Article
Medicine, General & Internal
Izabela Michalus, Anna Lupinska, Izabela Woch, Katarzyna Wieczorek-Szukala, Danuta Chlebna-Soko, Andrzej Lewinski
Summary: This retrospective study explored the bone turnover and bone mass disorders in children with hypophosphatemic rickets. The results showed that bone metabolism disturbances and worse bone quality were found in these patients. It is crucial to monitor the progress and treatment effects by determining bone turnover markers, dual-energy X-ray absorptiometry findings, and indices of quantitative ultrasound examination.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Endocrinology & Metabolism
Jakob Starup-Linde, Marie Juul Ornstrup, Thomas Nordstrom Kjaer, Simon Lykkeboe, Aase Handberg, Soren Gregersen, Torben Harslof, Steen Bonlokke Pedersen, Peter Vestergaard, Bente Lomholt Langdahl
Summary: This study compared bone structure, bone density, and bone turnover markers between non-diabetic overweight men with MetS and overweight men with T1D or T2D. The results showed lower bone turnover in men with T2D, but no clinically significant differences in bone density or structure.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Medicine, General & Internal
Arkadiusz Zygmunt, Kinga Krawczyk-Rusiecka, Elzbieta Skowronska-Jozwiak, Katarzyna Wojciechowska-Durczynska, Ewa Glowacka, Zbigniew Adamczewski, Andrzej Lewinski
Summary: The study found that recombinant human TSH (rhTSH) has an impact on the concentrations of sclerostin and other bone markers, with a significant increase in TSH concentration leading to decreases in sclerostin, osteocalcin, and beta-CrossLaps levels. Additionally, baseline PTH, age, and creatinine concentrations can affect the degree of TSH increase.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Nutrition & Dietetics
Minkyung Je, Kyeonghoon Kang, Jun-Il Yoo, Yoona Kim
Summary: This review aims to investigate the effects of macronutrients on bone health in elderly people based on human studies. The results suggest that carbohydrate intake has limited effects on bone fracture but further research is needed on its effects on bone mineral density and bone turnover markers. Additionally, inconsistent results were found regarding the beneficial effects of animal, vegetable, soy, or milk proteins on bone health. Further studies are required to establish a clear association between macronutrients and bone health in elderly people.
Article
Biochemistry & Molecular Biology
Aleksandra Ryl, Tomasz Miazgowski, Aleksandra Szylinska, Agnieszka Turon-Skrzypinska, Alina Jurewicz, Andrzej Bohatyrewicz, Iwona Rotter
Summary: The results suggest that the Zn/Cu ratio in both the serum and the bone may have a significant positive effect on total bone mineral density (BMD) and bone mineral content (BMC).
Article
Endocrinology & Metabolism
Yang Xu, Li Shen, Lianyong Liu, Zhenlin Zhang, Weiwei Hu
Summary: This study investigated the profile of serum undercarboxylated osteocalcin (ucOC) levels and their associations with bone mineral density (BMD), bone turnover markers (BTMs), and prevalence of osteopenia and osteoporosis in the Chinese population. The results showed that ucOC levels were higher in men than women and decreased with age until the age of 50, after which they increased. Higher ucOC levels were correlated with lower BMD values and higher levels of BTMs in both men and women. Furthermore, an increase in ucOC levels was associated with an increased risk of osteopenia and osteoporosis in both genders.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Laurent Maimoun, Safa Aouinti, Marion Puech, Patrick Lefebvre, Melanie Deloze, Pascal de Santa Barbara, Jean-Paul Cristol, Severine Brabant, Thomas Gautier, Marius Nedelcu, Eric Renard, Marie-Christine Picot, Denis Mariano-Goulart, David Nocca
Summary: Bariatric surgery leads to bone loss, and this study found that bone turnover increased following sleeve gastrectomy, resulting in reduced bone mineral density in the hip region.
