Article
Urology & Nephrology
Hyoungnae Kim, Joongyub Lee, Kyu-Beck Lee, Yeong-Hoon Kim, Namki Hong, Jung Tak Park, Seung Hyeok Han, Shin-Wook Kang, Kyu Hun Choi, Kook-Hwan Oh, Tae-Hyun Yoo
Summary: The study found a significant association between low bone mineral density and the progression of coronary arterial calcification, as well as the risk of major adverse cardiovascular events in patients with predialysis chronic kidney disease.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Sang Heon Suh, Tae Ryom Oh, Hong Sang Choi, Chang Seong Kim, Eun Hui Bae, Kook-Hwan Oh, Kyu-Beck Lee, Seung Hyeok Han, Suah Sung, Seong Kwon Ma, Soo Wan Kim
Summary: This study found that high body weight variability is independently associated with rapid progression of coronary artery calcification in patients with predialysis chronic kidney disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Chien-Te Lee, Wei-Hung Kuo, You-Lin Tain, Yi Wang, Wen-Chin Lee
Summary: This study found that exogenous BMP7 administration can improve disturbed CKD-MBD and vascular calcification in adenine-induced chronic uremic rats. The treatment shows potential in alleviating renal dysfunction, hyperphosphatemia, hyperparathyroidism, and skeletal structural abnormalities.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Urology & Nephrology
Brecht Van Berkel, Chantal Van Ongeval, Amaryllis H. Van Craenenbroeck, Hans Pottel, Katrien De Vusser, Pieter Evenepoel
Summary: Breast arterial calcification (BAC) is common among CKD patients and increases with disease progression. BAC is associated with age, cardiovascular disease, and inflammation. The progression rate of BAC is slower in transplant recipients. BAC is closely related to adverse cardiovascular outcomes.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Pharmacology & Pharmacy
Britt Opdebeeck, Ellen Neven, Jose Luis Millan, Anthony B. Pinkerton, Patrick C. D'Haese, Anja Verhulst
Summary: This study investigated the inhibition of arterial media calcification in CKD using the TNAP inhibitor SBI-425, PPi, or a combination of both in a rat model. The results showed that all treatments, except for SBI-425 alone, effectively blocked CKD-related arterial media calcification. Moreover, SBI-425 alone and in combination with PPi increased osteoid area, indicating a less efficient bone mineralization.
Article
Immunology
Camilo G. Sotomayor, Stan Benjamens, Antonio W. Gomes-Neto, Robert A. Pol, Dion Groothof, Charlotte A. te Velde-Keyzer, Guillermo Chong, Andor W. J. M. Glaudemans, Stefan P. Berger, Stephan J. L. Bakker, Riemer H. J. A. Slart
Summary: CKD-MBD and vascular calcification are common in kidney transplant recipients. This study found a high prevalence of BMD disorders in KTR, with an independent inverse association between BMD and AAC suggesting the existence of a bone-vascular axis post transplantation.
Article
Endocrinology & Metabolism
S. Hildebrand, J. Cunningham
Summary: The effects of bisphosphonates on vascular calcification are complex and variable, with no definitive evidence of accelerated vascular calcification. The kidneys play a crucial role in calcium buffering, and decreased GFR may increase the risk of hypercalcemia due to high calcium influx.
Article
Geriatrics & Gerontology
Si-Chong Ren, Nan Mao, Si Yi, Xin Ma, Jia-Qiong Zou, Xiaoqiang Tang, Jun Ming Fan
Summary: Chronic kidney disease leads to vascular calcification, while aging and metabolic disorders are risk factors. Recent progress has been made in treating vascular calcification, but there is a lack of systematic reviews.
Article
Biotechnology & Applied Microbiology
Zofia Wicik, Levi H. Jales Neto, Luis E. F. Guzman, Rodrigo Pavao, Liliam Takayama, Valeria F. Caparbo, Neuza H. M. Lopes, Alexandre C. Pereira, Rosa M. R. Pereira
Summary: This study utilized an original bioinformatic framework to analyze the association between Coronary Artery Calcification (CAC) and osteoporosis, revealing important roles of miRNA and lncRNA. The top non-coding RNAs in CAC were found to have significant interactions with genes regulating bone metabolism, vascularization processes, chromatin organization, prostaglandin, and calcium co-signaling. Key genes like PTGER3, FGFR1, and ONECUT2 were identified as susceptible to regulation by the top non-coding RNAs in CAC.
