Review
Cell & Tissue Engineering
Qianli Ma, Zahra Miri, Havard Jostein Haugen, Amirhossein Moghanian, Dagnjia Loca
Summary: In 1892, J.L. Wolff proposed that bone could respond to mechanical and biophysical stimuli as a dynamic organ, providing an opportunity for investigations on bone and its potential for tissue repair. Mechanical stimulation through activities like exercise or machinery application can affect the differentiation and development of mesenchymal tissue. The review aims to clarify the extent to which mechanical stimulation can aid in bone tissue repair and regeneration, the underlying mechanisms, and the importance of vascularization in nutrient supply for bone healing and regeneration.
JOURNAL OF TISSUE ENGINEERING
(2023)
Article
Hospitality, Leisure, Sport & Tourism
Kristin L. Popp, Jereme Outerleys, Sarah Gehman, Margaret Garrahan, Sara Rudolph, Elizabeth Loranger, Kathryn E. Ackerman, Adam S. Tenforde, Mary L. Bouxsein, Irene S. Davis
Summary: This study compared the impact variables during the beginning and exertion of treadmill running between female runners with no history of bone stress injuries (BSIs), those with a history of one BSI, and those with a history of multiple BSIs. The results showed that women with multiple BSIs had greater increases in impact loading during exertion compared to those without BSI history. These findings suggest that changes in gait biomechanics during exertion may contribute to the risk of BSI.
JOURNAL OF SPORT AND HEALTH SCIENCE
(2023)
Article
Computer Science, Interdisciplinary Applications
Enhao Zhang, Saeed Miramini, Lihai Zhang
Summary: This study investigates the combined effects of osteoporosis and diabetes on fracture healing process by developing numerical models. The results show that osteoporotic fractures have higher instability and disruption in mesenchymal stem cells' proliferation and differentiation compared to non-osteoporotic fractures. Moreover, when osteoporosis coexists with diabetes, the healing process of fractures can be severely impaired.
COMPUTER METHODS AND PROGRAMS IN BIOMEDICINE
(2024)
Article
Medicine, Research & Experimental
Maximilian M. Menger, Michelle Bleimehl, David Bauer, Claudia Scheuer, Sandra Hans, Dominik Saul, Sabrina Ehnert, Michael D. Menger, Tina Histing, Matthias W. Laschke
Summary: This study investigated the effects of cilostazol on bone regeneration in an atrophic non-union model in mice. The results showed that cilostazol promoted bone formation and vascularization, as well as increased the number of osteoclasts and macrophages. These findings suggest that cilostazol may be a promising drug candidate for the adjuvant treatment of atrophic non-unions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biotechnology & Applied Microbiology
Helen Rinderknecht, Andreas K. Nussler, Konrad Steinestel, Tina Histing, Sabrina Ehnert
Summary: Angiogenesis plays a crucial role in the early healing process of bone fractures. This study developed an in vitro model to simulate smoking conditions and investigate the impact of smoking on angiogenesis and fracture repair.
BIOENGINEERING-BASEL
(2022)
Article
Biochemistry & Molecular Biology
Chengyu Yang, Yang Liu, Ziyan Wang, Minmin Lin, Chao Liu
Summary: Controlled anabolic mechanical loading enhances bone formation mainly through Type H vessels in a S1Pr1-dependent manner.
Article
Engineering, Biomedical
Jonah M. Dimnik, Ifaz T. Haider, W. Brent Edwards
Summary: Predicting fatigue failure in whole bone is important for understanding stress fractures and developing prevention and rehabilitation methods. This study developed and validated a continuum damage mechanics finite element model for predicting fatigue damage and failure. The findings demonstrate the efficacy of this model in predicting damage evolution and fatigue failure of whole bone.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Review
Chemistry, Multidisciplinary
Jasna Nambiar, Sonali Jana, Samit Kumar Nandi
Summary: This review highlights the latest strategies to promote biomaterial-based scaffold vascularization, including the incorporation of cells, growth factors, inorganic ions, etc., as well as structural modifications, biophysical stimuli, and natural molecules.
