Article
Cell & Tissue Engineering
Nami Hayakawa, Hajime Matsumine, Kaori Fujii, Hironobu Osaki, Yoshifumi Ueta, Wataru Kamei, Yosuke Niimi, Mariko Miyata, Hiroyuki Sakurai
Summary: The study demonstrated the efficacy of a collagen nerve conduit for facial nerve reconstruction following nerve injury, although it was found to be less effective in promoting nerve regeneration compared to autograft.
REGENERATIVE THERAPY
(2021)
Review
Engineering, Biomedical
Behzad Shiroud Heidari, Rui Ruan, Ebrahim Vahabli, Peilin Chen, Elena M. De-Juan-Pardo, Minghao Zheng, Barry Doyle
Summary: Tendon and ligament injuries affect millions of people annually. Biopolymers play a significant role in TL tissue repair. Many different types of biopolymers have been studied in TL regeneration, but most have not been used clinically.
BIOACTIVE MATERIALS
(2023)
Article
Neurosciences
Chang-Feng Lu, Bo Wang, Pei-Xun Zhang, Shuai Han, Wei Pi, Yu-Hui Kou, Bao-Guo Jiang
Summary: Nerve grafts constructed from chitin biological conduits combined with small autogenous nerves (SANs) and platelet-rich plasma (PRP) significantly improved the repair of 10-mm sciatic nerve defects in rats, showing potential for future therapeutic applications in repairing peripheral nerve defects.
CNS NEUROSCIENCE & THERAPEUTICS
(2021)
Article
Multidisciplinary Sciences
Ema Onode, Takuya Uemura, Kiyohito Takamatsu, Takuya Yokoi, Kosuke Shintani, Shunpei Hama, Yusuke Miyashima, Mitsuhiro Okada, Hiroaki Nakamura
Summary: This study found that nerve conduits coated with human induced pluripotent stem cell (hiPSC)-derived neurospheres can promote nerve regeneration and functional recovery in repairing rat sciatic nerve defects. This nerve regeneration approach shows promise as a new clinical therapy for treating peripheral nerve defects.
SCIENTIFIC REPORTS
(2021)
Article
Engineering, Biomedical
Morshed Khandaker, Reuben Lane, Shannon Yeakley, Hussein Alizereej, Sadegh Nikfarjam, Abdellah Ait Moussa, Melville B. Vaughan, Amgad M. Haleem
Summary: In this study, a scaffold and fixation system for the reconstruction of long-bone segmental defects in a rabbit tibia model were designed and manufactured. Biocompatible and biodegradable materials, polycaprolactone (PCL) and PCL soaked with sodium alginate (PCL-Alg), were used to manufacture the scaffold, interlocking nail, and screws. Degradation and mechanical tests showed that both PCL and PCL-Alg scaffolds were suitable for faster degradation and early weight-bearing capacity. A surgical jig was designed and 3D-printed using biocompatible resin to ensure accurate placement of the scaffold and fixation system. Cadaver tests confirmed the potential of the designed jigs, nails, and screws for future reconstructive surgeries.
JOURNAL OF FUNCTIONAL BIOMATERIALS
(2023)
Article
Biotechnology & Applied Microbiology
Madeline Lane, Stefanie Van Wychen, Andy Politis, Lieve M. L. Laurens
Summary: Algal biomass composition is crucial for the economic viability of research and commercial products, and standardized language and methods are necessary for comparable results. Lack of consistency in analysis methods among different laboratories results in variability in biomass measurements.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2021)
Article
Polymer Science
Vladislav Andronov, Libor Beranek, Vojtech Kruta, Lucie Hlavunkova, Zdenka Jenikova
Summary: This study presents a comprehensive analysis of PLA materials for fused filament fabrication from eight European manufacturers. The study applies a consistent methodology and evaluates factors such as material color, printing temperature, printing orientation, filament diameter, and printer selection. The findings suggest that the second cheapest PLA material performs the best overall.
