FGF receptors control vitamin D and phosphate homeostasis by mediating renal FGF-23 signaling and regulating FGF-23 expression in bone

Bone proteins PHEX and DMP1 regulate fibroblastic growth factor Fgf23 expression in osteocytes through a common pathway involving FGF receptor (FGFR) signaling

(2011) Aline Martin et al.   FASEB JOURNAL

Fibroblast growth factor 23 regulates renal 1,25-dihydroxyvitamin D and phosphate metabolism via the MAP kinase signaling pathway in Hyp mice

(2011) Daniel Ranch et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regulation of Phosphate Homeostasis by PTH, Vitamin D, and FGF23

(2010) Clemens Bergwitz et al.   Annual Review of Medicine

The Fibroblast Growth Factor Receptor Inhibitor PD173074 Blocks Small Cell Lung Cancer Growth In vitro and In vivo

(2009) O. E. Pardo et al.   CANCER RESEARCH

Inactivation of klotho function induces hyperphosphatemia even in presence of high serum fibroblast growth factor 23 levels in a genetically engineered hypophosphatemic (Hyp) mouse model

(2009) Teruyo Nakatani et al.   FASEB JOURNAL

Therapeutic Effects of Anti-FGF23 Antibodies in Hypophosphatemic Rickets/Osteomalacia*

(2009) Yukiko Aono et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Reversal of mineral ion homeostasis and soft-tissue calcification of klotho knockout mice by deletion of vitamin D 1α-hydroxylase

(2009) Mutsuko Ohnishi et al.   KIDNEY INTERNATIONAL

The FGF23–Klotho axis: endocrine regulation of phosphate homeostasis

(2009) M. Shawkat Razzaque   Nature Reviews Endocrinology

Overview of the FGF23-Klotho axis

(2009) Makoto Kuro-o   PEDIATRIC NEPHROLOGY

Klotho ablation converts the biochemical and skeletal alterations in FGF23 (R176Q) transgenic mice to a Klotho-deficient phenotype

(2008) Xiuying Bai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Familial tumoral calcinosis and the role of O-glycosylation in the maintenance of phosphate homeostasis

(2008) Ilana Chefetz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

FGFR3 and FGFR4 Do not Mediate Renal Effects of FGF23

(2008) S. Liu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Endocrine FGFs and Klothos: emerging concepts

(2008) Makoto Kuro-o   TRENDS IN ENDOCRINOLOGY AND METABOLISM