Review
Medicine, Research & Experimental
Jeffery S. Staab, Alexander L. Kolb, Ryan E. Tomlinson, Paola Divieti Pajevic, Ronald W. Matheny, Julie M. Hughes
Summary: There is mounting evidence suggesting that NSAIDs may inhibit new bone formation and increase risk of stress fractures, particularly in physically active populations like endurance athletes and military recruits. However, human trials evaluating the effects of NSAIDs on exercise and bone adaptation have been inconclusive. Further research is needed to address knowledge gaps and support guidelines for at-risk populations.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Engineering, Biomedical
Jianhua Zhang, Julia Griesbach, Marsel Ganeyev, Anna-Katharina Zehnder, Peng Zeng, Gian Nutal Schaedli, Anke de Leeuw, Yuxiao Lai, Marina Rubert, Ralph Mueller
Summary: The study reveals that mechanical stimulation can promote the formation of 3D bioprinted bone organoids, and long-term mechanical loading is necessary for increasing the density and stiffness of the organoids, as well as promoting osteoblast differentiation.
Article
Green & Sustainable Science & Technology
Lamprini Papargyri, Panos Papanastasiou, George E. Georghiou
Summary: This study investigates the mechanical strength of PV modules using mathematical models, finding that material imperfections and Si thickness have a significant impact on failure load, crack initiation, and propagation. The results indicate that PV modules modeled with isotropic silicon exhibit higher resistance to cracking at lower loads.
Article
Orthopedics
Xiao Yang, Yong-xin Mai, Lan Wei, Li-yang Peng, Feng-xiang Pang, Ling-jun Wang, Zhi-peng Li, Jin-fang Zhang, An-min Jin
Summary: This study found that loss of MLK3 inhibits osteoblast differentiation and bone formation, and delays fracture healing by affecting metabolism and disrupting MAPK signaling.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Engineering, Mechanical
T. D. Campos, M. L. S. Barbosa, A. A. R. Olmos, M. Martins, F. A. M. Pereira, M. F. S. F. De Moura, A. Zille, N. Dourado
Summary: This study evaluates the strain energy release rate under mode I loading in a bone-cement bonded joint and measures cohesive zone laws using the finite element method and non-linear elastic fracture mechanics. The results show consistent fracture toughness in a cortical bone bonded joint with polymethylmethacrylate (PMMA).
THEORETICAL AND APPLIED FRACTURE MECHANICS
(2022)
Article
Endocrinology & Metabolism
Li Zhang, Lin Jin, Jialiang Guo, Kai Bao, Jinglue Hu, Yingze Zhang, Zhiyong Hou, Liping Zhang
Summary: The study demonstrated that CIHH treatment improves fracture healing, increases bone mineral density, and enhances bone strength through the activation of HIF-1 alpha and bone production-related genes.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Engineering, Geological
Zexu Ning, Yiguo Xue, Zhiqiang Li, Maoxin Su, Fanmeng Kong, Chenghao Bai
Summary: Through studying the cyclic loading-unloading compression of granite under hydro-mechanical coupling, it is found that the damage, permeability, and residual strain of the rock are interrelated. The magnitude of cyclic load has a controlling effect on the fatigue behavior of the material. The relationship between permeability and residual strain of the specimens varies with different loading magnitudes. Cyclic load not only causes fatigue damage to rock but also has a compaction effect.
