Review
Medicine, General & Internal
Akriti Nanda, Jesse Hu, Sarah Hodgkinson, Sanah Ali, Richard Rainsbury, Pankaj G. Roy
Summary: The evidence is uncertain about the oncological outcomes of OBCS compared to other surgical options for breast cancer. OBCS may have benefits in terms of reducing re-excision rates, but may also lead to more complications and higher recall rates. Further research is needed to evaluate the safety and efficacy of OBCS.
COCHRANE DATABASE OF SYSTEMATIC REVIEWS
(2021)
Article
Oncology
Shengyu Pu, Shaoran Song, Heyan Chen, Can Zhou, Huimin Zhang, Ke Wang, Jianjun He, Jian Zhang
Summary: Breast-conserving surgery (BCS) may bring better overall survival and breast cancer-specific survival for young breast cancer patients. A model was constructed to identify appropriate candidates who benefit from BCS.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Ivica Ratosa, Gaber Plavc, Nina Pislar, Tina Zagar, Andraz Perhavec, Pierfrancesco Franco
Summary: This study compared survival outcomes in 1360 patients with early-stage breast cancer, showing that patients treated with breast-conserving therapy had lower rates of recurrence and equivalent overall survival compared to those treated with mastectomy alone. The findings emphasize the importance of adjuvant treatments, including radiation therapy, in improving disease-specific outcomes for early-stage breast cancer patients.
Article
Oncology
Kate R. Pawloski, Marissa K. Srour, Tracy-Ann Moo, Varadan Sevilimedu, Jonas A. Nelson, Paula Garcia, Laurie J. Kirstein, Monica Morrow, Audree B. Tadros
Summary: This study examined the impact of timing of chemotherapy on patient-reported outcomes after breast surgery. The results showed that the satisfaction levels after breast-conserving surgery were not affected by the timing of chemotherapy, while the satisfaction levels after mastectomy with immediate reconstruction varied based on the timing of chemotherapy.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Shiao Li Oei, Anja Thronicke, Gerrit Grieb, Friedemann Schad, Jessica Gross
Summary: This study aimed to evaluate the impact of different surgical options on the quality of life (QoL) of breast cancer patients. The results showed that patients who underwent breast-conserving surgery reported significantly better QoL, while those who underwent mastectomy experienced a decline in QoL immediately after surgery, but gradually improved after 24 months.
Article
Oncology
Fei Wang, Ingrid Meszoely, Tuya Pal, Ingrid A. Mayer, Christina E. Bailey, Wei Zheng, Xiao-Ou Shu
Summary: The study found that elderly patients aged 70 and above who had undergone breast-conserving surgery for early-stage breast cancer had higher mortality rates if they did not receive post-surgery radiotherapy. This suggests that the current recommendations for radiotherapy omission in this patient group may need to be reconsidered.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Oncology
Dang Van Nguyen, Sang-Won Kim, Young-Taek Oh, O. Kyu Noh, Yongsik Jung, Mison Chun, Dae Sung Yoon
Summary: Young women undergoing breast conserving therapy have a higher risk of local recurrence compared to mastectomy alone. Despite aggressive salvage treatments, those with local recurrence after breast conserving therapy have poor prognosis. Novel systemic treatments are needed to improve outcomes for young women with breast cancer undergoing breast conserving therapy.
Article
Oncology
Jiali Ji, Shushu Yuan, Jiawei He, Hong Liu, Lei Yang, Xuexin He
Summary: This study compared the efficacy of breast-conserving therapy (BCT) and mastectomy in early-stage breast cancer patients using the SEER database. The results showed that BCT was associated with improved overall survival (OS) and breast cancer-specific survival (BCSS) compared to mastectomy. Patients with different subtypes and age groups also showed better survival outcomes with BCT compared to mastectomy.
Article
Surgery
Soo Kyung Ahn, Sohee Oh, Jongjin Kim, Jung-Seok Choi, Ki-Tae Hwang
Summary: This study assessed the impact of different types of breast surgery on rates of psychological disorders in breast cancer patients, and found that overall psychological disorders and insomnia rates were lower in patients who underwent total mastectomy (TM) compared to partial mastectomy (PM). Furthermore, breast reconstruction surgery (RS) after TM was associated with reduced rates of psychological disorders and insomnia in younger patients (< 50 years) and those who underwent sentinel lymph node biopsy.
WORLD JOURNAL OF SURGERY
(2022)
Article
Oncology
Mingdi Zhang, Kejin Wu, Peng Zhang, Maoli Wang, Fang Bai, Hongliang Chen
Summary: BCS shows independent favorable prognostic factor and can be acceptable and preferable alternative to mastectomy for well-selected early-stage T1 or T2 CLBC patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Oncology
Changjun Wang, Yan Lin, Hanjiang Zhu, Yidong Zhou, Feng Mao, Xin Huang, Xingtong Zhou, Xi Cao, Qiang Sun
Summary: This meta-analysis found that breast-conserving therapy (BCT) carries an increased risk of local recurrence but does not significantly impact patient survival in terms of disease-free survival, metastasis-free survival, breast cancer-specific survival, and overall survival.