Article
Surgery
Zi-Xiang Chen, Zhen Yi, Hai-Bin Lu, Lu-Lu Chen, Xiao-Nan Yang, Zuo-Liang Qi
Summary: This study compared the efficacy of conduits fabricated from fresh muscle versus conduits fabricated from predegenerated muscle for repairing peripheral nerve defects. The results showed that the fresh muscle conduit group had larger myelinated nerve fibers with thicker myelin sheaths, higher sciatic function index, and greater Bcl-2/Bax ratio and Schwann cell survival compared to the predegenerated muscle conduit group.
JOURNAL OF CRANIOFACIAL SURGERY
(2022)
Article
Engineering, Biomedical
Lorenz Semmler, Aida Naghilou, Flavia Millesi, Sonja Wolf, Anda Mann, Sarah Stadlmayr, Sascha Mero, Leon Ploszczanski, Lisa Greutter, Adelheid Woehrer, Eva Placheta-Gyoeri, Fritz Vollrath, Tamara Weiss, Christine Radtke
Summary: This study combines silk fibroin and spider dragline silk to create a silk-in-silk conduit for nerve repair. The results show that this conduit achieves comparable regenerative performance as autografts, with faster functional recovery and axonal re-growth. The guiding properties of spider dragline silk play a critical role in this process.
ADVANCED HEALTHCARE MATERIALS
(2023)
Article
Biochemistry & Molecular Biology
Johannes C. Heinzel, Viola Oberhauser, Claudia Keibl, Barbara Schaedl, Nicole Swiadek, Gregor Langle, Helen Frick, Cyrill Slezak, Cosima Prahm, Johannes Grillari, Jonas Kolbenschlag, David Hercher
Summary: This study evaluated the effects of ESWT on rat median nerve repair using either autografts or muscle-in-vein conduits. Although no direct positive effects of ESWT on peripheral nerve regeneration were found, the results after nerve repair with MVCs were significantly inferior to those after autograft repair.
Article
Chemistry, Multidisciplinary
Emily Kerr, Richard Alexander, Paul S. Francis, Rosanne M. Guijt, Gregory J. Barbante, Egan H. Doeven
Summary: The study found that unmodified carbon-based SPEs exhibited the most intense ECL signals in detection systems, and the incorporation of nanomaterials did not significantly enhance ECL intensity. Platinum and gold SPEs showed lower relative ECL intensities compared to carbonaceous materials, but the ECL signal at platinum electrodes could be increased by approximately 3-fold with the addition of a surfactant.
FRONTIERS IN CHEMISTRY
(2021)
Article
Engineering, Biomedical
Zonghuan Wang, Yibing Wu, Yang Xiang, Marie Beatrix Kruth, Peng Wei, Guangli Dai, Kedi Xu, Jun Yin, Yong Huang
Summary: The study illustrates that nerve conduits with micro-grooved inner textures significantly improve peripheral nerve regeneration, leading to enhanced nerve tissue repair efficiency. These conduits show similar repair capacity to autografts, demonstrating the potential for improved nerve tissue engineering strategies.
ANNALS OF BIOMEDICAL ENGINEERING
(2021)
Article
Chemistry, Physical
Yanwen Jing, Yanqi Lv, Ke Wang, Zhimin Xu, Xingfu Zhou
Summary: In this study, a novel perovskite absorber for organic-inorganic perovskite solar cells (PSCs) was fabricated, and the crystallization and electric field effect were improved by introducing a zinc additive, leading to enhanced conversion efficiency and stability of the solar cells.
JOURNAL OF ALLOYS AND COMPOUNDS
(2023)
Article
Microbiology
Janko Sattler, Janina Noster, Anne Brunke, Georg Plum, Pia Wiegel, Oliver Kurzai, Jacques F. Meis, Axel Hamprecht
Summary: In this study, two commercially available PCR assays were used to detect C. auris, with AurisID showing reliable detection but potential false positives with related species, while Fungiplex Candida Auris RUO demonstrated higher sensitivity and better specificity for C. auris detection.
