Article
Medicine, General & Internal
Izabela Michalus, Anna Lupinska, Izabela Woch, Katarzyna Wieczorek-Szukala, Danuta Chlebna-Soko, Andrzej Lewinski
Summary: This retrospective study explored the bone turnover and bone mass disorders in children with hypophosphatemic rickets. The results showed that bone metabolism disturbances and worse bone quality were found in these patients. It is crucial to monitor the progress and treatment effects by determining bone turnover markers, dual-energy X-ray absorptiometry findings, and indices of quantitative ultrasound examination.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Nutrition & Dietetics
Minkyung Je, Kyeonghoon Kang, Jun-Il Yoo, Yoona Kim
Summary: This review aims to investigate the effects of macronutrients on bone health in elderly people based on human studies. The results suggest that carbohydrate intake has limited effects on bone fracture but further research is needed on its effects on bone mineral density and bone turnover markers. Additionally, inconsistent results were found regarding the beneficial effects of animal, vegetable, soy, or milk proteins on bone health. Further studies are required to establish a clear association between macronutrients and bone health in elderly people.
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Physiology
Shuai Mu, Yang Xia, Qijun Wu, Chao Ji, Huixu Dai, Ming Zhang, Jiao Jiao, Feng Shi, Shengye Liu, Guangbin Wang, Tao Shen, Ye Tian, Liqing Yang, Qin Fu, Yuhong Zhao
Summary: The study revealed that after ice swimming, there were significant increases in PTH, Ca2+, and Pi, while decreases in TPINP and β-CTX, raising concerns about potential cardiovascular health risks. Additionally, there were significant correlations among bone metabolism markers and a special change of bone metabolism after cold exercise was identified.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Endocrinology & Metabolism
Julie Abildgaard, Thorkil Ploug, Anette Tonnes Pedersen, Pia Eiken, Bente Klarlund Pedersen, Jens Juul Holst, Bolette Hartmann, Birgitte Lindegaard
Summary: Despite higher fasting levels, postmenopausal women exhibit comparable postprandial suppression of bone turnover markers to premenopausal women. None of the postprandial gut hormone increases predict postprandial bone turnover suppression.
Article
Endocrinology & Metabolism
Xiaowen Zhang, Suhas Krishnamoorthy, Casey Tze-Lam Tang, Warrington Wen-Qiang Hsu, Gloria Hoi-Yee Li, Chor-Wing Sing, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Ian Chi-Kei Wong, Annie Wai-Chee Kung, Ching-Lung Cheung
Summary: This study investigated the association between bone health and incident type-2 diabetes mellitus (T2DM). The results showed that higher bone density is associated with an increased risk of T2DM.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Seok Woo Hong, Jeong-Hyun Kang
Summary: The development and progression of TMJ OA may be associated with bone metabolism and condylar quality according to this study. Significant correlations between various bone metabolism markers and the stages of TMJ OA were observed in young and post-menopausal females.
CLINICAL ORAL INVESTIGATIONS
(2021)
Article
Medicine, General & Internal
Ran Li, Xiaoyi Zhu, Mengxi Zhang, Guannan Zong, Keqin Zhang
Summary: The study aimed to investigate the serum periostin levels in Chinese postmenopausal women with different bone mass and its correlations with traditional bone turnover markers and bone mineral densities at different sites. The results showed no significant difference in serum periostin levels among the groups of women with normal bone mass, osteopenia, and osteoporosis. Additionally, the study found that serum P1NP and OC levels may be better predictors of osteoporosis in Chinese postmenopausal women than serum periostin.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2021)
Article
Orthopedics
Karina Norgaard Linde, Soren Rytter, Kjeld Soballe, Frank Madsen, Bente Langdahl, Maiken Stilling
Summary: The study found that the migration of cementless and cemented tibial components was similar at 1- and 2-year follow-up, but there was a higher proportion of continuous migration in cementless components. Cementless components showed an increase in bone density, while cemented components showed a decrease. Bone turnover markers increased post-surgery in both groups, but did not explain the difference in change in periprosthetic BMD.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Endocrinology & Metabolism
Jingmin Che, Weihao Ren, Xin Chen, Fang Wang, Gejing Zhang, Peng Shang
Summary: PTH 1-34 (teriparatide) is effective in attenuating bone loss induced by unloading in mice by regulating iron metabolism via the activation of Nrf2 and promotion of hepcidin expression in the liver. Additionally, PTH 1-34 promotes osteoblast differentiation and inhibits apoptosis by regulating iron metabolism and maintaining redox balance under unloading conditions.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Medicine, Research & Experimental
Krishna Bhan Singh, Reena Rai, Sonu Khanka, Divya Singh
Summary: This study investigated the potential of sequential treatment with NIL17 after PTH withdrawal as a promising therapeutic approach for osteoporosis. The results showed that SHIFT therapy could preserve bone density and microarchitectural parameters while suppressing osteoclast numbers, indicating its potential as a replacement therapeutic option post PTH discontinuation.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Review
Endocrinology & Metabolism
Josefa Mora Vallellano, Carmen Delgado Pecellin, Isabel Delgado Pecellin, Esther Quintana Gallego, Jose Luis Lopez-Campos
Summary: This study found that CF patients with normal nutritional status and without acute lung disease had normal bone mineral density but altered bone remodeling. Various bone turnover biomarkers were associated with CF, with factors like PTH, CTX, and OPG being significant predictors of BMD. Additionally, certain markers like PTH, TNF alpha, calcium, 1,25-vitamin D, and OPG were significantly linked to CF.
