Dysapoptosis of Osteoblasts and Osteocytes Increases Cancellous Bone Formation But Exaggerates Cortical Porosity With Age

Activation of resorption in fatigue-loaded bone involves both apoptosis and active pro-osteoclastogenic signaling by distinct osteocyte populations

(2012) Oran D. Kennedy et al.   BONE

Osteocyte apoptosis

(2012) Robert L. Jilka et al.   BONE

For whom the bell tolls: Distress signals from long-lived osteocytes and the pathogenesis of metabolic bone diseases

(2012) Stavros C. Manolagas et al.   BONE

Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee

(2012) David W Dempster et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Estrogen receptor-α signaling in osteoblast progenitors stimulates cortical bone accrual

(2012) Maria Almeida et al.   JOURNAL OF CLINICAL INVESTIGATION

Bax dimerizes via a symmetric BH3:groove interface during apoptosis

(2011) G Dewson et al.   CELL DEATH AND DIFFERENTIATION

Molecular definitions of cell death subroutines: recommendations of the Nomenclature Committee on Cell Death 2012

(2011) L Galluzzi et al.   CELL DEATH AND DIFFERENTIATION

Relationship of age to bone microstructure independent of areal bone mineral density

(2011) Kristy M Nicks et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Targeted ablation of the PTH/PTHrP receptor in osteocytes impairs bone structure and homeostatic calcemic responses

(2011) William F Powell et al.   JOURNAL OF ENDOCRINOLOGY

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Overexpression of Bcl2 in Osteoblasts Inhibits Osteoblast Differentiation and Induces Osteocyte Apoptosis

(2011) Takeshi Moriishi et al.   PLoS One

Decreased body weight in young Osterix-Cre transgenic mice results in delayed cortical bone expansion and accrual

(2011) Rachel A. Davey et al.   TRANSGENIC RESEARCH

Decreased oxidative stress and greater bone anabolism in the aged, when compared to the young, murine skeleton with parathyroid hormone administration

(2010) Robert L. Jilka et al.   AGING CELL

BH3-only proteins: Orchestrators of apoptosis

(2010) Aisha Shamas-Din et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

From Estrogen-Centric to Aging and Oxidative Stress: A Revised Perspective of the Pathogenesis of Osteoporosis

(2010) Stavros C. Manolagas   ENDOCRINE REVIEWS

Continuous elevation of PTH increases the number of osteoblasts via both osteoclast-dependent and -independent mechanisms

(2010) Robert L Jilka et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

The amazing osteocyte

(2010) Lynda F Bonewald   JOURNAL OF BONE AND MINERAL RESEARCH

Intracortical remodelling and porosity in the distal radius and post-mortem femurs of women: a cross-sectional study

(2010) Roger MD Zebaze et al.   LANCET

What old means to bone

(2010) Stavros C. Manolagas et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Does osteocytic SOST suppression mediate PTH bone anabolism?

(2010) Ina Kramer et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Identification of differentially expressed genes between osteoblasts and osteocytes

(2009) Frane Paic et al.   BONE

Increased Lipid Oxidation Causes Oxidative Stress, Increased Peroxisome Proliferator-activated Receptor-γ Expression, and Diminished Pro-osteogenic Wnt Signaling in the Skeleton

(2009) Maria Almeida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intermittent PTH stimulates periosteal bone formation by actions on post-mitotic preosteoblasts

(2008) Robert L. Jilka et al.   BONE

Soluble RANKL Induces High Bone Turnover and Decreases Bone Volume, Density, and Strength in Mice

(2008) S. A. J. Lloyd et al.   CALCIFIED TISSUE INTERNATIONAL

Parathyroid hormone signaling through low-density lipoprotein-related protein 6

(2008) M. Wan et al.   GENES & DEVELOPMENT