Article
Agriculture, Dairy & Animal Science
Liliana Rytel, Ignacy Gonkowski, Waldemar Grzegorzewski, Joanna Wojtkiewicz
Summary: The enteric nervous system (ENS) located in the gastrointestinal tract regulates stomach and intestine functions. Nitric oxide (NO) synthesized by enteric neurons is involved in intestinal regulation. Inflammation leads to an increase in nitrergic nerve structures, suggesting NO's involvement in pathological processes in the bowel.
Article
Gastroenterology & Hepatology
Jackson L. K. Yip, Gayathri K. Balasuriya, Sarah J. Spencer, Elisa L. Hill-Yardin
Summary: Mice and rats have fundamental differences in colon motility and response to inhibition of nitric oxide neurotransmitter, making them important animal models for different questions in gastrointestinal research.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Atchariya Chanpong, Osvaldo Borrelli, Nikhil Thapar
Summary: The enteric nervous system (ENS) is a critical nervous system in the gastrointestinal tract that controls key functions and is affected by the microbiota and other nervous systems. Its development during early life plays a significant role in human health and disease. Dysbiosis and pathogenic microorganisms may impact the integrity and function of the ENS. This article explores the relationship between the development and integrity of the ENS and the potential impact of dysbiosis and pathogenic microorganisms.
Review
Developmental Biology
Yi-Ning Kang, Candice Fung, Pieter Vanden Berghe
Summary: This review focuses on the innervation of the gut during embryonic development, highlighting the importance of intrinsic and extrinsic nerves in ensuring proper gut function. The three-dimensional architecture of innervation and the differences in development along the longitudinal and circumferential axes of the gut are discussed. In addition, the formation of intrinsic and extrinsic innervation, as well as the potential influences of external microbial and nutritional cues or neuroimmune interactions on gut innervation development, are reviewed.
Review
Biochemistry & Molecular Biology
Tinh Thi Nguyen, Peter Baumann, Oliver Tuescher, Sandra Schick, Kristina Endres
Summary: The gut and the brain communicate through various channels and interactions, collectively known as the gut-brain axis. The aging of the enteric nervous system (ENS) in the gut can lead to gastrointestinal dysfunction and contribute to age-related diseases of the brain. Understanding the mechanisms of the aging ENS can provide insights into the diagnosis and treatment of neurodegenerative diseases like Alzheimer's and Parkinson's.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Developmental Biology
Nandor Nagy, Tamas Kovacs, Rhian Stavely, Viktoria Halasy, Adam Soos, Emoke Szocs, Ryo Hotta, Hannah Graham, Allan M. Goldstein
Summary: The migration and proliferation of ENCCs are crucial for ENS formation, with the ceca playing an important role in ENS development. The non-canonical Wnt signaling pathway regulates ENCC differentiation by inhibiting enteric neuronal differentiation.
Article
Environmental Sciences
Jing Wang, Xinyao Meng, Chenzhao Feng, Jun Xiao, Xiang Zhao, Bo Xiong, Jiexiong Feng
Summary: Hirschsprung disease (HSCR) is a congenital disease characterized by a deficiency of enteric neurons, with genetic and environmental factors playing a role. Research suggests that the UV filter component BP-3 may inhibit the development of the enteric nervous system (ENS) through modulation of the MAPK/ERK signaling pathway. These findings provide insights into potential mechanisms for HSCR development and suggest therapeutic targets for intervention.
Review
Biology
Xindi Wang, Chenbo Ding, Hua-Bing Li
Summary: The gut is a crucial organ for digestion, immunity, and metabolism. The interaction between the enteric nervous system (ENS) and immune cells plays a vital role in maintaining intestinal homeostasis and preventing diseases. This review summarizes the importance of ENS-immune cell interactions in intestinal development and diseases, providing insights for potential immunotherapy targeting the ENS.
SCIENCE CHINA-LIFE SCIENCES
(2023)
Proceedings Paper
Gastroenterology & Hepatology
Nicolas R. Chevalier
Summary: This article outlines the development of intestinal motility in chicken embryos. The initial contractions are calcium waves driven by circular smooth muscles, which become regular when interstitial cells of Cajal become electrically active. As development progresses, longitudinal smooth muscle contractions become prominent and are controlled by the enteric nervous system through inhibitory neurotransmission. This leads to circular-longitudinal antagonism, the migrating motor complex, and the law of the intestine, which is a polarized pressure response.
ENTERIC NERVOUS SYSTEM II
(2022)
Article
Biology
Tao Li, Marco Morselli, Trent Su, Mulugeta Million, Muriel Larauche, Matteo Pellegrini, Yvette Tache, Pu-Qing Yuan
Summary: The porcine gut, specifically the colon, is shown to be a relevant model for studying human colonic function and neuromodulation. Transcriptomic analyses reveal highly conserved programs between pig and human, supporting the potential of using pigs as predictors in translational studies.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biology
Die Dai, Fandie Dai, Jingchao Chen, Menglu Jin, Mingyue Li, Desheng Hu, Zhi Liu, Zunjian Zhang, Fengguo Xu, Wei-Hua Chen
Summary: This study found that intestinal ischemia-reperfusion significantly affects the metabolic profiles of organs, showing notable correlations between gut content metabolism and other organs during IIR. Changes in neurotransmitters in gut contents during IIR were found to have significant correlations with remote organs.
