Article
Pharmacology & Pharmacy
Xiaoli Fan, Hengzhi Song, Xiaotian Xu, Xi Lu, Yuhui Wang, Xiaoqun Duan
Summary: The toxicity of sodium p-hydroxybenzoate was evaluated in rats through 90-day repeated oral toxicity experiments according to OECD guidelines. The results showed no adverse effects were observed below a dose of 250 mg/kg body weight per day.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ting Chen, Haitang Liu, Sheng Qiang, Jie Li, Jing Liu, Beibei Chen, Lin Chen, Fufeng Liu, Rui Liu, Xue Jiang, Xiaoyuan Liao
Summary: In this study, a novel polysaccharide-based preservative named carboxymethyl hemicellulose p-hydroxybenzoate (P-CMHC) was synthesized by modifying hemicellulose extracted from eucalyptus waste liquor. P-CMHC showed excellent antioxidant activity, hygroscopic and moisturizing properties, and negligible cytotoxicity, suggesting its potential as a safe and healthy preservative.
CARBOHYDRATE RESEARCH
(2023)
Article
Chemistry, Physical
Ying Han, Peng Yang, Yu Liu, Songgu Wu, Junbo Gong
Summary: This study investigates how polymers regulate the crystal habit of PABA from long rodlike to blocklike. Experiments including cooling crystallization, single crystal growth, and molecular simulation were conducted. Results show that PVP played a significant role in regulating crystal habit by inhibiting the growth of the long axis. Molecular simulation revealed that PVP selectively adsorbed on specific crystal faces, hindering diffusion and adsorption of solute molecules, thus inhibiting the growth of the long axis.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Article
Environmental Sciences
Shengpeng Zuo, Hao Yang, Xiaofeng Jiang, Yongqing Ma
Summary: This study demonstrates that magnetic Fe3O4 nanoparticles can enhance the efficiency of allelopathic chemicals in controlling cyanobacterial growth, triggering physiological responses in cyanobacteria and disrupting cell integrity. The nanoparticles also decrease protein content and the release of harmful substances. Mechanistically, nanomaterials can modify algal suppression by influencing radical production.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Plant Sciences
Fu-Cai Ren, Li Liu, Yong-Feng Lv, Xue Bai, Qian-Jin Kang, Xiao-Jing Hu, Hong-Dan Zhuang, Liu Yang, Jiang-Miao Hu, Jun Zhou
Summary: Twelve previously unknown tandem prenylated p-hydroxybenzoic acid derivatives, named oberoniamyosurusins A-L, were isolated from the plant Oberonia myosurus, along with five known derivatives. Some of the compounds exhibited moderate inhibitory activity against Staphylococcus aureus. The biosynthetic pathway of these compounds was investigated using transcriptome sequencing of O. myosurus, identifying potential enzymes involved in nervogenic acid biosynthesis.
JOURNAL OF NATURAL PRODUCTS
(2021)
Article
Chemistry, Medicinal
Jiaqi Lu, Ru Li, Binsong Mu, Yao Peng, Yi Zhao, Yuesen Shi, Li Guo, Li Hai, Yong Wu
Summary: In this study, pH-sensitive multi-targeted liposomes were developed for the co-delivery of doxorubicin and lonidamine to brain tumors. These liposomes exhibited excellent pharmacokinetic properties, crossed the blood-brain barrier, and targeted tumor cells. Once inside the cells, the liposomes were positively charged and accumulated in the mitochondria, resulting in the synergistic release of the two drugs and enhanced anti-tumor efficacy. In vitro and in vivo experiments demonstrated that these liposomes significantly inhibited tumor cell proliferation, migration, and invasion, induced apoptosis and necrosis, and interfered with mitochondrial function. They also prolonged the survival of mice with glioma, reduced tumor size, and inhibited tumor infiltration and metastasis.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2022)
Article
Agricultural Engineering
Jeanne Combes, Nabila Imatoukene, Julien Couvreur, Blandine Godon, Fanny Brunissen, Clementine Fojcik, Florent Allais, Michel Lopez
Summary: The liquid-liquid extraction in-situ product recovery process using oleyl alcohol as extractant effectively extracts p-coumaric acid from the fermentation broth and impacts strain metabolism. Biphasic fermentations increase p-CA production rates and decrease its decarboxylation into 4-vinylphenol.
