Article
Biochemistry & Molecular Biology
Hsin-Han Hou, Bor-Shiunn Lee, Yu-Cheng Liu, Yi-Ping Wang, Wei-Ting Kuo, I-Hui Chen, Ai-Chia He, Chern-Hsiung Lai, Kuo-Lun Tung, Yi-Wen Chen
Summary: This study aimed to create zinc (Zn)-, strontium (Sr)-, and magnesium (Mg)-multidoped hydroxyapatite (HAp) porous coatings on titanium discs and implants using the VIPF-APS technique. The results showed that the Zn-Sr-Mg-HAp group exhibited the most effective induction of osteogenesis-associated genes expression and antibacterial effects against periodontal bacteria. Moreover, histologic and micro-CT analysis demonstrated that the Zn-Sr-Mg-HAp group had the most prominent osteogenesis and bone growth along implant threads. Therefore, porous Zn-Sr-Mg-HAp coating using VIPF-APS could be a novel technique for coating titanium implant surfaces and preventing bacterial infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biotechnology & Applied Microbiology
Yang Liu, Sujeesh Sebastian, Jintian Huang, Tova Corbascio, Jacob Engellau, Lars Lidgren, Magnus Tagil, Deepak Bushan Raina
Summary: This study aimed to investigate the in vivo biodistribution of nHA particles and found that majority of the particles stayed locally at the implantation site after 28 days. The radioactivity observed in the kidney and spleen was minimal, and no pathological changes in vital organs were observed. These findings demonstrate the safety of locally implanted nHA particles for potential use in localized drug delivery.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kailash Venkatraman, Christopher T. Lee, Guadalupe C. Garcia, Arijit Mahapatra, Daniel Milshteyn, Guy Perkins, Keun-Young Kim, H. Amalia Pasolli, Sebastien Phan, Jennifer Lippincott-Schwartz, Mark H. Ellisman, Padmini Rangamani, Itay Budin
Summary: The architecture of the inner mitochondrial membrane is not only regulated by proteins, but also influenced by specific lipids. This study reveals the crucial role of cardiolipin in buffering the curvature loss and promoting cristae formation.
Article
Endocrinology & Metabolism
Taro Fujimaki, Takashi Ando, Takanori Hata, Yoshihiro Takayama, Tetsuro Ohba, Jiro Ichikawa, Yoshihisa Takiyama, Rikito Tatsuno, Katsuhiro Koyama, Hirotaka Haro
Summary: This study investigated the effect of PTH on skeletal muscle atrophy and dysfunction using an ovariectomized murine model. The results showed that PTH significantly ameliorated muscle weakness and attenuated exercise-induced lactate levels in ovariectomized mice. PTH could regulate several aspects of muscle function and physiology, and may represent a novel therapeutic strategy for patients with osteoporosis.
Article
Engineering, Environmental
Guoquan Zeng, Suyu Qiao, Xitong Wang, Mingping Sheng, Mingyang Wei, Qun Chen, Heng Xu, Fei Xu
Summary: The addition of 10 mM Ca2+ during the Microbially induced phosphate precipitation (MIPP) process significantly increased the removal ratio of Cd, potentially through the formation of a solid solution to remove the heavy metal cadmium.
JOURNAL OF HAZARDOUS MATERIALS
(2021)
Article
Biochemical Research Methods
Mari Takahara, Shinichi Mochizuki, Rie Wakabayashi, Kosuke Minamihata, Masahiro Goto, Kazuo Sakurai, Noriho Kamiya
Summary: This study utilized microbial transglutaminase (MTG) to efficiently conjugate lipids with proteins, designing water-soluble amphiphilic lipopeptides and protein conjugates. The successful lipid-protein conjugates demonstrated high cell adhesion efficiency and prolonged half-life, showing the potential for drug delivery systems.
BIOCONJUGATE CHEMISTRY
(2021)
Article
Chemistry, Multidisciplinary
Dania Grant-Serroukh, Morag R. Hunter, Ruhina Maeshima, Aristides D. Tagalakis, Ahmad M. Aldossary, Nour Allahham, Gareth R. Williams, Mark Edbrooke, Arpan Desai, Stephen L. Hart
Summary: Despite recent advances in mRNA therapy, the lack of safe and effective delivery vehicles remains a major challenge. In this study, lipid-peptide nanocomplexes were systematically optimized for mRNA delivery. The optimized formulation showed improved transfection efficiency in vitro and in vivo, and retained stable physicochemical properties for a prolonged period of time. This lipid-peptide nanocomplex provides a promising platform for the delivery of therapeutic mRNA.
