Daily administration of eldecalcitol (ED-71), an active vitamin D analog, increases bone mineral density by suppressing RANKL expression in mouse trabecular bone

A new active vitamin D3 analog, eldecalcitol, prevents the risk of osteoporotic fractures — A randomized, active comparator, double-blind study

(2011) Toshio Matsumoto et al.   BONE

Eldecalcitol, a second-generation vitamin D analog, drives bone minimodeling and reduces osteoclastic number in trabecular bone of ovariectomized rats

(2011) Paulo Henrique Luiz de Freitas et al.   BONE

Matrix-embedded cells control osteoclast formation

(2011) Jinhu Xiong et al.   NATURE MEDICINE

Evidence for osteocyte regulation of bone homeostasis through RANKL expression

(2011) Tomoki Nakashima et al.   NATURE MEDICINE

Effects of a synthetic vitamin D analog, ED-71, on bone dynamics and strength in cancellous and cortical bone in prednisolone-treated rats

(2010) Yuzo Tanaka et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Eldecalcitol is less effective in suppressing parathyroid hormone compared to calcitriol in vivo

(2010) Suguru Harada et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

1-Alpha, 25-dihydroxy vitamin D3 inhibits osteoclastogenesis through IFN-beta-dependent NFATc1 suppression

(2009) Sadaoki Sakai et al.   JOURNAL OF BONE AND MINERAL METABOLISM

Identification of cell cycle–arrested quiescent osteoclast precursors in vivo

(2009) Toshihide Mizoguchi et al.   JOURNAL OF CELL BIOLOGY

Modifying RANKL/OPG mRNA Expression in Differentiating and Growing Human Primary Osteoblasts

(2008) M. Giner et al.   HORMONE AND METABOLIC RESEARCH