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Multidisciplinary Sciences
Junko Nishio, Hideo Negishi, Mika Yasui-Kato, Shoji Miki, Kazuhiko Miyanaga, Kotaro Aoki, Takuma Mizusawa, Masami Ueno, Akira Ainai, Masafumi Muratani, Sho Hangai, Hideyuki Yanai, Hideki Hasegawa, Yoshikazu Ishii, Yasunori Tanji, Tadatsugu Taniguchi
Summary: A newly isolated phage, phiEG37k, associated with Enterococcus gallinarum, was found to protect the host from colitis by enhancing mucosal integrity, as evidenced by increased production of MUC2 in the colonized mice. These results suggest that certain bacteriophages can play a role in regulating intestinal inflammation and maintaining gut homeostasis.
SCIENTIFIC REPORTS
(2021)
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Veterinary Sciences
Yajing Guo, Guangzhi Yan, Shengnan Chen, Hui Han, Jiaming Li, Haoquan Zhang, Shicheng Luo, Mingjie Liu, Qingqing Wu, Qingxian Li, Changchun Tu, Liangzong Huang, Wenjie Gong
Summary: A new porcine parvovirus, named PPV8, was identified in pig herds in Guangdong province, China. It shares some similarities with known porcine parvoviruses but also has distinct characteristics. The virus has been detected in multiple regions in China for over two decades.
FRONTIERS IN VETERINARY SCIENCE
(2022)
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Microbiology
Ali H. A. Elbehery, Li Deng
Summary: Viruses are the most abundant life forms on Earth, but their diversity in freshwater environments is largely unknown. This study analyzed a large dataset of viral metagenomes and identified novel genomes, metabolic pathways, and taxonomic classifications. The findings provide valuable insights into freshwater viruses and serve as a resource for future virome studies.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Jian Zeng, Zijun Yang, Wentao Guo, Xiaochun Wang, Shixing Yang, Quan Shen, Hao Wang, Wen Zhang
Summary: Bats have been identified as natural reservoirs of infectious pathogens, and this study successfully isolated and sequenced two complete genomes of parechoviruses from bat feces in China, possibly representing a new species.
Article
Virology
Ziyuan Dai, Hao Wang, Shixing Yang, Quan Shen, Xiaochun Wang, Tianji Zhou, Zhanghao Feng, Wen Zhang
Summary: Through viral metagenomics and next-generation sequencing, a novel strain of bocaparvovirus was identified in the intestinal tract of tufted deer, potentially representing a new ungulate bocaparvovirus. The characterization of viruses in wildlife plays a crucial role in enhancing our understanding of genetic evolution and cross-species transmission, thereby mitigating potential threats to human and animal health.
ARCHIVES OF VIROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Liesbeth Aerts, Beatrice Miccoli, Aaron Delahanty, Hilda Witters, Sandra Verstraelen, Bart De Strooper, Dries Braeken, Patrik Verstreken
Summary: The use of animals in neuroscience and biomedical research is controversial, with policies promoting the development and adoption of animal-free methods. However, the majority of studies in Alzheimer's and Parkinson's disease research still rely on animals or animal-derived models. The limited contribution of innovative animal-free models suggests that the role and scientific value of both animal and animal-free approaches are intertwined. Calls to halt all animal experiments appear premature due to insufficient non-animal-based alternatives and their lag in development. Objective and unbiased monitoring, along with robust performance indicators of animal-free approaches, are highlighted as necessary.
Article
Immunology
Damien C. Tully, Judith A. Hahn, David J. Bean, Jennifer L. Evans, Meghan D. Morris, Kimberly Page, Todd M. Allen
Summary: Deep sequencing of hepatitis C virus (HCV) among self-described injecting partnerships showed that the majority of transmission events originate from outside of the injecting partnership, and the direction of transmission is often difficult to accurately infer, especially in high-risk networks with rapid transmission events.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Virology
Tian-Ning Liu, Cong-Xi Liu, Jing-Ying Liao, Wei-Jie Xiong, Jun-Yong Xia, Chao-Ting Xiao
Summary: In this study, a novel CRESS DNA virus was discovered in a growing pig with watery diarrhea. The genome of this virus showed high sequence similarity to porcine circo-like virus 51, but low similarity to other viruses. Phylogenetic analysis suggested that it could be a new member in the proposed family Kirkoviridae.
