Article
Endocrinology & Metabolism
Evelien Gielen, Jolan Dupont, Marian Dejaeger, Michael R. Laurent
Summary: Muscles and bones are closely related tissues and both osteoporosis and sarcopenia are associated with increased risk of adverse health outcomes. The concept of musculoskeletal frailty captures the overall loss of physiological reserves in the locomotor system with age. The term osteosarcopenia refers to the double jeopardy of osteoporosis and sarcopenia, and muscle-bone interactions at multiple levels may contribute to its pathophysiology.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Endocrinology & Metabolism
Graziana Colaianni, Mariella Errede, Lorenzo Sanesi, Angela Notarnicola, Monica Celi, Roberta Zerlotin, Giuseppina Storlino, Patrizia Pignataro, Angela Oranger, Vito Pesce, Umberto Tarantino, Biagio Moretti, Maria Grano
Summary: Irisin levels are positively correlated with bone density, delaying age-related osteoporosis and potentially impacting osteoblast aging through its effects on bone cells.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Rheumatology
Michael A. Clynes, Celia L. Gregson, Olivier Bruyere, Cyrus Cooper, Elaine M. Dennison
Summary: The coexistence of osteoporosis and sarcopenia, termed 'osteosarcopenia', is expected to increase significantly with an aging population, leading to increased personal and societal burden. Individuals with both conditions may face a greater risk of falls, fractures, institutionalization and mortality, with multifactorial etiology involving genetics, age, inflammation and obesity. Potential therapeutic agents targeting both muscle and bone are being developed, outlined in this review.
Article
Endocrinology & Metabolism
Ben Kirk, Stephanie L. Harrison, Jesse Zanker, Andrew J. Burghardt, Eric Orwoll, Gustavo Duque, Peggy M. Cawthon
Summary: This study aimed to investigate the interaction between bone and muscle in predicting fractures in older men. Cox proportional hazards models were used with prospective data from the Osteoporotic Fractures in Men study. The results showed an interaction between D3Cr muscle mass and distal tibia total volumetric BMD (Tt.BMD) in the occurrence of fractures in older men. Importance rating: 7/10.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Nutrition & Dietetics
Maryam Pourhassan, Bjoern Buehring, Ulrik Stervbo, Sven Rahmann, Felix Moelder, Sebastian Ruetten, Ulrike Trampisch, Nina Babel, Timm Henning Westhoff, Rainer Wirth
Summary: The study found that osteoporosis and sarcopenia are common in older hospitalized patients, with some overlap between the two conditions known as osteosarcopenia. Nearly all sarcopenic patients also had osteoporosis, while only a small percentage of patients with low BMD also had sarcopenia.
Article
Endocrinology & Metabolism
Chaoran Liu, Pui Yan Wong, Xin Tong, Simon Kwoon-Ho Chow, Vivian Wing-Yin Hung, Wing-Hoi Cheung, Ling Qin, Sheung Wai Law, Ronald Man Yeung Wong
Summary: This study aimed to investigate the roles of fat and muscle in bone structures and the relationship between obesity and sarcopenia in age-related osteoporosis. Data from 400 participants were analyzed to study the correlation between fat, muscle, and bone, and logistic regression analyses were used to explore the risk of osteoporosis. The results showed that low muscle mass and function were harmful to bone health, while obesity had limited protective roles in osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Orthopedics
Lulu Cheng, Siyu Wang
Summary: This study investigated the relationship between lumbar bone mineral density (BMD) and low muscle mass, as well as the muscle-bone-lipid link. The results showed a negative association between lumbar BMD and sarcopenia in US adults. This association may be related to the pathogenesis of bone loss.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Review
Pharmacology & Pharmacy
Thomas A. Nicholson, Michael Sagmeister, Susanne N. Wijesinghe, Hussein Farah, Rowan S. Hardy, Simon W. Jones
Summary: Age-related musculoskeletal disorders, such as sarcopenia, osteoporosis, and arthritis, are common chronic conditions worldwide. Developing safer and more effective pharmacological treatments for these disorders is a clinical necessity. This review explores the potential of oligonucleotide therapies in modifying pathological gene targets and cellular processes in relevant tissues and cells of the musculoskeletal system to address the unmet clinical need. It also discusses the challenges and current approaches in the clinical development of oligonucleotide therapies for musculoskeletal disorders.
Review
Nutrition & Dietetics
Stavroula Chaloulakou, Kalliopi Anna Poulia, Dimitrios Karayiannis
Summary: Due to various stressors in the space environment, astronauts experience pathophysiological changes. Nutrition plays a crucial role in mitigating these changes.
