期刊
JOURNAL OF BONE AND MINERAL RESEARCH
卷 27, 期 3, 页码 610-618出版社
WILEY-BLACKWELL
DOI: 10.1002/jbmr.1467
关键词
PERIOSTEAL CIRCUMFERENCE; BODY COMPOSITION; MUSCLE DENSITY; ALSPAC; INSULIN
资金
- UK Medical Research Council [G G0600705]
- Wellcome Trust [079960]
- University of Bristol
- United States National Institutes of Health (NIH): National Institute of Diabetes and Digestive and Kidney Diseases [R01 DK077659]
- Medical Research Council [G0600705] Funding Source: researchfish
- MRC [G0600705] Funding Source: UKRI
Recent studies suggest that patients with type 2 diabetes mellitus are at increased risk of fracture, possibly because hyperinsulinemia is a risk factor for low bone mineral density, which may in turn be a consequence of a lipotoxic effect of visceral and/or intramuscular fat on bone. In the current study, we investigated whether insulin plays a role in cortical bone development by performing a cross-sectional study based on the Avon Longitudinal Study of Parents and Children (ALSPAC), where we examined associations between fasting insulin levels and peripheral quantitative computed tomography (pQCT) parameters as assessed at the mid-tibia in 2784 boys and girls with a mean age 15.5 years. In particular, we wished to examine whether associations that we observed were independent of body composition, including intramuscular fat. We found that insulin was inversely related to cortical bone mineral density (BMDC) after adjustment for age and after further adjustment for height, muscle cross-sectional area (MCSA), subcutaneous fat (SAT), and muscle density (MD), which is inversely related to intramuscular fat (-0.018, 95% confidence interval [CI] -0.030, -0.006, p?
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