COMMUNICATIONS BIOLOGY
(2022)
Article
Oncology
Leticia Villalba-Benito, Daniel Lopez-Lopez, Ana Torroglosa, Carlos S. Casimiro-Soriguer, Berta Luzon-Toro, Raquel Maria Fernandez, Maria Jose Moya-Jimenez, Guillermo Antinolo, Joaquin Dopazo, Salud Borrego
Summary: This study reveals a decrease in global DNA methylation in HSCR patients in CpG context, along with a greater hypomethylation of DMRs. The downregulation of Methyltransferase 3b in EPCs from HSCR patients correlates with these findings. New potential susceptibility genes for HSCR have been identified through the comparative analysis of DMRs, highlighting the importance of an adequate methylation pattern for proper ENS development.
CLINICAL EPIGENETICS
(2021)
Review
Multidisciplinary Sciences
R. Diposarosa, N. A. Bustam, Edhyana Sahiratmadja, P. S. Susanto, Y. Sribudiani
Summary: Hirschsprung's disease is a developmental disorder of the enteric nervous system derived from neural crest cells, and changes in gene expression may contribute to its pathogenesis. Deviant genetic and epigenetic patterns, such as DNA methylation, histone modification, and miRNA regulation, can play a role in the development of neurocristopathy. Specifically, epigenetic regulation of miRNA expression and its relationship to cellular interactions and gene activation through major pathways are discussed in the context of Hirschsprung's disease.
Review
Biochemistry & Molecular Biology
Yue Ji, Paul Kwong-Hang Tam, Clara Sze-Man Tang
Summary: The development of the enteric nervous system relies on the interaction between enteric neural crest cells and the neural stem cell niche. Defects in ENCCs may lead to ENS dysfunction. HSCR patients may have niche defects affecting ECM-cell interaction, suggesting the need for complementary therapies involving drugs and niche-based treatments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Yuuki Shikaya, Yuta Takase, Ryosuke Tadokoro, Ryo Nakamura, Masafumi Inaba, Yoshiko Takahashi
Summary: Gut peristaltic movements are crucial for effective transportation and digestion/absorption of ingested materials. The cellular functions underlying these movements along the gut axis during development are largely unexplored. By studying chicken embryonic gut, we found that peristaltic movements start from the posterior duodenum and become confined to specific regions during development. Manipulations of the enteric nervous system disrupted the distribution patterns of peristaltic waves and affected the transportation of ingested material. We also discovered a functional coupling between the hindgut and cloaca.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Seyedeh Sara Esnaashari, Samad Muhammadnejad, Saeid Amanpour, Amir Amani
Article
Integrative & Complementary Medicine
Saieh Hajighasemlou, Mohsen Nikbakht, Saeedreza Pakzad, Samad Muhammadnejad, Safoora Gharibzadeh, Milad Mirmoghtadaei, Fariba Zafari, Iman Seyhoun, Jafar Ai, Javad Verdi
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2020)
Article
Biotechnology & Applied Microbiology
Abolfazl Razzaghdoust, Shahabedin Rahmatizadeh, Bahram Mofid, Samad Muhammadnejad, Mahmoud Parvin, Peyman Mohammadi Torbati, Abbas Basiri
Summary: This study aimed to identify and prioritize candidate antibody-drug conjugate targets across common types of cancer by mining the Human Protein Atlas, resulting in the identification of 23 cell surface proteins with translational potential. These targets have shown promise in clinical trials and have the potential to lead to the development of new clinically effective and safe antibody-drug conjugates.
BIOMED RESEARCH INTERNATIONAL
(2021)
Article
Oncology
N. Ahmadbeigi, S. Alatab, M. Vasei, A. Ranjbar, S. Aghayan, A. Khorsand, K. Moradzadeh, Z. Darvishyan, M. Jamali, S. Muhammadnejad
Summary: The development of chimeric antigen receptor (CAR) T cell therapy for B cell malignancies has revolutionized oncology. Using Raji cell line-derived xenograft models, researchers investigated the behavior of the lymphoma model and proposed outcome measures for CAR T cell studies without requiring imaging techniques.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2021)
Review
Cell Biology
Seyed Mostafa Monzavi, Mahmood Naderi, Naser Ahmadbeigi, Abdol-Mohammad Kajbafzadeh, Samad Muhammadnejad
Summary: Adoptive immunotherapeutic approaches have gradually gained recognition in the list of antiviral therapies for fatal and hard-to-treat viral diseases. These approaches involve inducing and generating viral-specific immune cells for targeting viral particles and infected cells, showing promise as alternative treatments in the context of the SARS-CoV2 pandemic.