Article
Surgery
Kevin Diao, Xiudong Lei, Weiguo He, Reshma Jagsi, Sharon H. Giordano, Grace L. Smith, Abigail Caudle, Yu Shen, Susan K. Peterson, Benjamin D. Smith
Summary: This study aims to compare long-term quality of life outcomes in breast cancer survivors who received different surgical treatments and identify other important factors.
Article
Oncology
Maria Paz Galeano Machuca, Wen-Ching Wu, Ben-Long Yu, Chih-Tao Cheng
Summary: This study used nationwide data and found that demographic and clinical factors, such as age, pay-for-performance program participation, number of affected lymph nodes, tumor size, and tumor location, are associated with the use of breast-conserving therapy.
CLINICAL BREAST CANCER
(2022)
Article
Oncology
Hakyoung Kim, Sae Byul Lee, Seok-Jin Nam, Eun Sook Lee, Byeong-Woo Park, Ho Yong Park, Hyouk Jin Lee, Jisun Kim, Yong Chung, Hee Jeong Kim, Beom Seok Ko, Jong Won Lee, Byung Ho Son, Sei Hyun Ahn
Summary: This study evaluated the long-term outcomes of Korean women with early breast cancer undergoing breast-conserving surgery plus radiotherapy or total mastectomy. Findings showed that the breast-conserving surgery plus radiotherapy group had better overall survival and breast cancer-specific survival than the total mastectomy group in both the Korean Breast Cancer Registry and Asan Medical Center cohorts. The results suggest that breast-conserving surgery plus radiotherapy is at least equivalent to total mastectomy in terms of overall survival and may influence treatment decisions for early breast cancer patients.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Article
Surgery
Hong Bae Jeon, Ji Hyuk Jung, Sang Hee Im, Yong Bae Kim, Jee Suk Chang, Seung Yong Song, Dae Hyun Lew, Tai Suk Roh, Won Jai Lee, Dong Won Lee
Summary: This study aimed to investigate the impact of immediate breast reconstruction on the risk of breast cancer-related lymphedema. The results showed that immediate breast reconstruction can reduce the incidence of lymphedema.
PLASTIC AND RECONSTRUCTIVE SURGERY
(2023)
Article
Rheumatology
Matthias Klimek, Gisela Buchele, Martin Rehm, Jan Beyersmann, Klaus-Peter Gunther, Hermann Brenner, Til Sturmer, Rolf E. Brenner, Dietrich Rothenbacher
Summary: This study aimed to investigate the relationship between OA-specific assessment values and long-term mortality in patients with advanced OA undergoing arthroplasty. The Ulm Osteoarthritis Study found that arthroplasty reduced pain and improved function, but there was no association between joint-specific WOMAC assessments and long-term mortality. However, generic function assessments were associated with increased risk of mortality.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Clinical Neurology
Hannah Stocker, Leon Beyer, Laura Perna, Dan Rujescu, Bernd Holleczek, Konrad Beyreuther, Julia Stockmann, Ben Schoettker, Klaus Gerwert, Hermann Brenner
Summary: This study aimed to investigate the association between blood biomarkers and Alzheimer's disease (AD) risk. It found that GFAP may be an early biomarker for AD, while p-tau181 and NfL are associated with intermediate risk. The impact of cardiovascular health on p-tau181 and NfL should be considered in risk stratification.
ALZHEIMERS & DEMENTIA
(2023)
Article
Gastroenterology & Hepatology
Feng Guo, Dominic Edelmann, Rafael Cardoso, Xuechen Chen, Prudence R. Carr, Jenny Chang-Claude, Michael Hoffmeister, Hermann Brenner
Summary: This study aimed to evaluate whether a polygenic risk score (PRS) could help define personalized and risk-adapted colorectal cancer (CRC) screening strategies. The study found significant variations in CRC risk based on the PRS, including among individuals with detection and removal of adenomas at colonoscopy. Considering genetic susceptibility, using the PRS to determine risk-adapted surveillance intervals may be helpful.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Clinical Neurology
Laura Perna, Ute Mons, Hannah Stocker, Leon Beyer, Konrad Beyreuther, Kira Trares, Bernd Holleczek, Ben Schoettker, Robert Perneczky, Klaus Gerwert, Hermann Brenner
Summary: This study examined the association between glial fibrillary acidic protein (GFAP), neurofilament light chain (NfL), phosphorylated tau181 (p-tau181) and dementia risk in individuals with comorbidity of neurodegenerative and cerebrovascular disease (mixed pathology). The results showed that the association of GFAP and NfL with dementia risk varied depending on cholesterol levels and APOE ε4 genotype, while no significant association was found with p-tau181. These findings suggest that GFAP and NfL may be better predictors of dementia risk in individuals with mixed pathology.