Article
Endocrinology & Metabolism
Christian Meier, Richard Eastell, Dominique D. Pierroz, Nancy E. Lane, Nasser Al-Daghri, Atsushi Suzuki, Nicola Napoli, Ambrish Mithal, Marlene Chakhtoura, Ghada El-Hajj Fuleihan, Serge Ferrari
Summary: This review provides a summary of current data on biochemical markers in relation to bone fragility and fracture risk in diabetes. The results show that although bone resorption and bone formation markers are not effective predictors of fracture risk in diabetes, osteoporosis drugs have similar effects on bone turnover markers in both diabetics and nondiabetics, resulting in reduced fracture risk. Other biochemical markers related to bone and glucose metabolism, such as sclerostin, glycated hemoglobin A(1c), and inflammatory markers, as well as hormones like insulin-like growth factor-1 and calciotropic hormones, are also associated with bone mineral density and fracture risk in diabetes. HbA(1c) levels appear to be the most reliable estimate of fracture risk, while bone turnover markers can be used to monitor the effects of antiosteoporosis therapy.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Nutrition & Dietetics
Jiaying Ge, Jiangping Zeng, Huihui Ma, Siqi Sun, Zheng Zhao, Yujie Jing, Chunhua Qian, Zhaoliang Fei, Ran Cui, Shen Qu, Ge Zhang, Hui Sheng
Summary: This study evaluated the effectiveness of serum sarcopenia index and creatinine/cystatin C ratio in diagnosing sarcopenia and predicting future falls and fractures. The results showed that serum sarcopenia index had a better predictive ability than creatinine/cystatin C ratio for sarcopenia. The study also found that lower serum sarcopenia index and creatinine/cystatin C ratio were independent risk factors for sarcopenia, new falls, and fractures in the low-BMD population.
Article
Genetics & Heredity
Jiaqin Yuan, Lipeng Peng, Fujun Luan, Jie Li, Jinglin Zhang, Wei Jiang, Wenting Wang
Summary: This study using Mendelian randomization (MR) found a causal association between serum cystatin C levels and osteoporosis.
FRONTIERS IN GENETICS
(2022)
Article
Endocrinology & Metabolism
Athanasios D. Anastasilakis, Stergios Papachatzopoulos, Polyzois Makras, Athina Gkiomisi, Panagiotis Nikolakopoulos, Stergios A. Polyzos, Charikleia Ntenti, Iris Ballaouri, Spyridon Gerou, Olga Tsachouridou, Athanasios Papatheodorou, Konstantinos Aliazis, Sofia Fermanoglou, Ilias Bisbinas, Maria P. Yavropoulou
Summary: Goserelin-induced menstrual cessation leads to bone loss and changes in bone turnover and expression of bone-related miRNAs, which are only partially reversed six months after menstrual restoration.
Article
Endocrinology & Metabolism
Julie Abildgaard, Thorkil Ploug, Anette Tonnes Pedersen, Pia Eiken, Bente Klarlund Pedersen, Jens Juul Holst, Bolette Hartmann, Birgitte Lindegaard
Summary: Despite higher fasting levels, postmenopausal women exhibit comparable postprandial suppression of bone turnover markers to premenopausal women. None of the postprandial gut hormone increases predict postprandial bone turnover suppression.
Article
Endocrinology & Metabolism
N. Binkley, E. Orwoll, R. Chapurlat, B. L. Langdahl, B. B. Scott, H. Giezek, A. C. Santora
Summary: Odanacatib showed significant efficacy in improving bone mineral density and reducing bone resorption in men with osteoporosis. However, its development was discontinued due to an increased risk of stroke in another study.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Xiaowen Zhang, Suhas Krishnamoorthy, Casey Tze-Lam Tang, Warrington Wen-Qiang Hsu, Gloria Hoi-Yee Li, Chor-Wing Sing, Kathryn Choon-Beng Tan, Bernard Man-Yung Cheung, Ian Chi-Kei Wong, Annie Wai-Chee Kung, Ching-Lung Cheung
