Article
Cell & Tissue Engineering
Kun Wang, Yiyang Wang, Yuanjian Wang, Shujie Liu, Chunyan Wang, Shuo Zhang, Tianli Zhang, Xingsheng Yang
Summary: The study reveals that EIF5A2 positively regulates stemness in ovarian cancer cells through the E2F1/KLF4 pathway, indicating its potential as a target for CSCs-targeted therapy in ovarian cancer.
STEM CELL RESEARCH & THERAPY
(2021)
Article
Medicine, Research & Experimental
Junsuke Uwada, Shoichiro Mukai, Naoki Terada, Hitomi Nakazawa, Mohammad Sayful Islam, Takahiro Nagai, Masato Fujii, Koji Yamasaki, Takanobu Taniguchi, Toshiyuki Kamoto, Takashi Yazawa
Summary: In 3D-cultured prostate cancer cells, probenecid demonstrated pleiotropic effects such as chemosensitization, growth suppression, inhibition of spheroid compaction, and suppression of anchorage-independent growth. Elucidating the detailed mechanism underlying these probenecid actions could result in the identification of novel therapeutic targets toward the advanced prostate cancer.
Article
Medicine, Research & Experimental
Yiping Wen, Yaya Hou, Xiaoqing Yi, Si Sun, Jing Guo, Xiaoqi He, Tao Li, Jing Cai, Zehua Wang
Summary: The study revealed that EZH2 plays a critical role in ovarian cancer stemness and chemo-resistance, with CHK1 being a target involved in CSC stemness regulated by EZH2. Clinical samples showed that high levels of EZH2 and CHK1 were associated with poorer prognosis and increased resistance to platinum drugs in ovarian cancer patients.
Article
Biochemistry & Molecular Biology
Abhilash Nitin Deo, Rahul Thorat, Ajit Chandrakant Dhadve, Abhijit De, Bharat Rekhi, Pritha Ray
Summary: Recurrent metastatic epithelial ovarian cancer (EOC) poses challenges due to treatment limitations, with chemoresistance exacerbating organ-specific metastasis through the IGF1R-alpha 6 integrin-S100A4 molecular network. S100A4 may serve as a potential target for treating recurrent metastatic EOC.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2022)
Article
Oncology
Evgeny Chirshev, Tise Suzuki, Hanmin Wang, Anthony Nguyen, Nozomi Hojo, Linda Sanderman, Saied Mirshahidi, Yevgeniya J. Ioffe, Juli J. Unternaehrer
Summary: Ovarian cancer has a poor prognosis and the loss of microRNA let-7 is associated with poor outcomes. Overexpression of let-7 in patient-derived cells can reduce aggressiveness, inhibit cancer stem cell attributes, and promote cell death, while also increasing sensitivity to PARP inhibitors. This highlights the potential of let-7 as a treatment option for ovarian cancer patients.
Article
Biochemistry & Molecular Biology
Sang-Hoon Yoon, Mi-Rae Bae, Hyeonwoo La, Hyuk Song, Kwonho Hong, Jeong-Tae Do
Summary: This study proposed an efficient method for deriving NSCs from mouse ESCs through a combination of 3D culture for early neural lineage commitment and 2D NSC derivation. The results demonstrated that ESCs could efficiently differentiate into tripotent NSCs through specification in 3D culture followed by 2D culture.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell Biology
Lu Chen, Wujiang Gao, Chunli Sha, Meiling Yang, Li Lin, Taoqiong Li, Hong Wei, Qi Chen, Jie Xing, Mengxue Zhang, Shijie Zhao, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The E3 ligase SIAH1 is decreased in epithelial ovarian cancer (EOC) and negatively correlated with RPS3 levels. Overexpression of SIAH1 can suppress tumor cell growth, invasion, and cisplatin resistance by promoting RPS3 degradation and subsequent NF-kappa B inactivation.
