Article
Endocrinology & Metabolism
P. Ferrer, I. Iglesia, B. Muniz-Pardos, M. L. Miguel-Berges, P. Flores-Barrantes, A. Gomez-Bruton, L. A. Moreno, G. Rodriguez
Summary: The study found that meeting World Health Organization physical activity recommendations has a beneficial effect on bone composition in childhood, not only for boys, but also for girls.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Georgia Colleluori, Lina Aguirre, Nicola Napoli, Clifford Qualls, Dennis T. Villareal, Reina Armamento-Villareal
Summary: The study found that hypogonadal men with T2D showed significant improvements in bone mass and density after 18 months of testosterone therapy, while those without T2D did not show significant changes.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Article
Medicine, General & Internal
Hyun Uk Moon, Seung Jin Han, Hae Jin Kim, Yoon-Sok Chung, Dae Jung Kim, Yong Jun Choi
Summary: This study found that the positive correlation between muscle mass and bone status was largely conserved in men with diabetes, and this association may be stronger in diabetic individuals.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Martine Amalie Johansen, Hilde Kristin Mikalsen, Pal Arild Lagestad
Summary: This study aimed to examine pupils' moderate to vigorous physical activity (MVPA) during schooltime longitudinally, including the transition from primary to secondary school. The results showed a significant decrease in pupils' MVPA and fulfillment of health recommendations during schooltime from 7th to 8th grade. Boys had higher MVPA during schooltime than girls at all three time periods and also contributed more to boys' fulfillment of health recommendations. The findings raise questions about whether physical activity is adequately facilitated for girls in school.
FRONTIERS IN PUBLIC HEALTH
(2023)
Article
Sport Sciences
Philip D. Chilibeck, Darren G. Candow, Julianne J. Gordon, Whitney R. D. Duff, Riley Mason, Keely Shaw, Regina Taylor-Gjevre, Bindu Nair, Gordon A. Zello
Summary: Two years of creatine supplementation and exercise had no effect on bone mineral density in postmenopausal women, but improved some bone geometric properties at the proximal femur.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2023)
Article
Hematology
Katharina Holstein, Leonora Witt, Anna Matysiak, Constantin Schmidt, Florian Barvencik, Michael Amling, Tim Rolvien, Florian Langer
Summary: Low bone mineral density is common in hemophilia patients, influenced by factors such as bone turnover, body mass index, inflammation, treatment regimen, joint status, and HCV infection. Self-reported sportive activity has a positive effect on bone mineral density.
THROMBOSIS AND HAEMOSTASIS
(2022)
Article
Sport Sciences
Katherine Brooke-Wavell, Dawn A. Skelton, Karen L. Barker, Emma M. Clark, Sarah De Biase, Susanne Arnold, Zoe Paskins, Katie R. Robinson, Rachel M. Lewis, Jonathan H. Tobias, Kate A. Ward, Julie Whitney, Sarah Leyland
Summary: Exercise and physical activity can improve bone strength and reduce the risk of falls in people with osteoporosis. Resistance and impact exercise, activities to improve strength and balance, and spinal extension exercise are recommended to optimize bone strength, reduce falls, and improve posture. The benefits of physical activity generally outweigh the risks.
BRITISH JOURNAL OF SPORTS MEDICINE
(2022)
Article
Endocrinology & Metabolism
Thiberiu Banica, Charlotte Verroken, Guy T'Sjoen, Stefan Goemaere, Hans-Georg Zmierczak, Tom Fiers, Jean-Marc Kaufman, Bruno Lapauw
Summary: Bone metabolism in men is influenced by sex steroid exposure, and declines in sex steroid levels during young and middle adulthood are associated with changes in bone mass and size.
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Nutrition & Dietetics
Mariangela Rondanelli, Milena Anna Faliva, Gaetan Claude Barrile, Alessandro Cavioni, Francesca Mansueto, Giuseppe Mazzola, Letizia Oberto, Zaira Patelli, Martina Pirola, Alice Tartara, Antonella Riva, Giovanna Petrangolini, Gabriella Peroni
Summary: This review evaluates the ideal dietary approach to reduce bone mineral density loss and suggests a food pyramid for osteopenia/osteoporosis patients. The pyramid emphasizes daily consumption of carbohydrates, fruits, vegetables, light yogurt, skim milk, extra virgin olive oil, and calcium water. Weekly portions include fish, white meat, legumes, eggs, cheeses, and red/processed meats. The pyramid also highlights the need for personalized supplementation and identifies certain foods to be avoided. Additionally, regular aerobic and resistance exercises are recommended.
Review
Orthopedics
Maribel Cagliari, Barbara Bressi, Maria Chiara Bassi, Stefania Fugazzaro, Giuseppe Prati, Cinzia Iotti, Stefania Costi
Summary: This study investigates the feasibility and safety of exercise programs aimed at preventing accidental falls, fractures, and bone mineral density loss in men with prostate cancer undergoing androgen deprivation therapy (ADT). The results show that multicomponent exercise programs targeting bone health are feasible and safe in this population, suggesting that exercise should be an important part of their lifestyle habits.