ARCHIVES OF VIROLOGY
(2022)
Article
Engineering, Environmental
Bridget Hegarty, Zihan Dai, Lutgarde Raskin, Ameet Pinto, Krista Wigginton, Melissa Duhaime
Summary: Viruses play an important role in microbial community ecology and evolution, but their effects in many environments, including drinking water systems, are still largely unknown. This study analyzed viral DNA sequences from drinking water metagenomes from six countries and found that environmental conditions and sample processing influenced viral composition. The use of free chlorine as a residual disinfectant resulted in lower viral taxonomic diversity and metabolic potential. Additionally, drinking water viruses carry antibiotic resistance genes and genes for survival in stressful conditions. These findings highlight the diversity of viral communities in drinking water systems and the potential impact on water quality.
Article
Microbiology
Colin J. Carlson, Rory J. Gibb, Gregory F. Albery, Liam Brierley, Ryan P. Connor, Tad A. Dallas, Evan A. Eskew, Anna C. Fagre, Maxwell J. Farrell, Hannah K. Frank, Renata L. Muylaert, Timothee Poisot, Angela L. Rasmussen, Sadie J. Ryan, Stephanie N. Seifert
Summary: Data on viral diversity on Earth are fragmented across various sources, formats, and levels of sharing, making it difficult for research on macroecology, evolution, and public health. To address this issue, a database called The Global Virome in One Network (VIRION), which contains a comprehensive collection of vertebrate-virus associations, has been established. The VIRION database is the largest open-source and open-access database of its kind, providing valuable information for studying microbiology, ecology, and evolution.
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Biochemistry & Molecular Biology
Eman Wehedy, Selvasankar Murugesan, Chinnu Reeba George, Ibrahim F. Shatat, Souhaila Al Khodor
Summary: This study aimed to optimize and develop reproducible metagenome and virome protocols using urine samples collected from healthy children, revealing significant differences in microbial composition between girls and boys, especially in the bacteriome and mycobiome of urinary samples.
Article
Immunology
Qiuyan Xie, Hongwen Yu, Zining Liu, Bangyi Zhou, Fuchun Fang, Wei Qiu, Hongle Wu
Summary: In this study, two ceRNA networks were constructed and 6 hub lncRNAs were identified, providing novel insights into the relationship between ferroptosis and irreversible pulpitis (IP). The LINC00943/hsa-miR-29a-3p/PDK4 axis was deemed to be the key node in this network.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kendra Reynaud, Anna M. McGeachy, David Noble, Zuriah A. Meacham, Nicholas T. Ingolia
Summary: We conducted an unbiased survey to quantify the regulatory activity of numerous proteins on mRNA translation and decay. Through our analysis of 50,000 protein fragments, we revealed that regulatory activity typically occurs outside RNA-binding domains and aligns with intrinsically disordered regions that can interact with other proteins.
