Article
Biochemistry & Molecular Biology
Fengqi Yang, Jimin Hyun, D. P. Nagahawatta, Young Min Kim, Moon-Soo Heo, You-Jin Jeon
Summary: Ishige okamurae Celluclast extract (IOC), a sulfated polysaccharide extracted from brown algae, possesses antioxidant, anti-inflammatory, and photoprotective activities, making it suitable for the cosmeceutical and functional food industries.
Article
Biochemistry & Molecular Biology
Oh Yun Kwon, Seung Ho Lee
Summary: The study demonstrated that Ishige okamurae extract could attenuate neurodegenerative processes by regulating MAPKs/Nrf-2/HO-1 antioxidant pathways, inhibiting neuronal dysregulation induced by TMT and glutamate.
Article
Chemistry, Medicinal
Seung-Hong Lee, Mihyang Kim, Mi Hwa Park
Summary: The study demonstrated that DPHC from Ishige okamurae has protective effects against oxidative damage in osteoblastic cells induced by H2O2 through the BMP2/Runx2 signaling pathway, improving cellular functions and promoting osteoblast differentiation. DPHC also reduced the expression levels of bone resorption-promoting factors and inhibited the generation of reactive oxygen species induced by oxidative stress.
Article
Chemistry, Medicinal
Su-Hyeon Cho, Hyun-Soo Kim, Hye-Yeon Jung, Jae-Il Park, You-Jee Jang, Juhee Ahn, Kil-Nam Kim
Summary: The study found that Ishophloroglucin A (IPA) has an effect on osteoclasts and osteoblasts in vitro. IPA inhibited osteoclastogenesis in RAW 264.7 cells and promoted osteoblastogenesis in MG-63 cells. This study suggests that IPA may be effective in treating bone diseases such as osteoporosis.
Article
Biotechnology & Applied Microbiology
Nalae Kang, Seyeon Oh, Seo-Young Kim, Hyosang Ahn, Myeongjoo Son, Soo-Jin Heo, Kyunghee Byun, You-Jin Jeon
Summary: In this study, the anti-obesity effects of ishophloroglucin A from Ishige okamurae were explored, targeting the appetite hormone leptin. The results showed that ishophloroglucin A possesses anti-obesity effects through the leptin signaling pathway, making it a potential sustainable and natural therapeutic ingredient for reducing obesity in leptin-deficient individuals.
ALGAL RESEARCH-BIOMASS BIOFUELS AND BIOPRODUCTS
(2022)
Article
Biochemistry & Molecular Biology
Yu An Lu, Yunfei Jiang, Hye-Won Yang, Jin Hwang, You-Jin Jeon, Bomi Ryu
Summary: This study is the first to investigate the effects of DPHC from Ishige okamurae on calcium levels and vasodilation. The results suggest that DPHC stimulates NO production by modulating calcium levels and expression of AchR and VEGFR2, potentially ameliorating cardiovascular diseases by improving vascular function.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Chemistry, Medicinal
Hye-Won Yang, Seyeon Oh, Dong-Min Chung, Minyoung Seo, Shin Jae Park, You-Jin Jeon, Kyunghee Byun, BoMi Ryu
Summary: This study evaluated the effect of Ishige okamurae extract (IO) and its component, Ishophloroglucin A (IPA), on muscle atrophy induced by dexamethasone. The results showed that IO and IPA supplementation improved muscle weight and width, enhanced grip strength, and regulated muscle protein metabolism by modulating gene expression related to protein synthesis, degradation, and muscle growth activation or inhibition.
Article
Chemistry, Medicinal
Seung Tae Im, Hyun-Soo Kim, Won-Kyo Jung, Seung-Hong Lee
Summary: This study found that Ishophloroglucin A (IPA) has a high inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) and can attenuate adipogenesis. The molecular docking analysis revealed a stable binding affinity between IPA and PTP1B, suggesting their interaction. These findings suggest that IPA may be a promising natural compound for the treatment of obesity and related diseases.
