Review
Biochemistry & Molecular Biology
Shogo Ichii, Izumi Matsuoka, Fumiyoshi Okazaki, Yasuhito Shimada
Summary: Human life expectancy has increased, leading to a rising proportion of elderly individuals and the associated issue of skeletal muscle aging. Exercise therapy is currently the only treatment option for this condition. This review explores strategies for modeling skeletal muscle aging in cell cultures and rodents, and discusses the potential of zebrafish models for future research.
Review
Immunology
Jie Xu, Linxin Yu, Feng Liu, Longbiao Wan, Zhenhua Deng
Summary: The complicated connections and cross talk between the skeletal system and the immune system are developing into the field of Osteoimmunology. Cytokines, such as TNF, IL, IFN, and chemokines, play a critical role in bone remodeling, particularly in the pathogenesis and development of osteoporosis. This review summarizes the effects of cytokines on osteoblasts and osteoclasts, offering a reference for the role of immunology in osteoporosis.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Samantha Donsante, Biagio Palmisano, Marta Serafini, Pamela G. Robey, Alessandro Corsi, Mara Riminucci
Summary: Bone formation begins in the embryonic stage and continues throughout life, involving stages of bone modeling and growth, remodeling, and regeneration. Osteoblasts produce, assemble, and control mineralization of the bone matrix, while regulating other cell processes and metabolic activities. Osteoblasts are derived from different skeletal stem cells under the control of multiple regulators at different developmental stages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Fasih Ahmad Rahman, Joe Quadrilatero
Summary: Remodeling of the mitochondrial network plays a critical role in maintaining cellular homeostasis and regulating skeletal muscle regeneration. The balance between biogenesis and mitophagy, as well as mitochondrial fission and fusion, are key processes in mitochondrial network remodeling.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Maria Elena Soto, Israel Perez-Torres, Maria Esther Rubio-Ruiz, Agustina Cano-Martinez, Linaloe Manzano-Pech, Veronica Guarner-Lans
Summary: Frailty is a global health problem that affects clinical practice. It has both physical and cognitive components and is influenced by multiple factors. Frailty leads to oxidative stress and increased proinflammatory cytokines in patients. It impairs various systems and reduces physiological reserve, making individuals more vulnerable to stress. Frailty is associated with aging and cardiovascular diseases, although there is limited research on its genetic factors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Endocrinology & Metabolism
Madelyn R. Lorenz, Jennifer M. Brazill, Alec T. Beeve, Ivana Shen, Erica L. Scheller
Summary: This study established comprehensive maps of sympathetic adrenergic and sensory peptidergic axons within and around the femur and tibia in mice, defining three distinct patterns of periosteal innervation. The results revealed a gradient of bone marrow axon density that increases along the length of the tibia and identified key regions of interest for neuroskeletal studies. This information serves as a guide for future studies and was compiled as a resource for the field as part of the NIH SPARC consortium.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Yoshimitsu Nakanishi, Sujin Kang, Atsushi Kumanogoh
Summary: This article reviews the recent advances in understanding the molecular mechanism of skeletal-neural interactions in bone homeostasis, with a focus on the functions of axon guidance molecules in the establishment and maintenance of the skeletal system.
Article
Endocrinology & Metabolism
Pia Rosgaard Jensen, Thomas Levin Andersen, Pascale Chavassieux, Jean-Paul Roux, Jean-Marie Delaisse
Summary: Bisphosphonates not only strongly inhibit bone resorption, but also negatively affect bone formation, limiting the ability to initiate bone formation. This study reveals a possible mechanism for impeding the recruitment of osteoprogenitor cells, which in turn impacts the process of bone formation.
