Article
Cell Biology
Xin He, Yue Xie, Qiongping Zheng, Zeyu Zhang, Shanshan Ma, Junyu Li, Mingtao Li, Qiaoying Huang
Summary: The transcription factor TFE3 has been found to play a crucial role in maintaining autophagy and the survival of dopaminergic neurons in Parkinson's disease. Activation of TFE3 may serve as a promising strategy for PD therapy.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Bingna Cai, Xiangtan Zhao, Lianxiang Luo, Peng Wan, Hua Chen, Jianyu Pan
Summary: In this study, a novel heteropolysaccharide called SP90-1 with immunostimulatory and antitumor activity was discovered from Spirulina platensis. The study found that SP90-1 significantly enhanced the phagocytic capacity of cells, promoted the secretion of certain substances, and remarkably inhibited the growth of certain tumor cells.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2022)
Article
Food Science & Technology
Yuhuan Liu, Yu Wang, Leipeng Cao, Zhenghua Huang, Yue Zhou, Ruijuan Fan, Congmiao Li
Summary: The dried cell weight of Spirulina platensis decreased after five cultivation cycles, while the intracellular and extracellular polysaccharide content increased. The highest yield of intracellular polysaccharide was achieved with thermal high-pressure homogenization. IPS had a more fibrous and porous structure with higher glucose content and molecular weight compared to EPS, indicating its superior viscosity and water holding capacity. IPS exhibited higher radical scavenging capacity and total phenol content, while EPS showed stronger metal ion chelating capacity.
Article
Biochemistry & Molecular Biology
Matthew L. Neal, Eric E. Beier, Muhammad M. Hossain, Alexa Boyle, Jiaying Zheng, Chunki Kim, Isha Mhatre-Winters, Long-Jun Wu, Jason R. Richardson
Summary: Through data mining and experiments, it was found that the expression of the HVCN1 gene is increased in the brains of Parkinson's disease patients, and the neuroinflammatory response mediated by the Hv1 protein is a crucial factor in the pathogenesis of Parkinson's disease. It was also observed that Hv1 deficiency can reduce neuroinflammation and protect dopaminergic neurons, indicating its potential as a novel target for neuroprotection in Parkinson's disease.
Article
Chemistry, Multidisciplinary
Jian Li, Yaqi Zhang, Shen Yang, Zhenhua Lu, Guiling Li, Jingwen Liu, Bo Zhou, Daren Wu, Li Wang
Summary: Crude polysaccharides from Spirulina platensis were isolated and fractionated into two purified fractions PSP-1 and PSP-2, which were found to be branching dextran composed mainly of glucose. These glucans can enhance macrophages' phagocytic ability, iNOS activity, NO production, and IL-6 mRNA expression, indicating potential immunomodulatory activity.
Article
Biochemistry & Molecular Biology
Chengcheng Xu, Yao Wu, Lili Tang, Yan Liang, Yang Zhao
Summary: The study demonstrates that Cistanoside A (CA) has neuroprotective effects against Parkinson's disease (PD) by promoting the PINK1/Parkin/p62 pathway to accelerate the degradation of damaged mitochondria, reducing oxidative stress.
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2023)
Article
Chemistry, Analytical
Xiaohua Jiang, Dabin Wang, Weiran Wu, Fengmin Li
Summary: This study investigated the effects and degradation mechanisms of enrofloxacin on the growth of Spirulina platensis. Enrofloxacin at low concentrations stimulated biomass accumulation, while high concentrations inhibited growth and remediation ability. Environmental stress caused changes in photosynthetic pigments and primary biocomponents, reflecting the adaptation of Spirulina platensis to the negative effects of enrofloxacin. The degradation products of enrofloxacin were identified, suggesting dealkylation and oxidation reactions primarily at the piperazine group. The study results contribute to understanding the role of enrofloxacin in Spirulina platensis growth and provide important support for risk assessment and hazard reduction.