Article
Endocrinology & Metabolism
Kristine E. Ensrud, Li-Yung Lui, Carolyn J. Crandall, Eric S. Orwoll, Lisa Langsetmo, John T. Schousboe, Howard A. Fink, Nancy E. Lane, Deborah M. Kado, Jane A. Cauley, Marcia L. Stefanick, Peggy M. Cawthon
Summary: This study evaluated the impact of a second bone mineral density (BMD) screening 7 years after the initial screening on fracture prediction in older men. The results showed that repeating the BMD screening did not significantly improve fracture prediction in community-dwelling older men.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Endocrinology & Metabolism
R. Patel, J. Shen, J. F. Nichols, J. T. Schousboe, G. N. Woods, W. B. Katzman, D. M. Kado
Summary: This study investigated the association between trabecular bone score (TBS) and hyperkyphosis (HK) in older men, revealing that men with degraded TBS were more likely to have HK.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Jae Hyun Lee, Ae Wha Ha, Woo Kyoung Kim, Sun Hyo Kim
Summary: This study found that bone mineral density in adolescents is significantly associated with both milk intake and physical activity. Among males, those in the group with no milk intake and low-level physical activity had the lowest BMD, while females in the group with milk intake and high-level physical activity showed significantly higher lumbar BMD values compared to other groups. These results suggest that encouraging moderate to vigorous physical activity and milk intake during adolescence is important for healthy bone growth.
Article
Endocrinology & Metabolism
Pawel Szulc, Dominique Foesser, Roland Chapurlat
Summary: In older men, higher areal bone mineral density, preserved cortical bone status, and higher estimated bone strength are associated with a lower risk of major adverse coronary events (MACE) after adjustment for relevant confounders.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Article
Orthopedics
Jiazhong Ji, Yue Hou, Zhaoyang Li, Ying Zhou, Huaming Xue, Tao Wen, Tao Yang, Long Xue, Yihui Tu, Tong Ma
Summary: This study analyzed the association between physical activity and total spine bone mineral density (BMD) in postmenopausal women. The findings showed that engaging in ≥38MET-h of activity per week was associated with a lower risk of osteoporosis. Furthermore, the association between total spine BMD and moderate-to-vigorous PA was more significant among postmenopausal women aged < 65 years or individuals with normal BMI (< 25 kg/m(2)).
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Gudmundur Vignir Sigurdsson, Susanne Schmidt, Dan Mellstrom, Claes Ohlsson, Robert Saalman, Mattias Lorentzon
Summary: Young adult men with childhood-onset IBD have decreased bone quality in both cortical and trabecular bone structures compared to age- and height-matched controls. This has implications for their skeletal health and quality of life.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Endocrinology & Metabolism
John A. A. Kanis, Helena Johansson, Nicholas C. C. Harvey, Mattias Lorentzon, Enwu Liu, Liesbeth Vandenput, Suzanne Morin, William D. D. Leslie, Eugene V. V. McCloskey
Summary: This study confirms the association between a greater propensity to falling and higher fracture risk, and provides adjustments to FRAX-based fracture probabilities accounting for the number of prior falls.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
John A. Kanis, Nicholas C. Harvey, Enwu Liu, Liesbeth Vandenput, Mattias Lorentzon, Eugene McCloskey, Roger Bouillon, Bo Abrahamsen, Lars Rejnmark, Helena Johansson
Summary: Patients with primary hyperparathyroidism have increased incidence of hip and major osteoporotic fractures, even if not referred for parathyroidectomy. The risk of death is also increased, which affects fracture probability. These findings support the need to widen the indications for parathyroidectomy in mild primary hyperparathyroidism.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Geriatrics & Gerontology
Leo D. Westbury, Charlotte Beaudart, Olivier Bruyere, Jane A. Cauley, Peggy Cawthon, Alfonso J. Cruz-Jentoft, Elizabeth M. Curtis, Kristine Ensrud, Roger A. Fielding, Helena Johansson, John A. Kanis, Magnus K. Karlsson, Nancy E. Lane, Laetitia Lengele, Mattias Lorentzon, Eugene McCloskey, Dan Mellstrom, Anne B. Newman, Claes Ohlsson, Eric Orwoll, Jean-Yves Reginster, Eva Ribom, Bjorn E. Rosengren, John T. Schousboe, Eric J. Shiroma, Nicholas C. Harvey, Elaine M. Dennison, Cyrus Cooper
Summary: The performance of recent sarcopenia definitions in terms of thresholds employed, concordance in individuals, and prediction of important health-related outcomes such as death is limited. This study addressed these limitations in a large multinational cohort study.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Endocrinology & Metabolism
M. Schini, P. Bhatia, H. Shreef, H. Johansson, N. C. Harvey, M. Lorentzon, J. A. Kanis, O. Bandmann, E. V. McCloskey
Summary: This study examined the relative contributions of muscle strength, falls risk, and low bone mineral density to increased fracture risk in Parkinson's Disease (PD) patients. It found that PD patients had lower bone density and weaker muscle strength, leading to a higher risk of fractures. Therefore, Parkinson's Disease may be an independent risk factor for fractures.
