Review
Immunology
Zhenzhen Xu, Xiangyang Yao, Chen Duan, Haoran Liu, Hua Xu
Summary: Kidney stone disease is still not well understood in terms of its formation mechanism and metabolic changes. This manuscript summarizes the progress in research on metabolic changes in kidney stone disease and proposes new potential targets. The influence of metabolism of various substances on stone formation is discussed, including oxalate regulation, reactive oxygen species release, macrophage polarization, hormone levels, and other substance alteration. Understanding these metabolic changes and utilizing emerging research techniques will provide new directions in the treatment of kidney stones.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Nutrition & Dietetics
Roswitha Siener
Summary: The prevalence of kidney stone disease is increasing globally, with a high recurrence rate for urinary stones. Dietary composition plays a crucial role, and inadequate fluid intake is a major risk factor for urolithiasis. Other nutritional factors like protein, carbohydrates, oxalate, calcium, and sodium chloride also influence the risk of kidney stone formation.
Review
Physiology
Hao Li, Yingjian Zhou, Wenchao Xu, Jihong Liu, Shaogang Wang, Hongyang Jiang
Summary: This systematic review discusses the role of autophagy in the pathogenesis of kidney stone and suggests that upregulation of autophagy may be a future research direction for kidney stone treatment.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Immunology
Kazumi Taguchi, Atsushi Okada, Rei Unno, Shuzo Hamamoto, Takahiro Yasui
Summary: This systematic review provides an update on the current understanding of macrophage involvement in calcium oxalate nephrolithiasis. Targeting M2-like macrophage function may offer a therapeutic strategy to prevent stones by phagocytosing crystals.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Yuqi Xia, Xiangjun Zhou, Zehua Ye, Weimin Yu, Jinzhuo Ning, Yuan Ruan, Run Yuan, Fangyou Lin, Peng Ye, Di Zheng, Ting Rao, Fan Cheng
Summary: This study identified potential ceRNAs and immune cell infiltration involvement in kidney stone pathogenesis, providing novel therapeutic targets for kidney stones. The ceRNA network includes specific molecules like NEAT1, PVT1, hsa-miR-23b-3p, hsa-miR-429, hsa-miR-139-5p, CCL7, and ROBO2, while immune cells like macrophages and mast cells play a role in the process.
FRONTIERS IN GENETICS
(2021)
Article
Biotechnology & Applied Microbiology
Zhu Wang, Qiong Deng, Yanli Gu, Min Li, Ying Zhang, Qiyi Hu, Shenping Zhang, Xisheng Wang, Hui Liang
Summary: This study investigated the gene expression changes in the kidney of a rat model with kidney stones. The results showed dysregulated genes related to injury, apoptosis, immune response, solute carriers, transporters, and metabolic factors. These findings contribute to a better understanding of the pathogenesis of nephrolithiasis and could potentially lead to the development of new strategies for prevention and treatment.
Article
Urology & Nephrology
Megan Prochaska, John Asplin, Arlene Chapman, Elaine Worcester
Summary: The study found that men had higher calcium oxalate supersaturation in urine before RYGB, while women had higher urine calcium oxalate supersaturation and calcium phosphate supersaturation, as well as lower urine volumes after RYGB.
AMERICAN JOURNAL OF NEPHROLOGY
(2021)
Article
Urology & Nephrology
Roi Bar, Efrat Ben-Shalom, Mordechai Duvdevani, Ruth Belostotsky, Martin R. Pollak, David B. Mount, Ruth Bar-Gal, Ehud Gnessin, Shay Tzur, Gary C. Curhan, Yaacov Frishberg
Summary: The study found that mutations in the HOGA1 gene do not confer a dominant phenotype of calcium-oxalate kidney stone disease or hyperoxaluria, based on research conducted on Ashkenazi Jews and non-Ashkenazi individuals.
JOURNAL OF UROLOGY
(2021)
Article
Urology & Nephrology
Stanislav Yuzhakov, Shavano D. Steadman, Brandon J. Otto, Vincent G. Bird, Benjamin K. Canales
Summary: The study demonstrates a correlation between 24-hour urine calcium oxalate supersaturation (CaOx SS) and in vivo stone growth in individuals with pure CaOx stones. Higher CaOx SS levels were associated with increased stone growth rates, indicating potential for noninvasive study of stone growth modulators and improved stone risk prediction through CT volumetric analysis.
