Article
Biotechnology & Applied Microbiology
Lorena R. Lizarraga-Valderrama, Giulia Ronchi, Rinat Nigmatullin, Federica Fregnan, Pooja Basnett, Alexandra Paxinou, Stefano Geuna, Ipsita Roy
Summary: The study demonstrated that PHA-NGCs are highly promising in promoting peripheral nerve regeneration, showing comparable outcomes to autografts in functional evaluation and nerve morphology.
BIOENGINEERING & TRANSLATIONAL MEDICINE
(2021)
Article
Anatomy & Morphology
Rebecca A. Wachs, Steven M. Wellman, Stacy L. Porvasnik, Emily H. Lakes, R. Chase Cornelison, Young Hye Song, Kyle D. Allen, Christine E. Schmidt
Summary: Peripheral nerve injury causes loss of motor and sensory function, and autologous nerve grafts are the gold standard for repair. However, there are limitations such as limited tissue supply and size mismatch. Decellularized cadaveric nerve tissue can alleviate some of these limitations. This study compares the utility of apoptosis-decellularized peripheral nerve scaffolds to detergent-decellularized scaffolds and isograft controls, and shows similar functional and histological outcomes.
CELLS TISSUES ORGANS
(2022)
Article
Engineering, Biomedical
Yao Liu, Xiaonong Zhang, Chunsheng Xiao, Bin Liu
Summary: Peripheral nerve injury (PNI) is a complex disease that commonly affects young adults and has limited treatment options and poor clinical outcomes. Tissue-engineered hydrogels have shown promising results in promoting neural tissue regeneration and recovery of impaired neural function. This review discusses recent advances and various therapeutic strategies of hydrogels in peripheral nerve repair, as well as the prospects and challenges in their application for PNI treatment.
MATERIALS TODAY BIO
(2023)
Review
Biotechnology & Applied Microbiology
Rebecca Powell, Despoina Eleftheriadou, Simon Kellaway, James B. Phillips
Summary: This review discusses the physical processes by which natural biomaterials mimic the function of the extracellular matrix and regulate cellular behavior, as well as highlights representative cases of controllable cell microenvironments developed through the combination of cell biology and tissue engineering principles.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Francesca Camponogara, Federica Zanotti, Martina Trentini, Elena Tiengo, Ilaria Zanolla, Elham Pishavar, Elisa Soliani, Marco Scatto, Paolo Gargiulo, Ylenia Zambito, Stefano De Luca, Letizia Ferroni, Barbara Zavan
Summary: Regenerative medicine utilizes stem cell therapy and tissue engineering strategies to guide the healing or replacement of damaged tissues or organs. Polymers play a crucial role in this field as they can be used as principal components, coatings, or vehicles to functionalize various biomaterials. This review provides an overview of the current state of polymer research in Italy for regenerative medicine, highlighting the importance for the development of novel biomaterials and strategies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Chemistry, Multidisciplinary
Ying Li, Shang Lv, Huipu Yuan, Gang Ye, Wenbo Mu, Yong Fu, Xuan Zhang, Zhiying Feng, Yong He, Wei Chen
Summary: The study compared three different treatment strategies for peripheral nerve regeneration and found that implanting multiscale scaffolds preloaded with Schwann cell progenitors derived from neural crest stem cells is the most effective strategy for promoting regeneration.
ADVANCED FUNCTIONAL MATERIALS
(2021)
Article
Polymer Science
Josefa Alarcon Apablaza, Maria Florencia Lezcano, Karina Godoy Sanchez, Gonzalo H. Oporto, Fernando Jose Dias
Summary: This scoping review summarizes the adequate quantitative/morphometric parameters of polymeric nerve guide conduits (NGCs) that provide a supportive environment for nerve regeneration. Optimal morphometric characteristics, such as wall thickness, fiber size, pore size, and porosity, are identified to enhance nerve regeneration and reduce the need for experimental studies.
Article
Engineering, Biomedical
Tong Qi, Xu Zhang, Xiaosong Gu, Shusen Cui
Summary: A novel bionic tissue-engineered nerve (TEN) graft with a biomimetic structure and composition is designed. The graft is composed of a chitin helical scaffold fabricated by mold casting and acetylation, and a fibrous membrane electrospun on its outer layer. The lumen of the graft is filled with human bone mesenchymal stem cell-derived extracellular matrix and fibers. Animal experiment results show that the repair effects of the bionic TEN grafts are similar to autografts. This study demonstrates the great potential of the bionic TEN graft for repairing clinical peripheral nerve defects.
ADVANCED HEALTHCARE MATERIALS
(2023)
Review
Medicine, Research & Experimental
Lingchi Kong, Xin Gao, Yun Qian, Wei Sun, Zhengwei You, Cunyi Fan
Summary: This review integrates the current understanding of the biomechanical microenvironment associated with peripheral nerve function and regeneration, introduces promising tissue engineering strategies based on biomechanical modulation, and provides suggestions and prospects for future directions.
Review
Biotechnology & Applied Microbiology
Zhiwen Yan, Cheng Chen, Gonzalo Rosso, Yun Qian, Cunyi Fan
Summary: This review examines the role of two-dimensional nanomaterials in promoting peripheral nerve regeneration by facilitating angiogenesis and supporting new vessel formation. The potential of two-dimensional nanomaterials as a solution for long-range peripheral nerve defects is highlighted, with strategies aimed at addressing energy deficiency post-injury being proposed to enhance therapeutic effects.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Engineering, Biomedical
Melissa L. D. Rayner, Adam G. E. Day, Kulraj S. Bhangra, John Sinden, James B. Phillips
Summary: This study provides evidence supporting the effectiveness of using engineered neural tissue (EngNT) as a replacement for nerve autografts, with functional regeneration assessed through histological and electrophysiological outcome measures demonstrating equivalent performance.
ACTA BIOMATERIALIA
(2021)
Article
Polymer Science
Fengshi Zhang, Meng Zhang, Songyang Liu, Ci Li, Zhentao Ding, Teng Wan, Peixun Zhang
Summary: This review summarizes the recent applications of conductive hydrogels to enhance peripheral nerve regeneration. Conductive hydrogels, with their unique physical and electrical properties, can mimic the biological and electrical characteristics of human nervous tissue.
Review
Clinical Neurology
Yin Li, Zhenjiang Ma, Ya Ren, Dezhi Lu, Tao Li, Wentao Li, Jinwu Wang, Hui Ma, Jie Zhao
Summary: This review summarizes the pathophysiology and tissue-engineered repairing strategies of PNI, discussing the scaffolds, seed cells, and the role of 3D printing in tissue engineering in nerve regeneration.
FRONTIERS IN NEUROLOGY
(2021)
Review
Chemistry, Multidisciplinary
Kai Liu, Lesan Yan, Ruotao Li, Zhiming Song, Jianxun Ding, Bin Liu, Xuesi Chen
Summary: Nerve autograft is currently the preferred treatment for peripheral nerve defects but has limitations. Emerging nerve guide conduits (NGCs), especially those made through 3D printing, offer effective platforms for repairing peripheral nerve defects.
Review
Polymer Science
Josefa Alarcon Apablaza, Maria Florencia Lezcano, Alex Lopez Marquez, Karina Godoy Sanchez, Gonzalo H. Oporto, Fernando Jose Dias
Summary: The study summarizes the main morphological characteristics of nerve guide conduits (NGC) that influence nerve regeneration, including diameter, wall thickness, porosity, pore size, fiber alignment, and thickness.