Article
Biochemistry & Molecular Biology
Chen Xie, Pen-Jen Lin, Jijun Hao
Summary: PDE4D is highly expressed in chemo-resistant prostate cancer cells, and inhibiting PDE4D with Eggmanone effectively reduces invasion, proliferation, and induces cell death in these cells. Eggmanone also enhances docetaxel cytotoxicity and down-regulates CSC marker gene expression, attenuating sphere formation in chemo-resistant prostate cancer cells.
Article
Medicine, Research & Experimental
Panpan Zhan, Xiong Shu, Meng Chen, Lixin Sun, Long Yu, Jun Liu, Lichao Sun, Zhihua Yang, Yuliang Ran
Summary: This study demonstrates that miR-98 inhibits gastric cancer cell stemness and chemoresistance by targeting BCAT1, indicating that the miR-98/BCAT1 axis may serve as a potential therapeutic target in gastric cancer.
Article
Chemistry, Multidisciplinary
Jiang Li, Qidong Xia, Can Di, Chunni Li, Hang Si, Boxuan Zhou, Shubin Yu, Yihong Li, Jingying Huang, Yiwen Lu, Min Huang, Huixin Liang, Xinwei Liu, Qiyi Zhao
Summary: Targeting CD96 in tumor cells has potential for cancer therapy, as discovered in clinical breast cancer samples. CD96 expression in tumor cells is correlated with poor prognosis, and CD96(+) cancer cell subpopulations display characteristics of breast cancer stem cells and chemoresistance. Inhibition of CD96 in tumor cells enhances chemotherapeutic response in a patient-derived tumor xenograft model.
Article
Biology
Claudia Paterson, Ethan J. Kilmister, Helen D. Brasch, Nicholas Bockett, Josie Patel, Erin Paterson, Gordon Purdie, Sean Galvin, Paul F. Davis, Tinte Itinteang, Swee T. Tan
Summary: The expression of stemness-associated markers in lung adenocarcinoma tissue suggests the presence of cancer stem cells. Further investigation is needed to explore the therapeutic potential of these markers for lung adenocarcinoma.
Review
Biochemistry & Molecular Biology
Sana Kouba, Frederic Hague, Ahmed Ahidouch, Halima Ouadid-Ahidouch
Summary: In the fight against cancer, the appearance of resistant cancer stem cells (CSCs) is a major obstacle for therapeutic strategies using cisplatin. Altered Ca2+ signaling, which is essential for various cellular processes, including proliferation and survival, has been linked to CSC functions and therapy resistance. Understanding the molecular mechanisms linking Ca2+ to cisplatin-induced resistance and CSC behaviors could lead to alternative therapeutic strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cell & Tissue Engineering
Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang, Xingsheng Yang
Summary: The study reveals that EIF5A2 positively regulates stemness in ovarian cancer cells through the E2F1/KLF4 pathway, indicating its potential as a target for CSCs-targeted therapy in ovarian cancer.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Oncology
Cristina Mir, Yoelsis Garcia-Mayea, Laia Garcia, Pol Herrero, Nuria Canela, Rocio Tabernero, Juan Lorente, Josep Castellvi, Eva Allonca, Juana Garcia-Pedrero, Juan Pablo Rodrigo, Angel Carracedo, Matilde Esther LLeonart
Summary: Syntenin-1 (SDCBP) has been identified as an important protein involved in chemoresistance and stemness of HNSCC tumors. Depletion of SDCBP sensitizes HNSCC cells to cisplatin and reduces CSC markers. SDCBP expression is associated with Src activation, poorly differentiated tumor grade, advanced tumor stage, and shorter survival rates in a series of 382 HNSCC patients, indicating it may be a promising therapeutic target for eliminating CSCs and cisplatin resistance.
Article
Chemistry, Multidisciplinary
Jinyuan Liu, Steve Smith, Congzhou Wang
Summary: Current CSC inhibitors lack specificity, efficacy, and applicability, therefore, we propose a nanomaterial-based approach called photothermal differentiation to induce the differentiation of CSCs, leading to the attenuation of cancer cell stemness, chemoresistance, and metastasis.
Article
Environmental Sciences
Zhi-Hui Zhang, Qian Hong, Zhi-Cheng Zhang, Wei-Yang Xing, Shen Xu, Qi-Xing Tian, Qing-Lin Ye, Hua Wang, De-Xin Yu, Dong-Dong Xie, De-Xiang Xu
Summary: This study found that chronic exposure to NaAsO2 may increase stemness and chemoresistance in prostate cancer cells, primarily through ROS-mediated genotoxic stress. This effect is likely to be independent of p53.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Ping Zhao, Jian Sun, Xinwei Huang, Xiangwu Zhang, Xin Liu, Rong Liu, Guangshi Du, Wenqiang Gan, Chuanyu Yang, Yiyin Tang, Ceshi Chen, Dewei Jiang
Summary: In this study, EphA2 was identified as an important gene in breast cancer, associated with cancer stemness and chemoresistance. The results showed that the inflammatory factor TNF-alpha promotes breast cancer stemness through activating the KLF5-EphA2 axis, and phosphorylation of EphA2 at S897 is related to chemoresistance in breast cancer.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Oncology
Marco Giordano, Alessandra Decio, Chiara Battistini, Micol Baronio, Fabrizio Bianchi, Alessandra Villa, Giovanni Bertalot, Stefano Freddi, Michela Lupia, Maria Giovanna Jodice, Paolo Ubezio, Nicoletta Colombo, Raffaella Giavazzi, Ugo Cavallaro
Summary: This study implicates L1CAM in the tumorigenic function of OCSC, showing that L1CAM promotes stemness-related properties in OC cells and tumor initiation. The L1CAM/FGFR1/SRC/STAT3 signaling pathway is identified as a novel driver of OC stemness, providing evidence for potential OC eradication through targeting this pathway.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Cell Biology
Meng Ding, Xiaozhi Zhao, Xiaoqing Chen, Wenli Diao, Yansheng Kan, Wenmin Cao, Wei Chen, Bo Jiang, Haixiang Qin, Jie Gao, Junlong Zhuang, Qing Zhang, Hongqian Guo
Summary: This study reveals that the enrichment of cancer-associated fibroblasts (CAFs) is positively correlated with tumor progression and cancer stemness in renal cell carcinoma (RCC). The study further demonstrates that CAFs enhance cancer stemness by delivering exosomes containing miR-181d-5p to RCC cells, which activates the Wnt/beta-catenin signaling pathway and promotes tumor progression.
CELL DEATH DISCOVERY
(2022)
Review
Oncology
Saravanakumar Marimuthu, Sanchita Rauth, Koelina Ganguly, Chunmeng Zhang, Imayavaramban Lakshmanan, Surinder K. Batra, Moorthy P. Ponnusamy
Summary: Mucins play a crucial role in aggressive cancers by regulating disease progression, tumor proliferation, and chemotherapy resistance. They also contribute to the epithelial to mesenchymal transition (EMT) of cancer cells and enriching and maintaining the cancer stem cell (CSC) population, leading to chemoresistance and tumor progression. Additionally, mucins are involved in metabolic reprogramming during oncogenesis and cancer progression, influencing tumor cell survival, proliferation, and resistance to drugs.
CANCER AND METASTASIS REVIEWS
(2021)
Article
Oncology
Liankun Song, Merci Mino, Jana Yamak, Vyvyan Nguyen, Derron Lopez, Victor Pham, Ali Fazelpour, Vinh Le, Dongjun Fu, Matthew Tippin, Edward Uchio, Xiaolin Zi
Summary: We found that flavokawain A (FKA) can significantly reduce the size and numbers of prostate tumor spheroids formed by prostate cancer stem cells. In addition, FKA also reduces the expression of stem cell markers and inhibits the expression of related proteins. These findings provide a new mechanism for the chemoprevention efficacy of FKA.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Fabrizio Fontana, Martina Anselmi, Patrizia Limonta
Summary: It has been found that obesity is associated with a higher risk of prostate cancer. The interaction between adipose tissue and prostate cancer is not fully understood. This study showed that adipocyte conditioned media can induce stemness properties in prostate cancer cells and promote certain gene expressions. Furthermore, exposure to adipocyte conditioned media led to partial epithelial-to-mesenchymal transition in the cancer cells, resulting in enhanced tumor aggressiveness and chemoresistance.
JOURNAL OF CELL COMMUNICATION AND SIGNALING
(2023)