ENVIRONMENTAL SCIENCE-PROCESSES & IMPACTS
(2023)
Article
Agriculture, Multidisciplinary
Vinayak Uppin, Shylaja M. Dharmesh, R. Sarada
Summary: Spirulina polysaccharide (Sp) exhibits inhibitory effects on galectin-3 modulation and cell proliferation in gastric cancer cells. It also shows significant inhibition of hemeagglutination mediated by galectin-3 and provides cytoprotective effects. These findings suggest the potential therapeutic application of Sp in gastric cancer management.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2022)
Article
Nutrition & Dietetics
Ning Zhou, Hairong Long, Lian Yu, Xianghua Xia, Zhenjun Zhu, Xiaoling Liu
Summary: This study found that selenium-containing polysaccharide from Spirulina platensis (Se-SPP) alleviates cadmium-induced toxicity in mice by targeting liver inflammation and gut microbiota. The beneficial effects were achieved through upregulation of antioxidant enzyme activity, restoration of the intestinal barrier, and modulation of inflammation-related substances in the liver.
FRONTIERS IN NUTRITION
(2022)
Article
Cell Biology
Tingting Zuo, Mo Xie, Meiling Yan, Zengyan Zhang, Tian Tian, Ying Zhu, Lihua Wang, Yanhong Sun
Summary: This study used synchrotron FTIR micro-spectroscopy technique to analyze the in situ changes of biochemical components and lipid peroxidation levels in dopaminergic neurons in PD mice treated with acupuncture. The results showed that acupuncture treatment can inhibit the level of lipid peroxides in dopaminergic neurons and protect neurons from oxidative damage.
CELL PROLIFERATION
(2022)
Article
Geriatrics & Gerontology
Zijie Wang, Dingting Yang, Yiru Jiang, Yong Wang, Mengxi Niu, Chong Wang, Hong Luo, Huaxi Xu, Jingwen Li, Yun-wu Zhang, Xian Zhang
Summary: Parkinson's disease (PD) is a common neurodegenerative movement disorder characterized by the degeneration of dopaminergic neurons. Loss-of-function mutations in the RAB39B gene have been linked to early-onset PD. In this study, Rab39b KO mice were treated with MPTP to investigate the role of RAB39B in PD pathogenesis. Surprisingly, RAB39B deficiency did not affect MPTP-induced impairments, suggesting that its involvement in PD requires further investigation.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Integrative & Complementary Medicine
Wen Jing, Zhang Yuan-Qiang, Liu Dong-Qing, Yao Xu-Tao, Jiang Hua, Zhang Yu-Bin
Summary: This study aimed to explore the neuroprotective effects and pharmacological mechanism of Demethylenetetrahydroberberine (DMTHB) on Parkinson's disease. The results showed that DMTHB could alleviate behavioral disorders, protect dopaminergic neurons, and exhibit multiple-target effects including anti-apoptotic, anti-inflammatory, and antioxidant properties.
CHINESE JOURNAL OF NATURAL MEDICINES
(2022)
Review
Cell Biology
Leonie M. Heger, Rachel M. Wise, J. Tabitha Hees, Angelika B. Harbauer, Lena F. Burbulla
Summary: This review assesses mitochondrial phenotypes in iPSC-derived neurons from PD patients, focusing on the role of mitochondrial respiration, morphology, trafficking, mitophagy, and calcium handling in health and disease. It also summarizes the unique advantages and challenges of iPSC disease modeling for future mechanistic and therapeutic applications, highlighting the importance of studying mitochondrial dynamics in PD pathophysiology.
Article
Neurosciences
Xin Gong, Mengyi Huang, Lei Chen
Summary: This study aims to investigate the effect and mechanism of miR-132-3p in regulating neuroinflammation and dopaminergic neuron degeneration in Parkinson's disease (PD). The results showed elevated expression of miR-132-3p and decreased expression of GLRX in PD patients and cell models. Overexpression of miR-132-3p induced activation of microglial cells, which could be reversed by GLRX overexpression.
Article
Neurosciences
Xiaoyi Xu, Xin He, Shanshan Ma, Mingtao Li, Qiaoying Huang
Summary: Research has shown that in the mouse model of Parkinson's disease, CREB inactivation leads to the downregulation of Nurr1, while restoring CREB activity can rescue Nurr1 expression and provide neuroprotection.
NEUROSCIENCE LETTERS
(2021)