Article
Medicine, General & Internal
Wael M. Said Ahmed, Amira M. Elsherbini, Nehal M. Elsherbiny, Mohamed El-Sherbiny, Nevine Ramzy, Ahmed F. Arafa
Summary: During the COVID-19 pandemic, patients are at high risk of fungal infections such as mucormycosis, which can be a direct result of the infection or a side effect of the drugs used in treatment. This report details 14 cases of maxillary mucormycosis osteomyelitis in patients immediately post-COVID-19.
Review
Clinical Neurology
Andrea Perna, Luca Ricciardi, Massimo Fantoni, Francesco Taccari, Riccardo Torelli, Domenico Alessandro Santagada, Caterina Fumo, Francesco Ciro Tamburrelli, Luca Proietti
Summary: The study conducted a systematic review on vertebral aspergillosis, analyzing 112 cases and summarizing the epidemiology, clinical features, treatment options, and outcomes of the disease.
Article
Biology
Christian D. Weber, Filippo Migliorini, Heide Delbrueck, Frank Hildebrand
Summary: Subchondral bone defects around the knee joint are uncommon in young patients. They require comprehensive management, especially if related to bacterial infections. Delayed or missed diagnosis and treatment may lead to septic arthritis.
Review
Microbiology
Erika Asperges, Giuseppe Albi, Francesco Truffelli, Andrea Salvaderi, Flavia Puci, Aurelia Sangani, Valentina Zuccaro, Valeria Scotti, Paolo Orsolini, Enrico Brunetti, Raffaele Bruno
Summary: This article is a systematic review that provides a practice-based global perspective on fungal osteomyelitis. The study found that fungal osteomyelitis most commonly affects the vertebrae, with Aspergillus being the most common causative pathogen. Major risk factors include diabetes mellitus, disseminated fungal infection, surgery, and local lesion. The article emphasizes the need for high-quality research on this rare disease.
Review
Health Care Sciences & Services
Thomas Keintzel, Tobias Raffelsberger, Lisa Niederwanger, Gina Gundacker, Thomas Rasse
Summary: Approximately 1 in 10 children with hearing loss has auditory neuropathy spectrum disorder (ANSD), which makes it difficult for them to understand speech or communicate. Treatment options include hearing aids and cochlear implants, with the latter showing promising results in improving speech understanding for ANSD patients.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Genetics & Heredity
Xiaoping Xie, Jiangbi Li, Feng Gu, Ke Zhang, Zilong Su, Qiangqiang Wen, Zhenjiang Sui, Pengcheng Zhou, Tiecheng Yu
Summary: This study identified several single-nucleotide polymorphisms (SNPs) in multiple genes that may increase or decrease the risk of bacterial osteomyelitis, suggesting the crucial role of inflammation in the development of the disease. Additionally, SNPs with significant biological functions were discovered to be associated with the pathogenesis of bacterial osteomyelitis.
FRONTIERS IN GENETICS
(2021)
Review
Medicine, General & Internal
Oscar Vazquez, Giacomo De Marco, Nathaly Gavira, Celine Habre, Marcia Bartucz, Christina N. Steiger, Romain Dayer, Dimitri Ceroni
Summary: This article reports an unusual case of subacute osteomyelitis in a toe phalanx caused by S. caprae in a 14.5-year-old girl. The conclusion suggests that subacute S. caprae osteomyelitis is a little-known and probably underestimated community-acquired infectious disease.
WORLD JOURNAL OF CLINICAL CASES
(2023)
Review
Oncology
Edoardo Virgilio, Alfredo Annicchiarico, Lorenzo Pagliai, Andrea Morini, Andrea Romboli, Filippo Montali, Renato Costi
Summary: IGIST in the inguinal region is rare, with a higher incidence in males over 60 years old and a significant association with inguinal hernia. Inguinal lymphadenopathy may be closely related to metastatic IGIST.