CELLULAR IMMUNOLOGY
(2021)
Article
Pharmacology & Pharmacy
Shahrokh Abdolahi, Zeinab Ghazvinian, Samad Muhammadnejad, Mohammad Ahmadvand, Hamid Asadzadeh Aghdaei, Somayeh Ebrahimi-Barough, Jafar Ai, Mohammad Reza Zali, Javad Verdi, Kaveh Baghaei
Summary: This study demonstrated that a combination therapy of ex vivo activated NK cells and anti-PD-1 treatment resulted in tumor growth inhibition and enhanced immune cell infiltration in a xenograft gastric cancer model. The cytotoxic potential of the treated NK cells against gastric cancer cell lines was evaluated through a series of assays, showing promising anti-tumor effects.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
S. R. Hashemi, H. A. Arab, B. Seifi, S. Muhammadnejad
Summary: The study aimed to compare the inhibitory effects of L-arginine and L-citrulline on CsA-induced adverse effects in rats. Results demonstrated that L-citrulline was more effective in inhibiting blood pressure and biochemical changes induced by CsA compared to L-arginine.
HIPERTENSION Y RIESGO VASCULAR
(2021)
Article
Biochemistry & Molecular Biology
Nastaran Moradi, Samad Muhammadnejad, Hamid Delavari, Negin Pournoori, Mohammad Ali Oghabian, Hossein Ghafouri
Summary: The conjugation of anti-CD3 monoclonal antibody with Fe3O4 coated by carboxymethyl dextran (CMD) using cyanogen bromide (CNBr) was shown to efficiently separate CD3+ T lymphocytes from whole blood with high purity. The method can be utilized for cell sorting and targeted MRI imaging in the future.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Obstetrics & Gynecology
Farideh Zafari Zangeneh, Samad Muhammadnejad, Mohammad Mehdi Naghizadeh, Mina Jafarabadi, Maryam Sarmast Shoushtari, Masoumeh Masoumi
Summary: In women with PCOS, the sympathetic nervous system is hyperactive, and clonidine can help modulate this activity. The study showed that clonidine can increase oocyte maturity and pregnancy rate in PCO women, both in vivo and in vitro. These findings have implications for the pharmacological treatment of anovulation and assisted reproductive technology.
JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Oncology
Maryam Behfar, Samad Muhammadnejad, Shahrokh Abdolahi, Rashin Mohseni, Alireza Shoae-Hassani, Seyed Mostafa Monzavi, Amir Ali Himidieh
Summary: This study evaluated the efficacy of adoptive NK-cell transfer as a potential treatment for high-risk WT. The effects of cell source and ex vivo activation strategy on the therapeutic efficacy of NK-cell product were also assessed.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Pharmacology & Pharmacy
Seyed Mostafa Monzavi, Amir Ali Hamidieh, Mohammad Vasei, Jafar Ai, Naser Ahmadbeigi, Hamid Arshadi, Samad Muhammadnejad, Abdol-Mohammad Kajbafzadeh
Summary: This study aimed to investigate the feasibility of isolating WT1-reactive T cells from PBMCs and assess their cytotoxicity against WiTu cells. The results showed higher proportions of WT1-reactive T cells were isolated from Wilms tumor patients compared to healthy donors. WT1-reactive T cells exhibited anti-tumoral activity in a dose-dependent manner and mediated significantly greater cytotoxicity than non-WT1-reactive PBMCs on WT1+ WiTu cells. The cytotoxicity of standard chemotherapy was significantly lower than that of WT1-reactive T cells.
Article
Biochemistry & Molecular Biology
Seyed Mostafa Monzavi, Ahad Muhammadnejad, Maryam Behfar, Amir Arsalan Khorsand, Samad Muhammadnejad, Abdol-Mohammad Kajbafzadeh
Summary: This study reports a serial occurrence of xenogeneic graft-versus-host disease (xGvHD) in consecutive passages of Wilms' tumor patient-derived xenografts (PDX) in severely immunocompromised NOG mice, and discusses potential solutions to prevent such complications.
ANIMAL MODELS AND EXPERIMENTAL MEDICINE
(2022)
Article
Medicine, Research & Experimental
Sanambar Sadighi, Ramezanali Sharifian, Monireh Kazemimanesh, Ahad Muhammadnejad, Zahra Shohosseini, Saeid Amanpour, Samad Muhammadnejad
Summary: The study showed that doxorubicin in neoadjuvant chemotherapy may enhance antitumor immunity through recruitment of TILs and down-regulation of PD-1 and TIM-3 checkpoints. Neoadjuvant chemotherapy containing carboplatin may also suppress PD-1 expression.
IRANIAN JOURNAL OF BASIC MEDICAL SCIENCES
(2021)
Article
Oncology
Sanaz Rismanchi, Pejman Mortazavi, Samad Muhammadnejad
Summary: In dogs, IMC shows similar clinical, pathological, and molecular characteristics to human IBC, making it a promising model for comparative oncology studies. The study found that high Ki67 expression was associated with increased risk of recurrence, suggesting its potential as a prognostic marker in IMC and possibly in human IBC.
TURK ONKOLOJI DERGISI-TURKISH JOURNAL OF ONCOLOGY
(2021)
Article
Pharmacology & Pharmacy
Ghazaleh Ghavami, Samad Muhammadnejad, Saeid Amanpour, Soroush Sardari
IRANIAN JOURNAL OF PHARMACEUTICAL RESEARCH
(2020)