Article
Endocrinology & Metabolism
Wei Wang, Rong Huang, Ping Tai Tang, Mei Tu, Xiu Li Guo
Summary: This study found that perirenal fat thickness is significantly associated with bone turnover markers, bone mineral density, and osteoporosis, suggesting that perirenal fat may play an important role in bone metabolism.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Orthopedics
Gao-Xiang Wang, Jun-Tong Li, Fang-ying Cai, Bao-Li Huang, Ze-Bin Fang, Heng-Xia Zhao, Shu-Fang Chu, De-Liang Liu, Hui-Lin Li
Summary: This study explored the correlation between bone turnover markers (BTMs) and lumbar bone mineral density (BMD) in middle-aged populations. Data from NHANES were analyzed in a cross-sectional analysis. Serum bone alkaline phosphatase (sBAP) and urinary N-telopeptide (uNTx) levels were used as representatives of bone turnover. Multivariable linear regression models were used to detect the correlation of sBAP and uNTx with lumbar BMD.
BMC MUSCULOSKELETAL DISORDERS
(2023)
Biographical-Item
Endocrinology & Metabolism
C. Zerbini, A. Orcesi Pedro, R. M. Pereira, M. Lazaretti-Castro, P. Halbout, C. Cooper
OSTEOPOROSIS INTERNATIONAL
(2022)
Correction
Endocrinology & Metabolism
C. Zerbini, A. Orcesi Pedro, R. M. Pereira, M. Lazaretti-Castro, P. Halbout, C. Cooper
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Livia Marcela Santos, Monique Ohe, Sthefanie Pallone, Isabela Nacaguma, Ilda Kunii, Renata Silva, Cynthia Maria Brandao, Jose Gilberto Vieira, Marise Lazaretti-Castro
Summary: This study aimed to investigate the association between 25OHD and bone mass and microarchitecture in PHPT patients and controls. The results showed that PHPT patients had lower bone density and microarchitecture values compared to controls, but there were no significant differences in 25OHD concentrations between the two groups.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Article
Endocrinology & Metabolism
Victoria Zeghbi Cochenski Borba, Marise Lazaretti-Castro, Sandra da Silva Moreira, Maria Conceicao Chagas de Almeida, Edson Duarte Moreira
Summary: This study confirmed the high prevalence of vitamin D deficiency and insufficiency even in the midsummer in a healthy population of Brazil. Vitamin D levels are associated with sun exposure, latitude, BMI, skin color, and use of supplements.
JOURNAL OF THE ENDOCRINE SOCIETY
(2022)
Review
Endocrinology & Metabolism
Fernanda Salles Reis, Marise Lazaretti-Castro
Summary: Hypophosphatasia (HPP) is an inherited disease characterized by low alkaline phosphatase activity, leading to the accumulation of metabolites and various clinical manifestations. Enzyme replacement therapy is the main treatment for HPP.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2023)
Correction
Endocrinology & Metabolism
Livia Marcela dos Santos, Monique Nakayama Ohe, Sthefanie Giovanna Pallone, Isabela Ohki Nacaguma, Ilda Sizue Kunii, Renata Elen Costa da Silva, Sergio Setsuo Maeda, Jose Gilberto Henriques Vieira, Marise Lazaretti-Castro
Article
Endocrinology & Metabolism
Livia Marcela dos Santos, Monique Nakayama Ohe, Sthefanie Giovanna Pallone, Isabela Ohki Nacaguma, Ilda Sizue Kunii, Renata Elen Costa da Silva, Sergio Setsuo Maeda, Jose Gilberto Henriques Vieira, Marise Lazaretti-Castro, Szu-Wen Chang, Hung-Chang Lee
Summary: This study evaluated the changes in different forms of 25(OH)D after supplementation with vitamin D3 in individuals with primary hyperparathyroidism and controls. The results showed that after supplementation, total 25(OH)D levels increased in both groups, but the increase was lower in the primary hyperparathyroidism group. Furthermore, total 25(OH)D had a better correlation with parathyroid hormone (PTH) in this situation.
