Article
Dentistry, Oral Surgery & Medicine
Hendrik Naujokat, Klaas Loger, Aydin Gulses, Christian Florke, Yahya Acil, Joerg Wiltfang
Summary: This study assessed the clinical and radiological outcomes of using autologous stem cells in situ to reduce bone graft resorption after iliac crest autografting. The results showed that the stem cell group had lower levels of resorption compared to the control group and the group using deproteinized bovine bone matrix and collagen membrane. The use of autologous bone-marrow aspirate concentrate improved the dimensional stability of the bone grafts and enhanced complex reconstruction of the alveolar ridge.
INTERNATIONAL JOURNAL OF IMPLANT DENTISTRY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Alshaimaa Ahmed Shabaan, Ahmad Salahuddin, Inass Aboulmagd, Reham Ragab, Khaled Amr Salah, Adel Rashid, Haytham Mohamed Ayad, Walaa Abd el Aty Ahmed, Shaimaa Mohsen Refahee
Summary: This study compared the bone density and volume in patients with alveolar cleft reconstructions using a combination of bone marrow aspirate concentrate with iliac graft versus iliac graft alone. The results showed that using bone marrow concentrate can significantly increase bone volume and density while reducing bone loss ratio.
CLINICAL ORAL INVESTIGATIONS
(2023)
Article
Dentistry, Oral Surgery & Medicine
H. -M. Chen, Y. -F. Kang, X. -M. Lv, X. -F. Shan, Z. -G. Cai
Summary: This study evaluates the resorption of the iliac bone after maxillary reconstruction using a vascularized free iliac flap. The results show that there is significant reduction in the total thickness and height of the iliac bone, as well as the cortical bone thickness and cancellous bone density, during the first year after the surgery.
INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
(2022)
Article
Endocrinology & Metabolism
Masanori Koide, Teruhito Yamashita, Keigo Nakamura, Hisataka Yasuda, Nobuyuki Udagawa, Yasuhiro Kobayashi
Summary: This study found that approximately two-thirds of bone formation is remodeling-based in Sost-deficient mice, while remodeling-based bone formation accounts for most of the bone formation in Sost(+/-) mice. Anti-RANKL antibody may be useful for detecting modeling-based bone formation on trabecular bone.
Article
Surgery
Yongzhen Lai, Xiao xian Jiang, Meng Lu, Chuanqing Mao, Zhiyu Cai, Chengyong Wang, Jing Liu, Weihui Chen
Summary: This study demonstrates that iliac crest cortical-cancellous bone block grafts combined with concentrated growth factor (CGF) can reduce bone resorption and improve the success rate in secondary alveolar bone grafting, especially in reducing nasal bone resorption. The further clinical application of this technique is of great significance.
JOURNAL OF CRANIOFACIAL SURGERY
(2023)
Article
Chemistry, Physical
Bin Wu, Yang Wu, Mao Liu, Jingjing Liu, Di Jiang, Songyun Ma, Bin Yan, Yi Lu
Summary: Studying the mechanical behavior of CBAB is crucial for predicting tooth movement and achieving optimal orthodontic treatment outcomes. Results showed that CBAB is a nonlinear viscoelastic and hyperelastic material, with stress-strain curve showing distinct stages in compression test and increasing strain over time in creep test.
Article
Medicine, Research & Experimental
Biao Wu, Jie Shang, Shiyuan Lin, Ning Jiang, Baizhou Xing, Rong Peng, Xianghe Xu, Huading Lu
Summary: Increased bone resorption caused by excessive osteoclasts is the main cause of osteoporosis. The expression of RILP, a protein, is induced by receptor activator of NF-KB ligand, and its inhibition decreases the number and function of osteoclasts. Inhibition of RILP also reduces preosteoclast migration and bone resorption. The study suggests that RILP plays a crucial role in osteoclast formation and bone resorption, and could be a therapeutic target for bone diseases caused by excessive osteoclasts.