BIORESOURCE TECHNOLOGY
(2021)
Article
Plant Sciences
Yaseen Mottiar, Shawn D. Mansfield
Summary: The occurrence of ester-linked p-hydroxybenzoate moieties in the lignin of poplar fibres is negatively correlated with syringyl units. This finding suggests alternative hypotheses on lignin acylation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Jun-Hui Choi, Seung Kim
Summary: This study explored the antithrombotic activity and hematological toxicity of three compounds (PA, IVA, and 4-HA) isolated from M. tricuspidata. The results showed that these compounds could reduce the formation and degrade existing blood clots, inhibit the activities of coagulation factors, prolong coagulation time, and lower platelet function and activation levels without being toxic to blood cells.
Article
Engineering, Environmental
Yang Liu, Zhenhao Zhao, Huiwen Yang, Liang Fu, Dandan Zhou
Summary: Combining microalgae cultivation with wastewater treatment and adding phenolic acids can alleviate the inhibition of toxic pollutants on microalgae growth, promote pollutant degradation and lipid accumulation. This study provides a promising new strategy for toxic wastewater treatment and bioresource recovery.
Article
Medicine, Research & Experimental
Alvaro A. Ordonez, Matthew F. L. Parker, Robert J. Miller, Donika Plyku, Camilo A. Ruiz-Bedoya, Elizabeth W. Tucker, Justin M. Luu, Dustin A. Dikeman, Wojciech G. Lesniak, Daniel P. Holt, Robert F. Dannals, Lloyd S. Miller, Steven P. Rowe, David M. Wilson, Sanjay K. Jain
Summary: This study successfully used C-11-PABA PET imaging to accurately detect and monitor pyogenic bacterial infections in multiple clinically relevant animal models. It also demonstrated the potential clinical translation of C-11-PABA for detecting and localizing a broad range of bacteria.
Article
Chemistry, Multidisciplinary
Rongsheng Li, Kou Wang, Dong Wang, Liping Xu, Yusong Shi, Zhubo Dai, Xueli Zhang
Summary: This study successfully increased the production of citronellol, geraniol, and nerol by reconstructing the biosynthetic pathways in yeast, leading to the synthesis of synthetic rose oil. This synthetic biology platform serves as a sustainable microbial source for important PVTs production.
Article
Biochemistry & Molecular Biology
Lindah S. L. Tshane, Samson S. Mashele, Godfrey R. Matowane, Susanna L. Bonnet, Tshepiso J. Makhafola, Anwar E. M. Noreljaleel, Shasank S. Swain, Mamello Sekhoacha, Chika Chukwuma
Summary: The study involved synthesizing a complex of zinc and p-hydroxybenzoic acid, which showed improved pharmacological properties with enhanced antihyperglycemic and antioxidative activities. The complex exhibited potent antiglycation and glucose uptake effects without significant cytotoxicity concerns, suggesting potential as a safe nutraceutical for diabetes and related complications.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Article
Chemistry, Physical
Hyunsoo Choi, Taeho Kim
Summary: Removal of ammonium in high-density fish cultures is traditionally achieved through time-consuming and costly biological treatments. In this study, a chitosan-based hydrogel modified with p-hydroxybenzoic acid was developed as a cheap and rapid chemical method for ammonium removal. The modified hydrogel showed enhanced adsorption capacity and stability compared to the unmodified hydrogel. Additionally, the hydrogel could be used for real-time detection of ammonium.
JOURNAL OF MOLECULAR LIQUIDS
(2023)
Review
Engineering, Environmental
Zhenhao Zhao, Wenqi Xue, Jinfeng Wang, Chongjun Zhang, Dandan Zhou
Summary: The phytohormone-like compound p-HBA can inhibit bacterial growth and promote the growth of Chlorella microalgae. This study establishes a strategy for using a trace amount of p-HBA to assist Chlorella in establishing survival dominance under bacterial contamination.
RESOURCES CONSERVATION AND RECYCLING
(2023)
Article
Food Science & Technology
C. Varela, C. Bartel, D. Espinase Nandorfy, E. Bilogrevic, T. Tran, A. Heinrich, T. Balzan, K. Bindon, A. Borneman
Summary: The use of Metschnikowia pulcherrima yeast preparations in winemaking can enhance desirable sensory attributes and reduce negative descriptors, providing winemakers with additional options to shape the sensory profile and style of wine.
