Article
Biochemistry & Molecular Biology
Jyotsana Singhal, Prakash Kulkarni, David Horne, Sanjay Awasthi, Ravi Salgia, Sharad S. Singhal
Summary: The study demonstrated that blocking RLIP can mitigate the harmful effects of p53 loss and inhibit the growth of human breast cancer. Treatment with 2HF reduces mammary hyperplasia and carcinoma incidence, decreases tumor cell proliferation, and increases apoptosis.
MOLECULAR CARCINOGENESIS
(2021)
Article
Biochemistry & Molecular Biology
Chien-Liang Liu, Wen-Chien Huang, Shih-Ping Cheng, Ming-Jen Chen, Chi-Hsin Lin, Shao-Chiang Chang, Yuan-Ching Chang
Summary: The aim of this study was to analyze the morphology and genetics of mammary tumors in MMTV-PyVT mice. It was found that the tumors showed progressive proliferation and invasion. Genetic analysis revealed frameshift insertions/deletions (indels) in Muc4. In conclusion, the MMTV-PyVT transgenic mice were validated as a multistage model for mammary carcinoma development and progression.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Immunology
Kirsti Hornigold, Martin J. Baker, Polly A. Machin, Stephen A. Chetwynd, Anna-Karin Johnsson, Chiara Pantarelli, Priota Islam, Melanie Stammers, Laraine Crossland, David Oxley, Hanneke Okkenhaug, Simon Walker, Rachael Walker, Anne Segonds-Pichon, Yoshinori Fukui, Angeliki Malliri, Heidi C. E. Welch
Summary: Tiam1 is a novel regulator of Rac-dependent neutrophil responses, controlling adhesion, migration, reactive oxygen species generation, degranulation, NETs release, and bacterial killing. It functions differently from other Rac-GEFs by restricting neutrophil adhesion and beta 2 integrin activity, and by promoting the expression of regulators of small GTPases and cytoskeletal dynamics.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Lyndsey A. A. Reich, Ana S. S. Leal, Edmund Ellsworth, Karen T. T. Liby
Summary: RXR agonists have shown efficacy in cancer models, but their downstream effects on gene expression vary. In this study, the effects of the novel RXR agonist MSU-42011 and the FDA approved agonist bexarotene on gene expression in HER2+ mammary tumors were analyzed. Both agonists regulated cancer-related gene categories, but the specific pathways affected differed. Understanding these differential effects can contribute to the development of targeted cancer therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Cell Biology
Aishwarya Payapilly, Ryan Guilbert, Tine Descamps, Gavin White, Peter Magee, Cong Zhou, Alastair Kerr, Kathryn L. Simpson, Fiona Blackhall, Caroline Dive, Angeliki Malliri
Summary: The study shows that the TIAM1-RAC1 signaling pathway promotes survival of SCLC cells through nuclear sequestration of Nur77.
Article
Environmental Sciences
Yang Yue, Huadong Zhang, Ping Deng, Miduo Tan, Chengzhi Chen, Bo Tang, Jingdian Li, Fengqiong Chen, Qi Zhao, Ling Li, Rongrong Hao, Hui Wang, Yan Luo, Li Tian, Jia Xie, Mengyan Chen, Zhengping Yu, Zhou Zhou, Huifeng Pi
Summary: Cadmium (Cd) exposure has been reported to be linked to breast cancer (BC) development. In this study, a transgenic mouse model (MMTV-Erbb2) was used to investigate the effects of Cd exposure on BC tumorigenesis. The results showed that Cd exposure accelerated tumor growth and increased Ki67 density in MMTV-Erbb2 mice. Furthermore, Cd exposure disturbed gut microbiota homeostasis, altering Glutamine (Gln) metabolism and promoting mammary tumorigenesis. This study provides new insights into Cd exposure-mediated carcinogenesis.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Biochemistry & Molecular Biology
Lengyun Wei, Xuyang Lu, Shengmei Weng, Shenglong Zhu, Yongquan Chen
Summary: The study found that CE can promote mammary tumor growth by upregulating the AKT/mTOR pathway, and blocking CE synthesis can suppress this signaling pathway, suggesting that SOAT1 may be a potential target for the treatment of breast cancer.
