期刊
JOURNAL OF BIOSCIENCES
卷 39, 期 3, 页码 381-388出版社
INDIAN ACAD SCIENCES
DOI: 10.1007/s12038-014-9418-z
关键词
Binding motif; beta-integrin; proteins; recognition; WSSV
类别
资金
- National Basic Research Program (973) of China [2012CB114401]
- National Science Foundation of China [30871942]
- Shrimp Research in the Public Interest [201103034]
- Taishan Scholar Project Fund of Shandong
The recognition and attachment of virus to its host cell surface is a critical step for viral infection. Recent research revealed that beta-integin was involved in White spot syndrome virus (WSSV) infection. In this study, the interaction of beta-integrin with structure proteins of WSSV and motifs involved in WSSV infection was examined. The results showed that envelope proteins VP26, VP31, VP37, VP90 and nucleocapsid protein VP136 interacted with LvInt. ROD-, YGL- and LDV-related peptide functioned as motifs of WSSV proteins binding with beta-integrin. The beta-integrin ligand of RGDT had better blocking effect compared with that of YGL- and LDV-related peptides. In vivo assay indicated that ROD-, LDV- and YGL-related peptides could partially block WSSV infection. These data collectively indicate that multiple proteins were involved in recognition of P-integrin. Identification of proteins in WSSV that are associated with P-integrin will assist development of new agents for effective control of the white spot syndrome.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据