ROCK MECHANICS AND ROCK ENGINEERING
(2022)
Review
Orthopedics
Leonardo Cavinatto, Betina B. Hinckel, Ryan E. Tomlinson, Sunny Gupta, Jack Farr, Arthur R. Bartolozzi
ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY
(2019)
Article
Endocrinology & Metabolism
Jino Park, Andrzej Fertala, Ryan E. Tomlinson
Article
Genetics & Heredity
Wei Zou, Nidhi Rohatgi, Jonathan R. Brestoff, Yan Zhang, Erica L. Scheller, Clarissa S. Craft, Michael D. Brodt, Nicole Migotsky, Matthew J. Silva, Charles A. Harris, Steven L. Teitelbaum
Review
Orthopedics
Russell P. Main, Sandra J. Shefelbine, Lee B. Meakin, Matthew J. Silva, Marjolein C. H. van der Meulen, Bettina M. Willie
JOURNAL OF ORTHOPAEDIC RESEARCH
(2020)
Article
Medicine, Research & Experimental
Zhu Li, Carolyn A. Meyers, Leslie Chang, Seungyong Lee, Zhi Li, Ryan Tomlinson, Ahmet Hoke, Thomas L. Clemens, Aaron W. James
JOURNAL OF CLINICAL INVESTIGATION
(2019)
Article
Biophysics
Brandon A. Coates, Matthew J. Silva
JOURNAL OF BIOMECHANICS
(2020)
Article
Endocrinology & Metabolism
Christopher J. Chermside-Scabbo, Taylor L. Harris, Michael D. Brodt, Ingrid Braenne, Bo Zhang, Charles R. Farber, Matthew J. Silva
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Genetics & Heredity
Flora Szeri, Stefan Lundkvist, Sylvia Donnelly, Udo F. H. Engelke, Kyu Rhee, Charlene J. Williams, John P. Sundberg, Ron A. Wevers, Ryan E. Tomlinson, Robert S. Jansen, Koen van de Wetering
Article
Endocrinology & Metabolism
Brandon A. Coates, Jennifer A. McKenzie, Susumu Yoneda, Matthew J. Silva
Summary: IL-6 plays a role in the inflammatory phase of fracture repair, but its impact on successful repair is not fully understood. In experiments using IL-6 KO mice, it was found that IL-6 knockout enhanced callus formation and bone response after stress fracture injury, possibly through direct action on osteoblast function.
Article
Endocrinology & Metabolism
Pei Hu, Jennifer A. McKenzie, Evan G. Buettmann, Nicole Migotsky, Michael J. Gardner, Matthew J. Silva
Summary: Type 1 diabetes impairs bone formation and fracture healing in humans. Akita mice, with a mutation in the insulin-2 gene, showed reduced bone mass and weaker bones, as well as impaired fracture healing. Akita mice exhibited osteopenia and decreased bone mechanical properties, mimicking some skeletal features of T1DM in humans.
Article
Endocrinology & Metabolism
Taylor L. Harris, Matthew J. Silva
Summary: Using Laser Capture Microdissection, osteocytes enriched intracortical bone tissues were analyzed for gene expression, revealing differential regulation of genes like Ngf, Wnt1, and MMP13 under mechanical loading. This method provided insights into the molecular changes in osteocytes in response to mechanical stimuli.
Article
Endocrinology & Metabolism
Lisa Y. Lawson, Michael D. Brodt, Nicole Migotsky, Christopher J. Chermside-Scabbo, Ramya Palaniappan, Matthew J. Silva
Summary: The secretion of Wnt ligands is essential for adult bone homeostasis, and inhibiting their secretion results in decreased bone formation and increased resorption. Additionally, osteoblast-derived Wnts play a crucial role in mediating the bone anabolic response to tibial loading.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Mingming Yan, Xin Duan, Lei Cai, Weili Zhang, Matthew J. Silva, Robert H. Brophy, Muhammad Farooq Rai
Summary: The study revealed that KIF26B plays a crucial role in injury-induced ectopic calcification. It was found that KIF26B represses osteogenesis by modulating Wnt/β-catenin signaling, making it a potential target for mitigating ectopic calcification.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Taylor L. Harris, Matthew J. Silva
Summary: This study assessed the contribution of osteoblast lineage cells to bone formation induced by mechanical loading. Preexisting Osx and Dmp1 lineage cells were found to play a predominant role in lamellar bone formation, while recruitment of earlier osteoprogenitors and increased cell proliferation supported robust woven bone formation.
Article
Endocrinology & Metabolism
Heather M. Zannit, Matthew J. Silva