudolf Kaaks
Summary: A study on lung cancer screening among long-term smokers revealed a risk of overdiagnosis in the screening group, especially for individuals with shorter life expectancies. The excess cumulative incidence in the screening arm was largely driven by adenocarcinomas, suggesting a major risk of overdiagnosis for individuals with comparatively short remaining life expectancies.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Mark O. Wielpuetz, Michael U. Puderbach, Stefan Delorme
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Christian J. Herold, Stefan Delorme, Marc-Andre Weber, Wolfgang Reith, Thomas Helmberger, Max Reiser
Article
Anatomy & Morphology
Ayaka Ando, Peter Parzer, Michael Kaess, Susanne Schell, Romy Henze, Stefan Delorme, Bram Stieltjes, Franz Resch, Romuald Brunner, Julian Koenig
Summary: By longitudinally tracking structural brain development during adolescence, this study found that age best predicted longitudinal changes, while pubertal status had a significant impact on certain brain regions. However, the major limitation of this study was the recruitment of only two cohorts, limiting the investigation of complete trajectories over 6 years of development. Further longitudinal studies in more diverse samples are needed to replicate these findings and explore mechanisms underlying norm-variants in brain development.
BRAIN STRUCTURE & FUNCTION
(2021)
Editorial Material
Radiology, Nuclear Medicine & Medical Imaging
Stefan Delorme, Christian Herold
Review
Radiology, Nuclear Medicine & Medical Imaging
Stefan Delorme, Rudolf Kaaks
Summary: Effective organization of low-dose CT screening requires the establishment of an articulated structure, with widely distributed pulmonology offices as primary contacts for participants, and central CT facilities with expert skills and high-level equipment. This ensures that the benefits of screening outweigh potential harms and are accepted by the public.
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Rudolf Kaaks, Stefan Delorme
Summary: Lung cancer screening should be targeted at individuals with elevated risk and sufficient residual life expectancy to ensure benefits outweigh risks.
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2021)
Article
Oncology
Sandra Gonzalez Maldonado, Theron Johnson, Erna Motsch, Stefan Delorme, Rudolf Kaaks
Summary: This study evaluated the early detection accuracy of a test panel of tumor-associated autoantibodies optimized for lung cancer detection, using blood samples from the German Lung Cancer Screening Intervention Trial. The results showed low sensitivity of the test panel in detecting lung cancer, compared to low-dose computed tomography screening, but higher specificity in control groups.
TRANSLATIONAL LUNG CANCER RESEARCH
(2021)
Article
Oncology
E. Wehrse, S. Sawall, L. Klein, P. Glemser, S. Delorme, H. -P. Schlemmer, M. Kachelriess, M. Uhrig, C. H. Ziener, L. T. Rotkopf
Summary: The study explored the potential of higher spatial resolution for imaging of bone metastases using Photon-counting detector (PCD) computed tomography (CT) technology. The experimental PCD CT scanning demonstrated improved visualization of lesion margins and content in breast cancer patients with bone metastases, suggesting a high potential for therapy monitoring in breast cancer. Further studies are warranted to confirm these findings.
Review
Radiology, Nuclear Medicine & Medical Imaging
E. Wehrse, L. Klein, L. T. Rotkopf, W. L. Wagner, M. Uhrig, C. P. Heussel, C. H. Ziener, S. Delorme, S. Heinze, M. Kachelriess, H. -P. Schlemmer, S. Sawall
Summary: Photon-counting detectors, a fundamentally new type of CT detectors, have shown superior capabilities in terms of radiation dose efficiency, contrast-to-noise ratio, metal artifact reduction, and spatial resolution. The authors illustrate the technical principles of this new technology by comparing it with conventional energy-integrating detectors and provide phantom and patient images acquired using whole-body photon-counting CT, laying the foundation for potential future applications in clinical CT.
Article
Oncology
Markus Wennmann, Thomas Hielscher, Laurent Kintzele, Bjoern H. Menze, Georg Langs, Maximilian Merz, Sandra Sauer, Hans-Ulrich Kauczor, Heinz-Peter Schlemmer, Stefan Delorme, Hartmut Goldschmidt, Niels Weinhold, Jens Hillengass, Marc-Andre Weber
Summary: This study analyzed the size and growth dynamics of focal lesions (FL) as well as quantified diffuse infiltration (DI) in untreated smoldering multiple myeloma (SMM) patients and correlated these MRI features with the timepoint and cause of progression. The findings indicated that the size and growth dynamics of FLs were significantly correlated with prognosis and local bone destruction.
Article
Oncology
Maria Pouyiourou, Timothy Wohlfromm, Bianca Kraft, Thomas Hielscher, Damian Stichel, Andreas von Deimling, Stefan Delorme, Volker Endris, Olaf Neumann, Albrecht Stenzinger, Alwin Kraemer, Tilmann Bochtler
Summary: Single-site carcinoma of unknown primary (CUP) is considered a favorable subtype according to ESMO classification, with surgery showing improved OS compared to radiation-based therapy. Baseline clinical parameters have minimal impact on prognosis, while deleterious TP53 mutations and DNA copy number loss are independent adverse risk factors.
EUROPEAN JOURNAL OF CANCER
(2021)
Review
Radiology, Nuclear Medicine & Medical Imaging
Rudolf Kaaks, Stefan Delorme
Summary: Screening with LDCT can reduce lung cancer mortality by approximately 20%, but the risk of over-diagnosis may increase rapidly with age, particularly above 75. Below 50, the incidence of lung cancer may be too low for screening to provide a positive balance of benefits to harms and financial costs.
ROFO-FORTSCHRITTE AUF DEM GEBIET DER RONTGENSTRAHLEN UND DER BILDGEBENDEN VERFAHREN
(2021)