Article
Pharmacology & Pharmacy
Abeer A. A. Salama, Rasha M. Allam
Summary: Colorectal cancer is one of the primary causes of cancer-related mortality worldwide, the study found that chrysin and daidzein have potential anticancer effects on colorectal cancer, improving biochemical alterations and histopathological findings.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Oncology
Magdalena Chrabanska, Magdalena Rynkiewicz, Pawel Kiczmer, Bogna Drozdzowska
Summary: CD44, MMP-2, and MMP-9 are potential molecular prognostic markers in renal cell carcinoma (RCC). The expression of CD44, MMP-2, and MMP-9 in association with the histopathological subtype of RCC affects the survival of patients with renal cancer. CD44 expression and the histopathological subtype of clear-cell RCC are independent risk factors for patient death.
Article
Pharmacology & Pharmacy
Guanyu Yu, Mengnan Xu, Leqi Zhou, Kuo Zheng, Xiaoming Zhu, Jinke Sui, Cheng Xin, Wenjun Chang, Wei Zhang, Fuao Cao
Summary: This study investigated the expression of phosphorylated Focal adhesion kinase (p-FAK) in colorectal cancer (CRC) and its association with prognosis. The results showed that high p-FAK expression was associated with poor prognosis and poor chemotherapeutic response in CRC. Therefore, the expression level of p-FAK can serve as an independent prognostic biomarker for CRC.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Wen-Xiang Li, Jia-Jia Zheng, Gang Zhao, Chen-Tao Lyu, Wei-Qi Lu
Summary: The study revealed that reduced expression of DSCR1 is associated with poor clinicopathologic features and shorter overall survival in CRC patients. Overexpression of DSCR1 isoform 4 led to inhibition of cell cycle and proliferation, as well as induction of senescence in CRC cells. Moreover, DSCR1-4 overexpression suppressed tumor growth and angiogenesis in vivo, highlighting its potential as a critical tumor suppressor in CRC progression.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Xia Li, Li Zha, Bo Li, Rong Sun, Jianhua Liu, Hongwei Zeng
Summary: Research indicates that MMP-9 overexpression is significantly associated with the risk, clinical features, and prognosis of endometrial cancer (EC). In Asian populations, MMP-9 overexpression is linked to tumor grade, FIGO stage, lymph node metastasis, and myometrial invasion. Overall, MMP-9 overexpression predicts a worse prognosis for EC.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Tao Xue, Kejing Yan, Yiqi Cai, Jiancheng Sun, Zhejing Chen, Xiaolei Chen, Wenyi Wu
Summary: Infiltration of CD163+ TAMs in CRC tissue is an independent adverse factor for the prognosis of CRC patients, with high-level infiltration associated with shorter overall survival and disease-free survival.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Jacek Kudelski, Anna Tokarzewicz, Monika Gudowska-Sawczuk, Barbara Mroczko, Piotr Chlosta, Marta Bruczko-Goralewska, Przemyslaw Mitura, Grzegorz Mlynarczyk
Summary: This study aimed to evaluate the expression and activity of matrix metalloproteinase 2 and 9 (MMP-2 and MMP-9) in urinary bladder cancer at different stages. The results showed that the content and activity of MMP-9 were higher than MMP-2, especially in high-grade cancer tissue. MMP-9 may have higher clinical utility as a potential therapeutic option and a diagnostic biomarker for urinary bladder cancer.
