HIF-1α induced by β-elemene protects human osteosarcoma cells from undergoing apoptosis

Acacetin inhibits VEGF expression, tumor angiogenesis and growth through AKT/HIF-1α pathway

(2011) Ling-Zhi Liu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hypoxia-mediated drug resistance: Novel insights on the functional interaction of HIFs and cell death pathways

(2011) Nadine Rohwer et al.   DRUG RESISTANCE UPDATES

Suppression of dual-specificity phosphatase–2 by hypoxia increases chemoresistance and malignancy in human cancer cells

(2011) Shih-Chieh Lin et al.   JOURNAL OF CLINICAL INVESTIGATION

Bortezomib represses HIF-1α protein expression and nuclear accumulation by inhibiting both PI3K/Akt/TOR and MAPK pathways in prostate cancer cells

(2011) Christina D. Befani et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Involvement of ROS in Curcumin-induced Autophagic Cell Death

(2011) Youn Ju Lee et al.   KOREAN JOURNAL OF PHYSIOLOGY & PHARMACOLOGY

β-Elemene Piperazine Derivatives Induce Apoptosis in Human Leukemia Cells through Downregulation of c-FLIP and Generation of ROS

(2011) Zhiying Yu et al.   PLoS One

Small interfering RNA targeting HIF-1α reduces hypoxia-dependent transcription and radiosensitizes hypoxic HT 1080 human fibrosarcoma cells in vitro

(2011) Adrian Staab et al.   STRAHLENTHERAPIE UND ONKOLOGIE

HIF-1α Partners with FoxA2, a Neuroendocrine-Specific Transcription Factor, to Promote Tumorigenesis

(2010) T.S. Karin Eisinger-Mathason et al.   CANCER CELL

Second-generation HIF-activated oncolytic adenoviruses with improved replication, oncolytic and antitumor efficacy

(2010) T Cherry et al.   GENE THERAPY

Antineoplastic effect ofβ-elemene on prostate cancer cells and other types of solid tumour cells

(2010) Qingdi Quentin Li et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

Cycling hypoxia increases U87 glioma cell radioresistance via ROS induced higher and long-term HIF-1 signal transduction activity

(2010) Hsieh   ONCOLOGY REPORTS

Efficient synthesis of the anticancer β-elemene and other bioactive elemanes from sustainable germacrone

(2010) Alejandro F. Barrero et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Contribution of HIF-1 and drug penetrance to oxaliplatin resistance in hypoxic colorectal cancer cells

(2009) D L Roberts et al.   BRITISH JOURNAL OF CANCER

Artemisinin induces doxorubicin resistance in human colon cancer cells via calcium-dependent activation of HIF-1α and P-glycoprotein overexpression

(2009) C Riganti et al.   BRITISH JOURNAL OF PHARMACOLOGY

PI3K/Akt activity has variable cell-specific effects on expression of HIF target genes, CA9 and VEGF, in human cancer cell lines

(2009) Norazizah Shafee et al.   CANCER LETTERS

HIF-1 is induced via EGFR activation and mediates resistance to anoikis-like cell death under lipid rafts/caveolae-disrupting stress

(2009) Seong-Hee Lee et al.   CARCINOGENESIS

Anti-tumor effect of β-elemene in glioblastoma cells depends on p38 MAPK activation

(2008) Yi-Qun Yao et al.   CANCER LETTERS

HIF-independent regulation of VEGF and angiogenesis by the transcriptional coactivator PGC-1α

(2008) Zoltan Arany et al.   NATURE

Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1α-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer

(2007) Stephen L. Archer et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY