Article
Biochemistry & Molecular Biology
Kuan Wang, Danyang Chen, Zhuoya Wang, Jianhai Yang, Wenguang Liu
Summary: This work presents an injectable supramolecular poly(N-(2-hydroxypropyl) acrylamide) (PHPAm) hydrogel that acts as a functional physical barrier to prevent peritendinous adhesions. The PHPAm hydrogel loaded with Prussian blue (PB) nanoparticles and platelet lysate (PL) can inhibit fibrin and fibroblast adhesion, attenuate local inflammation, and enhance tenocyte activity to balance extrinsic and intrinsic healing of tendons.
MACROMOLECULAR BIOSCIENCE
(2023)
Article
Orthopedics
Michael R. Carmont, Sara Brandt Knutsson, Annelie Brorsson, Jon Karlsson, Katarina Nilsson-Helander
Summary: Post-operative adhesions occurred in 5.6% of patients following minimally invasive repair of Achilles tendon rupture. Surgical release of adhesions led to significant improvement in outcome, with patients reporting higher ATRS scores and decreased symptoms of tightness and discomfort.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2022)
Article
Chemistry, Multidisciplinary
Andrea Marchesini, Francesco De Francesco, Pier Paolo Pangrazi, Letizia Senesi, Andrea Campodonico, Valentina Riccio, Stefano Geuna, Barbara Zavan, Michele Riccio
Summary: The local application of Hyaloglide(R) was found to be effective in preventing peritendinous adhesion formation and promoting normal healing with regeneration of the synovial sheath in a rabbit model of tenolysis.
APPLIED SCIENCES-BASEL
(2021)
Article
Engineering, Environmental
Xuemin Liu, Huihui Wang, Jiajie She, Qiang Zhang, Qingyu Hu, Dongdong Li, Hongliang Wu, Xiaofeng Ye, Ruiying Diao, Xuetao Shi, Liping Wang
Summary: Intrauterine adhesions (IUA) can cause menstrual irregularities, infertility, and repeated pregnancy loss. This study developed a hydrophilic hydrogel film with a negative surface potential that can absorb proinflammatory cytokines to alleviate inflammation and limit fibrosis in the uterus. The hydrogel film exhibited good biocompatibility and anti-fibroblast adhesion properties in vitro and reduced inflammation and fibrosis in vivo. By loading the film with vascular endothelial growth factor (VEGF) and implanting it into injured rat endometrial cavities, improved endometrial regeneration was observed during IUA treatment. Overall, this hydrogel film provides a promising strategy for treating and preventing IUA difficulties with broad clinical application potential.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Yuanping Hao, Weiping Zheng, Zhanyi Sun, Demeng Zhang, Kunyan Sui, Peili Shen, Peifeng Li, Qihui Zhou
Summary: Marine polysaccharide-based hydrogels have attracted attention for biomedical applications due to their excellent properties. These hydrogels, composed of chitosan, alginate, or fucoidan, can be easily prepared with tunable microporous architecture, swelling, and biodegradable properties. They exhibit high mechanical strength and excellent cytocompatibility, blood compatibility, and histocompatibility, making them promising bioscaffolds in biomedical applications.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Nanoscience & Nanotechnology
Chunhui Luo, Min Huang, Xinxin Sun, Ning Wei, Huan Shi, Hui Li, Min Lin, Jing Sun
Summary: Fabricating artificial materials that mimic the structures and properties of tendons is of great significance. Researchers have developed a poly(vinyl alcohol) hydrogel with hierarchically anisotropic structures, exhibiting excellent mechanical properties, swelling resistance, and cytocompatibility. This hydrogel holds potential for various biotechnological and biomedical applications.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Review
Biotechnology & Applied Microbiology
Jiacheng Hu, Shen Liu, Cunyi Fan
Summary: Despite efforts in tissue engineering, current treatments cannot fully restore tendon function after injuries. Hydrogels, with exceptional biocompatibility and plasticity, have been widely used as promising biomaterials for tissue regeneration. Various approaches have been developed to improve mechanical properties and degradation of hydrogels in tendon repair. Rational design of hydrogels has also been explored to promote stem-cell-based tendon tissue engineering. Additionally, the role of macrophages in tendon repair and their response to immunomodulatory hydrogels were discussed.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2023)
Article
Surgery
Qiyu Jia, Dongsheng Chen, Jian Guo, Xuefeng Luo, Abudusalamu Alimujiang, Jun Zhang, Ningning Hu, Yanshi Liu, Zengru Xie, Chuang Ma
Summary: This study retrospectively analyzed 1,031 hand trauma cases that underwent finger tendon repair to assess the risk factors associated with tendon adhesions. The risk factors identified were degloving injury, lack of functional exercise, zone II flexor tendon injury, time from injury to surgery >12 h, combined vascular injury, and multiple tendon injuries. Clinicians should pay attention to patients with these risk factors and provide individualized treatment measures and postoperative functional exercise.