Article
Transplantation
Pieter Evenepoel, Hanne Skou Jorgensen, Jordi Bover, Andrew Davenport, Justine Bacchetta, Mathias Haarhaus, Ditte Hansen, Carolina Gracia-Iguacel, Markus Ketteler, Louise McAlister, Emily White, Sandro Mazzaferro, Marc Vervloet, Rukshana Shroff, European Renal Osteodystrophy EUROD, European Renal Assoc ERA, European Soc Pediat Nephrology ESPN
Summary: Mineral and bone disorders are commonly seen in patients with chronic kidney disease, which can lead to adverse health outcomes. The management of calcium intake is crucial for maintaining a neutral calcium balance and preventing bone diseases and fractures. However, current clinical practice guidelines lack specific recommendations on calcium intake. Therefore, experts in the field have provided key practice points to assist healthcare professionals, but these recommendations should be individualized based on patient needs.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Endocrinology & Metabolism
Marciana L. Laster, Bryce Rowan, Hua-Chang Chen, Tae-Hwi Schwantes-An, Xin Sheng, Peter A. Friedman, T. Alp Ikizler, Janet S. Sinshiemer, Joachim H. Ix, Katalin Susztak, Ian H. de Boer, Bryan Kestenbaum, Adriana Hung, Sharon M. Moe, Farzana Perwad, Cassianne Robinson-Cohen
Summary: This study examined the genetic variants associated with mineral metabolism markers in patients with chronic kidney disease (CKD). The findings revealed that the rs4074995 (RGS14) gene variant was associated with lower phosphorus levels, lower plasma FGF23 levels, and a lower prevalence of hyperparathyroidism in CKD patients. This variant was also linked to lower gene expression in the kidney.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Medicine, General & Internal
Fernanda G. Rodrigues, Milene S. Ormanji, Ita P. Heilberg, Stephan J. L. Bakker, Martin H. de Borst
Summary: This article explores the deregulation of gut microbiota in patients with chronic kidney disease (CKD) and its impact on vascular and bone diseases. It discusses the influence of diet, medications, and other factors on gut microbiota composition and subsequently on the overall health of CKD patients.
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Endocrinology & Metabolism
Hanne Skou Jorgensen, Herman Borghs, Sam Heye, Dieter Smout, Kathleen Claes, Pieter Evenepoel
Summary: This study investigated the impact of abdominal aortic calcification on bone mineral density in patients with chronic kidney disease. The findings challenge the traditional belief that measurement of lumbar spine bone mineral density using DXA is unreliable in patients with CKD.
Article
Cardiac & Cardiovascular Systems
Mandy E. Turner, Tyler S. Rowsell, Austin P. Lansing, Paul S. Jeronimo, Lok Hang Lee, Bruno A. Svajger, Jason G. E. Zelt, Corey M. Forster, Martin P. Petkovich, Rachel M. Holden, Michael A. Adams
Summary: The study investigates the systemic response to acute phosphate challenges in the presence of vascular calcification (VC) and highlights the negative vascular consequence of fluctuations in circulating phosphate. The findings emphasize the importance of phosphate bioavailability and diet management in CKD patients as a mediator of cardiovascular risk.
CARDIOVASCULAR RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Xiadan Xiang, Ji He, Wei Zhang, Qiang He, Yueming Liu
Summary: This study found a close association between cardiovascular disease and chronic kidney disease in CKD patients, with vascular calcification as a major predictor of cardiovascular disease. Vascular calcification was found to be associated with changes in bone and mineral metabolism, and bone metabolism and inflammatory markers were positively correlated with CAC scores. Additionally, a higher risk of all-cause mortality and cardiovascular hospitalization was observed when the CAC score exceeded 400.
BMC CARDIOVASCULAR DISORDERS
(2022)
Article
Pediatrics
Emilia M. D. Soeiro, Lucimary Castro, Rejane Menezes, Rosilene M. Elias, Luciene M. dos Reis, Vanda Jorgetti, Rosa M. A. Moyses
PEDIATRIC NEPHROLOGY
(2020)
Article
Nutrition & Dietetics
Flavia Ramos de Siqueira, Karin Carneiro de Oliveira, Wagner Vasques Dominguez, Cesar Augusto Madid Truyts, Rosa Maria Affonso Moyses, Luciene Machado dos Reis, Vanda Jorgetti
Summary: The study found that PTx was effective in correcting mineral disorders, improving body composition, enhancing nutritional status, and preventing further weight loss progression in s-HPT patients.
EUROPEAN JOURNAL OF CLINICAL NUTRITION
(2021)
Editorial Material
Urology & Nephrology
Susan M. Ott, Hartmut H. Malluche, Vanda Jorgetti, Grahame J. Elder
Summary: Patients with chronic kidney disease-mineral and bone disorder often have low bone formation rates. While antiresorptive medications may not always be associated with negative outcomes in adynamic bone disease, current evidence does not support improvements in fracture risk or mortality in CKD-MBD patients with low bone turnover. Further research is needed to determine the best treatment approach.
KIDNEY INTERNATIONAL
(2021)
Article
Food Science & Technology
Irene Faria Duayer, Eduardo Jorge Duque, Clarice Kazue Fujihara, Ivone Braga de Oliveira, Luciene Machado dos Reis, Flavia Gomes Machado, Fabiana Giorgetti Graciolli, Vanda Jorgetti, Roberto Zatz, Rosilene Motta Elias, Rosa Maria Affonso Moyses
Summary: The study found that a high-phosphate diet may exacerbate the progression of chronic kidney disease, leading to renal interstitial inflammation and fibrosis, with phosphate possibly playing a role in dysregulating the renal cell autophagy mechanism.