AUSTRALIAN JOURNAL OF GRAPE AND WINE RESEARCH
(2021)
Review
Biotechnology & Applied Microbiology
Igor Vassilev, Nils J. H. Averesch, Pablo Ledezma, Marika Kokko
Summary: The translation mainly discusses the importance of redox balance and energy conservation of microorganisms in nature and industrial production, and the principle and advantages of achieving this balance through anodic electro-fermentation technology.
BIOTECHNOLOGY ADVANCES
(2021)
Article
Astronomy & Astrophysics
Nils Jonathan Helmuth Averesch
Summary: The article explores the potential of using microbial systems for in-situ resource utilization on Mars, highlighting two main approaches: direct conversion of atmospheric CO2 into target compounds or conversion of biomass into target compounds through a two-step process. Due to the diversity of microbial metabolism, classification is often challenging.
FRONTIERS IN ASTRONOMY AND SPACE SCIENCES
(2021)
Article
Astronomy & Astrophysics
Aaron J. Berliner, Jacob M. Hilzinger, Anthony J. Abel, Matthew J. McNulty, George Makrygiorgos, Nils J. H. Averesch, Soumyajit Sen Gupta, Alexander Benvenuti, Daniel F. Caddell, Stefano Cestellos-Blanco, Anna Doloman, Skyler Friedline, Davian Ho, Wenyu Gu, Avery Hill, Paul Kusuma, Isaac Lipsky, Mia Mirkovic, Jorge Luis Meraz, Vincent Pane, Kyle B. Sander, Fengzhe Shi, Jeffrey M. Skerker, Alexander Styer, Kyle Valgardson, Kelly Wetmore, Sung-Geun Woo, Yongao Xiong, Kevin Yates, Cindy Zhang, Shuyang Zhen, Bruce Bugbee, Douglas S. Clark, Devin Coleman-Derr, Ali Mesbah, Somen Nandi, Robert M. Waymouth, Peidong Yang, Craig S. Criddle, Karen A. McDonald, Lance C. Seefeldt, Amor A. Menezes, Adam P. Arkin
Summary: The passage discusses the potential use of biotechnologies in a crewed mission to Mars, emphasizing the need for an integrated biomanufacturing plant. It outlines the goals and constraints guiding the design of such a plant, including modules for microbial resource utilization and production of necessary materials.
FRONTIERS IN ASTRONOMY AND SPACE SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Cristian Varela, Anthony R. Borneman
Summary: Brettanomyces yeasts, particularly B. bruxellensis, play a significant role in industrial fermentation processes, either positively or negatively depending on the industry. Recent molecular biology tools can enhance our understanding of Brettanomyces physiology and improve its industrial potential.
FEMS YEAST RESEARCH
(2022)
Review
Electrochemistry
Andre Gemunde, Bin Lai, Laura Pause, Jens Kromer, Dirk Holtmann
Summary: This review discusses some of the key research questions regarding the use of redox mediators in microbial electrochemical systems, including the recycling of mediators, limitations in electron transfer rates, metabolic burden, and the interaction sites between mediators and electroactive microorganisms. To simplify the planning of mediator-based bioelectrochemical systems, molecular interaction sites are defined by their redox potential and assigned to specific mediators.
Article
Microbiology
Pablo Villarreal, Carlos Villarroel, Samuel O'Donnell, Nicolas Agier, Julian Quintero-Galvis, Tomas Pena, Roberto Nespolo, Gilles Fischer, Cristian Varela, Francisco Cubillos
Summary: Most organisms in the Saccharomycotina subphylum have high genetic diversity and diverse metabolisms and lifestyles. Lachancea cidri is an ideal yeast model for studying the interplay between genetics, ecological function, and evolution. This study used phylogenomics to explore the genetic variation of L. cidri isolates from Australia and South America and found two main lineages based on their geographic distribution. The divergence time estimation suggests that these lineages diverged during the last glacial maximum event in the Pleistocene. The study also revealed a close relationship between the French reference strain and Australian strains, likely due to human movements. Different lineages were identified within the South American population, with Patagonia showing similar genetic diversity to other S. cerevisiae lineages.