JOURNAL OF CONTROLLED RELEASE
(2022)
Article
Chemistry, Inorganic & Nuclear
Taishi Yokoi, Masahiro Watanabe, Fumiya Nakamura, Hiromi Kimura-Suda, Masaya Shimabukuro, Masakazu Kawashita
Summary: In this study, OCP with incorporated 3,3'-dithiodipropionate ions was successfully synthesized, which is beneficial for the development of novel OCP-based materials with dynamic properties derived from disulfide bonds.
DALTON TRANSACTIONS
(2023)
Article
Nanoscience & Nanotechnology
Xitong Cheng, Xiao Yang, Chengde Liu, Yizheng Li, Yangyang Zhang, Jinyan Wang, Xingdong Zhang, Xigao Jian
Summary: Apatite coatings play a critical role in enhancing the surface bioactivity and osteogenic activity of implant materials. This study proposes a strategy to improve the bonding ability between apatite coatings and substrates by constructing a three-dimensional nanoporous structure and introducing a polydopamine coating. The enhanced apatite coating exhibits better bioactivity and osteogenic differentiation, as confirmed by in vitro and in vivo experiments. This research shows great potential for the clinical application of orthopedic implants.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Xinlin Li, Baojuan Yang, Mengfei Xu, Fangyi Li, Zhaoli Geng, Weiqiang Cui, Xingfu Sun, Yanle Li, Yi Liu
Summary: A HASiGdCe coating with excellent antibacterial, angiogenic and osteogenic properties has been developed, and it holds promising applications in orthopedic and dental implants.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Chemistry, Physical
Zhenyu Ding, Qian Peng, Jun Zuo, Yuehong Wang, Hongbo Zhou, Zhangui Tang
Summary: This paper investigates the osteogenesis performance of the boronized Ti6Al4V/HA composite and confirms its potential as a highly promising dental implant based on both cell experiments in vitro and animal experiments in vivo. The composite exhibited the best inductive osteogenesis potential, promoting early osteogenic differentiation of osteoblasts, and had the highest new bone formation potential and best osseointegration property after implantation.
Article
Materials Science, Ceramics
Yagiz Yedekci, Emre Gedik, Zafer Evis, Lale Dogan, Gokhan Ozyigit, Murat Gurkaynak
Summary: Zinc-doped hydroxyapatite nanoparticles were synthesized and used to inhibit the proliferation of breast cancer cells in combination with ionizing radiation. Low-rate Zinc-doped HA enhanced the radiation effect on breast cancer cells, showing anti-proliferation and apoptosis-inducing properties.
INTERNATIONAL JOURNAL OF APPLIED CERAMIC TECHNOLOGY
(2021)
Article
Engineering, Chemical
Chen-Hsueh Lin, Yu-Sheng Chen, Wei-Lun Huang, Tzung-Chin Hung, Ten-Chin Wen
Summary: In this study, chitin and chitosan were used to provide an environment for calcium ion and phosphate ion, promoting the formation of HA crystallites. This hypothesis was supported by experiments, and the porous morphology after HA mineralization was observed. CH-CS-HA showed a high crystallinity index and a Young's modulus close to that of native bone.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2021)
Article
Chemistry, Multidisciplinary
Hiroyoshi Fujioka, Minoru Kawatani, Spencer John Spratt, Ayumi Komazawa, Yoshihiro Misawa, Jingwen Shou, Takaha Mizuguchi, Hina Kosakamoto, Ryosuke Kojima, Yasuteru Urano, Fumiaki Obata, Yasuyuki Ozeki, Mako Kamiya
Summary: By using 9CN-JCR and its derivatives, we have established a novel mechanism for Raman signal activation and applied it to simultaneously detect multiple enzyme activities in live cells, achieving specific visualization of target cells.
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
(2023)
Article
Engineering, Chemical
Chen-Hsueh Lin, Yu-Hua Xiao, Yan-Ting Lin, Ping-Hsuan Wu, Teng-Hao Chen, Wei-Cheng Li, Li-Hsiang Tseng, Po-Hsin Wang, Ten-Chin Wen
Summary: The use of hydroxyapatite induced by carboxylated chitosan as an active filler for pseudo solid-state supercapacitor can effectively reduce crystalline region, increase amorphous region, decrease internal resistance and heat dissipation, enhance segmental motion and ion migration, making it a novel filler for superior solid-state energy storage devices.
JOURNAL OF THE TAIWAN INSTITUTE OF CHEMICAL ENGINEERS
(2021)