Article
Medicine, Research & Experimental
Ginny Ching-Yun Hsu, Yiyun Wang, Amy Z. Lu, Mario A. Gomez-Salazar, Jiajia Xu, Dongqing Li, Carolyn Meyers, Stefano Negri, Sintawat Wangsiricharoen, Kristen Broderick, Bruno Peault, Carol Morris, Aaron W. James
Summary: By comparing microarrays of pericytes derived from human adipose tissue and periosteum, this study identified TIAM1 as a key regulator of cell morphology and differentiation decisions. TIAM1 acts as a tissue-specific determinant, promoting adipocytic differentiation in adipose tissue-derived pericytes and osteoblastic differentiation in periosteum-derived pericytes. These findings were confirmed in an animal model, where TIAM1 misexpression altered bone or adipose tissue generation. Small molecule inhibitors of Rac1 or RhoA/ROCK signaling reversed TIAM1-induced changes in pericyte differentiation potential.
Article
Oncology
Lin Yan, Sneha Sundaram, Bret M. Rust, Matthew J. Picklo, Michael R. Bukowski
Summary: The study revealed that adipose-derived MCP-1 plays a role in the development of male breast cancer. Mice with a deficiency in adipose Mcp-1 had lower tumor incidence and weight, impacting pathways of amino acid and carbohydrate metabolism. Further investigation into the potential role of adipose-derived MCP-1 in cancer metabolism and tumorigenesis is warranted.
FRONTIERS IN ONCOLOGY
(2021)
Review
Virology
Francesca Parisi, Giulia Freer, Chiara Maria Mazzanti, Mauro Pistello, Alessandro Poli
Summary: MMTV is a virus that may cause mammary carcinoma and lymphoma by exploiting the immune system and causing tumors through insertional mutations. Evidence suggests a possible association between an MMTV-like virus and human breast cancer, sparking controversy for over 40 years. The hypothesis of zoonotic transmission raises questions about prevention and treatment of breast cancer.
Article
Cell Biology
Jian Pu, Youguan Huang, Quan Fang, Jianchu Wang, Wenchuan Li, Zuoming Xu, Xianjian Wu, Yuan Lu, Huamei Wei
Summary: In solid tumors, hypoxia-induced upregulation of Fascin-1 in liver cancer is associated with larger tumor size, lymph node metastasis, distant metastasis, and shorter overall survival in patients. Knockdown of Fascin-1 suppresses migration, invasion, EMT, stemness, and tumor xenograft growth of liver cancer cells, while forced expression of Fascin-1 has the opposite effects.
CELL DEATH DISCOVERY
(2021)
Article
Multidisciplinary Sciences
K. A. Pickering, K. Gilroy, J. W. Cassidy, S. K. Fey, A. K. Najumudeen, L. B. Zeiger, D. F. Vincent, D. M. Gay, J. Johansson, R. P. Fordham, B. Miller, W. Clark, A. Hedley, E. B. Unal, C. Kiel, E. McGhee, L. M. Machesky, C. Nixon, A. E. Johnsson, M. Bain, D. Strathdee, S. R. van Hoof, J. P. Medema, K. Anderson, S. M. Brachmann, V. M. Stucke, A. Malliri, M. Drysdale, M. Turner, L. Serrano, K. Myant, A. D. Campbell, O. J. Sansom
Summary: Indirect targeting of RAC1 via RAC-GEFs can effectively suppress hyperproliferation and tumorigenesis in the murine intestine without affecting normal intestinal homeostasis. Combined targeting of three RAC-GEFs can effectively inhibit RAC1 activity and delay intestinal tumorigenesis.