JOURNAL OF UROLOGY
(2021)
Article
Biotechnology & Applied Microbiology
Lei Yan, Jinhu Chen, Weihua Fang
Summary: This study found that exosomes derived from CaOx-treated macrophages promote apoptosis of HK-2 cells by promoting autophagy. This suggests that macrophage-derived exosomes play a vital role in CaOx-induced human proximal tubular cell damage.
Article
Urology & Nephrology
James C. Williams, Haider Al-Awadi, Manognya Muthenini, Sharon B. Bledsoe, Tarek El-Achkar, Andrew P. Evan, Fredric Coe, James E. Lingeman, Elaine M. Worcester
Summary: This study investigates the differences between patients with kidney stones containing Randall's plaque (RP) and those without RP. The study found that the growth of many small stones on plaque seems to be the mechanism for the formation of RP, while the pathogenesis of stones without RP is less clear. Additionally, non-RP patients had more papillary plugging, suggesting a role of plugs in stone formation.
JOURNAL OF ENDOUROLOGY
(2022)
Review
Physiology
Jialin Li, Sigen Huang, Shengyin Liu, Xinzhi Liao, Sheng Yan, Quanliang Liu
Summary: The SLC26 protein family consists of multifunctional carriers that transport substances such as oxalate, sulphate, and chloride. Disorders in oxalate metabolism can lead to hyperoxalemia and hyperoxaluria, causing urinary calcium oxalate precipitation and urolithogenesis. Abnormal expressions of SLC26 proteins during kidney stone formation suggest that they could be potential therapeutic targets. Preclinical development of SLC26 protein inhibitors is currently ongoing. This review integrates recent reports and clinical data to investigate the role of SLC26 proteins in oxalate metabolism during urolithogenesis, and discusses the limitations of current studies and future research directions.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Urology & Nephrology
Nasser A. Dhayat, Lisa Schneider, Albrecht W. Popp, David Luthi, Cedric Mattmann, Bruno Vogt, Daniel G. Fuster
Summary: This study identified predictors of bone mineral density in stone formers and found that commonly available clinical parameters, such as kidney stone composition results, can be used to identify stone formers at risk for low bone mineral density.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Agriculture, Multidisciplinary
Seyed Fazel Mirahmadi, Mohammadreza Hassandokht, Reza Fatahi, Mohammad Reza Naghavi, Karamatollah Rezaei
Summary: This study identified three biosynthetic patterns of oxalate accumulation in spinach and introduced a unique type with high oxalate accumulation, which could be beneficial for improving the nutritional value of spinach. The research also suggested a small role for ascorbic acid as a precursor to oxalate production in spinach, highlighting the significance of glyoxylate as the most critical precursor in this plant.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2022)
Article
Biochemistry & Molecular Biology
Chan Jung Liu, Yau Sheng Tsai, Ho Shiang Huang
Summary: This study demonstrates that statins can suppress hyperlipidemia-induced CaOx nephrolithiasis by restoring the expression of anti-lithic protein, leading to a decrease in renal CaOx stone deposits and a change in the dominant calcium crystal composition.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Urology & Nephrology
Hidenori Nishio, Kentaro Mizuno, Taiki Kato, Tetsuji Maruyama, Takahiro Yasui, Yutaro Hayashi
Summary: Posterior urethral valves (PUVs) are a common cause of congenital urethral obstruction, leading to symptoms such as straining during voiding. Diagnosis of PUV can be confirmed through uroflowmetry and voiding cystourethrography (VCUG), followed by appropriate treatment.
UROLOGY CASE REPORTS
(2022)
Article
Urology & Nephrology
Toshiki Etani, Minami Asaoka, Shuhei Kondo, Chiharu Wachino, Nami Tomiyama, Tatsuya Hattori, Takashi Nagai, Keitaro Iida, Kazumi Taguchi, Taku Naiki, Shuzo Hamamoto, Atsushi Okada, Noriyasu Kawai, Takeshi Yanagita, Atsushi Nakamura, Takahiro Yasui
Summary: This study investigated the effectiveness of fosfomycin sodium and cefotiam in preventing infection after endoscopic combined intrarenal surgery, with results showing no significant differences between the two in terms of postoperative fever and other indicators.