ALZHEIMERS & DEMENTIA
(2023)
Article
Gastroenterology & Hepatology
Tomotaka Ugai, Koichiro Haruki, Tabitha A. Harrison, Yin Cao, Conghui Qu, Andrew T. Chan, Peter T. Campbell, Naohiko Akimoto, Sonja Berndt, Hermann Brenner, Daniel D. Buchanan, Jenny Chang-Claude, Kenji Fujiyoshi, Steven J. Gallinger, Marc J. Gunter, Akihisa Hidaka, Michael Hoffmeister, Li Hsu, Mark A. Jenkins, Roger L. Milne, Victor Moreno, Polly A. Newcomb, Reiko Nishihara, Rish K. Pai, Lori C. Sakoda, Martha L. Slattery, Wei Sun, Efrat L. Amitay, Elizabeth Alwers, Stephen N. Thibodeau, Amanda E. Toland, Bethany Van Guelpen, Michael O. Woods, Syed H. Zaidi, John D. Potter, Marios Giannakis, Mingyang Song, Jonathan A. Nowak, Amanda I. Phipps, Ulrike Peters, Shuji Ogino
Summary: Early-onset colorectal cancer is on the rise, and the prevalence of certain tumor molecular characteristics varies along different subsites of the colon. Understanding these differences by age and tumor location is crucial for personalized patient management.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Oncology
Miguel Garcia-Pardo, Amy Chang, Sabine Schmid, Mei Dong, M. Catherinen Brown, David Christiani, Hilary Aurora Tindel, Paul Brennan, Chu Chen, Jie Zhang, Brid M. Ryan, David Zaridze, Matthew B. Schabath, Leticia Ferro Leal, Rui Manuel Reis, Adonina Tardon, Guillermo Fernandez-Tardon, Sanjay S. Shete, Angeline Andrew, Hermann Brenner, Wei Xu, Rayjean J. Hung, Geoffrey Liu
Summary: This study examined the association between respiratory and cardiometabolic comorbidities and overall survival (OS) and lung cancer-specific survival (LCSS) in non-small cell lung cancer (NSCLC) patients. The analysis showed that NSCLC patients with respiratory comorbidities had worse LCSS, while those with cardiometabolic comorbidities had a higher risk of death from competing causes. Patients with respiratory comorbidities were also less likely to undergo surgical resection.
JOURNAL OF THORACIC ONCOLOGY
(2023)
Review
Cell Biology
Sabine Kuznia, Anna Zhu, Taisuke Akutsu, Julie E. Buring, Carlos A. Camargo Jr, Nancy R. Cook, Li-Ju Chen, Ting-Yuan David Cheng, Sari Hantunen, I. -Min Lee, JoAnn E. Manson, Rachel E. Neale, Robert Scragg, Aladdin H. Shadyab, Sha Sha, John Sluyter, Tomi-Pekka Tuomainen, Mitsuyoshi Urashima, Jyrki K. Virtanen, Ari Voutilainen, Jean Wactawski-Wende, Mary Waterhouse, Hermann Brenner, Ben Schoettker
Summary: A systematic review and meta-analysis of randomized, placebo-controlled trials (RCTs) and individual patient data (IPD) was conducted to evaluate the effect of vitamin D3 supplementation on cancer mortality in the general population and on prognosis in cancer patients. The main meta-analysis of the 14 RCTs showed a non-significant reduction in cancer mortality by 6%. Subgroup analyses revealed a significant reduction in cancer mortality in trials with daily dosing, while no reduction was seen in trials using a bolus regimen. The IPD meta-analysis confirmed the findings of all trials.
AGEING RESEARCH REVIEWS
(2023)
Letter
Medicine, General & Internal
Hermann Brenner, Thomas Heisser, Rafael Cardoso, Michael Hoffmeister
ANNALS OF INTERNAL MEDICINE
(2023)
Article
Computer Science, Artificial Intelligence
Zhe Liu
Summary: Multi-sensor data fusion is important for integrating information efficiently, but the collected information may be uncertain and conflicting. This paper proposes a novel belief Sorensen coefficient (BSC) to quantify the conflict of evidence based on belief functions theory (BFT). The BSC is further used to design a new multi-sensor data fusion method, which is demonstrated to be effective and practical through numerical examples and application cases.