ANTICANCER RESEARCH
(2021)
Review
Allergy
Marion Delplanque, Lionel Galicier, Eric Oziol, Stephanie Ducharme-Benard, Eric Oksenhendler, David Buob, Gilles Grateau, David Boutboul, Sophie Georgin-Lavialle
Summary: This study presented French cases of PID-related AAA and conducted a systematic literature review. It found that renal involvement was the most common manifestation of AAA, with bacterial infections being the most frequent. The delay between the first symptoms of PID and AAA diagnosis was 16.18 years on average, indicating a lack of clinical attention to this complication.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY-IN PRACTICE
(2021)
Review
Immunology
Haruka Fukayama, Shota Myojin, Takanori Funaki, Yoshitsugu Fukuda, Tomoo Nakamura, Akira Ishiguro, Chikara Ogimi
Summary: We present a case of septic arthritis of the hip caused by Haemohilus parainfluenzae in a healthy 5-year-old boy without apparent risk factors. A literature review found only 4 pediatric cases of osteoarticular infection caused by this pathogen. To our knowledge, this may be the first pediatric case of septic arthritis of the hip caused by H. parainfluenzae.
PEDIATRIC INFECTIOUS DISEASE JOURNAL
(2023)
Review
Pharmacology & Pharmacy
Dong Wang, Li Song, Li Shen, Kaihui Zhang, Yuqiang Lv, Min Gao, Jian Ma, Ya Wan, Zhongtao Gai, Yi Liu
Summary: This study identified ANK1 and SPTB as the most frequently mutated genes in Chinese patients with HS, with higher mutation frequency of ANK1 in specific exons. Missense mutations were more common in SLC4A1, while most mutations in ANK1 and SPTB were nonsense or frameshift mutations. The study expanded the mutation spectrum of ANK1 and SPTB, providing insights into the mutational characteristics of causative genes in Chinese HS patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Dermatology
Xinling Zhang, Yujie Chen, Guanhuier Wang, Pengbing Ding, Xin Yang, Zhenmin Zhao
Summary: Based on the data analysis of this study, abdominal expander implantation combined with flap technique showed good clinical efficacy in the treatment of adult chronic osteomyelitis of lower limb with soft tissue defects, achieving the goal of increasing the skin harvesting area and reducing suture tension and scar hyperplasia of the abdominal skin harvesting area.
INTERNATIONAL WOUND JOURNAL
(2022)
Article
Orthopedics
Jenny J. J. Yan, Alexander J. J. Chou, Lisa Giulino-Roth, Christy B. B. Pomeranz
Summary: Primary lymphoma of the bone (PLB) is a rare disease that primarily affects children, usually involving the metaphysis of long bones. However, there have been only a few reported cases of pediatric PLB originating from the epiphysis, particularly in the proximal tibia. We present a pediatric case of PLB in the tibial epiphysis, which initially presented as knee pain. Accurate diagnosis is crucial as lymphoma in the epiphysis of children is often mistaken for infectious causes or other types of tumors, leading to inappropriate treatment and disease progression.
SKELETAL RADIOLOGY
(2023)
Review
Endocrinology & Metabolism
F. Robin, S. Cadiou, J-D Albert, G. Bart, G. Coiffier, P. Guggenbuhl
Summary: Methotrexate (MTX)-related osteopathy, characterized by pain, osteoporosis, and atypical fractures, is a rare condition that has been reported in patients treated with low doses of MTX for inflammatory diseases. Pathophysiological studies suggest a possible dose-dependent residual effect of MTX on osteo-forming bone cells.
OSTEOPOROSIS INTERNATIONAL
(2021)
Review
Infectious Diseases
Elyne M. M. Brunink, Lotje A. A. Hoogervorst, Koen Steentjes, Demien Broekhuis, Mark G. J. de Boer
Summary: This paper provides an overview of the clinical presentation, prognosis, and treatment of hematogenous osteomyelitis caused by Streptococcus intermedius in immunocompetent adults. Through a systematic literature review, four case reports were identified, and the most common symptoms were localized pain and fever. Treatment strategies varied, but antibiotics (penicillins) were administered in each case, and some patients underwent surgical debridement. Limited data is available, but based on the available evidence, the clinical presentation, prognosis, and treatment of hematogenous osteomyelitis caused by Streptococcus intermedius in immunocompetent adults were summarized.
EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES
(2023)
Article
Gastroenterology & Hepatology
Mohamed Abbas, Nadia Gaia, Nicolas C. Buchs, Vaihere Delaune, Myriam Girard, Diego O. Andrey, Jeremy Meyer, Jacques Schrenzel, Frederic Ris, Stephan Harbarth, Vladimir Lazarevic
Summary: This study found that there were rapid changes in the rectal microbiota following colon cancer surgery, mainly characterized by significant increases in the genus Enterococcus. There were also significant differences in the postoperative microbiome between patients who received different antimicrobial prophylaxis regimens.