Article
Chemistry, Applied
Wei Wang, Yuran Huang, Wenhong Zhao, Hao Dong, Juan Yang, Weidong Bai
Summary: This study identified and compared umami peptides from eight commercial dry-cured Spanish mackerels via molecular simulation. The results showed that the sequence of peptides varied in different samples, with only ten sequences being repeated across multiple samples. Four peptides were found to exhibit umami taste and umami-enhancing effects, forming hydrogen bonds and hydrophobic bonds in ligand-receptor interactions.
Article
Surgery
Liselotte F. Bulstra, Caroline A. Hundepool, Delaney M. Shin, Allen T. Bishop, Alexander Y. Shin
Article
Biotechnology & Applied Microbiology
Tiam M. Saffari, Katelyn Chan, Sara Saffari, Kevin J. Zuo, Renee M. McGovern, Joel M. Reid, Gregory H. Borschel, Alexander Y. Shin
Summary: The study explored the potential of using tacrolimus and mesenchymal stem cells combined with a fibrin gel-based drug delivery system to enhance peripheral nerve regeneration. The results showed that the combined delivery method did not result in cytotoxic effects and could be beneficial for promoting peripheral nerve regeneration.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Article
Biotechnology & Applied Microbiology
Sara Saffari, Tiam M. Saffari, Katelyn Chan, Gregory H. Borschel, Alexander Y. Shin
Summary: The study investigated the combined effect of mesenchymal stem cells (MSC) and local delivery of tacrolimus (FK506) on nerve regeneration in nerve autografts and decellularized allografts. Results showed that either MSC or FK506 treatment alone improved neurite outgrowth, and their combination further enhanced neurite extension in both types of grafts.
BIOTECHNOLOGY AND BIOENGINEERING
(2021)
Review
Orthopedics
Alexander Y. Shin, Mariano Socolovsky, Ketan Desai, Michael Fox, Shufeng Wang, Robert J. Spinner
Summary: This expert opinion study examined regional differences in adult traumatic pan brachial plexus injuries, including demographics, injury mechanisms, patient evaluation, and treatment strategies. Variations in reconstructive surgery were identified across regions/surgeons, highlighting the need for future studies to accurately compare outcomes in different regions.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2022)
Article
Orthopedics
Derek B. Asserson, Taylor J. North, Peter C. Rhee, Allen T. Bishop, Jeffrey S. Brault, Alexander Y. Shin
Summary: A retrospective review compared ultrasound guided thread carpal tunnel release (TCTR) and open carpal tunnel release (OCTR) in hospital employees and found that TCTR resulted in a quicker return to work compared to OCTR. Regardless of the surgical technique, all patients experienced symptom resolution without any complications.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2022)
Review
Orthopedics
Anthony J. Archual, Allen T. Bishop, Alexander Y. Shin
Summary: Vascularized bone grafts have shown superior outcomes compared to nonvascularized grafts in challenging clinical situations. Pedicled grafts from the distal radius, medial femoral condyle, ribs, and fibula, as well as free grafts from the fibula and medial femoral condyle/trochlea, have demonstrated particular usefulness and versatility.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Article
Orthopedics
Christina M. Webber, Jason S. Egginton, Alexander Y. Shin, Kenton R. Kaufman
Summary: The study explored patient perspectives on using an MEO after surgical treatment for traumatic BPI. Patients showed a positive attitude towards using an MEO as a rehabilitation tool, and desired a more streamlined and stronger device. Continued patient engagement in evaluating and developing medical devices and treatment plans can lead to improved outcomes that are important to patients.
