Review
Health Care Sciences & Services
Andreas Frodl, Markus Siegel, Andreas Fuchs, Ferdinand C. C. Wagner, Hagen Schmal, Kaywan Izadpanah, Tayfun Yilmaz
Summary: This study aimed to analyze and synthesize data from the latest literature on minced cartilage procedure and compare its effectiveness to standard repair techniques. The results showed that minced cartilage is a promising one-step procedure for cartilage repair, with similar short-term improvement in clinical scores compared to standard techniques. However, more research is needed, as the evidence is limited and only accounts for results two years post-surgery.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Orthopedics
Jani Puhakka, Teemu Paatela, Eve Salonius, Virpi Muhonen, Anna Meller, Anna Vasara, Hannu Kautiainen, Jussi Kosola, Ilkka Kiviranta
Summary: In an animal cartilage repair model, the ICRS scoring system demonstrated poor to moderate reliability. The results showed disagreement among observers, with poor to moderate interrater and intrarater reliability for ICRS total scores and individual subscores.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
John Garcia, Helen S. McCarthy, Jan Herman Kuiper, James Melrose, Sally Roberts
Summary: Articular cartilage has limited regenerative capacity, and therapies to limit its destruction are being sought. Perlecan, a heparan sulphate proteoglycan, plays a crucial role in cartilage development and repair. Removing heparan sulphate from perlecan affects chondrocytes' behavior, suggesting heparanase treatment as a potential way to improve cartilage repair in damaged joints.
Article
Biochemistry & Molecular Biology
Fernando Canonici, Cristiano Cocumelli, Antonella Cersini, Daniele Marcoccia, Alessia Zepparoni, Annalisa Altigeri, Daniela Caciolo, Cristina Roncoroni, Valentina Monteleone, Elisa Innocenzi, Cristian Alimonti, Paola Ghisellini, Cristina Rando, Eugenia Pechkova, Roberto Eggenhoeffner, Maria Teresa Scicluna, Katia Barbaro
Summary: Cartilage injuries in animals and humans can lead to the progression of osteoarthritis and joint deterioration. A new experimental protocol for treating osteochondral lesions involves isolating chondrocytes from equine hyaline cartilage and using them to repair equine joint cartilage injuries. The chondrocytes, taken from autologous tracheal cartilage, are grown in a laboratory and implanted arthroscopically into the injured joint. Histological and immunohistochemical evaluation of the treated cartilage after 8 and 13 months shows progressive maturation, with tissue comparable to native articular cartilage detected after 24 months.
Review
Engineering, Biomedical
Muzhe Li, Han Yin, Zineng Yan, Huiyun Li, Jiang Wu, Yue Wang, Fu Wei, Guangzhao Tian, Chao Ning, Hao Li, Cangjian Gao, Liwei Fu, Shuangpeng Jiang, Mingxue Chen, Xiang Sui, Shuyun Liu, Zhiwei Chen, Quanyi Guo
Summary: The limited ability of articular cartilage to repair itself is hindered by inflammatory problems. Immune response plays a crucial role in both promoting cartilage repair and accelerating cartilage degradation. Multi-dimensional regulation of the inflammatory microenvironment is needed for cartilage regeneration.
ACTA BIOMATERIALIA
(2022)
Article
Chemistry, Medicinal
Jiaxiang Gu, Bin Wang, Tianliang Wang, Naichen Zhang, Hongjun Liu, Jianchao Gui, Yiming Lu
Summary: In this study, the effects of cartilage progenitor cells (CPCs), bone marrow mesenchymal stem cells (BMSCs), and chondrocytes (CCs) on cartilage repair were investigated. The results showed that CPCs had higher proliferation ability compared to CCs and BMSCs. Moreover, CPCs seeded in agarose gel exhibited significantly higher levels of collagen, glycosaminoglycan, DNA content, and chondrocyte-related gene expression. Integration strength in the CPCs seeded gel was also higher than the other two gels. These findings suggest that CPCs have advantages over CCs and BMSCs as seed cells in tissue engineering for cartilage repair.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2022)
Article
Orthopedics
Darryl A. Dickerson, Lisa A. Fortier, Eric A. Nauman, Hollis G. Potter, Cassandra Quinlan
Summary: This study evaluated the efficacy and safety of a naturally derived osteochondral biotemplate in an ovine model as a regenerative solution for articular cartilage defects. The results showed that the biotemplate outperformed microfracture in cartilage regeneration and integration with surrounding tissue. This work demonstrated the clinical potential of a new biomaterial template in re-creating the complex mechanical interface between cartilage and bone.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Chemistry, Applied
Yaqiang Li, Xiaowei Xun, Yong Xu, Anqi Zhan, Erji Gao, Fan Yu, You Wang, Honglin Luo, Chunxi Yang
Summary: The study successfully developed 3D hierarchical porous BC/DCECM scaffolds with biomimetic cartilage regeneration microenvironment, which showed enhanced cell adhesion and proliferation. The scaffolds achieved satisfactory neocartilage tissue regeneration in both in vitro and in vivo experiments, demonstrating their potential for further application in cartilage tissue engineering.