NATURE STRUCTURAL & MOLECULAR BIOLOGY
(2023)
Article
Microbiology
Yong Li, Sai Liu, Kun Guo, Wanlong Ding, Rong Wang
Summary: This study reveals that Pseudostellaria heterophylla is infected by nine different viruses, including three novel carlaviruses and one novel amalgavirus. Additionally, known virus variants were also detected. This research enhances our understanding of the viral composition in P. heterophylla and provides valuable information for the development of molecular diagnostic techniques and control of viral diseases in this medicinal plant.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Immunology
Xiaoxiang Wang, Bo Liang, Jiehua Li, Xiaobing Pi, Peng Zhang, Xinzhu Zhou, Xiaodong Chen, Sitong Zhou, Ronghua Yang
Summary: We identified four immune signaling molecules associated with keloid and explored their pathological mechanisms. These immune-related signaling molecules may serve as novel therapeutic targets for the treatment of keloid.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Virology
Piet Maes, Gaya K. Amarasinghe, Maria A. Ayllon, Christopher F. Basler, Sina Bavari, Kim R. Blasdell, Thomas Briese, Paul A. Brown, Alexander Bukreyev, Anne Balkema-Buschmann, Ursula J. Buchholz, Kartik Chandran, Ian Crozier, Rik L. de Swart, Ralf G. Dietzgen, Olga Dolnik, Leslie L. Domier, Jan F. Drexler, Ralf Duerrwald, William G. Dundon, W. Paul Duprex, John M. Dye, Andrew J. Easton, Anthony R. Fooks, Pierre B. H. Formenty, Ron A. M. Fouchier, Juliana Freitas-Astua, Elodie Ghedin, Anthony Griffiths, Roger Hewson, Masayuki Horie, Julia L. Hurwitz, Timothy H. Hyndman, Daohong Jiang, Gary P. Kobinger, Hideki Kondo, Gael Kurath, Ivan V. Kuzmin, Robert A. Lamb, Benhur Lee, Eric M. Leroy, Jianrong Li, Shin-Yi L. Marzano, Elke Muhlberger, Sergey V. Netesov, Norbert Nowotny, Gustavo Palacios, Bernadett Palyi, Janusz T. Paweska, Susan L. Payne, Bertus K. Rima, Paul Rota, Dennis Rubbenstroth, Peter Simmonds, Sophie J. Smither, Qisheng Song, Timothy Song, Kirsten Spann, Mark D. Stenglein, David M. Stone, Ayato Takada, Robert B. Tesh, Keizo Tomonaga, Noel Tordo, Jonathan S. Towner, Bernadette van den Hoogen, Nikos Vasilakis, Victoria Wahl, Peter J. Walker, David Wang, Lin-Fa Wang, Anna E. Whitfield, John V. Williams, Gongyin Ye, F. Murilo Zerbini, Yong-Zhen Zhang, Jens H. Kuhn
ARCHIVES OF VIROLOGY
(2019)
Article
Gastroenterology & Hepatology
Chris Davis, George S. Mgomella, Ana da Silva Filipe, Eric H. Frost, Genevieve Giroux, Joseph Hughes, Catherine Hogan, Pontiano Kaleebu, Gershim Asiki, John McLauchlan, Marc Niebel, Ponsiano Ocama, Cristina Pomila, Oliver G. Pybus, Jacques Pepin, Peter Simmonds, Joshua B. Singer, Vattipally B. Sreenu, Clara Wekesa, Elizabeth H. Young, Donald G. Murphy, Manj Sandhu, Emma C. Thomson
Review
Infectious Diseases
Seilesh Kadambari, Heli Harvala, Peter Simmonds, Andrew J. Pollard, Manish Sadarangani
LANCET INFECTIOUS DISEASES
(2019)
Review
Microbiology
Peter Simmonds, Pakorn Aiewsakun, Aris Katzourakis
NATURE REVIEWS MICROBIOLOGY
(2019)
Article
Multidisciplinary Sciences