NATURE COMMUNICATIONS
(2021)
Article
Agriculture, Dairy & Animal Science
Francesca Parisi, Luisa Vera Muscatello, Prospero Civita, Francesca Lessi, Michele Menicagli, Francesca Millanta, Barbara Brunetti, Cinzia Benazzi, Giuseppe Sarli, Giulia Freer, Mauro Pistello, Chiara Maria Mazzanti, Alessandro Poli
Summary: The study revealed the presence of MMTV-like sequences and protein in feline mammary carcinomas from Tuscany and Bologna in Italy, with molecular phenotyping showing that positive FMCs were predominantly basal-like or luminal-like. This highlights the potential role of MMTV-like virus in FMC tumor biology.
Article
Oncology
Heba Allah M. Alsheikh, Brandon J. Metge, Hawley C. Pruitt, Sarah C. Kammerud, Dongquan Chen, Shi Wei, Lalita A. Shevde, Rajeev S. Samant
Summary: The molecular dynamics of developmental processes are repurposed by cancer cells to support cancer initiation and progression. The interaction between NMI and STAT5A plays a crucial role in regulating normal mammary development, while ISG20 expression is found to be involved in tumor progression and metastasis. NMI and STAT5A cooperatively mediate signaling to keep a check on ISG20 expression via the miR-17-92 cluster, which drives tumor progression and metastasis.
Article
Virology
Waqar Ahmad, Neena G. Panicker, Shaima Akhlaq, Bushra Gull, Jasmin Baby, Thanumol A. Khader, Tahir A. Rizvi, Farah Mustafa
Summary: This study aimed to identify genes and pathways dysregulated by MMTV expression in mouse mammary epithelial cells. mRNAseq analysis revealed differentially expressed genes and pathway dysregulation upon MMTV expression. Bioinformatics analysis identified hub genes and dysregulated molecular pathways, including the down-regulation of the PI3-AKT-mTOR pathway. Comparison with other mouse models provided insights into the molecular mechanisms and potential of MMTV to cause cell transformation. These findings have important implications for the understanding of MMTV replication and its involvement in breast cancer.
Review
Virology
Alireza Tahamtan, Masoumeh Tavakoli-Yaraki, Tomasz P. Rygiel, Talat Mokhtari-Azad, Vahid Salimi
JOURNAL OF MEDICAL VIROLOGY
(2016)
Review
Cell Biology
Ceren Eyileten, Kinga Majchrzak, Zofia Pilch, Katarzyna Tonecka, Joanna Mucha, Bartlomiej Taciak, Katarzyna Ulewicz, Katarzyna Witt, Alberto Boffi, Magdalena Krol, Tomasz P. Rygiel
MEDIATORS OF INFLAMMATION
(2016)
Article
Oncology
Magdalena Gabrysiak, Malgorzata Wachowska, Joanna Barankiewicz, Zofia Pilch, Anna Ratajska, Ewa Skrzypek, Magdalena Winiarska, Antoni Domagala, Tomasz P. Rygiel, Alicja Jozkowicz, Louis Boon, Jakub Golab, Malgorzata Firczuk
Article
Biochemistry & Molecular Biology
Tamar Tak, Tomasz P. Rygiel, Guruswamy Karnam, Okan W. Bastian, Louis Boon, Marco Viveen, Frank E. Coenjaerts, Linde Meyaard, Leo Koenderman, Janesh Pillay
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2018)
Article
Multidisciplinary Sciences
Bartlomiej Taciak, Maciej Bialasek, Agata Braniewska, Zuzanna Sas, Paulina Sawicka, Lukasz Kiraga, Tomasz Rygiel, Magdalena Krol
Article
Oncology
Zofia Pilch, Katarzyna Tonecka, Agata Braniewska, Zuzanna Sas, Marcin Skorzynski, Louis Boon, Jakub Golab, Linde Meyaard, Tomasz P. Rygiel
