Article
Medicine, General & Internal
Jaehoon Lee, Yuntae Kim, Hyunji Park, Changsoo Kim, Sihyun Cho, Jongyoun Kim
Summary: This study investigated the association between different types of hormone replacement therapy (HRT) and atrial fibrillation (AF). The findings showed that current HRT users, except those using estradiol-only HRT, had significantly elevated AF risk, while past users who used estradiol plus progestin HRT had a reduced AF risk.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Hayoung Choi, Kyungdo Han, Bumhee Yang, Dong Wook Shin, Jang Won Sohn, Hyun Lee
Summary: This study aimed to evaluate the impacts of endogenous estrogen exposure and hormone replacement therapy (HRT) on the risk of nontuberculous mycobacterial pulmonary disease (NTM-PD) in postmenopausal women. The results showed no significant association between endogenous estrogen exposure and NTM-PD risk, but there was a dose-dependent relationship between the duration of HRT and the risk of NTM-PD.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Clinical Neurology
Kimberly M. Albert, Brian D. Boyd, Warren D. Taylor, Paul A. Newhouse
Summary: This study investigated the modulation effect of estrogen on neural and emotional cognitive responses to stress in postmenopausal women. The results suggest a differential effect of estrogen on emotional and neural responses in postmenopausal women with and without a history of MDD.
JOURNAL OF AFFECTIVE DISORDERS
(2021)
Article
Psychiatry
Hyewon Kim, Juhwan Yoo, Kyungdo Han, Mi Jin Park, Hyun Soo Kim, Jihyun Baek, Hong Jin Jeon
Summary: This study investigated the association between female reproductive factors and the development of newly diagnosed bipolar disorder (BD). The study found that later menopause and breastfeeding for more than one year were associated with a decreased risk of BD occurrence, while receiving hormone therapy was associated with an increased risk.
JOURNAL OF PSYCHIATRIC RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Swati Sucharita Mohanty, Prafulla Kumar Mohanty
Summary: Breast cancer is the second most prevalent cancer globally, with a significant relationship between obesity and increased risk of developing the disease. Premature menopause and premenopausal obesity decrease the risk, while postmenopausal obesity amplifies it due to adipose tissue being a major reservoir for estrogen biosynthesis. High estrogen levels in overweight postmenopausal women are seen as a major factor in breast cancer development.
Article
Multidisciplinary Sciences
Hetal Bhadricha, Vainav Patel, Amit Kumar Singh, Lalita Savardekar, Anushree Patil, Suchitra Surve, Meena Desai
Summary: The study indicates that the increase in Th17 cell frequency and IL-17 levels in postmenopausal women may be associated with decreased bone density, possibly due to estrogen deficiency. Th17 cells and IL-17 could be potential targets for immunotherapy in the treatment of osteoporosis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Ashley M. Geczik, Roni T. Falk, Xia Xu, Daniel Ansong, Joel Yarney, Beatrice Wiafe-Addai, Lawrence Edusei, Florence Dedey, Verna Vanderpuye, Nicholas Titiloye, Ernest Adjei, Francis Aitpillah, Ernest Osei-Bonsu, Joseph Oppong, Richard Biritwum, Kofi Nyarko, Seth Wiafe, Baffour Awuah, Joe-Nat Clegg-Lamptey, Thomas U. Ahearn, Jonine Figueroa, Montserrat Garcia-Closas, Louise A. Brinton, Britton Trabert
Summary: This study aimed to investigate the relationship between circulating estrogen levels and anthropometric measures in African women and their relevance to breast cancer risk factors. The results showed that measured BMI and WHR were positively associated with estrogen levels, similar to the relationship previously observed in postmenopausal White women at higher risk for breast cancer. However, height was not associated with estrogen levels in African women.
BREAST CANCER RESEARCH
(2022)
Review
Endocrinology & Metabolism
Alleigh G. Wiggs, Justin K. Chandler, Aynur Aktas, Susan J. Sumner, Delisha A. Stewart
Summary: Endogenous estrogens are associated with breast cancer risk, particularly in postmenopausal women. Nutritional and exercise interventions have been shown to modify estrogen levels and metabolism, potentially reducing the risk of breast cancer. Studies combining diet and exercise interventions demonstrate better control of estrogen forms and levels, suggesting they may be the most effective strategies for preventing breast cancer in postmenopausal women.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Biology
Lizett Castrejon-Delgado, Osvaldo D. Castelan-Martinez, Patricia Clark, Juan Garduno-Espinosa, Victor Manuel Mendoza-Nunez, Martha A. Sanchez-Rodriguez
Summary: Tibolone increases bone mineral density in the lumbar spine and femoral neck compared to non-active controls, with no significant difference compared to estrogen therapy.
Article
Endocrinology & Metabolism
Bo Mi Kim, Sung Eun Kim, Dong-Yun Lee, DooSeok Choi
Summary: In this study, 40 postmenopausal Korean women underwent 12 months of TSEC treatment, showing a significant increase in total hip bone mineral density and specific changes in the parameters of HSA. The findings suggest that TSEC treatment could potentially improve bone geometry in postmenopausal women, providing a promising option for fracture prevention and osteoporosis.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Nutrition & Dietetics
Arun Maharaj, Stephen M. Fischer, Katherine N. Dillon, Yejin Kang, Mauricio A. Martinez, Arturo Figueroa
Summary: This study found that L-CIT supplementation improves endothelial function and aortic blood pressure in hypertensive postmenopausal women through increased availability of L-ARG.
Article
Allergy
Bright I. Nwaru, Syed A. Shah, Holly Tibble, Rebecca Pillinger, Susannah McLean, Dermot Ryan, Hilary Critchley, Catherine M. Hawrylowicz, Colin R. Simpson, Ireneous N. Soyiri, Francis Appiagyei, David Price, Aziz Sheikh
Summary: This study found that previous use of HRT, particularly for more than 2 years, combined HRT, and estrogen-only HRT, is associated with an increased risk of severe asthma exacerbation in perimenopausal/postmenopausal women with established asthma. Lean women and smokers are at greater risk than heavier women and nonsmokers, respectively.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Pharmacology & Pharmacy
Andrea M. P. Romani
Summary: Phytoestrogens have been identified as a natural alternative to synthetic estrogens for post-menopausal women, and have shown beneficial effects in attenuating severe complications in diseases such as type 2 diabetes, metabolic syndrome, NAFLD, and obesity. However, uncertainties regarding their effectiveness, conversion to active principles in the gut microbiome, and synergistic effects of different phytoestrogens remain, highlighting the need for further research in the field.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Geriatrics & Gerontology
Ekta Kapoor, Stephanie S. Faubion, Liliana Gazzuola Rocca, Michelle M. Mielke, Carin Y. Smith, Walter A. Rocca
Summary: The study aimed to investigate the trajectories of metabolic parameters after bilateral oophorectomy. The results showed significant differences in weight, body mass index (BMI), and high-density lipoprotein cholesterol (HDL-C) among the three groups. Although there were baseline differences, the changes primarily occurred in the initial 4-5 years. Women who received estrogen therapy after bilateral oophorectomy had similar weight and BMI trends as the control group and experienced an increase in HDL-C over time.
Article
Nutrition & Dietetics
Seong-Hee Ko, YunJae Jung
Summary: Hormonal changes during menopause in women lead to body composition changes, muscle loss, and abdominal obesity, with increased visceral fat as a result. These changes in fat distribution also contribute to metabolic abnormalities, insulin resistance, and metabolic diseases, due to enhanced lipolysis of visceral fat.