PROSTHETICS AND ORTHOTICS INTERNATIONAL
(2021)
Article
Orthopedics
Joshua J. Meaike, Christian Athens, Nicole Sgromolo, Alexander Y. Shin, Peter C. Rhee
Summary: The study found that there is no increased risk of wound healing complications with the use of multiple skin incisions (>= 2) in the surgical management of distal radius fractures. Surgeons should have the confidence to utilize the necessary number of skin incisions to effectively reconstruct distal radius fractures.
JOURNAL OF WRIST SURGERY
(2022)
Article
Orthopedics
John J. Bartoletta, Dana Rioux-Forker, Raahil S. Patel, Katharine M. Hinchcliff, Alexander Y. Shin, Peter C. Rhee
Summary: The study found that concomitant PRC might not improve union rates or reduce complications in patients undergoing TWA.
JOURNAL OF WRIST SURGERY
(2022)
Article
Orthopedics
Sean R. Cantwell, Andrew W. Nelson, Brandon P. Sampson, Robert J. Spinner, Allen T. Bishop, Nicholas Pulos, Alexander Y. Shin
Summary: Selective amputation is an effective treatment for BPI patients in whom surgical reconstruction fails. It can reduce pain, increase employment rates, and result in high satisfaction. MEPs allow for terminal grasp/release in amputees with sufficient signal and are associated with high rates of prosthesis use.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Review
Orthopedics
Alexander Y. Shin, Allen T. Bishop, Michelle F. Loosbroch, Robert J. Spinner
Summary: A multidisciplinary brachial plexus clinic is a new approach to treating brachial plexus injuries that involves collaboration between different surgical specialties. This review provides a detailed account of the history, philosophy of care, development/implementation, and impact of a multidisciplinary brachial plexus team at the Mayo Clinic.
JOURNAL OF HAND SURGERY-EUROPEAN VOLUME
(2022)
Article
Rehabilitation
James B. Meiling, John H. Hollman, Alexander Y. Shin, Jeffrey S. Brault
Summary: This study demonstrates that the ultrasound-measured interstructural safe zone distance was significantly greater in the ulnarly deviated position than in either the neutral position or radially deviated position. These findings may have important implications for improving the safety of ultrasound-guided injections.
Article
Orthopedics
Sandesh G. Bhat, Emily J. Miller, Alexander Y. Shin, Kenton R. Kaufman
Summary: This study compared the neuromuscular control of elbow flexors in unimpaired control subjects and patients with traumatic brachial plexus injury who underwent nerve transfer surgery. The results showed significant differences in neuromuscular control and torque generation between the two groups. The control group exhibited better modulation of myoelectric activation and achieved greater variability in neuromuscular control with varying torque demand, while the nerve transfer group could not modulate their myoelectric activation effectively. Further research on improving neuromuscular control is necessary for optimizing functional outcomes in nerve injury patients.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Sara Saffari, Daan J. Rademakers, Nicholas Pulos, Alexander Y. Shin
Summary: Modulating the nerve's microenvironment using exosomes can enhance nerve regeneration. This study aimed to determine the optimal dose of purified exosome product (PEP) for maximal neurite extension. Treatment with 5% PEP resulted in the longest neurite extension and was superior to the untreated control, while treatment with higher concentrations showed no significant difference. Live cell imaging suggested that PEP migrated towards the neural regeneration site. Overall, 5% PEP was found to be the optimal concentration for nerve regeneration based on this in vitro dose-response analysis.
BIOTECHNOLOGY AND BIOENGINEERING
(2023)
Article
Orthopedics
J. J. Meaike, J. D. Meaike, M. S. Collins, A. T. Bishop, A. Y. Shin
Summary: The study compared preoperative MRI findings with intraoperative bleeding in the proximal scaphoid. The results showed that MRI was not reliable in assessing the vascularity of the proximal fragment compared to intraoperative assessment. Future efforts should focus on developing objective measures of osseous blood flow that can be performed during surgery.
BONE & JOINT JOURNAL
(2023)