Article
Surgery
Amanda Azer, Dhruv Mendiratta, Anthony Saad, Yajie Duan, Matthew Cedarstrand, Sree Chinta, Aedan Hanna, Dhvani Shihora, Aleksandra Mcgrath, Alice Chu
Summary: This study compares the outcomes of humeral osteotomies and soft tissue procedures in correcting shoulder movement imbalances in children with neonatal brachial plexus palsy. The results show that both bony and soft tissue procedures improve most of the assessed outcomes, but soft tissue procedures have more consistent results.
FRONTIERS IN SURGERY
(2023)
Article
Medicine, General & Internal
Chiaowen Joyce Hsiao, Joseph N. Paulson, Sarabdeep Singh, Emmanuel F. Mongodin, Karen C. Carroll, Claire M. Fraser, Peter Rock, Nauder Faraday
Summary: This study aimed to investigate the association between the nasal microbiome and infectious outcomes in surgical patients. The findings suggest that the nasal microbiome may serve as an independent risk factor associated with infection susceptibility in individuals who undergo elective surgical procedures.
Review
Orthopedics
Sachin Allahabadi, Luis M. Salazar, Obianuju A. Obioha, Thomas W. Fenn, Jorge Chahla, Shane J. Nho
Summary: The aim of this review is to discuss the evaluation, treatment options and surgical decision-making for hamstring injuries based on patient presentation and injury patterns. Hamstring injuries, commonly caused by forceful eccentric contraction mechanisms, can occur in different areas of the hamstring muscles. Magnetic resonance imaging is the preferred diagnostic tool, and treatment depends on the specific tendon(s) injured, tear location, severity, and chronicity. Nonoperative measures such as activity modification and physical therapy can be effective, and platelet-rich plasma injections are under investigation. Surgical treatment is reserved for more severe cases that do not improve with nonoperative management. Acute surgical treatment tends to have favorable outcomes for proximal hamstring injuries.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2023)
Review
Orthopedics
Francesco Oliva, Emanuela Marsilio, Filippo Migliorini, Nicola Maffulli
Summary: Chronic ruptures, ruptures following total knee arthroplasty (TKA), and re-ruptures of the quadriceps tendon (QT) are rare conditions that require individualized surgical approaches based on the macroscopic quality of the tendon stumps rather than the timing of intervention. Future efforts should focus on developing evidence-based preventive and therapeutic strategies for these complex tendon injuries.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Article
Engineering, Civil
Hossein Heydarinouri, Masoud Motavalli, Alain Nussbaumer, Elyas Ghafoori
Summary: A mechanical anchorage was proposed for prestressed CFRP rods, relying solely on friction without adhesives; fatigue tests revealed the significance of wedge seating distance in preventing slippage, leading to the development of a new displacement-controlled presetting system.
JOURNAL OF COMPOSITES FOR CONSTRUCTION
(2021)
Article
Chemistry, Multidisciplinary
Kao-Shang Shih, Pei-Yu Chen, Wen-Ling Yeh, Hsiao-Li Ma, Chui-Jia Farn, Chun-Han Hou, Wei-Chen Peng, Hsing-Kuo Wang
Summary: The study compared the electromyographic and dynamic characteristics in the injured and non-injured legs after Achilles tendon repair. The results showed significant changes in EMG and dynamic characteristics in the repaired legs during heel-raise exercise, affecting jumping performance.
APPLIED SCIENCES-BASEL
(2021)
Article
Sport Sciences
B. E. N. J. A. M. I. N. STAEDLE, O. L. I. V. I. E. R. SEYNNES, G. U. I. D. O. LAPS, F. A. B. I. A. N. GOELL, GERT-PETER BRUEGGEMANN, K. I. R. S. T. E. N. ALBRACHT
Summary: The study found that in ATR patients, the affected side had a longer, larger, and stiffer gastrocnemius medialis tendon, shorter muscle fascicles, and greater pennation angles, leading to a deficit in plantarflexion moment. Compensatory remodeling in the affected side may not fully restore muscle function.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2021)
Article
Orthopedics
Susanna Aufwerber, Karin Gravare Silbernagel, Paul W. Ackermann, Josefine E. Naili
Summary: This study aimed to compare the effects of early functional mobilization (EFM) with standard treatment (ST) on calf muscle function in patients with Achilles tendon rupture. The results showed that EFM did not lead to superior recovery of heel-rise performance compared with ST. Increased knee flexion seemed to be a compensatory strategy for decreased ankle plantarflexion. Medial gastrocnemius atrophy and increased body weight were associated with a decreased ankle plantarflexion angle.
AMERICAN JOURNAL OF SPORTS MEDICINE
(2022)
Article
Chemistry, Analytical
Steve Hunter, Julian Werth, Darren James, Yiannis Lambrianides, Kenton Smith, Kiros Karamanidis, Gaspar Epro
Summary: This study presents a time-efficient ultrasound method for assessing Achilles tendon mechanical properties. The method was validated through comparisons with manual frame by frame tracking, and showed similar results in measuring maximal tendon force, elongation, strain, and stiffness index. Additionally, the method was able to detect significant differences in tendon force and stiffness index between different groups of individuals. This analysis has the potential to accurately monitor changes in the mechanical properties of the Achilles tendon due to aging and altered loading.
