Review
Endocrinology & Metabolism
A. Bastounis, T. Langley, S. Davis, Z. Paskins, N. Gittoes, J. Leonardi-Bee, O. Sahota
Summary: This study investigated the persistence and compliance of bisphosphonate treatment and found that users of intravenously administered bisphosphonates were the most adherent. The variations in adherence among different bisphosphonates contribute to a more precise estimation of their clinical and cost-effectiveness.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Ambika Gupta, Mu Lin, Finlay A. McAlister, Carrie Ye
Summary: Prior adherence to statins predicts subsequent short-term and long-term adherence and persistence with oral bisphosphonates, but not with parenteral osteoporosis therapies. Other factors associated with oral bisphosphonate adherence at 1 year include older age, history of bone mineral density scan, and history of pap smear.
JOURNAL OF BONE AND MINERAL METABOLISM
(2021)
Review
Rheumatology
Silvia Migliaccio, Antimo Moretti, Annalisa Biffi, Raffaella Ronco, Gloria Porcu, Giovanni Adami, Rosaria Alvaro, Riccardo Bogini, Achille Patrizio Caputi, Luisella Cianferotti, Bruno Frediani, Davide Gatti, Stefano Gonnelli, Andrea Lenzi, Salvatore Leone, Tiziana Nicoletti, Marco Paoletta, Annalisa Pennini, Eleonora Piccirilli, Raffaella Michieli, Umberto Tarantino, Maurizio Rossini, Giovanni Corrao, Maria Luisa Brandi, Giovanni Iolascon
Summary: This article summarizes the results of a systematic review that examined the association between the continuity of medication treatment and various outcomes in patients with fragility fractures. The findings indicate that adherence to antiosteoporotic drugs can reduce the risk of nonvertebral fractures and refracture, and improve survival rates in patients who continue treatment. Therefore, clinicians should encourage patients to adhere to antiosteoporotic medication.
THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE
(2023)
Article
Biochemistry & Molecular Biology
Nerea Ugartondo, Nuria Martinez-Gil, Monica Esteve, Natalia Garcia-Giralt, Neus Roca-Ayats, Diana Ovejero, Xavier Nogues, Adolfo Diez-Perez, Raquel Rabionet, Daniel Grinberg, Susanna Balcells
Summary: Osteoporosis, a common metabolic bone disorder, is often treated with nitrogen-containing bisphosphonates. Prolonged use of bisphosphonates may lead to rare atypical femoral fractures, possibly due to rare mutations in the CYP1A1 gene.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Medicine, General & Internal
SeokJoon Hwang, Minsu Seo, Dongin Lim, Min Suk Choi, Jin-Woo Park, Kiyeun Nam
Summary: This literature review investigated the characteristics and management of bisphosphonate-associated bilateral atypical femoral fractures (AFFs). A comprehensive analysis of 43 patients with bilateral AFFs revealed that 67% had prodromal symptoms, 49% occurred simultaneously, and 51% occurred sequentially. X-ray was used for initial diagnosis, with 53% having complete fractures. Surgical treatment was performed for all patients, except for those with incomplete fractures who received either surgical or medical treatments. Teriparatide was the most commonly used medication after bisphosphonate discontinuation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Dennis M. Black, Katherine Condra, Annette L. Adams, Richard Eastell
Summary: Bisphosphonate use is associated with an increased risk of atypical femur fractures (AFFs), but it significantly reduces the risk of hip fractures and osteoporosis. The risk of AFFs varies between Asians and Caucasians, potentially due to differences in femoral geometry.
Review
Pharmacology & Pharmacy
Holly Tibble, Mary Flook, Aziz Sheikh, Athanasios Tsanas, Rob Horne, Bernard Vrijens, Sabina De Geest, Helen R. Stagg
Summary: Medication non-adherence can lead to increased morbidity, mortality, and side effects, while reducing effectiveness. Methodological issues exist in measuring and reporting adherence for asthma and TB, with variations between and within diseases. The communicable nature of TB has made dose-by-dose monitoring a recommended treatment standard.