CARBOHYDRATE POLYMERS
(2022)
Article
Biochemistry & Molecular Biology
Marija Mazor, Eric Lespessailles, Thomas M. Best, Mazen Ali, Hechmi Toumi
Summary: Recent research has shown that cells isolated from osteoarthritic cartilage have the potential to form hyaline-like cartilage tissue. In this study, the researchers examined the marker expression and chondrogenetic potential of cells from mild, moderate, and severe osteoarthritic tissue. They found that only cells from moderate osteoarthritis were able to form hyaline cartilage-like tissue, while cells from severe and mild osteoarthritis did not. These findings have implications for understanding the repair capacity of articular cartilage in osteoarthritis and suggest that these progenitor cells may be a candidate for cartilage repair.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Orthopedics
Martyn Snow, Lee Middleton, Samir Mehta, Andrew Roberts, Richard Grey, James Richardson, Jan Herman Kuiper, ACTIVE Consortium
Summary: This study compared the long-term outcomes of autologous chondrocyte implantation (ACI) versus alternative forms of surgical cartilage management in patients with failed previous treatment. The results showed that there was no significant difference in Lysholm scores between ACI and alternative management after 5 years, indicating that both methods were equally effective. However, ACI had more adverse events compared to the alternatives.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Markus M. Schreiner, Marcus Raudner, Sebastian Roehrich, Martin Zalaudek, Michael Weber, Georg Kaiser, Silke Aldrian, Catharina Chiari, Reinhard Windhager, Siegfried Trattnig
Summary: The MOCART 2.0 knee score demonstrates good intra- and interrater reliability in the assessment of cartilage repair tissue after various cartilage repair techniques, such as ACI, osteochondral repair techniques, and MFX, as well as different lesion types. Interscan reliability was higher for osteochondral lesions compared to chondral lesions.
EUROPEAN RADIOLOGY
(2021)
Article
Multidisciplinary Sciences
Jiawei Li, Huiming Jiang, Zhongyang Lv, Ziying Sun, Chaoqun Cheng, Guihua Tan, Maochun Wang, Anlong Liu, Heng Sun, Hu Guo, Fufei Chen, Zizheng Liu, Yuxiang Fei, Yuan Liu, Rui Wu, Xingquan Xu, Wenjin Yan, Qing Jiang, Dongquan Shi
Summary: This study proposed a new strategy for cartilage regeneration by hyalinizing fibrocartilage through stabilizing the cytoskeleton. The use of docetaxel was found to inhibit cartilage fibrosis and promote the regeneration of hyaline cartilage.
Article
Polymer Science
Yisi Liu, Meng Wang, Yixuan Luo, Qianyi Liang, Yin Yu, Fei Chen, Jun Yao
Summary: Stem cells hold promise for cartilage repair in osteoarthritis, but challenges in large-scale production, viability maintenance, and therapeutic activity hinder clinical application. Advanced hydrogel technologies, particularly microgels and dynamic hydrogel systems, show potential in improving stem cell survival and regulation of stem cell fate.
Article
Engineering, Biomedical
Guillermo Bauza-Mayol, Marcos Quintela, Ava Brozovich, Michael Hopson, Shazad Shaikh, Fernando Cabrera, Aaron Shi, Federica Banche Niclot, Francesca Paradiso, Emma Combellak, Tom Jovic, Paul Rees, Ennio Tasciotti, Lewis W. Francis, Patrick Mcculloch, Francesca Taraballi
Summary: The use of biomimetic scaffolds in cartilage tissue engineering shows promising results in enhancing cartilaginous tissue formation and suppressing host cartilage degeneration. This approach may provide a clinical solution for cartilage tissue repair by modulating the immune environment to favor regenerative processes and suppress cartilage degeneration.
ADVANCED HEALTHCARE MATERIALS
(2022)
Review
Biotechnology & Applied Microbiology
Zhen Yang, Jianwei Li, Haoyuan Deng, Hao Li, Tianyuan Zhao, Tianze Gao, Dan Xing, Jianhao Lin
Summary: 3D printing technology offers hope for the repair and regeneration of cartilage defects, but research in this area is still limited. Through bibliometric analysis, we summarized the research status of 3D printing technology and cartilage repair and regeneration from 2002 to 2022. Based on the analysis, we discussed the current advantages, limitations, and future development prospects in this field, aiming to guide researchers and promote clinical application.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