Article
Medicine, Research & Experimental
Wander Barros do Carmo, Barbara Bruna Abreu Castro, Luisa Cardoso Manso, Priscylla Aparecida Vieira do Carmo, Clovis Antonio Rodrigues, Melani Ribeiro Custodio, Vanda Jorgetti, Helady Sanders-Pinheiro
Summary: The study found that the chitosan-iron III chelator was effective in reducing phosphorus excretion without iron accumulation, paving the way for potential use of this class of chelators in clinical settings in the future.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2022)
Article
Multidisciplinary Sciences
Jader Joel Machado Junqueira, Juliana Dias Lourenco, Kaique Rodrigues da Silva, Vanda Jorgetti, Rodolfo P. Vieira, Amanda Aparecida de Araujo, Katia De Angelis, Aristides Tadeu Correia, Luan Henrique Vasconcelos Alves, Iolanda de Fatima Lopes Calvo Tiberio, Alexandre Povoa Barbosa, Fernanda Degobbi Tenorio Quirino dos Santos Lopes
Summary: The study found that long-term exposure to cigarette smoke can lead to changes in bone structural parameters and bone loss, with an increase in markers of osteoclast activity and bone resorption in the early stages, leading to a reduction in the OPG/RANKL ratio.
Letter
Urology & Nephrology
Iara da Silva Santos, Maria Julia Correia Lima Nepomuceno Araujo, Vanda Jorgetti, Rosilene Motta Elias, Jordi Bover
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Biographical-Item
Endocrinology & Metabolism
Vanda Jorgetti, Sampaio-Barros Pd, Shinjo Sk, Eloisa Bonfa
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Urology & Nephrology
Cinthia E. M. Carbonara, Noemi A. V. Roza, Luciene M. dos Reis, Aluizio B. Carvalho, Vanda Jorgetti, Rodrigo Bueno de Oliveira
Summary: The Brazilian Registry of Bone Biopsy (REBRABO) is a national multicenter cohort that provides clinical information on renal osteodystrophy (ROD). This subanalysis described the profile of ROD, including the most frequent diagnoses and associated findings. The results showed a high proportion of patients with osteoporosis, vascular calcification, and clinical symptoms.
JORNAL BRASILEIRO DE NEFROLOGIA
(2023)
Article
Urology & Nephrology
Cesar Truyts, Melani Custodio, Roberto Pecoit-Filho, Thyago Proenca de Moraes, Vanda Jorgetti
Summary: This study showed a significant association between high phosphorus serum levels and low parathyroid hormone levels with cardiovascular mortality in peritoneal dialysis patients, according to KDOQI and KDIGO guidelines.
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Urology & Nephrology
Rafael Weissheimer, Sergio Gardano Elias Bucharles, Cesar Augusto Madid Truyts, Vanda Jorgetti, Ana Elizabeth Figueiredo, Pasqual Barrett, Marcia Olandoski, Roberto Pecoits-Filho, Thyago Proenca de Moraes
Summary: The study aimed to describe the prevalence of CKDMBD biomarkers in a large cohort of PD patients in Brazil. The findings showed a significant presence of biochemical disorders related to CKD-MBD in this dialysis population.
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Urology & Nephrology
Shirley Ferraz Crispilho, Eduardo Jorge Duque, Kalyanna Soares Bezerra, Rosa Maria R. Pereira, Vanda Jorgetti, Rosilene M. Elias, Rosa M. A. Moyses
Summary: Body composition evaluation in CKD patients using DXA and BIA may have discrepancies, especially in patients with SHPT. Factors such as serum phosphate levels and patient group are independently associated with the differences in BMC measurement between the two methods, and PTX surgery can help reduce this difference.
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Urology & Nephrology
Fellype Carvalho Barreto, Sergio Gardano Elias Bucharles, Vanda Jorgetti
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Urology & Nephrology
Sergio Gardano Elias Bucharles, Lillian Pires de Freitas do Carmo, Aluizio Barbosa Carvalho, Vanda Jorgetti
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Medicine, General & Internal
Climerio Pereira Nascimento, Sergio Samir Arap, Melani Ribeiro Custodio, Ledo Mazzei Massoni Neto, Marilia D'Elboux Guimaraes Brescia, Rosa Maria Affonso Moyses, Vanda Jorgetti, Fabio Luiz de Menezes Montenegro
Summary: After total parathyroidectomy and autograft, dialysis patients exhibit four distinct patterns of graft function, each requiring varied therapeutic management. These patterns include stable function, early function with later failure, graft recurrence, and complete graft failure. Patterns of parathormone levels become statistically different after 36 months, highlighting the importance of long-term monitoring.
REVISTA DA ASSOCIACAO MEDICA BRASILEIRA
(2021)