ENVIRONMENTAL MICROBIOLOGY
(2022)
Article
Microbiology
Nils J. H. Averesch, Graham K. Shunk, Christoph Kern
Summary: In space, developing advanced shielding against ionizing and non-ionizing radiation is crucial to protect astronauts. Researchers have found that certain microscopic fungi have high radioresistance and can thrive in high-radiation environments on Earth. These fungi may be able to adapt to radiation in space due to their pigment melanin. A recent experiment cultivating one type of fungus in the International Space Station showed a higher growth rate compared to a control group and a reduction in radiation.
FRONTIERS IN MICROBIOLOGY
(2022)
Editorial Material
Biotechnology & Applied Microbiology
Bin Lai, Jens Kroemer, Federico Aulenta, Hui Wu, Pablo Ivan Nikel
MICROBIAL BIOTECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Cristian Varela, Lucien Alperstein, Joanna Sundstrom, Mark Solomon, Maggie Brady, Anthony Borneman, Vladimir Jiranek
Summary: This study characterized yeast isolates from the fermentation of way-a-linah and tuba, traditional fermented beverages of Australian Indigenous people. The isolates demonstrated the potential to produce fermented beverages with unique aroma and flavor profiles, highlighting the microbial diversity associated with beverages produced by Australia's Indigenous peoples.
Article
Multidisciplinary Sciences
Rosa Santomartino, Nils J. H. Averesch, Marufa Bhuiyan, Charles S. Cockell, Jesse Colangelo, Yosephine Gumulya, Benjamin Lehner, Ivanna Lopez-Ayala, Sean McMahon, Anurup Mohanty, Sergio R. Santa R. Maria, Camilla Urbaniak, Rik Volger, Jiseon Yang, Luis Zea
Summary: Establishing sustainable approaches for human space exploration is crucial for achieving independence from terrestrial resources and for ethical considerations. Microbial biotechnologies are highlighted as a means to support sustainable processes for in situ resource utilization and loop-closure in space, with potential applications on Earth.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Nils J. H. Averesch, Aaron J. Berliner, Shannon N. Nangle, Spencer Zezulka, Gretchen L. Vengerova, Davian Ho, Cameran A. Casale, Benjamin A. E. Lehner, Jessica E. Snyder, Kevin B. Clark, Lewis R. Dartnell, Craig S. Criddle, Adam P. Arkin
Summary: As interest in human space exploration grows, it is becoming increasingly important to develop a coherent and modern strategy for mission design and planning. Biotechnology has emerged as a promising approach to enhance the resilience, flexibility, and efficiency of missions by utilizing in situ resources and reclaiming resources from waste streams. This article outlines four primary mission classes on the Moon and Mars and discusses the challenges and benefits of integrating biomanufacturing into these missions. The advancements in space-related technology development are likely to have significant implications for creating a sustainable circular bioeconomy on Earth.
NATURE COMMUNICATIONS
(2023)
Article
Biotechnology & Applied Microbiology
Laura Pause, Anna Weimer, Nicolas T. Wirth, Anh Vu Nguyen, Claudius Lenz, Michael Kohlstedt, Christoph Wittmann, Pablo I. Nikel, Bin Lai, Jens O. Kroemer
Summary: In a bio-electrochemical system, the obligate aerobe Pseudomonas putida is able to survive anaerobically and produce chemicals via oxidative pathways. The utilization of carbon in the cytoplasm is not limited by the stoichiometry of the sugar uptake routes, but could be affected by energy constraints or an oxygen-dependent regulatory mechanism.
MICROBIAL BIOTECHNOLOGY
(2023)
Article
Materials Science, Multidisciplinary
Monisha Joy Williams, Sudhaker Raboni Grace, Varnitha Manikantan, Aleyamma Alexander, Govindaraj Sri Varalakshmi, Sivaraj Ramasamy, Archana Sumohan Pillai, Israel V. M. V. Enoch, Dariela Nunez
Summary: In this study, lanthanum-doped carbon dots were developed as a nanocomposite for delivering the anticancer drug camptothecin. The nanocomposite showed promising results as a drug delivery agent, with a high encapsulation efficiency and slow release of the drug.
Article
Biotechnology & Applied Microbiology
Cristian Varela, Kathleen Cuijvers, Anthony Borneman
Summary: This study utilized amplicon-based phylotyping to map microbial communities in an Australian winery before, during, and after the 2020 vintage. The research found that resident bacterial and yeast populations changed over time, with varying relative abundance and location within the winery according to sampling date. The results provide insights into the microbial ecology during wine fermentation.
FERMENTATION-BASEL
(2021)