FRONTIERS IN SURGERY
(2023)
Review
Materials Science, Biomaterials
Yunkai Tang, Zhen Wang, Lei Xiang, Zhenyu Zhao, Wenguo Cui
Summary: This article summarizes the latest progress in cells, biomaterials, active molecules and construction technology in treating tendon/ligament injuries. The characteristics of supports made of different materials and the development and application of different manufacturing methods are discussed. The development of electrospinning and hydrogel technology has diversified the production and treatment of materials.
REGENERATIVE BIOMATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Yanan Miao, Zuwu Tang, Qingwei Zhang, Aikebaier Reheman, He Xiao, Min Zhang, Kai Liu, Liulian Huang, Lihui Chen, Hui Wu
Summary: In this study, biocompatible hydrogels with self-adhesion, conductivity, UV shielding, and antioxidant activity were successfully prepared for wearable sensors, which could accurately monitor body motion signals.
ACS APPLIED POLYMER MATERIALS
(2022)
Article
Biochemistry & Molecular Biology
Alba Cano-Vicent, Alberto Tunon-Molina, Hamid Bakshi, Iman M. Alfagih, Murtaza M. Tambuwala, Angel Serrano-Aroca
Summary: In this study, a novel calcium alginate/acetic acid film was developed and evaluated for its biological properties. The film exhibited biocompatibility with human keratinocyte cells and Caenorhabditis elegans, and demonstrated antiviral and anticancer properties. The findings suggest that this film has potential applications in the biomedical and pharmaceutical industries for developing broad-spectrum antiviral and anticancer materials.
Article
Polymer Science
Shengda Liu, Shengchao Deng, Tengfei Yan, Xin Zhang, Ruizhen Tian, Jiayun Xu, Hongcheng Sun, Shuangjiang Yu, Junqiu Liu
Summary: A dual dynamic bind, cross-linked, self-healing protein hydrogel was prepared, based on Schiff base bonds and diselenide bonds, which showed a dual response in visible light and desirable self-healing ability. The protein hydrogel containing diselenide bonds demonstrated efficient self-healing up to nearly 100% without compromising mechanical properties under visible light at room temperature.
Article
Chemistry, Physical
Lei Wang, Jingtao Jiang, Chenghao Dai, Huilan Zeng, Yifan Shang, Yongqi Liu, Qiyan Yin, Gengsheng Weng
Summary: This study demonstrates a new paradigm for designing materials that can mimic complex shape-morphing phenomena by combining photothermal shape-transformable polymer films and patterned inactive layers. Various reversible 3D shapes, including a complex human face and gripping-force-tunable soft grippers, can be fabricated with tunable deformation degree and rate. The shape transformations are achieved through simple peeling off and repatterning of black-tape strip layers, providing guidance for fabricating new soft robotics and biomimetic systems without intricate heterogeneity design in material properties.
CHEMISTRY OF MATERIALS
(2022)
Article
Biotechnology & Applied Microbiology
Oguz Kayiran, Suphan Tunc, Guler Gamze Eren Ozcan, Neslihan Kaya, Derya Karabulut
Summary: This study compared the effects of different administration methods of TAM and found that local administration of TAM can effectively reduce peritendinous adhesion. This provides new insights for the development of new therapies to prevent peritendinous adhesions.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Materials Science, Multidisciplinary
Lingling Yuan, Xueyu Jiang, Min Jiang, Ye Guo, Yunfei Liu, Piaoye Ming, Silei Li, Peirong Zhou, Rui Cai, Ke Yu, Gang Tao
Summary: This study prepared gellan gum/sericin hydrogels containing PDA-encapsulated halloysite nanotubes (halloysite@polydopamine) to achieve fast hemostasis and photothermally antibacterial effects. The composite hydrogel showed improved mechanical performance and hemostatic effect due to the introduction of halloysite@polydopamine. It also exhibited high effectiveness against E. coli and S. aureus under near-infrared light irradiation.
MATERIALS & DESIGN
(2023)
Article
Engineering, Biomedical
Kazuhiko Ishihara, Mingwei Mu, Tomohiro Konno
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
(2018)
Review
Engineering, Biomedical
Kazuhiko Ishihara, Haruka Oda, Tomohiro Konno
Article
Chemistry, Analytical
Katsuhiko Sato, Tomohiro Konno
Article
Polymer Science
Kazuhiko Ishihara, Shohei Hachiya, Yuuki Inoue, Kyoko Fukazawa, Tomohiro Konno
Article
Biochemistry & Molecular Biology
Kazuhiko Ishihara, Masashi Abe, Kyoko Fukazawa, Tomohiro Konno
Summary: This study investigates the relationship between cell adhesion, sugar chain density on cell membranes, and the cell proliferation cycle by introducing an affinity phenylboronic acid group into a polymer containing a phosphorylcholine group. The adhesion rate of human promyelocytic leukemia cells on the polymer substrate increases with pretreatment using an alkaline solution. Cell adhesion is found to be dependent on sugar additives in the culture medium, suggesting a specific separation process based on cell adhesion and sugar chain density related to the cell proliferation cycle.
