期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 28, 期 2, 页码 404-411出版社
WILEY
DOI: 10.1002/jbmr.1714
关键词
HIP FRACTURE; OSTEOPOROSIS; ACUTE MYOCARDIAL INFARCTION
资金
- Taipei Veterans General Hospital, Taipei, Taiwan [V99B1-011, V99C1-125, V100B-013]
- Yen Tjing Ling Medical Foundation, Taipei, Taiwan [CI-97-13, CI-98-16]
- National Science Council [NSC 100-2314-B-075-055]
- UST-UCSD International Center of Excellence in Advanced Bio-engineering [NSC-99-2911-I-009-101]
- Taiwan National Science Council I-RiCE Program
Osteoporotic fractures are associated with increased mortality risk. However, little data are available on the risk of acute myocardial infarction (AMI) after hip fracture. Therefore, we investigated whether hip fracture increased the risk of AMI in a large, nationwide cohort study. We obtained data from 8758 patients diagnosed with hip fracture from 2000 to 2009 and from 4 matched controls for each patient from the Longitudinal Health Insurance Database (LHID 2000), Taiwan. Controls were matched for age, sex, comorbid disorders, and enrollment date. All subjects were followed up from the date of enrollment until AMI, death, or the end of data collection (2009). Cox's regression model adjusted for age, sex, comorbid disorders, and medication was used to assess independent factors determining the risk of development of AMI. As expected, despite the matching, the hip fracture patients had more risk factors for AMI at baseline. A total of 8758 subjects with hip fractures and 35,032 controls were identified. Among these patients, 1183 (257 hip fracture patients and 926 controls) developed AMI during the median 3.2-year (interquartile range 1.4 to 5.8 years) follow-up period. Patients with hip fractures had a higher incidence of AMI occurrence when compared with controls (8.7/1000 person-years versus 6.82/1000 person-years). Multivariate analysis adjusted for baseline covariates indicated that hip fracture was associated with a greater risk for AMI development (hazard ratio [HR] 1.29; 95% confidence interval [CI] 1.12-1.48; p<0.001). We conclude that hip fracture is independently associated with a higher risk of subsequent AMI. (C) 2013 American Society for Bone and Mineral Research.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据