Article
Chemistry, Medicinal
Chun-Feng Huang, Ming-Shi Shiao, Tso-Yen Mao
Summary: This study demonstrates for the first time that zoledronic acid monotherapy not only benefits bone mass but also muscle mass in osteoporosis patients.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Geriatrics & Gerontology
Fanny Petermann-Rocha, Lyn D. Ferguson, Stuart R. Gray, Irene Rodriguez-Gomez, Naveed Sattar, Stefan Siebert, Frederick K. Ho, Jill P. Pell, Carlos Celis-Morales
Summary: The study found that pre-sarcopenia in men and sarcopenia in women were associated with a higher risk of developing osteoporosis. Low muscle mass and slow gait speed were associated with an increased risk of incident osteoporosis, while low grip strength was specifically linked to higher risk in men.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2021)
Article
Multidisciplinary Sciences
Xuejuan Xu, Nuo Xu, Ying Wang, Jinsong Chen, Lushi Chen, Shengjian Zhang, Jingxian Chen, Hongwen Deng, Xiaojun Luan, Jie Shen
Summary: The study aimed to investigate the longitudinal associations between bone mineral densities (BMDs) and appendicular skeletal muscle (ASM) mass in Chinese middle-aged and elderly men. Three different indicators were used to define ASM mass, and a linear relationship was found between BMDs and ASM mass. The results showed that SMI was more sensitive in screening for low lean mass, and skull BMD was negatively associated with ASM mass while BMDs throughout the rest of the body were positively correlated with ASM mass.
Article
Environmental Sciences
Francesco Cattaneo, Ilaria Buondonno, Debora Cravero, Francesca Sassi, Patrizia D'Amelio
Summary: The study aimed to examine the contribution of musculoskeletal diseases to frailty syndrome. The results showed that muscle strength, performance, and mood significantly predicted the diagnosis of frailty, while bone density and turnover did not.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Endocrinology & Metabolism
Evan G. Buettmann, Rachel C. DeNapoli, Lovell B. Abraham, Joseph A. Denisco, Madelyn R. Lorenz, Michael A. Friedman, Henry J. Donahue
Summary: Patients with bone and muscle loss from prolonged disuse have a higher risk of falls and fractures. Fracture patients with continued disuse and delayed rehabilitation have worse clinical outcomes. This study aimed to investigate the effects of prior disuse followed by physical reambulation on fracture healing and recovery. The results suggest that immediate weight-bearing activity following fracture can improve callus healing and prevent further fall risk by stimulating skeletal muscle anabolism and decreasing callus resorption.
Article
Oncology
Rayne de Almeida Marques Bernabe, Mariana de Souza Vieira, Vanusa Felicio de Souza, Luana Gomes Fontana, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Valdete Regina Guandalini
Summary: This study investigated the association between sarcopenia phenotypes and fracture risk in women with breast cancer, and found that low muscle strength was associated with fracture risk.
Article
Medicine, General & Internal
Jason A. Sherer, Qiuxi Huang, Douglas P. Kiel, Emelia J. Benjamin, Ludovic Trinquart
AMERICAN JOURNAL OF MEDICINE
(2020)
Article
Endocrinology & Metabolism
Kathleen T. Nevola, Douglas P. Kiel, Andrew R. Zullo, Stefan Weiss, Georg Homuth, Ines Foessl, Barbara Obermayer-Pietsch, Katherine J. Motyl, Christine W. Lary
Summary: Osteoporosis is a common disease, and recent studies have found that individuals using beta blockers have higher bone density and lower fracture risk. Certain miRNAs have been associated with adrenergic signaling and bone density. This study investigates the potential role of miRNAs in the association between beta blocker use and bone density.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Endocrinology & Metabolism
Douglas P. Kiel, John P. Kemp, Fernando Rivadeneira, Jennifer J. Westendorf, David Karasik, Emma Duncan, Yuuki Imai, Ralph Muller, Jason Flannick, Lynda Bonewald, Noel Burtt
JOURNAL OF BONE AND MINERAL RESEARCH
(2020)
Article
Endocrinology & Metabolism
F. Johannesdottir, B. Allaire, D. L. Kopperdahl, T. M. Keaveny, S. Sigurdsson, M. A. Bredella, D. E. Anderson, E. J. Samelson, D. P. Kiel, V. G. Gudnason, M. L. Bouxsein
Summary: In this population-based study, CT-based bone density and strength measurements from the thoracic spine were found to predict incident vertebral fracture, similarly to measurements from the lumbar spine. Both thoracic and lumbar bone measurements showed similar sensitivity and specificity in predicting incident vertebral fracture.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Xiaoyu Zhang, Hanfei Xu, Gloria H. Y. Li, Michelle T. Long, Ching-Lung Cheung, Ramachandran S. Vasan, Yi-Hsiang Hsu, Douglas P. Kiel, Ching-Ti Liu