Article
Endocrinology & Metabolism
Kristian F. Axelsson, Henrik Litsne, Mattias Lorentzon
Summary: There is limited evidence on which fracture types carry the highest risk for subsequent fractures. Recent fractures, including major osteoporotic fractures and non-major osteoporotic fractures, as well as older fractures, increase the risk of subsequent fracture. Therefore, it is recommended to include all recent fractures in fracture liaison services and consider case-finding strategies for those with older fractures to prevent further fractures.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Raju Jaiswal, Michail Zoulakis, Kristian F. Axelsson, Anna Darelid, Robert Rudang, Daniel Sundh, Henrik Litsne, Lisa Johansson, Mattias Lorentzon
Summary: This prospective cohort study aimed to evaluate the association between the bone material strength index (BMSi) and the risk of incident fracture in older women. The study found that increasing BMSi was associated with a greater risk of fracture.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
William D. Leslie, Neil Binkley, Eugene V. McCloskey, Helena Johansson, Nicholas C. Harvey, Mattias Lorentzon, John A. Kanis, Didier Hans
Summary: The study found that TBS can be used to predict fracture risk independently of FRAX. Adding TBS to the FRAX calculation can adjust for femoral neck BMD and improve fracture risk prediction, even without measuring hip DXA.
JOURNAL OF CLINICAL DENSITOMETRY
(2023)
Article
Endocrinology & Metabolism
Louise Grahnemo, Anna L. Eriksson, Maria Nethander, Robert Johansson, Mattias Lorentzon, Dan Mellstroem, Ulrika Pettersson-Kymmer, Claes Ohlsson
Summary: This study found a robust association between circulating valine and hip fractures, which was confirmed in a replication study. Further analysis showed that high circulating valine levels were associated with increased cortical bone area and trabecular thickness. Therefore, circulating valine may be an important marker for predicting hip fractures.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Suchita Desai, Jianyao Wu, Karin Horkeby, Maria Norgard, Claes Ohlsson, Sara H. Windahl, Cecilia Engdahl
Summary: Mechanical loading enhances bone strength and counteracts arthritis-induced inflammation-mediated bone loss in female mice. It is unknown whether nonsteroidal anti-inflammatory drugs (NSAIDs; eg, COX-2 inhibitors) can reduce inflammation without affecting the loading-associated bone formation in male mice. The aim of this study was to investigate if loading combined with a COX-2 inhibitor (NS-398) could prevent arthritis-induced bone loss and inflammation in male mice. The results showed that loading prevented arthritis-induced bone loss and NS-398 reduced knee swelling without affecting the bone-protective effects of loading.
Editorial Material
Endocrinology & Metabolism
Mattias Lorentzon, Andrew J. Burghardt
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Letter
Endocrinology & Metabolism
Raju Jaiswal, Michail Zoulakis, Kristian F. Axelsson, Daniel Sundh, Henrik Litsne, Lisa Johansson, Mattias Lorentzon
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
Johan Svensson, Klara Sjogren, Lina Lawenius, Antti Koskela, Juha Tuukkanen, Karin H. Nilsson, Sofia Moverare-Skrtic, Claes Ohlsson
Summary: Insulin-like growth factor-I (IGF-I) levels and cortical bone dimensions play important roles in determining fracture risk in elderly people. Inactivation of liver-derived circulating IGF-I reduces periosteal bone expansion in young and older mice. This study investigates the effect of inducible inactivation of IGF-I specifically in bone on the bone phenotype in adult/old mice, finding that it results in reduced radial growth of cortical bone, suggesting the importance of locally derived IGF-I in regulating the cortical bone phenotype in older mice.
Article
Endocrinology & Metabolism
Hannah Collden, Malin Hagberg Thulin, Andreas Landin, Karin Horkeby, Marie Lagerquist, Jianyao Wu, Karin H. Nilsson, Louise Grahnemo, Matti Poutanen, Henrik Ryberg, Liesbeth Vandenput, Claes Ohlsson
Summary: Progesterone levels in males with advanced prostate cancer have been identified as a potential predictor for treatment effect. This study found that progesterone levels remained high in orchiectomized male mice, with the highest levels observed in white adipose tissue and the gastrointestinal tract. Additionally, dietary intake of progesterone, particularly from female animals of reproductive age, was found to contribute to tissue levels of progesterone in male mice. These findings suggest that food containing high levels of progesterone may be a significant source of progesterone in males, possibly affecting men undergoing androgen deprivation therapy for prostate cancer.