ARTIFICIAL INTELLIGENCE REVIEW
(2023)
Article
Genetics & Heredity
Chiara Corradi, Giulia Lencioni, Manuel Gentiluomo, Alessio Felici, Anna Latiano, Gediminas Kiudelis, Casper H. J. van Eijck, Katalin Marta, Rita T. Lawlor, Francesca Tavano, Ugo Boggi, Frederike Dijk, Giulia Martina Cavestro, Roel C. H. Vermeulen, Thilo Hackert, Maria Chiara Petrone, Faik Guentac Uzunoglu, Livia Archibugi, Jakob R. Izbicki, Luca Morelli, Alessandro Zerbi, Stefano Landi, Hannah Stocker, Renata Talar-Wojnarowska, Gregorio Di Franco, Peter Hegyi, Cosimo Sperti, Silvia Carrara, Gabriele Capurso, Maria Gazouli, Hermann Brenner, Stefania Bunduc, Olivier Busch, Francesco Perri, Martin Oliverius, Peter Jeno Hegyi, Mara Goetz, Pasquale Scognamiglio, Andrea Mambrini, Paolo Giorgio Arcidiacono, Edita Kreivenaite, Juozas Kupcinskas, Tamas Hussein, Stefano Ermini, Anna Caterina Milanetto, Pavel Vodicka, Vytautas Kiudelis, Viktor Hlavac, Pavel Soucek, George E. Theodoropoulos, Daniela Basso, John P. Neoptolemos, Mateus Nobrega Aoki, Raffaele Pezzilli, Claudio Pasquali, Roger Chammas, Sabrina Gloria Giulia Testoni, Beatrice Mohelnikova-Duchonova, Maurizio Lucchesi, Cosmeri Rizzato, Federico Canzian, Daniele Campa
Summary: This study identified a novel risk locus for PDAC which modulates cancer risk by controlling gene expression through DNA methylation.
JOURNAL OF MEDICAL GENETICS
(2023)
Article
Cardiac & Cardiovascular Systems
Paul M. Haller, Alina Gossling, Christina Magnussen, Hermann Brenner, Ben Schoettker, Licia Iacoviello, Simona Costanzo, Frank Kee, Wolfgang Koenig, Allan Linneberg, Chaterina Sujana, Barbara Thorand, Veikko Salomaa, Teemu J. Niiranen, Stefan Soederberg, Henry Voelzke, Marcus Doerr, Susana Sans, Teresa Padro, Stephan B. Felix, Matthias Nauck, Astrid Petersmann, Luigi Palmieri, Chiara Donfrancesco, Roberto De Ponti, Giovanni Veronesi, Marco M. Ferrario, Kari Kuulasmaa, Tanja Zeller, Francisco M. Ojeda, Stefan Blankenberg, Dirk Westermann
Summary: This study demonstrates the role of cardiac biomarkers in predicting cardiovascular events and death in both general population and individuals with known diabetes. The findings suggest that these biomarkers can help identify individuals at highest risk for cardiovascular events and improve early identification of high-risk individuals. Therefore, they should be considered for routine risk assessment and can enhance the initiation of preventive therapies.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Nutrition & Dietetics
Tafirenyika Gwenzi, Anna Zhu, Petra Schrotz-King, Ben Schoettker, Michael Hoffmeister, Hermann Brenner
Summary: This systematic review and meta-analysis evaluated the effects of vitamin D3 supplementation on serum inflammatory biomarkers among patients with cancer or pre-cancerous lesions. The study found that vitamin D3 supplementation significantly reduced TNF-a levels and may have a suppressive effect on tumor-promoting inflammatory response in patients with cancer or pre-cancerous lesions.
CLINICAL NUTRITION
(2023)
Article
Oncology
Thu Thi Pham, Katharina Nimptsch, Nikos Papadimitriou, Krasimira Aleksandrova, Mazda Jenab, Marc J. Gunter, Loic Le Marchand, Li Li, Brigid M. Lynch, Sergi Castellvi-Bel, Amanda I. Phipps, Stephanie L. Schmit, Hermann Brenner, Shuji Ogino, Edward Giovannucci, Tobias Pischon
Summary: This study used Mendelian randomization to investigate the association between genetically determined circulating resistin concentrations and the risk of colorectal cancer (CRC). The results showed no evidence of a relationship between genetically determined circulating resistin concentrations and the risk of CRC.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Editorial Material
Nutrition & Dietetics
Hermann Brenner
Article
Oncology
Mani Etemad, Foteini Christodoulou, Stefanie Uhlig, Jessica C. Hassel, Petra Schrotz-King, Hermann Brenner, Cornelia M. Ulrich, Karen Bieback, Harald Klueter, Peter Bugert
Summary: This study investigated the effect of platelet activation on CLEC-2 expression and sCLEC-2 plasma level. PDPN significantly increased the aggregation response induced by classical agonists. Stimulation of platelets with ADP or PDPN caused a significant decrease in CLEC-2 on platelets and sCLEC-2 in the plasma. The plasma level of sCLEC-2 was lower in most tumor patients, except for glioblastoma patients who displayed higher levels.