Article
Cell Biology
Mattia Scalabrin, Viktor Engman, Amanda Maccannell, Annabel Critchlow, Lee D. Roberts, Nadira Yuldasheva, T. Scott Bowen
Summary: In hind limb ischemia (HLI), early-stage ischemic muscles show overt remodeling with excessive autophagy signaling, which normalizes over time. Early activation of the sestrin-AMPK signaling axis may regulate autophagy to stimulate rapid and overt muscle atrophy in HLI, which is normalized within weeks and accompanied by recovery of muscle mass. A complex interplay between Sestrins likely regulates autophagy signaling during early-to-late muscle remodeling in HLI.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Article
Orthopedics
Belle Yu-Hsuan Wang, Allen Wei-Ting Hsiao, Nicodemus Wong, Yi-Fan Chen, Chien-Wei Lee, Wayne Yuk Wai Lee
Summary: This study compared naturally aged mice and dexamethasone-induced mice as models for primary and secondary sarcopenia, respectively. The results showed similar muscle qualities between the two models, suggesting that the dexamethasone-induced mouse model could serve as an alternative model for primary sarcopenia.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Biochemistry & Molecular Biology
Lena-Christin Ingwersen, Marcus Frank, Hendrik Naujokat, Klaas Loger, Rainer Bader, Anika Jonitz-Heincke
Summary: Long-term exposure to BMP-2 promotes osteogenic differentiation and adipogenesis, and regulates mediators involved in osteoclast activation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Cardiac & Cardiovascular Systems
Daniela Carnevale, Giuseppe Lembo
Summary: Our body continuously interacts with the external environment through the nervous system and the immune system to maintain homeostasis; the integration of these two systems provides a unique opportunity to regulate the body's internal balance.
CARDIOVASCULAR RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Alessandra Renzini, Carles Sanchez Riera, Isidora Minic, Chiara D'Ercole, Biliana Lozanoska-Ochser, Alessia Cedola, Giuseppe Gigli, Viviana Moresi, Luca Madaro
Summary: The skeletal muscle, as a highly responsive tissue, undergoes metabolic changes in response to external demand. Various atrophic conditions, such as aging, ALS, and cancer-induced cachexia, lead to muscle wasting through different molecular signaling pathways. Nutritional interventions and physical exercise have been shown to be effective tools for counteracting muscle wasting in atrophic conditions.
Article
Agriculture, Multidisciplinary
Peiyuan Li, Sha Zhang, Hui Song, Stanislav Seydou Traore, Jiangtao Li, David Raubenheimer, Zhenwei Cui, Guangning Kou
Summary: Naringin can promote the transition of skeletal muscle fibers from fast-twitch to slow-twitch through the AdipoR1 signaling pathway, improving exercise endurance and muscle fiber deficiencies related diseases.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Acoustics
Wanzhao Wang, Yi Zhong, Yaling Zhou, Yanan Yu, Jiaxiang Li, Sufang Kang, Zhanke Ma, Xiushan Fan, Lijun Sun, Liang Tang
Summary: This study investigates the effect of low-intensity pulsed ultrasound (LIPUS) on cognitive impairment caused by muscle atrophy in hindlimb unloaded mice. The results show that LIPUS prevents muscle loss and improves cognitive dysfunction in hindlimb unloaded mice. The study also reveals the involvement of the MSTN/AKT/BDNF pathway in LIPUS-mediated cognitive improvement.
JOURNAL OF THE ACOUSTICAL SOCIETY OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Carley Giffert L. Nongpiur, Akalesh Kumar Verma, Rohit Kumar Singh, Mayur Mohan Ghate, Krishna Mohan Poluri, Werner Kaminsky, Mohan Rao Kollipara
Summary: A series of new complexes of ruthenium(II), rhodium(III), and iridium(III) with pyrazoline-based ligands were synthesized and characterized. These compounds exhibited good antibacterial activity against Gram-positive bacteria and moderate antioxidant activity. They also showed moderate affinity for binding to Salmon Milt DNA and demonstrated higher cytotoxicity in Dalton's lymphoma cell lines.
JOURNAL OF INORGANIC BIOCHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Benjamin S. Mitchell, Andrei Chirila, Kevin J. Anderton, Werner Kaminsky, Alexandra Velian
Summary: This study provides insights into the electronic structure of the Fe/Co6Se8 cluster and the redox cooperativity between the Fe active site and the Co6Se8 support. Different types of oxidized Fe/Co6Se8 clusters are isolated depending on the counterion used, and experimental characterization and computational analysis are used to investigate the charge distribution. The findings show that the charge is shared between the Fe edge site and the Co6Se8 core upon oxidation.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Gurunath Sahu, Sushree Aradhana Patra, Pratikshya Das Pattanayak, Werner Kaminsky, Rupam Dinda
Summary: In this study, four new oxidovanadium complexes were synthesized and characterized. These complexes showed interactions with DNA and BSA, and exhibited anticancer activity. Among them, complex 2 showed the highest anticancer activity against HT-29 cell line.
INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Inorganic & Nuclear
Suman Adhikari, Afzal Hussain Sheikh, Nabajyoti Baildya, Ghodrat Mahmoudi, Nurul Alam Choudhury, Obinna Okpareke, Tanushree Sen, Akalesh Kumar Verma, Rohit Kumar Singh, Surajit Pathak, Werner Kaminsky
Summary: A new Pd(II) coordination compound with a distorted square planar geometry has been synthesized and characterized. Supramolecular networks have been formed through various intermolecular interactions. The compound exhibits cytotoxicity and apoptotic effects on cancer cells.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Abdullah A. Alotaibi, Sabrine Hermi, Fouzia Perveen, Abdelhak Othmani, Hamdy A. Hassan, Werner Kaminsky, Cherif Ben Nasr, Mohamed Habib Mrad
Summary: A new layered hybrid compound was synthesized and characterized. The compound has a monoclinic structure composed of alternating corrugated layers. Intermolecular interactions among organic and inorganic groups and water molecules were investigated, and complex impedance spectroscopy was used to analyze the electrical behavior. Molecular docking revealed stable and spontaneous interactions with double-stranded DNA. The compound showed significant antibacterial activity against Klebsiella pneumonia and Staphylococcus aureus when combined with antibiotics.
JOURNAL OF CLUSTER SCIENCE
(2023)
Article
Chemistry, Inorganic & Nuclear
Keisham S. S. Singh, Prabha Devi, Ramila R. R. Gaonkar, Werner Kaminsky
Summary: Reaction of thiazole ligands (L) with [(?(5)-C5Me5)MCl2](2) [M = Ir (1) or Rh (2)] at room temperature yielded iridium(III) and rhodium(III) complexes [(?(5)-C5Me5)M(L)Cl-2] [M = Ir; L = atz (5), ctz (6); M = Rh, L=atz (7), catz (8)]. Characterization was done by FTIR, NMR (H-1 and C-13), and mass spectroscopic data. The molecular structures of 5 and 6 were determined by single-crystal X-ray diffraction. All complexes were obtained as neutral complexes with the ligand coordinated monodentate to the metal. The compounds exhibited moderate to good activity against tested marine fouling bacteria in vitro.
JOURNAL OF COORDINATION CHEMISTRY
(2023)
Article
Chemistry, Physical
Emna Jaziri, Hitler Louis, Chaima Gharbi, Frederic Lefebvre, Werner Kaminsky, Ernest C. Agwamba, ThankGod C. Egemonye, Tomsmith O. Unimuke, Onyinye J. Ikenyirimba, Gideon E. Mathias, Lamia Khedhiri, Cherif Ben Nasr
Summary: This article presents the psychopharmacological potential of piperazine derivatives as antineurotic agents. The crystal and molecular structures of newly synthesized hybrid piperazine derivatives were characterized using various analytical techniques. Computational investigations revealed the conformational correlation with experimental results and the potential binding sites of the derivatives with neurotic enzymes.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Crystallography
Werner Kaminsky, Max Kaganyuk
Summary: This paragraph describes the structures of four different enantiomers, which exhibit monoclinic symmetry with two independent molecules. The structures form R-2(2)(8) hydrogen-bonded ring synthons through N-H...S hydrogen bonds that connect the two independent molecules. Despite the same ring synthon, there are two distinct packing patterns.
ACTA CRYSTALLOGRAPHICA SECTION E-CRYSTALLOGRAPHIC COMMUNICATIONS
(2023)
Article
Chemistry, Inorganic & Nuclear
Robert D. Robinson Jr, Werner Kaminsky, Jeremiah J. Scepaniak
Summary: The complexes Cp(MeIm)IrI2 and Cp-Me4(MeIm)IrCl2 were prepared and methylated to Cp(MeIm)IrMe2 and Cp-Me4(MeIm)IrMe2. Protonation with weak acid led to the formation of methane and Ir-III methyl chloride complexes. Attempting to use larger pyridinium salts gave an intractable mixture.
