期刊
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
卷 137, 期 6, 页码 947-952出版社
SPRINGER
DOI: 10.1007/s00432-010-0959-8
关键词
Meta-analysis; Polymorphism; TNF-alpha; Interleukin; Hepatocellular carcinoma
类别
资金
- Harbin Special Funds for Research of Scientific and Technological Innovative Talents [RC2011QN004139]
TNF-alpha-308 G/A, TNF-alpha-238 G/A, IL-1B-31 T/C, IL-1B-511 C/T, and IL-10-1082 G/A polymorphisms have been reported to influence the risk for hepatocellular carcinoma (HCC) in many studies; however, the results still remains controversial and ambiguous. The aim of this study was to determine more precise estimations for the relationship between TNF-alpha, IL-1B, and IL-10 polymorphisms and the risk for HCC by meta-analysis. Electronic searches for all publications were conducted on associations between these variants and HCC in several databases through September 2010. Odds ratios (OR) with 95% confidence intervals (95% CI) were calculated to estimate the strength of this association in a random-effect model. Twenty studies were identified, involving 2,763 HCC patients and 4,152 controls. This meta-analysis showed significant association between TNF-alpha-308 polymorphism and HCC (AA + GA vs. GG: OR = 1.74, 95% CI = 1.12-2.72). In Caucasian and Asian subgroups, OR values (95% CI) were 1.49 (0.58-3.82) and 1.84 (1.06-3.20), respectively. While the ORs for TNF-alpha-238 G/A, IL-1B-31 T/C, -511 C/T and IL-10-1082 G/A polymorphisms and HCC were 1.37 (0.95-2.00), 1.24 (0.99-1.55), 1.12 (0.66-1.88) and 0.91 (0.74-1.12), respectively. The sensitivity analysis further strengthened the overall strong positive correlations. No publication bias was observed in this study. TNF-alpha-308 G/A polymorphism is assumed to confer a higher risk for HCC, especially in Asian population. TNF-alpha-238 G/A, IL-1B-31 T/C, -511 C/T, and IL-10-1082 G/A polymorphisms were not detected to be related to the risk for HCC.
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