Review
Engineering, Biomedical
Eric N. Horst, Michael E. Bregenzer, Pooja Mehta, Catherine S. Snyder, Taylor Repetto, Yang Yang-Hartwich, Geeta Mehta
Summary: Traditional cancer treatments are often non-specific, limiting efficacy, especially in heterogeneous patient populations. Personalized tumor-specific models offer potential breakthroughs in precision medicine, allowing for tailored therapies based on individual patient characteristics. By analyzing patient biopsies and generating precise 3D models, these personalized cancer models can have significant clinical applications and inform the development of new targeted therapies.
ACTA BIOMATERIALIA
(2021)
Review
Health Care Sciences & Services
Yuuki Shichi, Fujiya Gomi, Norihiko Sasaki, Keisuke Nonaka, Tomio Arai, Toshiyuki Ishiwata
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a difficult-to-diagnose and incurable cancer. Recent studies have found that PDAC cell lines can be divided into epithelial and mesenchymal cell lines, which show differences in morphology, function, and drug effects. Understanding the characteristics of these cell lines may contribute to the development of new anticancer drugs.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Oncology
Taoqiong Li, Li Lin, Qin Liu, Wujiang Gao, Lu Chen, Chunli Sha, Qi Chen, Wenlin Xu, Yuefeng Li, Xiaolan Zhu
Summary: The study revealed that exosomal transfer of miR-429 enhances chemoresistance and proliferation of epithelial ovarian cancer cells. NF-κB promotes miR-429 expression, affecting the calcium-sensing receptor pathway and leading to drug resistance in cells.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Review
Oncology
Chalaithorn Nantasupha, Chanisa Thonusin, Kittipat Charoenkwan, Siriporn Chattipakorn, Nipon Chattipakorn
Summary: Cancer cells show adaptations to their metabolism to facilitate growth, invasiveness, and metastasis. While aerobic glycolysis has been thought to be the dominant energy metabolism in cancer, recent data suggest that oxidative phosphorylation may be more likely in some cancer cells, particularly in epithelial ovarian cancer.
AMERICAN JOURNAL OF TRANSLATIONAL RESEARCH
(2021)
Article
Oncology
Jie Yin, Yiping Wen, Jing Zeng, Yanyan Zhang, Jiayu Chen, Yanmei Zhang, Tiantian Han, Xiaoying Li, Hong Huang, Yan Cai, Ying Jin, Yan Li, Wei Guo, Lingya Pan
Summary: This study aimed to screen and validate biomarkers of ovarian cancer-initiating cells to investigate the recurrence mechanisms of epithelial ovarian cancer. Through proteomics technology, candidate protein CDC50A was identified and validated with significantly differential expression in SP cells, showing characteristics of cancer-initiating cells and correlation with tumor metastasis and clinical prognosis.
Article
Cell Biology
Ying Wang, Chenming Yan, Junxia Qi, Chunyan Liu, Juan Yu, Huabin Wang
Summary: The study found that the downregulation of miR-874-3p in epithelial ovarian cancer cells is associated with cisplatin resistance, and reversing cisplatin resistance and enhancing sensitivity to cisplatin-induced apoptosis can be achieved by targeting XIAP.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2022)
Article
Engineering, Environmental
Wenting Yu, Xiaoxia Su, Moxiao Li, Wanting Wan, Ang Li, Hong Zhou, Feng Xu
Summary: This study investigated the effects of matrix strain on the characteristics and bioactivity of MSC-derived exosomes by culturing PDLSCs in three-dimensional magnetically stretched collagen hydrogels. The results showed that altering the miRNA content in exosomes significantly enhanced their bioactivity, leading to improved repair of bone defects in vivo. This research suggests a novel strategy for promoting tissue regeneration through engineered mechanical microenvironments.
CHEMICAL ENGINEERING JOURNAL
(2021)
Article
Medicine, Research & Experimental
Shruthi Sriramkumar, Riddhi Sood, Thomas D. Huntington, Ahmed H. Ghobashi, Truc T. Vuong, Tara X. Metcalfe, Weini Wang, Kenneth P. Nephew, Heather M. O'Hagan
Summary: This study reveals the impact of platinum-based chemotherapy on metabolic pathways and identifies key targets that can be therapeutically exploited to inhibit platinum-induced enrichment of OCSCs, ultimately improving the survival of OC patients.
JOURNAL OF TRANSLATIONAL MEDICINE
(2022)