LABORATORY INVESTIGATION
(2023)
Article
Clinical Neurology
Woojin Cho, Adam Nessim, Ariella Gartenberg, Richard Sekerak, Sam Brill, Jayson Lian, Karen Sperling, Dong-Gune Chang
Summary: This retrospective cohort study aimed to investigate the correlation between race and the ratio of cancellous to total bone at the iliac crest in American white and black patients. The results showed that American black patients had a lower mean cancellous bone ratio compared to American white patients, suggesting that alternative graft options should be considered for this population in fusion surgeries.
CLINICAL SPINE SURGERY
(2022)
Article
Dentistry, Oral Surgery & Medicine
Yongzhen Lai, Chuanqing Mao, Zhiyu Cai, Chengyong Wang, Lu Meng, Liu Jing, Wei Hui Chen
Summary: In this study, the donor-site morbidity of children undergoing alveolar bone grafting with cartilage-preserving outer and inner cortico-cancellous iliac crest bone block grafting was compared. The results showed that the outer cortico-cancellous iliac crest bone block grafting had the advantage of less early postoperative donor-site pain and a lower risk of nerve damage.
JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY
(2023)
Article
Endocrinology & Metabolism
Ji Hyun Lee, JooYong Park, Jung Hee Kim, Ji-Yeob Choi, Hyung Jin Choi, Eu Jeong Ku, A. Ram Hong, Chan Soo Shin, Nam H. Cho
Summary: This Korean prospective cohort study found that decreasing waist circumference and lean muscle mass loss were significant risk factors for hip bone loss in both men and women. Other factors may have sex-specific or age-specific effects on hip bone loss. None of the genetic factors tested were associated with hip bone loss after multiple testing adjustments, indicating that modifiable factors may play a larger role in determining bone health.
Article
Medicine, General & Internal
Yun Sun Lee, So Jeong Park, Jin Young Lee, Eunah Choi, Beom-Jun Kim
Summary: The study found a negative correlation between lumican concentrations in bone marrow and fragility hip fractures, with higher lumican levels significantly associated with bone density and bone-specific alkaline phosphatase levels.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Cell Biology
Michele Roy, Elizabeth Stephens, Sophie Bouhour, Sophie Roux
Summary: TBC1D25, a RabGAP identified in bone-resorbing osteoclasts, plays a role in bone resorption by regulating osteoclast polarization, absorption, and multinucleation. Inhibiting TBC1D25 expression decreases bone resorption and the formation of multinucleated cells.
EUROPEAN JOURNAL OF CELL BIOLOGY
(2021)
Article
Immunology
Noreen Mumtaz, Marijke Koedam, Johannes P. T. M. van Leeuwen, Marion P. G. Koopmans, Bram C. J. van der Eerden, Barry Rockx
Summary: Bone-related complications are common following arbovirus infection, including Zika virus (ZIKV). This study investigated the effect of ZIKV infection on osteoclastogenesis and found that infection reduced osteoclast formation and bone resorption. Additionally, antibody-dependent enhancement may play a role in ZIKV-associated bone pathology.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Chemistry, Physical
Bin Wu, Le Yuan, Mao Liu, Miaoning Tang, Di Jiang, Yang Yi, Songyun Ma, Bin Yan, Yi Lu
Summary: Orthodontic treatment can affect the remodeling of cancellous bone in alveolar bone and its bone mineral density. This study quantified the effect of bone mineral density on the viscoelastic behavior of alveolar bone and assessed orthodontic forces at different bone mineral densities.
Article
Medicine, Research & Experimental
Ni Su, Cassandra Villicana, Carl Zhang, Jeehee Lee, Sauradeep Sinha, Andrew Yang, Fan Yang
Summary: Mineral particle-coated scaffolds combined with aspirin have a synergistic effect in promoting endogenous bone regeneration and reducing bone resorption. The optimized formulation shows promising potential for repairing critical-sized cranial bone defects.