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Kazumi Taguchi, Shuzo Hamamoto, Atsushi Okada, Teruaki Sugino, Rei Unno, Taiki Kato, Hidekatsu Fukuta, Ryosuke Ando, Noriyasu Kawai, Yung Khan Tan, Takahiro Yasui
Summary: This study compared the surgical outcomes of robotic-assisted fluoroscopic-guided (RAF group) and ultrasound-guided (US group) renal access in mini-percutaneous nephrolithotomy (PCNL). The results showed no significant difference in single puncture success rate and stone-free rate between the two groups. However, the RAF group had significantly fewer needle punctures and shorter puncture duration. This suggests that RAF guidance may have further potential applications in this field.
JOURNAL OF UROLOGY
(2022)
Article
Urology & Nephrology
Masahiko Isogai, Shuzo Hamamoto, Kengo Kawase, Tomoki Okada, Tatsuya Hattori, Ryosuke Chaya, Takashi Hamakawa, Teruaki Sugino, Kazumi Taguchi, Yukihiro Umemoto, Atsushi Okada, Takahiro Yasui
Summary: Ultrasound-assisted monitoring may increase the stone-free rate for patients with kidney calculi, but it does not have a significant impact on patients with proximal ureteral calculi.
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Editorial Material
Urology & Nephrology
Taku Naiki, Takahiro Yasui
INTERNATIONAL JOURNAL OF UROLOGY
(2022)
Article
Andrology
Tomoki Takeda, Shoichiro Iwatsuki, Satoshi Nozaki, Atsushi Okada, Kentaro Mizuno, Yukihiro Umemoto, Takahiro Yasui
Summary: The study developed a method for observing spermatogenesis in testicular tissue without sectioning. Fluorescent labeling and multiphoton microscopy were used to identify and observe spermatogenic stages. The method showed potential for live imaging of testicular tissue.
Article
Urology & Nephrology
Hidenori Nishio, Kentaro Mizuno, Daisuke Matsumoto, Takahiro Yasui, Yutaro Hayashi
Summary: Ureterocele prolapse can lead to voiding difficulty and the condition may go unnoticed if the abnormal voiding behavior is not observed. A 6-year-old boy with this condition was treated with transvesicoscopic ureteral reimplantation and ureterocele removal, resulting in improved voiding. Diagnosing congenital bladder obstructions can be challenging if the patient adapts to the voiding difficulty.
UROLOGY CASE REPORTS
(2023)
Article
Urology & Nephrology
Hidenori Nishio, Kentaro Mizuno, Taiki Kato, Hideyuki Kamisawa, Satoshi Kurokawa, Akihiro Nakane, Tetsuji Maruyama, Noriyasu Kawai, Takahiro Yasui, Yutaro Hayashi
Summary: This study retrospectively analyzed the surgical management of prepubertal testicular tumors based on cases observed over approximately 30 years. The results showed that patients who underwent testis-sparing surgery (TSS) had significantly smaller tumor sizes compared to those who underwent radical orchiectomy (RO). Patients treated after 2005 were more likely to undergo TSS, but there were no significant differences in tumor size or the rate of preoperative ultrasound.
INTERNATIONAL JOURNAL OF UROLOGY
(2023)
Article
Multidisciplinary Sciences
Mihoko Maruyama, Koichi P. Sawada, Yutaro Tanaka, Atsushi Okada, Koichi Momma, Masanori Nakamura, Ryota Mori, Yoshihiro Furukawa, Yuki Sugiura, Rie Tajiri, Kazumi Taguchi, Shuzo Hamamoto, Ryosuke Ando, Katsuo Tsukamoto, Kazufumi Takano, Masayuki Imanishi, Masashi Yoshimura, Takahiro Yasui, Yusuke Mori
Summary: We conducted a study to quantitatively analyze calcium oxalate (CaOx) kidney stones at the micrometer level, with a focus on the identification of calcium oxalate monohydrate (COM) and dihydrate (COD). We used Fourier transform infrared (FTIR) spectroscopy, powder X-ray diffraction (PXRD), and microfocus X-ray computed tomography measurements (microfocus X-ray CT) to compare their results. By analyzing the FTIR spectrum at the 780 cm(-1) peak, we successfully achieved a reliable analysis of the COM/COD ratio. This quantitative analysis method provides valuable information on the composition and formation processes of kidney stones.