Summary: This study investigated the association between bone health and incident type-2 diabetes mellitus (T2DM). The results showed that higher bone density is associated with an increased risk of T2DM.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Toxicology
Giovanna Muscogiuri, Barbara Altieri, Cedric Annweiler, Giancarlo Balercia, H. B. Pal, Barbara J. Boucher, John J. Cannell, Carlo Foresta, Martin R. Gruebler, Kalliopi Kotsa, Luca Mascitelli, Winfried Maerz, Francesco Orio, Stefan Pilz, Giacomo Tirabassi, Annamaria Colao
ARCHIVES OF TOXICOLOGY
(2017)
Article
Endocrinology & Metabolism
Orsolya Karola Csenteri, Janos Sandor, Edit Kalina, Harjit Pal Bhattoa, Sandor Godeny
GYNECOLOGICAL ENDOCRINOLOGY
(2017)
Article
Endocrinology & Metabolism
B. Juhasz, K. Gulyas, A. Horvath, Z. Petho, H. P. Bhattoa, A. Vancsa, E. Szekanecz, C. Horvath, J. Kocsis, Z. Horvath, K. Hodosi, S. Szanto, G. Szucs, Z. Szekanecz
OSTEOPOROSIS INTERNATIONAL
(2017)
Review
Endocrinology & Metabolism
Harjit Pal Bhattoa, Jerzy Konstantynowicz, Natalia Laszcz, Marek Wojcik, Pawel Pludowski
REVIEWS IN ENDOCRINE & METABOLIC DISORDERS
(2017)
Review
Cardiac & Cardiovascular Systems
Giovanna Muscogiuri, Cedric Annweiler, Guillaume Duval, Spyridon Karras, Giacomo Tirabassi, Gianmaria Salvio, Giancarlo Balercia, Samantha Kimball, Kalliopi Kotsa, Luca Mascitelli, Harjit Pal Bhattoa, Annamaria Colao
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2017)
Article
Biochemistry & Molecular Biology
William B. Grant, Harjit Pal Bhattoa, Barbara J. Boucher
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2017)
Article
Endocrinology & Metabolism
E. Jakab, E. Kalina, Z. Petho, Z. Pap, A. Balogh, W. B. Grant, H. P. Bhattoa
OSTEOPOROSIS INTERNATIONAL
(2017)
Article
Rheumatology
Zsofia Kardos, Csaba Olah, Mariann Sepsi, Attila Sas, Laszlo Kostyal, Tunde Bta, Harjit Pal Bhattoa, Katalin Hodosi, Gyorgy Kerekes, Laszlo Tamasi, Daniel Bereczki, Zoltan Szekanecz
CLINICAL RHEUMATOLOGY
(2018)
Article
Biochemistry & Molecular Biology
William B. Grant, Barbara J. Boucher, Harjit P. Bhattoa, Henry Lahore
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2018)
Article
Engineering, Biomedical
Laszlo Andrassy, Izabella Gomez, Agnes Horvath, Katalin Gulyas, Zsofia Petho, Balazs Juhasz, Harjit Pal Bhattoa, Zoltan Szekanecz
LASERS IN MEDICAL SCIENCE
(2018)
Article
Biochemistry & Molecular Biology
Judit Marton, Maria Peter, Gabor Balogh, Beata Bodi, Andras Vida, Magdolna Szanto, Dora Bojcsuk, Laura Janko, Harjit Pal Bhattoa, Imre Gombos, Karen Uray, Ibolya Horvath, Zsolt Torok, Balint L. Balint, Zoltan Papp, Laszlo Vigh, Peter Bai
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2018)
Review
Pharmacology & Pharmacy
Giovanna Muscogiuri, Luigi Barrea, Barbara Altieri, Carolina Di Somma, Harjit Pal Bhattoa, Daniela Laudisio, Guillaume T. Duval, Gabriella Pugliese, Cedric Annweiler, Francesco Orio, Hana Fakhouri, Silvia Savastano, Annamaria Colao
CURRENT VASCULAR PHARMACOLOGY
(2019)
Article
Nutrition & Dietetics
William B. Grant, Hana M. A. Fakhoury, Spyridon N. Karras, Fatme Al Anouti, Harjit P. Bhattoa
Article
Rheumatology
Csaba Olah, Zsofia Kardos, Mariann Sepsi, Attila Sas, Laszlo Kostyal, Harjit Pal Bhattoa, Katalin Hodosi, Gyoergy Kerekes, Laszlo Tamasi, Attila Valikovics, Daniel Bereczki, Zoltan Szekanecz
ARTHRITIS RESEARCH & THERAPY
(2017)
Review
Immunology
Agnes Szentpetery, Agnes Horvath, Katalin Gulyas, Zsofia Petho, Harjit Pal Bhattoa, Sandor Szanto, Gabriella Szucs, Oliver FitzGerald, Georg Schett, Zoltan Szekanecz
AUTOIMMUNITY REVIEWS
(2017)