Article
Endocrinology & Metabolism
Mariana Zuccolotto Foroni, Maysa Seabra Cendoroglo, Eliane Naomi Sakane, Rosangela Villa Marin-Mio, Patricia Ferreira do Prado Moreira, Sergio Setsuo Maeda, Marise Lazaretti-Castro
Summary: The study aimed to assess the serum concentrations of 25 hydroxyvitamin D in elderly individuals in Sao Paulo, Brazil and investigate its associations with musculoskeletal system, physical performance, and health markers. The findings revealed a high prevalence of vitamin D deficiency and showed positive correlations between serum 25 hydroxyvitamin D concentrations with bone mass and dynamic balance, and negative correlations with PTH levels and osteoporosis diagnosis.
Article
Endocrinology & Metabolism
Debora Meira Ramos Amorim, Gustavo Kendy Camargo Koga, Rodrigo Nolasco dos Santos, Paulo Fernando Carvalho Secundo, Eloy de Avila Fernandes, Leonardo Cardili, Sergio Setsuo Maeda, Artur da Rocha Correa Fernandes, Marise Lazaretti-Castro
Summary: This study reports a case of OI type VI in which a deletion in exon 8 of the SERPINF1 gene was identified, and discusses the relationship between this genetic abnormality and tumor formation.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Review
Endocrinology & Metabolism
Andrea Giustina, Roger Bouillon, Bess Dawson-Hughes, Peter R. Ebeling, Marise Lazaretti-Castro, Paul Lips, Claudio Marcocci, John P. Bilezikian
Summary: This paper presents the findings of the 5th International Conference Controversies in Vitamin D held in Italy. The conference aimed to discuss the relationship between Vitamin D and aging. The results indicate that vitamin D deficiency can lead to various skeletal and extra-skeletal outcomes, and older adults are at a higher risk due to factors such as reduced sun exposure. Strategies to prevent negative outcomes include sun exposure, food fortification, and supplementation. The most effective and practical strategy for the aging population is vitamin D supplementation.
Article
Geriatrics & Gerontology
Osvaldo Daniel Messina, Maritza Vidal, Jorge A. Morales Torres, Luis Fernando Vidal, Constanza Arguissain, Rosa Maria Pereira, Patricia Clark, Sonia Cerdas Perez, Claudia Campusano, Marise Lazaretti-Castro, Cristiano Zerbini, Juan J. Scali, Lucia Mendez Sanchez, Maria L. Peralta-Pedrero, Andrea Cavallo, Francisco J. Valdivia Ibarra, Talina Hernandez Perez
Summary: This study compiled guidelines and recommendations for the diagnosis and management of glucocorticoid-induced osteoporosis (GIO) in Latin America. Through systematic literature review and expert voting, 50 consistent recommendations were formed, providing guidance for general practitioners and primary care physicians in their clinical practice.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Isabela Cristina Januario Silva, Marise Lazaretti-Castro
Summary: Vitamin D deficiency is a common health problem worldwide, affecting the musculoskeletal system as well as various other physiological functions. Further clinical analysis and long-term follow-up studies are needed to determine the impact of vitamin D on extraskeletal health and to establish standardized assessment methods.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)
Meeting Abstract
Geriatrics & Gerontology
M. Lazaretti-Castro
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2022)
Meeting Abstract
Endocrinology & Metabolism
Livia Marcela Santos, Monique Nakayama Ohe, Sthefanie Giovanna Pallone, Isabela Ohki Nacaguma, Ilda Sizue Kunii, Renata Elen Costa da Silva, Jose Gilberto Henriques Vieira, Marise Lazaretti-Castro
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Article
Endocrinology & Metabolism
Sthefanie Giovanna Pallone, Ilda Sizue Kunii, Renata Elen Costa da Silva, Marise Lazaretti-Castro
Summary: Hyperphosphatemic familial tumor calcinosis (HFTC) is a rare disease characterized by high levels of phosphate in the blood and deposition of calcium and phosphorus crystals. This case report describes a 50-year-old woman diagnosed with HFTC, who had a homozygous variant in the GALNT3 gene. Despite treatment with acetazolamide, sevelamer, and a phosphorus-restricted diet, her phosphatemia remained high and calcifications continued to progress. The use of teriparatide (TPTD) showed some effectiveness in reducing phosphatemia, but also led to increased calciuria.
CALCIFIED TISSUE INTERNATIONAL
(2022)