CANCER IMMUNOLOGY RESEARCH
(2018)
Article
Medicine, Research & Experimental
Magdalena Winiarska, Kamil Bojarczuk, Beata Pyrzynska, Jacek Bil, Marta Siernicka, Michal Dwojak, Malgorzata Bobrowicz, Nina Miazek, Piotr Zapala, Agnieszka Zagozdzon, Magdalena Krol, Aleksandra Syta, Paulina Podszywalow-Bartnicka, Zofia Pilch, Anna Dabrowska-Iwanicka, Przemyslaw Juszczynski, Dimitar G. Efremov, Mikolaj Slabicki, Thorsten Zenz, Aude Le Roy, Daniel Olive, Tomasz P. Rygiel, Jeanette H. W. Leusen, Jakub Golab
Article
Multidisciplinary Sciences
Lorenzo Calisti, Matilde Cardoso Trabuco, Alberto Boffi, Claudia Testi, Linda Celeste Montemiglio, Amedee des Georges, Irene Benni, Andrea Ilari, Bartlomiej Taciak, Maciej Bialasek, Tomasz Rygiel, Magdalena Krol, Paola Baiocco, Alessandra Bonamore
Article
Multidisciplinary Sciences
Lukasz Kiraga, Lukasz Cheda, Bartlomiej Taciak, Kamila Rozanska, Katarzyna Tonecka, Aleksandra Szulc, Krzysztof Kilian, Emilia Gorka, Zbigniew Rogulski, Tomasz P. Rygiel, Magdalena Krol
Article
Multidisciplinary Sciences
Zofia Pilch, Katarzyna Tonecka, Marcin Skorzynski, Zuzanna Sas, Agata Braniewska, Tomasz Kryczka, Louis Boon, Jakub Golab, Linde Meyaard, Tomasz P. Rygiel
Article
Oncology
Malgorzata Wachowska, Joanna Stachura, Katarzyna Tonecka, Klaudyna Fidyt, Agata Braniewska, Zuzanna Sas, Iwona Kotula, Tomasz Piotr Rygiel, Louis Boon, Jakub Golab, Angelika Muchowicz
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2020)
Article
Biochemistry & Molecular Biology
Katarzyna Tonecka, Agata Braniewska, Zofia Pilch, Zuzanna Sas, Marcin Skorzynski, Elisabetta Manuali, Tomasz P. Rygiel
Summary: Inflammatory bowel disease is characterized by immune cells infiltration and chronic inflammation. CD200 plays a key role in regulating immune cell activation to prevent excessive inflammation. Experimental data showed that Cd200(-/-) mice displayed reduced severity of colitis compared to WT mice, and CD200(+) cells can inhibit TNF-alpha secretion by macrophages. However, TNF-alpha secretion during DSS-induced intestinal inflammation appears to be independent of CD200 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Oncology
Ewa Cendrowicz, Zuzanna Sas, Edwin Bremer, Tomasz P. Rygiel
Summary: Tumor-Associated Macrophages (TAMs) play a crucial role in tumor development and are potential targets for cancer therapy due to their influence on immunity and tumor microenvironment.
Review
Biochemistry & Molecular Biology
Zuzanna Sas, Ewa Cendrowicz, Isabel Weinhauser, Tomasz P. Rygiel
Summary: The prevalence of liver cancer is increasing in Europe and the USA, with hepatocellular carcinoma being the most common subtype. Chronic liver inflammation leads to the formation of a complex tumor microenvironment in liver cancer. Therapies for liver cancer are challenged by the TME, but new immune-based treatments are being developed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Physiology
R. Pingwara, K. Witt-Jurkowska, K. Ulewicz, J. Mucha, K. Tonecka, Z. Pilch, B. Taciak, K. Zabielska-Koczywas, M. Mori, S. Berardozzi, B. Botta, T. P. Rygiel, M. Krol
JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
(2017)