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
J. Everts-Graber, S. Reichenbach, B. Gahl, H. R. Ziswiler, U. Studer, T. Lehmann
Summary: Patients who received zoledronate after denosumab discontinuation had fewer vertebral fractures, while all subsequent therapies were able to maintain bone mineral density to some extent. Factors such as age, BMI, treatment duration, prior therapy, and BMD gains during denosumab treatment influenced bone mineral density loss, while bone turnover markers correlated with total hip bone loss and treatment duration.
Article
Allergy
Oliver Pfaar, Philippe Devillier, Jochen Schmitt, Pascal Demoly, Ole Hilberg, Lawrence DuBuske, Nicole Hass, Ted Klok, Caroline Beutner
Summary: The 'Adherence and Persistence in AIT (APAIT)' checklist has been developed as a guide for reporting, designing, and interpreting retrospective studies on adherence or persistence to allergen immunotherapy (AIT). The checklist highlights the importance of transparency in reporting and identifies potential sources of bias in these studies.
Article
Endocrinology & Metabolism
Gareth Crouch, Nitesh D. Dhanekula, Karen Byth, Emma Burn, Sue Lynn Lau, Lillias Nairn, Liza Nery, Jean Doyle, Edward Graham, Andrew Ellis, Roderick J. Clifton-Bligh, Christian M. Girgis
Summary: The Sydney AFF score, based on demographic and femoral geometry variables, provides a quantitative means of identifying female patients with atypical femur fractures. In an independent validation set at a different center in Sydney, a score ≥ 2 demonstrated 73.3% sensitivity and 69.6% specificity for AFF.
JOURNAL OF BONE AND MINERAL RESEARCH
(2021)
Review
Allergy
Caroline Beutner, Jochen Schmitt, Margitta Worm, Martin Wagenmann, Christian Albus, Timo Buhl
Summary: Allergen immunotherapy (AIT) involves gradually increasing the dose of allergen extract until immunologic tolerance is achieved. Adherence to AIT is crucial for long-term success, but measuring adherence and persistence rates has been inconsistent. The development of standardized tools and parameters for measuring adherence in AIT is necessary. Additionally, exploring methods from adherence research in other chronic diseases could help improve outcomes in AIT.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2023)
Article
Endocrinology & Metabolism
Masayuki Iki, Kenji Fujimori, Shinichi Nakatoh, Junko Tamaki, Shigeyuki Ishii, Nobukazu Okimoto, Kuniyasu Kamiya, Sumito Ogawa
Summary: This study aimed to investigate whether physicians prescribe anti-osteoporosis medications (AOMs) for patients on long-term glucocorticoid therapy and whether a delay in AOM initiation affects the incidence of hip and vertebral fractures. The results showed that less than 40% of women and less than 30% of men received AOMs within 90 days of glucocorticoid therapy initiation. Delayed initiation of AOMs was associated with increased fracture events, highlighting the importance of early initiation of AOMs to reduce fracture risk.
Review
Medicine, Research & Experimental
Faisal I. Almohaileb, Zafar Rasheed
Summary: This systematic review compared the efficacies of bisphosphonates therapies for patient persistence and compliance in the treatment of osteoporosis. The analysis showed that alendronate therapy had the highest patient persistence, while etidronate therapy had the highest patient compliance.
CURRENT MOLECULAR MEDICINE
(2022)
Article
Clinical Neurology
Sang Min Lee, Hyeon-Kyoung Cheong, In-Hwan Oh, Minha Hong
Summary: This study divided adults with ADHD into groups based on their childhood and adulthood diagnosis, and compared characteristics, medication adherence, and persistence. Results showed that treatment in private clinics and initial monotherapy with bupropion were significantly associated with adherence.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2021)
Article
Endocrinology & Metabolism
Manju Chandran, Ying Hao, Ann Kerwen Kwee, Mcvin Hua Heng Cheen, Yun Ann Chin, Valerie Yun Ting Ng
Summary: The COVID-19 lockdown significantly decreased adherence to denosumab, with patients managed by endocrinologists more likely to be adherent. Healthcare providers' counseling and education on the importance of medication adherence for osteoporosis patients may vary among specialties and should be further investigated.