Article
Biochemistry & Molecular Biology
Darya Meshalkina, Elena Tsvetkova, Anastasia Orlova, Renata Islamova, Maria Grashina, Daria Gorbach, Vladimir Babakov, Antonio Francioso, Claudia Birkemeyer, Luciana Mosca, Elena Tarakhovskaya, Andrej Frolov
Summary: Phaeophyceae, or brown algae, play a significant role in cold and temperate seas as they are rich in biologically active natural products, particularly phlorotannins. These phlorotannins are complex polyphenols with diverse structures, known for their strong antioxidant properties and broad range of biological activities. While the biological activities of extractable intracellular phlorotannins have been well-studied, the properties of cell wall-bound polyphenol fraction are still largely unknown. In this study, the antioxidant, cytotoxic, neuroprotective, and antibacterial properties of the cell wall-bound phlorotannin fractions from two representatives of the order Fucales, Fucus vesiculosus and Pelvetia canaliculata, were investigated. The cell wall-bound phlorotannins exhibited softer antioxidant activity, stronger antibacterial properties, and lower cytotoxicity compared to the intracellular fraction. However, both sub-cellular phlorotannin fractions of F. vesiculosus and P. canaliculata showed similar neuroprotective effects. Therefore, due to their lower cytotoxicity, cell wall-bound phlorotannins hold promise as antioxidants and neuroprotectors.
Review
Biotechnology & Applied Microbiology
Shou Jin Phang, Huey Xhin Teh, Mee Lee Looi, Bavani Arumugam, Mh Busra Fauzi, Umah Rani Kuppusamy
Summary: Phlorotannins, derived from marine brown algae, possess excellent antioxidant properties and can be potential therapeutics for oxidative stress-mediated diseases. However, their poor bioavailability hinders their translational applications, and research on encapsulation techniques is needed to enhance their value.
JOURNAL OF APPLIED PHYCOLOGY
(2023)
Article
Engineering, Environmental
Farideh Pahlavan, Anthony Lamanna, Ki-Bum Park, Sk Faisal Kabir, Joo-Sik Kim, Elham H. Fini
Summary: This study investigated the impact of phenol-rich bio-oils on the durability of asphalt binder. The results showed that phenol-rich bio-oils can slow down the aging process of asphalt binder, and the antioxidant activity of bio-oils is mainly influenced by the content and molecular structures of their phenolic compounds.
RESOURCES CONSERVATION AND RECYCLING
(2022)
Article
Biochemistry & Molecular Biology
Jieyu Yan, Haiwang Lai, Boning Zeng, Liqing Wang, Feiyue Xing, Pu Xiao
Summary: Phototherapy is a promising noninvasive and efficient therapeutic method that can replace traditional treatments. This study reveals the antitumor effects of TPO on breast cancer, showing inhibition of cell growth and promotion of cell apoptosis through a mitochondrial pathway. The results provide a proof of concept for the potential application of TPO as a novel photolatent therapeutic drug.
PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Archana Yadav, Chetna Singh
Summary: This study investigated the role of COX-2 in MB-and PQ-induced toxicity in PMNs. The results showed that MB and PQ induced oxidative stress and apoptosis in PMNs and HL60 cells, with the involvement of COX-2 and activation of NF-kappa B and JNK signaling pathways.
PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Yuki Matsuki, Nagisa Ohnishi, Yuki Kakeno, Shunsuke Takemoto, Takuya Ishii, Kazunori Nagao, Hirohisa Ohmiya
Summary: This article discusses the successful application of NHC-catalyzed aryl radical reactions in various arylations. The method allows for the generation of aryl radicals from halides through single electron transfer processes, providing a metal-free approach for radical reactions.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Medicinal
Ryosuke Taniguchi, Chihiro Ito, Saki Keitoku, Yoshiaki Miyake, Masataka Itoigawa, Takuya Matsui, Toshiyuki Shibata
Summary: This study identified three phlorotannins from Sargassum carpophyllum and isolated and identified tetraphlorethol C and pentaphlorethol A for the first time from brown seaweed collected from the East China Sea and coastal areas of Japan. These phlorethols showed good antioxidant properties in the experiments.
NATURAL PRODUCT COMMUNICATIONS
(2022)