MACROMOLECULAR BIOSCIENCE
(2021)
Review
Pharmacology & Pharmacy
Tomohiro Konno
Summary: This study has designed bioinspired polymeric biomaterials with excellent cytocompatibility, including materials such as MPC and PMB, which have good water-solubility and low cytotoxicity. In addition, phospholipid polymers can spontaneously form reversible polymeric hydrogels with polyol compounds for cell engineering and cell immobilization.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2021)
Article
Oncology
Hiroto Fujisaki, Yutaka Nakano, Sachiko Matsuda, Keiichi Suzuki, Osamu Itano, Masayuki Tanaka, Shutaro Hori, Yasushi Hasegawa, Yuta Abe, Hiroshi Yagi, Minoru Kitago, Tomohiro Konno, Kazuhiko Ishihara, Keiko Ohno, Satoshi Kishino, Kazuo Umezawa, Yuko Kitagawa
Summary: The study showed that aggregation with PMB improved the solubility of DHMEQ and effectively inhibited pancreatic cancer cell growth. In both in vitro and in vivo experiments, PMB-DHMEQ exhibited more significant anticancer effects compared to CMC-DHMEQ.
ANTICANCER RESEARCH
(2021)
Article
Materials Science, Biomaterials
Sachi Moriwaki, Yuta Yoshizaki, Tomohiro Konno
Summary: A reversible and spontaneously forming phospholipid polymer hydrogel was developed as a cell immobilization matrix, causing no harm to the cells. By designing stimuli-responsive dissociation rate, the recovery ratio of the immobilized cells was improved.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Article
Chemistry, Physical
Kohei Yokosawa, Shinji Kajimoto, Daiki Shibata, Kunisato Kuroi, Tomohiro Konno, Takakazu Nakabayashi
Summary: This study quantified the change in protein concentration in protein droplets generated by liquid-liquid phase separation using Raman imaging. Small changes in protein concentration with variations in pH and salt concentration were observed, and it was shown that the concentration in the droplet decreases as the conditions become less favorable for droplet formation. The effect of exposure to 1,6-hexanediol on protein concentration in the droplet was also examined, and a model was proposed to explain the decrease in protein concentration and disappearance of the droplet under certain conditions.
JOURNAL OF PHYSICAL CHEMISTRY LETTERS
(2022)
Article
Biochemistry & Molecular Biology
Yuta Yoshizaki, Tomohiro Konno
Summary: A branched polymer, 4-armed star-shaped PMB (4armPMB), was synthesized and compared with linear PMB. The 4armPMB showed faster cellular internalization and exiting behaviors compared to LinearPMB.
Article
Multidisciplinary Sciences
Takuma Sumi, Hideaki Yamamoto, Yuichi Katori, Koki Ito, Satoshi Moriya, Tomohiro Konno, Shigeo Sato, Ayumi Hirano-Iwata
Summary: Reservoir computing is a machine learning paradigm that utilizes the dynamics of high-dimensional nonlinear systems for processing time-series data. In this study, optogenetics and calcium imaging were used to investigate the computational capabilities of biological neuronal networks (BNNs) through a reservoir computing framework. The modular architecture of BNNs was found to positively correlate with classification accuracy, and BNNs exhibited short-term memory and categorical learning abilities. These findings contribute to our understanding of information representation in BNNs and have implications for the development of physical reservoir computing systems.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Hideaki Yamamoto, F. Paul Spitzner, Taiki Takemuro, Victor Buendia, Hakuba Murota, Carla Morante, Tomohiro Konno, Shigeo Sato, Ayumi Hirano-Iwata, Anna Levina, Viola Priesemann, Miguel A. Munoz, Johannes Zierenberg, Jordi Soriano
Summary: High-level information processing in the mammalian cortex requires both segregated processing in specialized circuits and integration across multiple circuits. One possible way to implement these demands is by flexibly switching between states with different levels of synchrony. The control of complex synchronization patterns in neuronal networks remains elusive, but this study provides insights by manipulating and stimulating networks of cortical neurons in vitro. Results show that a modular architecture enhances the network's sensitivity to external asynchronous stimulation and that the depletion of synaptic resources in stimulated neurons is the underlying mechanism for this effect.
Correction
Biochemical Research Methods
Yan Xu, Madoka Takai, Tomohiro Konno, Kazuhiko Ishihara
Article
Materials Science, Biomaterials
Ren Zhang, Yuuki Inoue, Tomohiro Konno, Kazuhiko Ishihara
BIOMATERIALS SCIENCE
(2019)
Article
Materials Science, Multidisciplinary
Mingwei Mu, Tomohiro Konno, Kazuhiko Ishihara