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2023)
Article
Chemistry, Physical
Merrily Sawkmie, Mayuri Bhattacharyya, Venkanna Banothu, Werner Kaminsky, Paige M. Gannon, Suktilang Majaw, Mohan Rao Kollipara
Summary: A convenient synthesis of twelve complexes of ruthenium(II), rhodium(III), and iridium(III) containing fluorenyl benzohydrazone ligands has been carried out. The complexes were characterized by various analytical techniques. The antibacterial activity of the complexes was tested, and complex 4 and 6 showed significant activity against both Gram-positive and Gram-negative bacteria. In vitro cytotoxicity assessment indicated that complex 9 exhibited promising results with the lowest IC50 value against HeLa cell lines, suggesting its potential as an anticancer agent.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Carley Giffert L. Nongpiur, Akalesh Kumar Verma, Mayur Mohan Ghate, Krishna Mohan Poluri, Werner Kaminsky, Mohan Rao Kollipara
Summary: We designed and synthesized a series of new structurally related Ru(II), Rh(III), and Ir(III) chelating complexes. The complexes were characterized by physicochemical and spectroscopic methods. The antibacterial and cytotoxic activities of the synthesized ligands and metal complexes were evaluated. The results showed that the metal complexes exhibited good antibacterial activity and act as potent anticancer agents.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Suman Adhikari, Afzal Hussain Sheikh, Sevgi Kansiz, Necmi Dege, Nabajyoti Baildya, Ghodrat Mahmoudi, Nurul Alam Choudhury, Raymond J. Butcher, Werner Kaminsky, Savannah Talledo, Eric M. Lopato, Stefan Bernhard, Julia Klak
Summary: Two supramolecular Co(II)-based coordination compounds were synthesized and characterized. Compound 1 consists of two ([tris (2-aminoethyl) amine Co] 1,1-dicyano-2,2-ethylenedithiolate)+ per thiosulphate ion linked through hydrogen bonds. Compound 2 is stabilized by intramolecular O -H center dot center dot center dot O hydrogen bonds, building ribbons that propagate along the crystals. Both compounds exhibit interesting magnetic and catalytic properties.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Physical
Aiborlang Thongni, Pynskhemborlang T. Phanrang, Chayan Pandya, Danny F. Diengdoh, Paige M. Gannon, Werner Kaminsky, Ridahunlang Nongkhlaw, Jyothi Kumari, D. Sriram, Akella Sivaramakrishna, Rishanlang Nongkhlaw
Summary: In this research, a magnetically retrievable heterogenous catalyst, Fe 3 O 4 @PPCA, was successfully prepared and characterized. The nanocatalyst exhibited high catalytic efficiency in the synthesis of spirooxindole derivatives. The use of ultrasonication further demonstrated the versatility of this protocol, which also featured simple work-up procedure, mild reaction conditions, simple catalyst recovery, short reaction time, and the use of environmentally friendly solvents. In vitro biological evaluation revealed the antitubercular and antioxidant activities of the synthesized compounds. Computational study using density functional theory (DFT) was also conducted to investigate the mechanistic pathway for the organic conversions and confirm the catalytic role of PPCA.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Chemistry, Multidisciplinary
Keisham Sarjit Singh, Ramila R. Goankar, Kushal Banerjee, Werner Kaminsky
Summary: A series of pyrazolo[5,1-a]isoquinolines were synthesized by ruthenium(II)-catalyzed annulation of pyrazole derivatives with alkynes in the presence of Cu(OAc)(2)?H2O and AgSbF6. The reaction showed high efficiency and yielded excellent products under a nitrogen atmosphere in water. The annulation process could also be carried out in alcohol at a lower temperature without Cu(OAc)(2)?H2O and silver salt, but with the presence of a carboxylate ligand under air. The compounds were characterized by spectroscopic data, and the crystal structure of a representative compound, pyrazolo[5,1-a]isoquinoline derivative, was determined by single-crystal X-ray crystallography.
MONATSHEFTE FUR CHEMIE
(2023)
Article
Chemistry, Multidisciplinary
Ashlyn A. Kamin, Tara D. Clayton, Claire E. Otteson, Paige M. Gannon, Sebastian Krajewski, Werner Kaminsky, Ramesh Jasti, Dianne J. Xiao
Summary: Due to their unique topology and distinct physical properties, cycloparaphenylenes (CPPs) are attractive building blocks for new materials synthesis. Nucleophilic aromatic substitution reactions on polyfluorinated CPPs can produce polycatechol nanohoop ligands, which can be metalated to produce well-defined, multimetallic CPP complexes. These polycatechol nanohoop ligands provide new strategies for the bottom-up synthesis of atomically precise CPP-based materials and open the door to new carbon nanohoop-based metal-organic materials.