Xiaodong Zhuang, Andrea Magri, Michelle Hill, Alvina G. Lai, Abhinav Kumar, Srinivasa Bhargav Rambhatla, Claire L. Donald, Andrea F. Lopez-Clavijo, Simon Rudge, Katherine Pinnick, Wai Hoong Chang, Peter A. C. Wing, Ryan Brown, Ximing Qin, Peter Simmonds, Thomas F. Baumert, David Ray, Andrew Loudon, Peter Balfe, Michael Wakelam, Sam Butterworth, Alain Kohl, Catherine L. Jopling, Nicole Zitzmann, Jane A. McKeating
NATURE COMMUNICATIONS
(2019)
Article
Immunology
Charlotte Hedskog, Bandita Parhy, Silvia Chang, Stefan Zeuzem, Christophe Moreno, Stephen D. Shafran, Sergio M. Borgia, Tarik Asselah, Laurent Alric, Armand Abergel, Jyh-Jou Chen, Jane Collier, Dharmesh Kapoor, Robert H. Hyland, Peter Simmonds, Hongmei Mo, Evguenia S. Svarovskaia
OPEN FORUM INFECTIOUS DISEASES
(2019)
Article
Virology
Abulikemu Abudurexiti, Scott Adkins, Daniela Alioto, Sergey V. Alkhovsky, Tatjana Avsic-Zupanc, Matthew J. Ballinger, Dennis A. Bente, Martin Beer, Eric Bergeron, Carol D. Blair, Thomas Briese, Michael J. Buchmeier, Felicity J. Burt, Charles H. Calisher, Chenchen Chang, Remi N. Charrel, Il Ryong Choi, J. Christopher S. Clegg, Juan Carlos de la Torre, Xavier de Lamballerie, Fei Deng, Francesco Di Serio, Michele Digiaro, Michael A. Drebot, Xiaomei Duan, Hideki Ebihara, Toufic Elbeaino, Koray Ergunay, Charles F. Fulhorst, Aura R. Garrison, George Fu Gao, Jean-Paul J. Gonzalez, Martin H. Groschup, Stephan Guenther, Anne-Lise Haenni, Roy A. Hall, Jussi Hepojoki, Roger Hewson, Zhihong Hu, Holly R. Hughes, Miranda Gilda Jonson, Sandra Junglen, Boris Klempa, Jonas Klingstrom, Chun Kou, Lies Laenen, Amy J. Lambert, Stanley A. Langevin, Dan Liu, Igor S. Lukashevich, Tao Luo, Chuanwei Lu, Piet Maes, William Marciel de Souza, Marco Marklewitz, Giovanni P. Martelli, Keita Matsuno, Nicole Mielke-Ehret, Maria Minutolo, Ali Mirazimi, Abulimiti Moming, Hans-Peter Muehlbach, Rayapati Naidu, Beatriz Navarro, Marcio Roberto Teixeira Nunes, Gustavo Palacios, Anna Papa, Alex Pauvolid-Correa, Janusz T. Paweska, Jie Qiao, Sheli R. Radoshitzky, Renato O. Resende, Victor Romanowski, Amadou Alpha Sall, Maria S. Salvato, Takahide Sasaya, Shu Shen, Xiaohong Shi, Yukio Shirako, Peter Simmonds, Manuela Sironi, Jin-Won Song, Jessica R. Spengler, Mark D. Stenglein, Zhengyuan Su, Surong Sun, Shuang Tang, Massimo Turina, Bo Wang, Cheng Wang, Hualin Wang, Jun Wang, Taiyun Wei, Anna E. Whitfield, F. Murilo Zerbini, Jingyuan Zhang, Lei Zhang, Yanfang Zhang, Yong-Zhen Zhang, Yujiang Zhang, Xueping Zhou, Liying Zhu, Jens H. Kuhn
ARCHIVES OF VIROLOGY
(2019)
Article
Virology
Gaya K. Amarasinghe, Maria A. Ayllon, Yiming Bao, Christopher F. Basler, Sina Bavari, Kim R. Blasdell, Thomas Briese, Paul A. Brown, Alexander Bukreyev, Anne Balkema-Buschmann, Ursula J. Buchholz, Camila Chabi-Jesus, Kartik Chandran, Chiara Chiapponi, Ian Crozier, Rik L. de Swart, Ralf G. Dietzgen, Olga Dolnik, Jan F. Drexler, Ralf Duerrwald, William G. Dundon, W. Paul Duprex, John M. Dye, Andrew J. Easton, Anthony R. Fooks, Pierre B. H. Formenty, Ron A. M. Fouchier, Juliana Freitas-Astua, Anthony Griffiths, Roger Hewson, Masayuki Horie, Timothy H. Hyndman, Daohong Jiang, Elliott W. Kitajima, Gary P. Kobinger, Hideki Kondo, Gael Kurath, Ivan V. Kuzmin, Robert