OSTEOPOROSIS INTERNATIONAL
(2022)
Article
Economics
Mark D. Danese, Michelle Gleeson, Robert I. Griffiths, David Catterick, Lucie Kutikova
JOURNAL OF MEDICAL ECONOMICS
(2017)
Article
Medicine, General & Internal
Mark D. Danese, Eduard Sidelnikov, Lucie Kutikova
CURRENT MEDICAL RESEARCH AND OPINION
(2018)
Letter
Hematology
Robert Griffiths, Michelle Gleeson, Carolina Reyes, Kevin Knopf, Mark Danese
AMERICAN JOURNAL OF HEMATOLOGY
(2010)
Article
Oncology
Robert Griffiths, Michelle Gleeson, Kevin Knopf, Mark Danese
Article
Oncology
Robert I. Griffiths, Mark D. Danese, Michelle L. Gleeson, Jose M. Valderas
Article
Oncology
Mark D. Danese, Deepa Lalla, Melissa Brammer, Quan Doan, Kevin Knopf
Article
Oncology
Robert I. Griffiths, Michelle L. Gleeson, Joseph Mikhael, Martin H. Dreyling, Mark D. Danese
Article
Public, Environmental & Occupational Health
Ryan D. Kilpatrick, Mark D. Danese, Vasily Belozeroff, Karen Smirnakis, William G. Goodman, Kenneth J. Rothman
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2011)
Article
Oncology
Mark D. Danese, Aaron Katz, Karynsa Cetin, Victoria Chia, Michelle L. Gleeson, Michael Kelsh, Robert Griffiths
LEUKEMIA & LYMPHOMA
(2019)
Article
Medical Informatics
Mark D. Danese, Marc Halperin, Jennifer Duryea, Ryan Duryea
BMC MEDICAL INFORMATICS AND DECISION MAKING
(2019)
Article
Urology & Nephrology
Geoffrey A. Block, Glenn M. Chertow, Kerry Cooper, Shan Xing, Bruno Fouqueray, Marc Halperin, Mark D. Danese
Summary: Our study indicates that FGF23 levels are associated with the risk of CV events in patients with CKD-MBD receiving maintenance hemodialysis, suggesting FGF23 as a potential biomarker and therapeutic target for this population.
HEMODIALYSIS INTERNATIONAL
(2021)
Article
Economics
Joshua A. Roth, Yong Yuan, Megan Othus, Mark Danese, Samuel Wagner, John R. Penrod, Scott D. Ramsey
Summary: This study evaluated the cost-effectiveness of nivolumab compared to usual care as third-line therapy for patients with recurrent small cell lung cancer. Different survival modeling approaches were used to assess the impact on survival estimates and cost-effectiveness.
JOURNAL OF MEDICAL ECONOMICS
(2021)
Article
Oncology
Mark Danese, Joseph Gricar, Pranav Abraham
Summary: This study assessed the treatment patterns and outcomes of older patients with advanced/metastatic esophageal squamous cell carcinoma (ESCC). The results showed that only 14% of patients received second-line therapy, which was associated with short treatment duration and poor overall survival. This highlights the need for more effective treatments for older patients with advanced/metastatic ESCC.
Article
Medicine, Research & Experimental
Mark D. Danese, Jennifer Schenfeld, Jaime Shaw, Prasad Gawade, Akhila Balasubramanian, Michael Kelsh, Rohini K. Hernandez, Gary Lyman
Summary: The use of G-CSF in breast and lung cancer patients is associated with an increased risk of MDS-AML, but the absolute risk difference is very low.
ADVANCES IN THERAPY
(2022)
Article
Medicine, General & Internal
Mark Danese, Eduard Sidelnikov, Guillermo Villa, David Catterick, Mazhar Iqbal, Michelle Gleeson, Deborah Lubeck, Jeetesh Patel
Summary: Despite an increase in high-intensity therapy use and a decline in revascularisation, more than half of patients did not receive high-intensity lipid-lowering therapy by 2017 and incidence rates of MI and IS remained virtually unchanged.