Review
Immunology
Abdessalam Cherkaoui, Jacques Schrenzel
Summary: Total laboratory automation (TLA) has a significant impact on improving laboratory efficiency, particularly in enhancing antimicrobial susceptibility testing. Implementing these methods may have a positive impact on clinical outcomes.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2022)
Article
Infectious Diseases
Aline Cuenod, Martina Aerni, Claudia Bagutti, Banu Bayraktar, Efe Serkan Boz, Cynthia Beisert Carneiro, Carlo Casanova, Alix T. Coste, Peter Damborg, Dirk W. van Dam, Mehmet Demirci, Pavel Drevinek, Olivier Dubuis, Jose Fernandez, Gilbert Greub, Jaroslav Hrabak, Gulen Hurkal Yigitler, Jakub Hurych, Thoger Gorm Jensen, Geraldine Jost, Greetje A. Kampinga, Sonja Kittl, Christine Lammens, Claudia Lang, Reto Lienhard, Julie Logan, Carola Maffioli, Ivana Marekovic, Matthias Marschal, Jacob Moran-Gilad, Oliver Nolte, Michael Oberle, Michael Pedersen, Valentin Pfluger, Sigrid Pranghofer, Julia Reichl, Rob J. Rentenaar, Arnaud Riat, Belen Rodriguez-Sanchez, Camille Schilt, Ann-Kathrin Schlotterbeck, Jacques Schrenzel, Shani Troib, Elise Willems, Mandy Wootton, Dominik Ziegler, Adrian Egli
Summary: The study assessed the mass spectral quality (MSQ) of MALDI-TOF MS and identified simple workflow adaptations to improve it. The intervention of providing feedback and instructions on acquiring MALDI-TOF mass spectra showed improvements in MSQs.
CLINICAL MICROBIOLOGY AND INFECTION
(2023)
Article
Microbiology
Camille d'Humieres, Nadia Gaia, Signara Gueye, Victoire de Lastours, Veronique Leflon-Guibout, Naouale Maataoui, Marion Duprilot, Marie Lecronier, Marc-Antoine Rousseau, Naura Gamany, Francois-Xavier Lescure, Olivia Senard, Laurene Deconinck, Marion Dollat, Valentina Isernia, Anne-Claire Le Hur, Marie Petitjean, Anissa Nazimoudine, Sylvie Le Gac, Solaya Chalal, Stephanie Ferreira, Vladimir Lazarevic, Ghislaine Guigon, Gaspard Gervasi, Laurence Armand-Lefevre, Jacques Schrenzel, Etienne Ruppe
Summary: Clinical metagenomics (CMg) plays an important role in the diagnosis of bone and joint infections (BJIs). Compared to conventional methods, CMg can detect more bacterial species and provide additional information. Additionally, CMg is valuable in guiding antibiotic therapy.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Nursing
Tarsila Vieceli, Sofia Tejada, Raquel Martinez-Reviejo, Tomas Pumarola, Jacques Schrenzel, Grant W. Waterer, Jordi Rello
Summary: This review summarizes the evidence of the impact of air pollution on the respiratory microbiome. It suggests that air pollution can alter the composition of respiratory microbiota, increase the colonization of pathogenic microorganisms, and contribute to the development of respiratory infections with antimicrobial resistance.
INTENSIVE AND CRITICAL CARE NURSING
(2023)
Article
Immunology
Mikael de Lorenzi-Tognon, Etienne Ruppe, Jacques Schrenzel
MICROBES AND INFECTION
(2023)
Review
Biochemistry & Molecular Biology
Patrice Francois, Jacques Schrenzel, Friedrich Goetz
Summary: Despite advances in medical procedures, staphylococci remain major pathogens causing disease, especially in patients with indwelling catheters and prosthetic devices. Biofilms produced by staphylococci increase resistance to treatment and host immunity. This review explores the composition and regulation of biofilm development, as well as its clinical significance. Recent studies on destroying biofilms as a therapeutic strategy are also discussed.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Adele Rakotonirina, Tatiana Galperine, Maxime Audry, Marie Kroemer, Aurelie Baliff, Laurent Carrez, Farshid Sadeghipour, Jacques Schrenzel, Benoit Guery, Eric Allemann
Summary: Clostridioides difficile infection (CDI) is a severe nosocomial infection with a high mortality rate. Although antibiotic treatment is the standard of care, the relapse rate is high and less effective against recurrent infection. Fecal microbiota transplantation (FMT) is a recommended treatment with a high efficacy. The formulation of diluted donor stool needs innovation, and the administration routes should be optimized.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2023)
Article
Public, Environmental & Occupational Health
N. Hassoun-Kheir, N. Buetti, V. Olivier, M. Perez, J. Frossard, G. Renzi, J. Schrenzel, P. Saudan, S. Harbarth
Summary: This study investigated the mupirocin resistance in haemo-dialysis patients and found that it was infrequent in both blood and colonizing Staphylococcus aureus isolates. Moreover, a decreasing trend in the annual rate of S. aureus bloodstream infections was observed. Therefore, targeted mupirocin-based decolonization is a sustainable measure for preventing healthcare-associated infections in S. aureus carriers undergoing haemodialysis.