A. Lamb, Antonio Lavazza, Benhur Lee, Davide Lelli, Eric M. Leroy, Jianrong Li, Piet Maes, Shin-Yi L. Marzano, Ana Moreno, Elke Muhlberger, Sergey V. Netesov, Norbert Nowotny, Are Nylund, Arnfinn L. Okland, Gustavo Palacios, Bernadett Palyi, Janusz T. Paweska, Susan L. Payne, Alice Prosperi, Pedro Luis Ramos-Gonzalez, Bertus K. Rima, Paul Rota, Dennis Rubbenstroth, Mang Shi, Peter Simmonds, Sophie J. Smither, Enrica Sozzi, Kirsten Spann, Mark D. Stenglein, David M. Stone, Ayato Takada, Robert B. Tesh, Keizo Tomonaga, Noel Tordo, Jonathan S. Towner, Bernadette van den Hoogen, Nikos Vasilakis, Victoria Wahl, Peter J. Walker, Lin-Fa Wang, Anna E. Whitfield, John V. Williams, F. Murilo Zerbini, Tao Zhang, Yong-Zhen Zhang, Jens H. Kuhn
ARCHIVES OF VIROLOGY
(2019)
Article
Evolutionary Biology
Jakub Barylski, Francois Enault, Bas E. Dutilh, Margo B. P. Schuller, Robert A. Edwards, Annika Gillis, Jochen Klumpp, Petar Knezevic, Mart Krupovic, Jens H. Kuhn, Rob Lavigne, Hanna M. Oksanen, Matthew B. Sullivan, Ho Bin Jang, Peter Simmonds, Pakorn Aiewsakun, Johannes Wittmann, Igor Tolstoy, J. Rodney Brister, Andrew M. Kropinski, Evelien M. Adriaenssens
SYSTEMATIC BIOLOGY
(2020)
Article
Virology
Franziska Hufsky, Bashar Ibrahim, Sejal Modha, Martha R. J. Clokie, Stefanie Deinhardt-Emmer, Bas E. Dutilh, Samantha Lycett, Peter Simmonds, Volker Thiel, Aare Abroi, Evelien M. Adriaenssens, Marina Escalera-Zamudio, Jenna Nicole Kelly, Kevin Lamkiewicz, Lu Lu, Julian Susat, Thomas Sicheritz, David L. Robertson, Manja Marz
News Item
Virology
Peter J. Walker, Stuart G. Siddell, Elliot J. Lefkowitz, Arcady R. Mushegian, Donald M. Dempsey, Bas E. Dutilh, Balazs Harrach, Robert L. Harrison, R. Curtis Hendrickson, Sandra Junglen, Nick J. Knowles, Andrew M. Kropinski, Mart Krupovic, Jens H. Kuhn, Max Nibert, Luisa Rubino, Sead Sabanadzovic, Peter Simmonds, Arvind Varsani, Francisco Murilo Zerbini, Andrew J. Davison
ARCHIVES OF VIROLOGY
(2019)
Article
Virology
Lieke Brouwer, Kimberley S. M. Benschop, Dung Nguyen, Everlyn Kamau, Dasja Pajkrt, Peter Simmonds, Katja C. Wolthers
Article
Virology
Agathe M. G. Colmant, Jody Hobson-Peters, Teun A. P. Slijkerman, Jessica J. Harrison, Gorben P. Pijlman, Monique M. van Oers, Peter Simmonds, Roy A. Hall, Jelke J. Fros
Summary: The study found that the zinc-finger antiviral protein (ZAP) in vertebrate cells effectively prevents insect-specific flaviviruses (ISF) from replicating in vertebrate cells. This research reveals how ISFs are inhibited, providing new insights into flavivirus evolution and mechanisms associated with host switching.
Article
Microbiology
Heli Harvala, Kimberley S. M. Benschop, Natasa Berginc, Sofie Midgley, Katja Wolthers, Peter Simmonds, Susan Feeney, Jean-Luc Bailly, Audrey Mirand, Thea K. Fischer
Summary: ENPEN has developed standardized protocols for a multi-center study in Europe to collect data on EV and PeV infections, providing guidance for future prevention measures and policy making.
Article
Immunology
Everlyn Kamau, Heli Harvala, Soile Blomqvist, Dung Nguyen, Peter Horby, Richard Pebody, Peter Simmonds
EMERGING INFECTIOUS DISEASES
(2019)