Article
Pharmacology & Pharmacy
Takashi Nagai, Noriyasu Kawai, Masakazu Gonda, Keitaro Iida, Toshiki Etani, Daichi Kobayashi, Taku Naiki, Aya Naiki-Ito, Ryosuke Ando, Sataro Yamaguchi, Yuto Sugahara, Sakyo Ueno, Kaname Tsutsumiuchi, Toyoko Imae, Takahiro Yasui
Summary: In this study, hyperthermia was investigated as an alternative treatment for castration-resistant prostate cancer (CRPC). Silencing the HIKESHI gene expression enhanced the effect of hyperthermia and a novel magnetic nanoparticle, CNH-APTES-IONP, showed significant suppression of tumor growth in a mouse model. These findings suggest that HIKESHI silencing and CNH-APTES-IONP have potential as therapeutic options for hyperthermia treatment.
Article
Medicine, General & Internal
Keita Nakane, Hiromitsu Watanabe, Taku Naiki, Kiyoshi Takahara, Takahiro Yasui, Hideaki Miyake, Ryoichi Shiroki, Takuya Koie
Summary: The introduction of second-generation androgen receptor axis-targeted agents (ARATs) has greatly improved the treatment of metastatic hormone-sensitive prostate cancer (mHSPC). A retrospective study involving 581 newly diagnosed mHSPC patients was conducted to compare the efficacy of different ARATs. It was found that there were no significant differences in patient characteristics or biochemical recurrence-free survival (BRFS) among patients receiving different ARATs as first-line treatment. Neutrophil-to-lymphocyte ratio (NLR) and PSA level were identified as independent predictors of biochemical recurrence (BCR) following first-line treatment of mHSPC patients.
Article
Medicine, General & Internal
Nayuka Matsuyama, Taku Naiki, Shuzo Hamamoto, Yosuke Sugiyama, Yasue Kubota, Takashi Hamakawa, Toshiki Etani, Shoichiro Iwatsuki, Kazumi Taguchi, Yuya Ota, Masakazu Gonda, Maria Aoki, Toshiharu Morikawa, Taiki Kato, Atsushi Okada, Takahiro Yasui
Summary: This study investigated the incidence and clinical predictive factors of de novo overactive bladder (OAB) after robot-assisted radical prostatectomy (RARP). The findings suggest that the postoperative BNPS ratio may be a practical predictive indicator of the emergence of de novo OAB after RARP.
Article
Oncology
Taku Naiki, Kiyoshi Takahara, Hiromitsu Watanabe, Keita Nakane, Yosuke Sugiyama, Takuya Koie, Ryoichi Shiroki, Hideaki Miyake, Takahiro Yasui
Summary: Malnutrition is associated with prognosis in cancer. The geriatric nutritional risk index (GNRI), a simple screening tool for assessing nutrition, may be a practical prognostic indicator in the evaluation of survival outcomes in patients with high-risk metastatic hormone-sensitive prostate cancer (mHSPC).
Article
Oncology
Yusuke Noda, Taku Naiki, Yosuke Sugiyama, Takashi Nagai, Aya Naiki-Ito, Tatsuya Kawai, Shuzo Hamamoto, Toshiki Etani, Keitaro Iida, Nami Tomiyama, Maria Aoki, Nobuhiko Shimizu, Yoshinobu Moritoki, Hidetoshi Akita, Ryosuke Ando, Noriyasu Kawai, Takahiro Yasui
Summary: This study evaluated the oncological outcomes of patients with bladder cancer after RP-LRC and assessed the impact of mGPS on patient outcomes. The results showed that >= cT3 stage, worse clinical N stage, and poor mGPS status were significant prognostic factors for short-term disease-free survival and cancer-specific survival.
Article
Urology & Nephrology
Teruaki Sugino, Kazumi Taguchi, Shuzo Hamamoto, Tomoki Okada, Masahiko Isogai, Yutaro Tanaka, Rei Unno, Yasuhiro Fujii, Takashi Hamakawa, Ryosuke Ando, Atsushi Okada, Takahiro Yasui
Summary: The purpose of this study was to investigate the factors affecting the outcomes of endoscopic management for stone-related ureteral stricture. The study found that ureteroscopic lithotripsy as a cause and stricture length > 15 mm could affect the success rate of endoscopic management. In such cases, reconstructive management should be considered in the early stages.