Article
Chemistry, Medicinal
Mohammed Salah Ayoup, Marwa M. Abu-Serie, Laila F. Awad, Mohamed Teleb, Hanan M. Ragab, Adel Amer
Summary: A novel series of quinoxaline-based dual MMP-9/MAO-A inhibitors were synthesized to suppress CRC progression. These compounds showed good anticancer potential against HCT116 cells while maintaining safety profiles on normal colonocytes. They exhibited strong inhibitory effects on CRC cell migration and invasion, with considerable selectivity against MAO-A. Experimental results suggested that these compounds may have significant therapeutic implications for CRC treatment.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Zainab Ahmed Rashid, Sanaa K. Bardaweel
Summary: Matrix metalloproteinases (MMPs), especially MMP-9, play a significant role in cancer pathogenesis and progression. However, no effective MMP-9 inhibitor has been approved by the FDA. This review focuses on exploring the strategies for designing MMP-9 inhibitors and their anticancer effects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Aleksandra Salagacka-Kubiak, Dawid Zawada, Lias Saed, Radzislaw Kordek, Agnieszka Jelen, Ewa Balcerczak
Summary: ABCG2 is a cell membrane pump encoded by the ABCG2 gene, which can protect cells against compounds initiating and/or intensifying neoplasia and is considered a marker of cancer stem cells. Its prognostic significance in colorectal cancer remains unclear. Using publicly available data, ABCG2 was shown to be underexpressed in colon and rectum adenocarcinomas, and this downregulation could result from the methylation level of some sites of the ABCG2 gene. However, no association was found between ABCG2 expression level and survival of colorectal cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pathology
Soo Hyung Kim, Jung-Soo Pyo, Byoung Kwan Son, Il Hwan Oh, Kyueng-Whan Min
Summary: This study found that the expression of FABP4 in colorectal cancer is closely correlated with clinical pathological characteristics such as patient age, tumor location, tumor stage, lymph node metastasis, and survival rate.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Oncology
Junpeng Cui, Fangyu Guo, Yifan Yu, Zihuan Ma, Yuting Hong, Junyan Su, Yang Ge
Summary: This study aimed to develop a prognostic gene signature for colorectal cancer (CRC) patients. By analyzing CRC RNA sequencing data, a gene signature significantly associated with patient prognosis was inferred. The signature showed excellent predictive power and was validated in multiple datasets. This research expands the methods for evaluating prognosis in CRC patients.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Sara Silva, Ana Cavaco, Bianca Basso, Joana Mota, Raquel Cruz-Duarte, Miguel Costa, Lara Carvalho, Ana Lima, Luis Costa, Ricardo Ferreira, Marta Martins
Summary: This study investigated the role of a protein called deflamin in colorectal cancer treatment. The research found that deflamin can inhibit tumor growth and metastasis, promote tumor cell apoptosis, and impair cancer cell migration and invasion by reducing the activity of MMP-2 and MMP-9. The use of a zebrafish model also revealed deflamin's ability to inhibit collagen degradation and angiogenesis in the tumor microenvironment.
Article
Biochemistry & Molecular Biology
Jacek Kiezun, Marta Kiezun, Bartlomiej Emil Krazinski, Lukasz Paukszto, Anna Koprowicz-Wielguszewska, Zbigniew Kmiec, Janusz Godlewski
Summary: This study found that the expression levels of GALR1 and GALR3 proteins were elevated in colorectal cancer tissue, and higher GALR3 expression was associated with better prognosis. The expression of GALR1 and GALR3 slightly decreased in myenteric plexuses close to the cancer, but showed no correlation with tumor progression. The expression levels of GALRs in submucosal plexuses did not significantly change between distal and close to the tumor. However, elevated GALR1 expression in submucosal plexuses close to the tumor correlated with poor prognosis, higher tumor grading, and shorter overall survival.
Article
Biochemistry & Molecular Biology
Carla Loreto, Alessandro Polizzi, Veronica Filetti, Giuseppe Pannone, Jean Nunes Dos Santos, Pietro Venezia, Rosalia Leonardi, Gaetano Isola
Summary: This study analyzed the immunohistochemical expression of stromal myofibroblasts in odontogenic keratocysts (OKCs) associated with nevoid basal cell carcinoma syndrome (NBCCS). The results showed a significantly increased expression of alpha-smooth muscle actin (alpha SMA), caldesmon, MMP-7, and MMP-9 in NBCCS-OKCs compared to non-syndromic OKCs. However, the expression of desmin did not show a significant difference between the two types of OKCs. NBCCS-OKCs exhibited a greater distribution of myofibroblasts compared to other OKCs subtypes. Further studies are needed to investigate the correlation between the expression of these markers and the clinical behavior of OKCs.