Article
Surgery
Ryan Howard, Jyothi Thumma, Michael Englesbe
Summary: This study evaluated the reliability of surgeon outcomes in common operations. The results showed that the reliability of these measures was relatively low and most surgeons did not have sufficient case volume to achieve acceptable reliability. Therefore, these measures likely offer little to no meaningful information for decision-making.
Article
Surgery
Brian T. Bucher, Meng Yang, Rebecca Richards Steed, Alison Fraser, Samuel R. G. Finlayson, Heidi A. Hanson
Summary: The geographic proximity of family members is significantly associated with decreased healthcare utilization after complex cardiovascular and oncologic surgical procedures.
Article
Engineering, Multidisciplinary
Qingyu Yang, Di Yao, Jiachuan Yan, Mengsha Liu, Feng Fan, Zhizhong Fu
Summary: This study investigated the prestressed concrete containment (PCC) of nuclear power plants using a combination of theoretical analysis and numerical simulation. By improving three widely accepted concrete creep models, a variable stress creep model was obtained. The effects of concrete creep on the PCC structure during prestressed tensioning and long-term service were systematically analyzed. The internal pressure bearing capacity of the PCC in long-term service was assessed, and the effects of long-term concrete creep on the mechanical properties of the PCC were evaluated.
INTERNATIONAL JOURNAL OF PRESSURE VESSELS AND PIPING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Harold Goerne, Diego de la Fuente, Miguel Cabrera, Abhishek Chaturvedi, Daniel Vargas, Phillip M. Young, Sachin S. Saboo, Prabhakar Rajiah
Summary: Coronary artery interventions and surgical procedures can lead to various complications, such as restenosis, stent migration, and reperfusion injury. Different imaging modalities like MRI and CT can be used for evaluating these complications, each with its own limitations.
Article
Orthopedics
Martin Lind, Marc J. Strauss, Torsten Nielsen, Lars Engebretsen
Summary: Using data from the DKRR, this study compared revision rates in patients undergoing ACLR with QT, HT, and PT grafts based on individual clinic surgical routines. It found that in clinics with lower activity levels, QT grafts had a higher revision rate compared to higher-activity clinics.
KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY
(2021)
Article
Anesthesiology
Basavana Goudra, Arjun Guthal, Preet Mohinder Singh
Summary: The study examined postoperative opioid consumption in orthopedic surgical patients, finding that some patients experienced euphoria, some switched to marijuana, some opted not to use opioids at all post-surgery, and even shared their prescriptions with family or friends.
Article
Cell Biology
Lucas R. Smith, Rajeswari Pichika, Rachel C. Meza, Allison R. Gillies, Marwan N. Baliki, Henry G. Chambers, Richard L. Lieber
Summary: This study aimed to investigate the changes in extracellular protein composition in the muscles of children with cerebral palsy and their relationship with mechanical properties. The results revealed an increase in various collagen types, collagen crosslinks, total proteoglycan, and uronic acid in patients with cerebral palsy. Total collagen and total proteoglycan were positive predictors of stiffness, while biglycan was a negative predictor.
CONNECTIVE TISSUE RESEARCH
(2021)
Article
Engineering, Biomedical
Shawn M. O'Connor, Kenton R. Kaufman, Samuel R. Ward, Richard L. Lieber
Summary: The study investigated the use of intramuscular pressure (IMP) measurements for estimating muscle tension in vivo, showing good agreement between active stress and IMP with perpendicular sensor insertions. However, poor agreement was found with parallel insertions, highlighting the importance of sensor anchoring/orientation for accurate tension estimation. These findings suggest that IMP measurements have potential for estimating muscle tension across various contraction conditions.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Review
Clinical Neurology
Richard L. Lieber, Tim Theologis
Summary: Surgical correction of muscle-tendon units in children with cerebral palsy is complex and requires understanding of its basic properties and adaptations. This review provides information on short- and long-term adaptations of the muscle-tendon unit for therapists, surgeons, and scientists to advance in this field. Surgical releases, lengthening, and transpositions, as well as tissue, cellular, and molecular adaptations are discussed.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Clinical Neurology
Sudarshan Dayanidhi, Elisa H. Buckner, Robin S. Redmond, Henry G. Chambers, Simon Schenk, Richard L. Lieber
Summary: Skeletal muscle mitochondrial oxidative enzyme activity is significantly reduced in independently ambulatory children with cerebral palsy, but this decrease is not due to lower mitochondrial content. This may explain the increased energy consumption and fatigue experienced by ambulatory children with cerebral palsy during movement.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2021)
Article
Orthopedics
Mario A. Vargas-Vila, Michael C. Gibbons, Isabella T. Wu, Mary C. Esparza, Kenji Kato, Seth D. Johnson, Koichi Masuda, Samuel R. Ward
Summary: The study on the rabbit model of rotator cuff tear found that muscle degeneration increased, fat accumulation and fibrosis persisted, and the collagen and fat content increased by 4 weeks and remained through 16 weeks post-tenotomy.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Review
Clinical Neurology
Noelle G. Moreau, Richard L. Lieber
Summary: This article discusses the structural adaptation of muscles in children with cerebral palsy when performing voluntary exercise, emphasizing the impact of exercise details on muscles, and proposing the goal of improving activity and participation in children with cerebral palsy.
DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lydia A. Sibley, Nicole Broda, Wendy R. Gross, Austin F. Menezes, Ryan B. Embry, Vineeta T. Swaroop, Henry G. Chambers, Matthew J. Schipma, Richard L. Lieber, Andrea A. Domenighetti
Summary: The study found that myoblast progenitors from children with CP suffering from muscle contractures are hyperproliferative, associated with DNA hypermethylation and specific gene expression patterns favoring cell proliferation. Treatment with a DNA hypomethylating agent reduced this epigenetic imprint, promoting exit from mitosis and molecular mechanisms of cellular quiescence in CP myoblasts. This suggests a potential mechanism for contracture formation due to epigenetic modifications altering the myogenic program of muscle-generating stem cells.
Review
Biophysics
Benjamin Binder-Markey, Danielle Sychowski, Richard L. Lieber
Summary: Understanding passive skeletal muscle mechanics is essential in defining structure-function relationships and recognizing pathologically impaired muscle. A systematic review revealed various methodological differences in the study of passive muscle mechanics across different species and scales, highlighting the need for standardized methods and recommendations for future studies. Addressing these differences will allow for a more comprehensive exploration of passive force relationships within and between species to enhance our understanding of passive muscle mechanics.
JOURNAL OF BIOMECHANICS
(2021)
Review
Orthopedics
Richard L. Lieber, Jan Friden
Summary: This paragraph summarizes the elements of a successful collaboration between a surgeon and a scientist, emphasizing its uniqueness and significance.
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2022)
Article
Medicine, Research & Experimental
Tanvi Potluri, Matthew J. Taylor, Jonah J. Stulberg, Richard L. Lieber, Hong Zhao, Serdar E. Bulun
Summary: Researchers have discovered two potentially unique fibroblast clusters associated with hernias through single-cell RNA sequencing, which are enriched in estrogen receptor genes and express genes related to regulation and inflammatory fibrosis. This discovery may provide clues for the development of new non-surgical treatments for preventing or reversing inguinal hernias.
Letter
Orthopedics
Severin Ruoss, Chanond A. Nasamran, Anshuman Singh, John G. Lane, Samuel R. Ward
JOURNAL OF ORTHOPAEDIC RESEARCH
(2022)
Article
Orthopedics
Richard L. Lieber
Summary: The NIH R01 grant is highly prestigious but difficult to obtain, with less than 10% of proposals being funded. However, once funded, there is little accountability for achieving the proposed aims. Requiring excessive grant writing creates inefficiencies, therefore a fail quickly model with lower barriers and higher short-term accountability should be considered.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2023)
Article
Neurosciences
Benjamin I. Binder-Markey, Lomas S. Persad, Alexander Y. Shin, William J. Litchy, Kenton R. Kaufman, Richard L. Lieber
Summary: By transplanting the gracilis muscle from the thigh to the arm and directly measuring its properties and function, this study validated the relationship between isometric contractile properties and whole muscle properties in the human body.
JOURNAL OF PHYSIOLOGY-LONDON
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
D. B. Berry, V. L. Galinsky, E. B. Hutchinson, J. P. Galons, S. R. Ward, L. R. Frank
Summary: This study investigates the sensitivity of double pulsed field gradient diffusion MRI to key features of muscle microstructure. Through simulations and experimental scans on a rat model of muscle hypertrophy, the study demonstrates that diffusion tensor subspace imaging analysis can accurately predict important microstructural features related to muscle function. The scalar value of spherical anisotropy (SA) shows a wider dynamic range compared to fractional anisotropy, making it more sensitive to changes in tissue microstructure.
MAGNETIC RESONANCE IN MEDICINE
(2023)
Article
Engineering, Biomedical
Megan K. O'Brien, Sung Y. Shin, Rushmin Khazanchi, Michael Fanton, Richard L. Lieber, Roozbeh Ghaffari, John A. Rogers, Arun Jayaraman
Summary: This study demonstrates the potential of using high-resolution data from wireless, wearable motion sensors to predict post-stroke ambulation function. The incorporation of IMU data improved the prediction accuracy of discharge ambulation ability, showing promise for early prognosis and personalized care strategies in stroke rehabilitation.
IEEE JOURNAL OF TRANSLATIONAL ENGINEERING IN HEALTH AND MEDICINE
(2022)