Summary: The study identified metabolites associated with bone mineral density (BMD) that can predict fracture risk with experimental validation. The glycine, serine, and threonine metabolism pathway may be related to osteoporosis.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Cardiac & Cardiovascular Systems
Kevin Leow, Pawel Szulc, John T. Schousboe, Douglas P. Kiel, Armando Teixeira-Pinto, Hassan Shaikh, Michael Sawang, Marc Sim, Nicola Bondonno, Jonathan M. Hodgson, Ankit Sharma, Peter L. Thompson, Richard L. Prince, Jonathan C. Craig, Wai H. Lim, Germaine Wong, Joshua R. Lewis
Summary: This study found that any or more advanced abdominal aortic calcification was associated with increased risk of cardiovascular events, fatal cardiovascular events, and all-cause mortality. Patients with chronic kidney disease and the elderly population were more likely to have AAC and have higher cardiovascular risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Editorial Material
Endocrinology & Metabolism
Christine W. Lary, Clifford J. Rosen, Douglas P. Kiel
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Endocrinology & Metabolism
Eric S. Orwoll, Neeta Parimi, Jack Wiedrick, Jodi Lapidus, Nicola Napoli, Jeremy E. Wilkinson, Curtis Huttenhower, Lisa Langsetmo, Douglas P. Kiel
Summary: This study investigated the associations between fecal microbiota and bone density, microarchitecture, and strength. The findings suggest a role for gut microbiota in skeletal homeostasis, although the effect sizes were small and larger cohort sizes may be needed for more confident associations.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Editorial Material
Rheumatology
Jennifer J. Westendorf, Lynda F. Bonewald, Douglas P. Kiel, Noel P. Burtt
Summary: The Musculoskeletal Knowledge Portal (MSK-KP) is a platform built by and for the research community to help researchers display, access, distill, and explore results from large genomic and epigenomic studies, in order to accelerate the development of patient-centered therapeutics for complex, multi-factorial conditions such as osteoarthritis.
NATURE REVIEWS RHEUMATOLOGY
(2022)
Article
Nutrition & Dietetics
Courtney L. Millar, Douglas P. Kiel, Marian T. Hannan, Shivani Sahni
Summary: This study found that there was no significant association between dairy food intake and bone microarchitecture, except for an inverse relationship between cheese intake and cortical BMD in women. Further investigation is needed on the relationship between cheese intake and bone microarchitecture in women.
Article
Endocrinology & Metabolism
Tanchanok Chattaris, Gahee Oh, Natalia A. Gouskova, Dae Hyun Kim, Douglas P. Kiel, Sarah D. Berry
Summary: In frail older adults, taking osteoporosis medications for more than 90 days reduces the risk of subsequent fractures. However, treatment rates are particularly low in frail individuals, and clinicians should carefully consider treatment options in this population.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Ching-Ti Liu, Timothy Tsai, Brett T. Allaire, Mary L. Bouxsein, Marian T. Hannan, Thomas G. Travison, Douglas P. Kiel
Summary: This study examines the association between changes in visceral adipose tissue (VAT) over 6 years and paraspinal muscle density, finding that greater accumulation of VAT is associated with lower muscle density.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Jack Dalla Via, Abadi K. Gebre, Cassandra Smith, Zulqarnain Gilani, David Suter, Naeha Sharif, Pawel Szulc, John T. Schousboe, Douglas P. Kiel, Kun Zhu, William D. Leslie, Richard L. Prince, Joshua R. Lewis, Marc Sim
Summary: Abdominal aortic calcification (AAC), a measure of vascular disease, is associated with increased cardiovascular risk and poorer prognosis. An automated machine-learning algorithm has been developed for assessing AAC, which is associated with long-term incident fractures and falls.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Jack Dalla Via, Marc Sim, John T. Schousboe, Douglas P. Kiel, Kun Zhu, Jonathan M. Hodgson, Abadi K. Gebre, Robin M. Daly, Richard L. Prince, Joshua R. Lewis
Summary: This study found no significant association between abdominal aortic calcification assessed by dual-energy X-ray absorptiometry (DXA) and peripheral bone density and structure in older women.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Robert R. McLean, Elizabeth J. Samelson, Amanda L. Lorbergs, Kerry E. Broe, Marian T. Hannan, Steven K. Boyd, Mary L. Bouxsein, Douglas P. Kiel
Summary: Muscle loading plays a key role in bone health, with grip strength positively correlated with distal radius bone strength in older adults. Higher grip strength was associated with larger bone size and higher bone strength, suggesting that bone size may be a primary driver of this relationship.