JOURNAL OF HOSPITAL INFECTION
(2023)
Review
Clinical Neurology
E. Berthouzoz, V. Lazarevic, A. Zekeridou, M. Castro, I. Debove, S. Aybek, J. Schrenzel, P. R. Burkhard, V. Fleury
Summary: Parkinson's disease (PD) is associated with dysbiosis of the microbiota, which can influence the development of symptoms and lead to metabolic changes and inflammation. Dysbiosis also decreases the effectiveness of dopaminergic treatments. Analysis of dysbiosis can serve as a biomarker of PD, and interventions modulating the gut microbiota may influence the course of the disease.
REVUE NEUROLOGIQUE
(2023)
Article
Genetics & Heredity
Aitana Neves, Daniel Walther, Trinidad Martin-Campos, Valerie Barbie, Claire Bertelli, Dominique Blanc, Gerard Bouchet, Frederic Erard, Gilbert Greub, Hans H. Hirsch, Michael Huber, Laurent Kaiser, Stephen L. Leib, Karoline Leuzinger, Vladimir Lazarevic, Mirjam Mausezahl, Jorge Molina, Richard A. Neher, Vincent Perreten, Alban Ramette, Tim Roloff, Jacques Schrenzel, Helena M. B. Seth-Smith, Roger Stephan, Dillenn Terumalai, Fanny Wegner, Adrian Egli
Summary: The SPSP is a secure platform that enables surveillance and monitoring of pathogens in human, veterinary, environmental, and foodborne sources. It utilizes whole genome sequencing data and metadata to quickly track and monitor the transmission and outbreak of pathogens. It provides controlled data access, complex dynamic queries, dedicated dashboards, and automated data sharing with international repositories, aiming to improve public health and societal well-being.
MICROBIAL GENOMICS
(2023)
Article
Microbiology
Electine Magoye, Lukas Nageli, Andreas Buhlmann, Maja Hilber-Bodmer, Peter Keller, Konrad Muhlethaler, Arnaud Riat, Jacques Schrenzel, Florian M. Freimoser
Summary: Fungicide applications can lead to the evolution of resistant, pathogenic fungi, and the sensitivity of environmental fungi to fungicides is mostly unknown. This study found that clinical Aureobasidium isolates were more fungicide sensitive compared to agricultural isolates, suggesting the selection for fungicide tolerance of non-target fungi in agricultural ecosystems.
MICROBIOLOGY SPECTRUM
(2023)
Article
Microbiology
Florian Mauffrey, Nadia Gaia, Chiraz Chaabane, Gesuele Renzi, Adrien Fischer, Abdessalam Cherkaoui, Diane Bandeira, Jacques Schrenzel, Vladimir Lazarevic
Summary: We present the genome of a Neisseria meningitidis strain (GE-156) isolated from a bacteremia patient in Switzerland. This strain belongs to a rare mixed serogroup W/Y and sequence type 11847 (clonal complex 167), identified through both routine laboratory examination and genomic sequencing.
MICROBIOLOGY RESOURCE ANNOUNCEMENTS
(2023)
Letter
Critical Care Medicine
Sylvain Meyer, Nadia Gaia, Vladimir Lazarevic, Jacques Schrenzel, Bruno Francois, Olivier Barraud
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Editorial Material
Infectious Diseases
Aude Nguyen, Ludovica Ferrero, Vladimir Lazarevic, Nadia Gaia, Begona Martinez de Tejada, Jacques Schrenzel, Nadia Berkane
Summary: This article presents the first case of postpartum septic arthritis of the pubic symphysis caused by Sneathia sanguinegens, Sneathia vaginalis, and Mageeibacillus indolicus, identified using next generation sequencing.
NEW MICROBES AND NEW INFECTIONS
(2023)