Article
Medicine, Research & Experimental
Hunian Li, Ping Chou, Fang Du, Liang Sun, Jie Liu, Wei Wang
Summary: The study demonstrated that down-regulated miR-183-3p or up-regulated SIRT1 can attenuate AKI through inhibition of PUMA induced by FOXO3a deacetylation. Therefore, miR-183-3p and SIRT1 could be potential therapeutic targets for AKI.
Review
Biochemistry & Molecular Biology
Dominika Ewa Habrowska-Gorczynska, Marta Justyna Koziel, Karolina Kowalska, Agnieszka Wanda Piastowska-Ciesielska
Summary: FOXO3a is a crucial transcription factor involved in cellular responses to stress and damage, with potential implications in cancer treatment. Its deregulation in cancer cells is associated with tumorigenesis, highlighting its role as a tumor suppressor, while also presenting opportunities for targeted therapies using common anti-cancer drugs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Masanari Taniguchi, Mayu Saito, Takahisa Kuga, Nobuyuki Yamagishi
Summary: Cu2+ plays a key role in the conformational conversion and aggregate formation of Aβ 1-29, while Zn2+ does not confer resistance against MMP-7 cleavage. Cu2+ may play an important role in the aggregation mechanism of Aβ and the pathology of AD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Toxicology
Jianli Sun, Qunfen Cao, Saizheng Lin, Yonghua Chen, Xiao Liu, Qiongyi Hong
Summary: This study identified calmodulin 2 (CALM2) as a novel factor contributing to the resistance of gastric cancer (GC) cells to afatinib. Knockdown of CALM2 overcame the resistance by promoting mitochondrial apoptosis in a caspase-dependent manner. Mechanistically, downregulation of CALM2 led to the upregulation of the FoxO3a/Puma axis and inhibited Akt signaling.
TOXICOLOGY IN VITRO
(2023)
Article
Biochemistry & Molecular Biology
Chang Woo Han, Han Na Lee, Mi Suk Jeong, So Young Park, Se Bok Jang
Summary: PUMA is a direct target in p53-mediated apoptosis and can trigger mitochondrial apoptosis through transcription-dependent and independent mechanisms. Experimental results demonstrate the interaction between PUMA peptide and the DNA binding domain of p53 inhibits the growth of a lung cancer cell line. These findings contribute to understanding the mechanism responsible for p53-mediated apoptosis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Jie Lou, Jian-Xin Lv, You-Ping Zhang, Zhan-Ju Liu
Summary: This study found that the mTOR inhibitor OSI-027 induces apoptosis of colon cancer cells by activating FOXO3a and upregulating PUMA. Moreover, OSI-027 inhibits tumor growth of colon cancer by suppressing the mTOR/c-Myc/FOXO3a axis.
CELL BIOLOGY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Ravit Malishev, Shani Ben-Zichri, Ofek Oren, Nitzan Shauloff, Tal Peretz, Ran Taube, Niv Papo, Raz Jelinek
Summary: The BIM-BH3 motif is a key pro-apoptotic domain that forms toxic amyloid fibrils, leading to cell death and impacting mitochondrial functions.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Article
Sport Sciences
Dong-Joo Hwang, Dong-Hun Choi, Ki-Chun Kwon, Eon-Ho Kim, Tae-Kyung Kim, Jung-Hoon Koo, Joon-Yong Cho
Summary: This study found that regular moderate exercise can improve cognitive function and behavioral symptoms in patients with Alzheimer's disease, and it also has positive effects on transcriptional responses in the brain. These findings suggest that exercise can reverse the pathological features and behavioral symptoms caused by the accumulation of amyloid beta-peptide in the hippocampus.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Review
Chemistry, Medicinal
Weimin Qiu, Hui Liu, Yijun Liu, Xin Lu, Lei Wang, Yanyu Hu, Feng Feng, Qi Li, Haopeng Sun
Summary: Alzheimer's disease (AD) is a difficult to treat progressive neurodegenerative disease characterized by the accumulation of amyloid beta (A beta) plaques in the brain. A beta interacts with various receptors on the plasma membrane and mediates signaling pathways that contribute to the development of AD. Despite ongoing research, there are currently no effective medications for AD. This review discusses the importance of A beta in the pathogenesis of AD, recent progress in targeting A beta-related receptors and compounds, and the challenges and opportunities in developing effective therapies for AD.
MEDICINAL RESEARCH REVIEWS
(2023)
Review
Biochemistry & Molecular Biology
Ruifeng Zhang, Miao Zeng, Xiaolu Zhang, Yujia Zheng, Nuan Lv, Luming Wang, Jiali Gan, Yawen Li, Xijuan Jiang, Lin Yang
Summary: Saponins, specifically ginsenoside Rg1 and pseudoginsenoside-F11, show the most promise in treating Alzheimer's disease by reducing amyloid beta peptide deposition, inhibiting tau phosphorylation, modulating oxidative stress, reducing inflammation, and antiapoptosis. This review provides a comprehensive summary and classification of common saponins studied for their therapeutic potential in Alzheimer's disease, showcasing their underlying mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Marine & Freshwater Biology
Jianqing Chen, Dechun Chen, Jingxin Li, Yuanlong Liu, Xianhong Gu, Xiaohua Teng
Summary: Cadmium-induced damage in carp gills is associated with apoptosis, mainly involving oxidative stress, immunosuppression, and apoptosis-related genes. Cadmium exposure resulted in cadmium accumulation and apoptotic injury caused by mitochondrion, along with oxidative stress and immunosuppression mediated through the JNK-FoxO3a-PUMA pathway.
AQUATIC TOXICOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Wenbo Sun, Hengyuan Kou, Yao Fang, Fan Xu, Zhi Xu, Xiumei Wang, Rong Yin, Qin Zhang, Qin Jiang, Yong Xu
Summary: Abnormal arginine metabolism contributes to the progression of ESCC through the regulation of ASS1, ASL, and FOXO3a expression at different stages. Activation of FOXO3a inhibits primary tumor growth, while inhibition of FOXO3a impairs metastasis.
Article
Endocrinology & Metabolism
Yu Feng, Hantao Wang, Zhi Chen, Bin Chen
Summary: Research suggests that high glucose levels in T2D-IDD patients lead to overactivation of glucose transporters and subsequent gene dysregulation, resulting in apoptosis and IDD development. Inhibiting GLUTs can reverse IDD defects caused by high glucose levels.
Article
Biochemistry & Molecular Biology
Huaxin Li, Mengxue Zhang, Yuanyu Wang, Ke Gong, Tengteng Yan, Dandan Wang, Xianshe Meng, Xiaoxiao Yang, Yuanli Chen, Jihong Han, Yajun Duan, Shuang Zhang
Summary: This study demonstrates that Daidzein (DAI) can alleviate heart failure (HF) by regulating cardiac energy metabolism, improving cardiac function, reducing inflammation, oxidative stress, apoptosis, and fibrosis.
Article
Oncology
Hong-Chieh Tsai, Kuo-Chen Wei, Pin-Yuan Chen, Chiung-Yin Huang, Ko-Ting Chen, Ya-Jui Lin, Hsiao-Wei Cheng, Yi-Rou Chen, Hsiang-Tsui Wang
Summary: Combination treatment of TMZ and VPA in GBM patients can be beneficial for survival, depending on the p53 gene status. In cellular experiments, VPA enhances the antineoplastic effect of TMZ by promoting p53 activation.
FRONTIERS IN ONCOLOGY
(2021)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)